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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Syntax Literate: Jurnal Ilmiah Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) International Journal Of Science, Technology & Management (IJSTM) Jurnal EduHealth Journal of Health Research Science Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP) Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences.
Wienaldi, Wienaldi
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Journal : Jurnal EduHealth

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Effectiveness Test of Topical Application of Coffee Bean Extract in Accelerating the Wound Healing Process of Incised Wounds on the Dorsal Area of White Rats (Rattus norvegicus) Wistar Strain Chandra, Dody; Nasution, Sri Wahyuni; Wienaldi, Wienaldi
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

This study aimed to evaluate the effectiveness of the topical application of coffee bean extract (Coffea) in accelerating the wound healing process of cut wounds on the backs of Wistar strain white rats (Rattus norvegicus). The research was conducted using an experimental design with a completely randomized design (CRD) consisting of four treatment groups, namely the negative control group (receiving base ointment), the positive control group (receiving antibiotic ointment), and two treatment groups receiving coffee bean extract at concentrations of 1% and 2%. A total of 20 Wistar-strain white rats were used as the research subjects. Cut wounds were created on the backs of the rats using sterile sharp instruments. After the formation of the cut wounds, the treatments were applied topically to the wound area according to the assigned treatment groups. Observations were made periodically for 14 days, and the parameters observed included wound healing time, presence of secondary infection, inflammation, and scar formation. The study showed that topical application of coffee bean extract at concentrations of 1% and 2% significantly accelerated the wound healing process in the Wistar strain white rats. The wound healing time in the treatment groups receiving 1% and 2% coffee bean extract was significantly faster compared to the negative control group (p < 0.05). Still, it did not differ significantly from the positive control group (p > 0.05). Furthermore, the treatment groups receiving coffee bean extract also exhibited a significant reduction in inflammation and secondary infection compared to the negative control group. However, there was no significant difference in scar formation between the treatment and control groups. In conclusion, topical application of 1% and 2% coffee bean extract effectively accelerated the wound healing process of cut wounds on the backs of Wistar strain white rats. This study provides insights into the potential use of coffee bean extract as an alternative therapy for wound healing. However, further research is needed to evaluate the mechanisms of action and possible side effects associated with using coffee bean extract.
Comparison of the Effectiveness of Dermapen Using Trambosit Plasma and Scar Serum Dermapen Actions on Scar Acne Areas on the Skin Surface of Wistar Female Rats (Rattus Norvegicus) Riza Al Djoefri, Mohamad; Wienaldi, Wienaldi; Chailur, Muhammad; Marthin Simbolon, Boyke
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

This study aimed to analyze and compare the effectiveness of the action of dermapen using plasma from platelets with the movement of dermapen using scar serum on pockmarked areas on the skin surface of female Wistar rats (Rattus norvegicus). The results of wound observations based on the period (days) with an average healing time of 10.4 days and 12 days needed by each mouse to close the wound in the PRP dermapen group were faster than the serum scar group. This can be explained by the PRP content containing growth factors important for wound healing and tissue regeneration, thus accelerating healing. Meanwhile, scar serum contains concentrates that are useful for nourishing and moisturizing the skin, which can easily penetrate the deepest layers of the skin, thereby accelerating skin regeneration. Further microscopic studies, such as histopathological studies, are needed to examine the number of fibroblasts.
Co-Authors Adrian Adrian Afni Kartika, Ajeng Angnes, Odri Aulia, Hilda Rafni Balkis, Tiara Br. Sitorus, Irma Yeni Chailur, Muhammad Chandra, Dody Cristoffel, Abraham Darmadi, Suhartina Davin, Radhitya Qowiyyul Edy Fachrial Elisabeth Elisabeth Fioni, Fioni Ginting, Chrismis Novalinda Girsang, Ermi Harta Winata, Jaya Hati Harefa, Lurusan Jonathan Samuel Gultom, Andre Lestari Nasution, Sri Mahani, Yensielia Manalu, Angelia Tesalonika Mawarni Marthin Simbolon, Boyke Napiah Nasution, Ali Nazar Syahputri, Iskandar Oetari, Widyaningsih Pardianto, Gede Purba, Greace Hasianna RAngelin Purba, Rona Riza Al Djoefri, Mohamad Santy Deasy Siregar Sari Mutia, Maya Selviana Barus, Shella Sidabutar, Mitra Juniaty Sinurat, Buenita Siregar, Hernita Sitompul, Fernades Sri Lestari Ramadhani Nasution Suandy, Suandy Suhartina Suhartina, Suhartina Wahyuni Nasution, Sri Widhiasi, Lia Kristiani Willim, Devannie Alberta