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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Abdi Geomedisains Indonesian Journal of Pharmacy and Natural Product Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy
Fadhilah, Arini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Efficacy of Starfruit Leaf Ethanol Extract Gel on Second-Degree Burns in Wistar Rats Pancarani, Amalia Rizky; Fadhilah, Arini
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4338

Abstract

Burn injuries are injures caused by heat, electricity, chemicals, or radiation exposure. Secondary metabolites found in starfruit (Averrhoa carambola) leaves—such as saponins, alkaloids, and flavonoids—have the potential to accelerate the healing of burn wounds. The main objective of this research is to evaluate the effects of a topical gel made from ethanol extract of starfruit leaves at concentrations of 5%, 10%, and 15%, and to determine the most effective concentration for burn wound healing. This study used an experimental method involving 25 Wistar rats, divided into 5 groups. The burn wound model was created by inducing second-degree burns on the rats' backs using a metal disc with a diameter of 2 cm, applied to the skin for 5 seconds. After the burn was induced, the gel was applied topically twice a day for 15 consecutive days. The healing process was observed macroscopically by measuring the percentage of wound closure and using a modified Nagaoka scoring system. The data obtained from this study showed that the ethanol extract gel of starfruit leaves effectively accelerated the healing of second-degree burns. Tukey's test results indicated that the 15% concentration of the gel produced a statistically significant effect compared to the negative control group (p = 0.012), and was identified as the most effective treatment group, with a burn wound healing percentage of 86.15±0.90%, which was noticeably higher than that of the other groups. Based on analysis using wound healing percentage and Nagaoka scores, the optimal concentration was 15% with healing time equivalent to the positive control group.
Co-Authors Abida, Alya Arifah Sri Wahyuni Astuti , Dina Puji Bakhtiar, Muhammad Cita Hanif Muflihah Fauzi Ahmad Muda Haryoto Husada, Dani Fahri Niam, Muhammad Labib Qotrun Ningrum, Nur Faizah Setya Norhikami, Norhikami Oksaputra, Amar Khoiri Pancarani, Amalia Rizky Pratama, Nafik Hafiz Sayekti, Nurul Cahyaning Nardi Wati, Nita Ratna Ziah, Nur Khalida