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All Journal Medula Jurnal Medika Hutama JK Unila (Jurnal Kedokteran Universitas Lampung) Prosiding Konferensi Nasional PKM-CSR Majority Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Mukhlis Imanto
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Kurkumin Aerosol dengan Media Nasal Spray sebagai Terapi Preventif dan Kuratif Penderita Alzheimer Nabila Rayhan Yasmin; Rr Astri Nur Azizah Utama; Mukhlis Imanto
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

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Abstract

Alzheimer is a neurodegenerative disease which is the third leading cause of death for elderly in the world. Until now, no effective therapeutic management has been found for Alzheimer's patient. Curcumin is known to have powerful antioxidant, anti-inflammatory, and anti-amylogenic properties so it has the potential to prevent and treat Alzheimer's disease. A review of the journals obtained using search engines such as Google Scholar, Proquest, Sciencedirect, NCBI, PubMed, and Springer were conducted with a publication year spanning 2011-2021. The journals obtained are then selected to obtain valid and reliable journals. Then a literature review and article writing are conducted. Curcumin has the ability to inhibit the formation and spread of free radicals, affect the work of macrophages in cleaning β-amyloid plaque, reduce the production of proinflammatory cytokines, and mainly inhibit the accumulation and aggregation of β-amyloid. Curcumin needs to be distributed appropriately in order to have its maximum therapeutic effect. Aerosol-based delivery of curcumin has been shown to deliver most of the therapeutic compounds to the brain without causing systemic toxicity or drug degradation in the liver. The use of nasal spray media can support the delivery of aerosol curcumin via the nasal route because it can transport drugs through the brain more efficiently. Aerosol curcumin with nasal spray device has the potential as a preventive and curative therapy for Alzheimer's disease
Hubungan Perilaku Hidup Bersih dan Sehat Terhadap Otitis Media Supuratif Kronik (OMSK) Mai Rista Nila Sari; Mukhlis Imanto
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

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Chronic suppurative otitis media is a chronic infection in the middle ear with perforation of the tympanic membrane and secretions from the middle ear or intermittent. Watery or thick secretions, clear or pus. Chronic suppurative otitis media is a complication of acute otitis media with perforation of the tympanic membrane more than 2 months and discharge, which if not treatment properly will increase the disease progression. The risk factors for the incidence of otitis media are reliable, especially in the nasopharynx and eustachian tube. Risk factors of chronic suppurative otitis media is host factors, infectious factors, environmental factors, sociodemographic factors, lack of patient knowledge about the disease and patient behavior in daily life. Results of Basic Health Research (Riskesdas) The prevalence of Clean and Healthy Life Style in Indonesian 2011 was still low at 38.7%, compared to the National target until 2013 of 65.0%. This paper aims to determine the relationship between clean and healthy life style with chronic suppurative otitis media.
HUBUNGAN FAKTOR RISIKO DENGAN KEJADIAN OTITIS EKSTERNA DI POLIKLINIK THT-KL RSUD PROVINSI LAMPUNG TAHUN 2019 Tondi Rosalinda Mandalahi; Mukhlis Imanto; Tri Umiana Soleha; Reni Zuraida
MAJORITY Vol 11 No 2 (2023): MAJORITY
Publisher : Majority

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Otitis externa is an inflammation of the outer part of the ear which includes auricle, external audiotory canal, or both. The inflammation can be acute and chronic that ussually caused by bacteria, viral, and fungal infections. The objective of this study was to determine the association between risk factor with otitis externa occurrence in otorhinolaryngology head and neck surgery clinic of RSUD Abdul Moeloek Provinsi Lampung in 2019. This study was an observational analytic study with a case control design. The sample divided into 56 respondents who had otitis externa and 56 respondents who did not have otitis extena. The sample taken using consecutive sampling technique. Data analysis using chi square test (α = 0,05). Respondents who had otitis externa were highest among respondents with history of ear cleaning (62,5%), without history of activity in water (62,5%), and without history of diabetes mellitus (91,1%). The results of chi square analysis indicate an association between history of ear cleaning (p value = 0,001) and activity in water (p value = 0,036) with otitis externa occurrence. While history of diabetes mellitus (p value = 0,500) did not affect otitis externa occurrence. There was an association between history of ear cleaning and activity in water with otitis externa occurrence. While history diabetes mellitus did not affect the otitis externa occurrence.
Co-Authors Aironi Irsyahma Anggraeni Janar Wulan Ari Wahyuni Arilinia Pratiwi Diana Mayasari Dinni Istiqomah Dyah Wulan Sumekar Dyah Wulan Sumekar RW Ety Apriliana Helmi Ismunandar Intan Fajar Ningtyas Intan Nurhaliza Nurhaliza Intanri Kurniati Isnida Shela Arlovi Jhons Fatriyadi Suwandi M. Farhan Rozak Mai Rista Nila Sari Muhammad Yusran Muhartono Muhartono Nabila Rayhan Yasmin Nadia Rosmalia Dewi Nisrina Aulia Amirah Rani Himayani Rasmi Zakiah Oktarlina Reni Zuraida Retno Ariza Rizky Hanriko Rr Astri Nur Azizah Utama Salsabila Dwi Irga Syarif Septia Eva Lusiana TA Larasati Tondi Rosalinda Mandalahi Tri Umiana Soleha Tri Umiana Soleha Wildan Kautsar Irawan Wulan Noventi Yona Arisena Magdalena Silitonga