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All Journal Pharmaciana: Jurnal Kefarmasian Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Pengabdian Pada Masyarakat Health Information : Jurnal Penelitian Jurnal Aisyah : Jurnal Ilmu Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Astrid Feinisa Khairani
Department Of Biomedical Sciences Faculty Of Medicine Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Althea Medical Journal

 1 
Characteristics of Anterior Segment Dysgnesis in Pediatric and Strabismus Ophthalmology Unit at Cicendo Eye Hospital 2012-2014 Ramadanti, Sarah Nurul; Irfani, Irawati; Khairani, Astrid Feinisa
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.069 KB)

Abstract

Background: Developmental anomalies in congenital anomalies cause malformation, such as Anterior Segment Dysgenesis (ASD). Disorder in maturation of anterior segment of the eye occurs in ASD, associated with increased risk of glaucoma. This relation is not supported with enough data about characteristics pediatric patients with ASD in Indonesia. The aim of the study was to describe characteristics ASD in pediatric patient Cicendo Eye Hospital based on patients’ identity, clinical profile and obstetrics profile.Methods: This study used a descriptive method and conducted retrospectively. Data were collected from medical records of patient with ASD in Pediatric Ophthalmology and Strabismus Unit at Cicendo Eye Hospital, from January 2012 to December 2014. This study was conducted from July to November 2015. Total sampling based on inclusion criteria were used in this study. Statistic software was used to analyze data. Results: This study used a descriptive method and conducted retrospectively. Data were collected from medical records of patient with ASD in Pediatric Ophthalmology and Strabismus Unit at Cicendo Eye Hospital, from January 2012 to December 2014. This study was conducted from July to November 2015. Total sampling based on inclusion criteria were used in this study. Statistic software was used to analyze data. Conclusions: Characteristics pediatric patients with ASD at Cicendo Eye Hospital based on patients identity are mostly patients diagnosed in infant age group, from outside Bandung, and mostly boys. Based on clinical profile most diagnosis is congenital glaucoma, bilateral dominantly, and without complication. Based on obstetric profile most patients with ASD were born at term without difficulties. [AMJ.2016;3(4):616–70] DOI: 10.15850/amj.v3n4.948
Characteristics of Anterior Segment Dysgnesis in Pediatric and Strabismus Ophthalmology Unit at Cicendo Eye Hospital 2012-2014 Sarah Nurul Ramadanti; Irawati Irfani; Astrid Feinisa Khairani
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.069 KB)

Abstract

Background: Developmental anomalies in congenital anomalies cause malformation, such as Anterior Segment Dysgenesis (ASD). Disorder in maturation of anterior segment of the eye occurs in ASD, associated with increased risk of glaucoma. This relation is not supported with enough data about characteristics pediatric patients with ASD in Indonesia. The aim of the study was to describe characteristics ASD in pediatric patient Cicendo Eye Hospital based on patients’ identity, clinical profile and obstetrics profile.Methods: This study used a descriptive method and conducted retrospectively. Data were collected from medical records of patient with ASD in Pediatric Ophthalmology and Strabismus Unit at Cicendo Eye Hospital, from January 2012 to December 2014. This study was conducted from July to November 2015. Total sampling based on inclusion criteria were used in this study. Statistic software was used to analyze data. Results: This study used a descriptive method and conducted retrospectively. Data were collected from medical records of patient with ASD in Pediatric Ophthalmology and Strabismus Unit at Cicendo Eye Hospital, from January 2012 to December 2014. This study was conducted from July to November 2015. Total sampling based on inclusion criteria were used in this study. Statistic software was used to analyze data. Conclusions: Characteristics pediatric patients with ASD at Cicendo Eye Hospital based on patients identity are mostly patients diagnosed in infant age group, from outside Bandung, and mostly boys. Based on clinical profile most diagnosis is congenital glaucoma, bilateral dominantly, and without complication. Based on obstetric profile most patients with ASD were born at term without difficulties. [AMJ.2016;3(4):616–70] DOI: 10.15850/amj.v3n4.948
Assessment of Alpha-Tocopheryl Acetate and Metformin Hydrochloride as Independent Agents on Human Dermal Fibroblast Viability: Findings from MTT Assay Alfarafisa, Nayla Majeda; Khairani, Astrid Feinisa; Achadiyani, Achadiyani; Chou, Yoan; Aulia, Fitri; Firdaus, Muhammad Bintang
Althea Medical Journal Vol 12, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.3954

Abstract

Background: Alpha-tocopheryl acetate (Vitamin E) and metformin hydrochloride have been tested as anti-aging compounds at various concentrations. This study aimed to identify the most effective concentrations of alpha-tocopheryl acetate and metformin hydrochloride in promoting the viability of human dermal fibroblasts (HDFs), a primary cell type in skin aging research.Methods: HDFs were isolated using a mechanical isolation method and cultured under standard conditions. Cells were treated with varying concentrations of alpha-tocopheryl acetate and metformin hydrochloride as independents agents. After 48 hours of incubation, cell viability was measured using the MTT assay.Results: Alpha-tocopheryl acetate had the highest HDF cell viability (107%) at a concentration of 50 μM. Metformin hydrochloride had the maximum HDF cell viability (158%) at 5 μM. However, the viability response varied across different concentrations for both agents, indicating that optimal dosing was essential for maximizing their effectiveness.Conclusions: Alpha-tocopheryl acetate at 50 μM and metformin hydrochloride at 50 μM yield the highest viability of HDFs in vitro. These findings suggest potential roles for both agents in anti-aging skin therapies. Further research is recommended to explore their mechanisms of action and to optimize dosing strategies for clinical applications.
Co-Authors Achadiyani Alfarafisa, Nayla Majeda Anjani, Gebby Reviana Apriliani, Ardhia Rizki Arima Kurnia Sari Dewi Nurcahyani Atika Hana Ilyasa Bashari, Muhammad Hasan Chou, Yoan Cynthia Noviyanti Defi Ardia Pramesti Dika Widia Nur Azizah Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dimpuulina Erna Mariati Dini, Dini Dwi Andini Enny Rohmawaty Febriana Kurniasari Firdaus, Muhammad Bintang Fitri Aulia Fitrianti Darusman Hanna Goenawan Hanna Goenawan Hermin Aminah Usman Irawati Irfani Jose Arimathea Julia Windi Gunadi Khafifah, Dinda Salsa Kuheinderan Radha Krishnan Labibah, Salma Nur Lala Yuliani Lantika, Uci Ary Laraswita, Sarah Meinarni, Retno Nadiah, Zahra Nadifah Diana Zalia Naura Mardhiyah Nugraha, Marwan Agung Nur Atik Nurhasanah Nurhasanah Putri Halleyana Putri Halleyana Adrikni Rahman Rahman, Putri Halleyana A Ramadanti, Sarah Nurul Ramdhani, Muhammad Farid Rani Septriana Rani Septrina Ratumanan, Samuel Permana Resti Santika Rika Mustika Risqi Dwi Putra Ronny Lesmana Sarah Nurul Ramadanti Setiawan Silvana Anggreini Rosa Siti Aminah Sobana Sudigdo Adi Sunarjati Sudigdo Adi Sunarjati Sudigdoadi Titing Nurhayati Uci Ary Lantika Umar Islami Unang Supratman Vita Murniati Tarawan Widad Aghnia Shalannandia Widad Aghnia Shalannandia