Article Per Year (5 Year)
p-Index From 2021 - 2026
1.554
P-Index
This Author published in this journals
All Journal Novum : Jurnal Hukum Akuntabel : Jurnal Ekonomi dan Keuangan JURNAL PENGABDIAN KEPADA MASYARAKAT JKPM (Jurnal Kajian Pendidikan Matematika) Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Masyarakat Mengabdi Nusantara Jurnal Ilmiah Research and Development Student Jurnal Yudistira Dinamika Publik: Jurnal Manajemen dan Administrasi Bisnis Jurnal Ilmiah Ekonomi dan Manajemen Jurnal Praba: Jurnal Rumpun Kesehatan Umum
NURUL KARIMAH
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Comparative Evaluation Of Transdermal Patch Formulations From Ethanol Extract Of Soursop Leaves (Annona Muricata L.) Using Pvp–Ethyl Cellulose And Chitosan Polymer Systems Ernawaty Ginting; Syarifah Nadia; Nilsya Febrika Zebua; Nurul Karimah; Laila Nirwana Sari; Cindy Agustina; Manuella sinaga
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 3 (2026): September : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v4i3.960

Abstract

Background: Soursop leaves (Annona muricata L.) contain bioactive compounds including acetogenins, flavonoids, alkaloids, and tannins, which possess antioxidant, anti-inflammatory, and antitumor activities. Transdermal patch delivery systems offer significant advantages by bypassing hepatic first-pass metabolism, enabling controlled drug release, and improving patient adherence. Two independent formulation strategies were pursued: (1) a hydrophilic–hydrophobic PVP–Ethyl Cellulose (EC) matrix system, and (2) a chitosan-based biopolymer matrix system. Objectives: This study aimed to formulate and comparatively evaluate transdermal patches of soursop leaf ethanol extract using PVP K-30/ethyl cellulose (Study 1) and chitosan (Study 2) as polymer systems, and to determine the optimal formulation for each system based on physicochemical characteristics and in vitro diffusion performance. Methods: Ethanol extracts were prepared by maceration with 96% ethanol. Study 1 evaluated three PVP:EC ratios (F1: 1:1, F2: 1:2, F3: 1:3). Study 2 evaluated three chitosan concentrations (F1: 250 mg/50%, F2: 225 mg/45%, F3: 200 mg/40%). Both systems incorporated PEG 400 as plasticizer and oleic acid as penetration enhancer. Patches were evaluated for organoleptic properties, thickness, pH, folding endurance, and in vitro diffusion using Franz diffusion cells with phosphate buffer pH 7.4, measured by UV-Vis spectrophotometry at 266 nm. Results: Both polymer systems produced patches meeting pharmacopoeial physical requirements. Study 1: pH 5.26–5.47, thickness 0.1 mm, folding endurance >300; optimal formula F3 (PVP:EC = 1:3) achieved the highest cumulative diffusion of 119.087 µg/cm² at 360 min (R² calibration = 0.99909). Study 2: pH 4.30–4.59, thickness 0.35 mm, folding endurance >300; optimal formula F3 (chitosan 40%) achieved the highest cumulative diffusion of 327.44 µg/cm at 360 min with cumulative release of 0.655%. A clear inverse relationship between chitosan concentration and diffusion rate was established. Conclusion: Soursop leaf ethanol extract can be successfully formulated into transdermal patches using both PVP–EC and chitosan polymer systems. The chitosan-based system (F3: 40%) demonstrated superior total drug diffusion, while the PVP–EC system (F3: 1:3) produced a thinner, more uniform patch with controlled diffusion. Both formulations are promising candidates for further in vivo and stability studies.
Co-Authors AA Sudharmawan, AA Ade Anggraini Kartika Devi Afakhrul Masub Bakhtiar Agus Sugiono Ahmad Fatiin Akhmad Muhid Akmal Amaliya Alnamira Alnamira Aminatus Zakhra Annisa Shofiana Asih Kusuma Watie Bahari Bahari Budiyono Budiyono Cindy Agustina Dehli Syah Rizri Ernawaty Ginting Fadhil Musyafa Gunawan Aji Haiffa Nur Nafisah Ilham, Mochamad Iqnatia Alfiansyah Isepputri Laila Nirwana Sari Manuella sinaga Maulida Sarah Azzahra Muhammad Rinzat Iriansyah Muhammad Taufiq Abadi Nilsya Febrika Zebua, Nilsya Febrika Noneng Nurhayani Nur Yasin Nurul Alfiah Pani Akhiruddin Siregar Rena Wulandara Resa Narulita Riska Dwi Amalia Rosa Pitri Selvi Rosdiana Sinta Fatimah SITI AISAH Soffan Rizqi Syahrul Ihsan Syamaidzar Arban Jadid Syarifah Nadia Yunussita Fitri Alifia