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All Journal Journal of Food and Pharmaceutical Science VALENSI Microbiology Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kimia dan Kemasan Biopropal Industri MPI (Media Pharmaceutica Indonesiana) Jurnal Kesehatan Bakti Tunas Husada Journal of Pharmacopolium MATAPPA: Jurnal Pengabdian Kepada Masyarakat Media Ilmu Kesehatan Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Kimia dan Kemasan Jurnal Farmasi dan Sains Indonesia (JFSI) Berkala Ilmiah Kimia Farmasi Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Jurnal Pengabdian Pada Masyarakat Prosiding Seminar Nasional Universitas Ma Chung Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Journal of Food and Pharmaceutical Sciences Journal of Scientific Insights Jurnal Farmasi Galenika Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Lina Rahmawati Rizkuloh
Universitas Perjuangan Tasikmalaya
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Pengujian Aktivitas Antioksidan Sediaan Stick Mask Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis): Aktivitas Antioksidan Sediaan Stick Mask Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) Selvia Maslamah Aan; Lina Rahmawati Rizkuloh; Srie Rezeki Nur Endah
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i1.62836

Abstract

The development of the cosmetic industry created many new variations of cosmetic products. One of the beauty products that was developing was a stick mask with the benefit of preventing premature aging. Binahong (A. cordifolia) leaf was one of the plants that had antioxidant activity because of flavonoids that prevent premature aging of the skin. The study aimed to make a stick mask of ethanol extract of binahong (A. cordifolia) leaf and evaluation and test the antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method of the stick mask preparation. The preparation formulation was performed with variations in extract concentration at F0 0%, F1 25%, F2 30%, and F3 35%. Evaluation of the preparation includes organoleptic test, homogeneity, pH, spreadability, adhesives, dry time, and melting point test showed that the preparations met the standard requirements. The antioxidant activity of binahong (A. cordifolia) leaf ethanol extract stick mask in F3 with 35% extract concentration resulted in very strong antioxidant category with IC₅₀ 1,500 μg/mL.   Keywords:  Antioxidant, Binahong leaf (Anredera cordifolia (Ten.) Steenis), DPPH (2,2-diphenyl-1-picrylhydrazyl), Mask
Effect of Soyghurt Fortification with Syzygium myrtifolium Walp. Leaves Extract on Antioxidant Activity Susanti, Susanti; Rizkuloh, Lina Rahmawati; Mardianingrum, Richa
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21223

Abstract

Soyghurt contains antioxidant compounds such as isoflavones which is derived from soybeans as main ingredient for making soyghurt. To increase antioxidant activity, it is necessary to add other antioxidant compounds such as anthocyanins which is found in Syzygium myrtifolium Walp. which also acts as a red pigment. The aim of this study was to determine the effect of adding Syzygium myrtifolium leaf extract to the antioxidant activity of soyghurt. It began with the making of soy milk then fermented with Lactobacillus bulgaricus into soyghurt. Plants were extracted by maceration in ethanol and made a dry extract. The addition of dried extract to soyghurt was carried out in 3 concentrations, 1%, 3% and 5%. The results of antioxidant activity assay using the free radical DPPH scavenging method showed that there was a decrease in the IC50 in soyghurt fortified with extract compared to soyghurt without extract. The higher concentration of extract, the smaller IC50 value. Soyghurt with 5% extract had the smallest IC50 (694.14 g/mL) while the IC50 of soyghurt without extract was 2823.17 g/mL. The conclusion is that fortification of Syzygium myrtifolium leaf extract has an effect on the antioxidant activity of soyghurt.
Effect of Soyghurt Fortification with Syzygium myrtifolium Walp. Leaves Extract on Antioxidant Activity Susanti, Susanti; Rizkuloh, Lina Rahmawati; Mardianingrum, Richa
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21223

Abstract

Soyghurt contains antioxidant compounds such as isoflavones which is derived from soybeans as main ingredient for making soyghurt. To increase antioxidant activity, it is necessary to add other antioxidant compounds such as anthocyanins which is found in Syzygium myrtifolium Walp. which also acts as a red pigment. The aim of this study was to determine the effect of adding Syzygium myrtifolium leaf extract to the antioxidant activity of soyghurt. It began with the making of soy milk then fermented with Lactobacillus bulgaricus into soyghurt. Plants were extracted by maceration in ethanol and made a dry extract. The addition of dried extract to soyghurt was carried out in 3 concentrations, 1%, 3% and 5%. The results of antioxidant activity assay using the free radical DPPH scavenging method showed that there was a decrease in the IC50 in soyghurt fortified with extract compared to soyghurt without extract. The higher concentration of extract, the smaller IC50 value. Soyghurt with 5% extract had the smallest IC50 (694.14 g/mL) while the IC50 of soyghurt without extract was 2823.17 g/mL. The conclusion is that fortification of Syzygium myrtifolium leaf extract has an effect on the antioxidant activity of soyghurt.
Aktivitas Ekstrak Daun Teh Hijau (Camellia sinensis (L.) Kuntze) Terhadap Bakteri Streptococcus Mutans Dengan Perbedaan Tingkat Kepolaran Pelarut Rosalina L.S, Fazrisa; Septiani Agustien, Gina; Rizkuloh, Lina Rahmawati
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.352

Abstract

Oral health is an important aspect that should be considered as part of broader efforts to improve overall health (Ministry of Health of the Republic of Indonesia, 2019). The prevalence of dental issues has increased from 23.3% to 25.9%. One of the major dental problems in Indonesia is dental caries, which is classified as a disease. Research on the activity of green tea leaf extract (Camellia sinensis (L.) Kuntze) from various solvent polarity levels has been conducted. This study aims to identify the activity of green tea leaf extract and its inhibitory effect on the growth of Streptococcus mutans bacteria. The extraction method used in this study was maceration with three solvent polarities: n-hexane (non-polar), ethyl acetate (semi-polar), and ethanol (polar). The extract's ability to inhibit bacteria was tested using the disc diffusion method. The results showed that 96% ethanol at a concentration of 10% had an inhibition zone of 11.02 mm (strong category).
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN ACNE PATCH EKSTRAK ETANOL DAUN CENGKIH (Syzygium aromaticum) TERHADAP BAKTERI Propionibacterium acnes Nurfadilah, Ratna; Rizkuloh, Lina Rahmawati; Nofriyaldi, Ali
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p145-155

Abstract

There are many major problems with the skin, especially the face, that occur in some men and women. Acne is a skin disorder characterized by inflammation of the skin. Acne caused by Propionibacterium acnes bacteria is generally treated by Clindamycin capsules 300 g. However, the drug clyndamicin used by the oral route has side effects. So, there are alternative anti-acne drugs that have fewer side effects. Clove leaves from the clove tree can be used as medicine. The tannin compounds in clove leaves have antibacterial activity. In this research method, an acne patch preparation is made from clove leaf extract (includes collecting the ingredients to be tested, namely clove leaves, processing simplicia, making extracts, making acne patch formulations, and testing the antibacterial activity of Propionibacterium acnes using the well method. The results of the highest inhibition large, namely at F3 (10%) at 21,213mm very strong, F2 (7.5%) at 19,658mm strong and F1 (5%) at 18,788mm strong.  
AKTIVITAS ANTIOKSIDAN SERUM WAJAH BERBASIS EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) SEBAGAI PRODUK KOSMETIK ALAMI Anisa Dhea, Octavia; Lina Rahmawati, Rizkuloh; Salsabila, Adlina
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2253

Abstract

Ekstrak etanol daun sukun (Artocarpus altilis) berpotensi menjadi sumber antioksidan alami untuk mengatasi masalah penuaan dini dan kerusakan kulit akibat radikal bebas. Penelitian ini bertujuan mengembangkan formulasi serum wajah berbahan dasar ekstrak daun sukun dan mengevaluasi aktivitas antioksidannya. Pembuatan ekstrak dilakukan dengan metode maserasi dengan perbandingan simplisia terhadap pelarut sebesar 1:10. Simplisia direndam dalam wadah tertutup dengan penggantian pelarut secara bertahap setiap 24 jam selama 3 hari pada suhu 500C, lalu dilakukan skrining fitokimia pada ekstrak yang mengkonfirmasi keberadaan senyawa flavonoid serta tanin. Sediaan serum wajah dibuat menggunakan seri konsentrasi ekstrak 0% (F0), 0,25% (F1), 0,5% (F2), dan 0,75% (F3). Hasil uji evaluasi fisik semua sediaan homogen, daya sebarnya berada di rentang 5,0-7,0 cm, nilai pH di rentang 6,9-8,0, serta nilai viskositas berada pada rentang 2000-5000 mPa.S.  Pengujian aktivitas antioksidan menggunakan metode DPPH menghasilkan angka IC₅₀ 44,14 ppm (F0), 27,80 ppm (F1), 16,73 ppm (F2), dan 4,08 ppm (F3), yang tergolong sangat kuat. Sehingga berpotensi sebagai alternatif bahan aktif dalam produk perawatan kulit berbasis bahan alami.
Efektivitas Larvasida Ekstrak Etanol Bunga Kecombrang (Etlingera elaitor) dan Daun Jambu Biji (Psidium guajava) terhadap Mortalitas Larva Aedes aegypti Bachtiar, Kamiel Roesman; Rizkuloh, Lina Rahmawati; Susanti, Susanti; Nur Endah, Srie Rezeki
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.3421

Abstract

Berbagai jenis tanaman di Indonesia telah diketahui mengandung senyawa bioaktif yang dapat dimanfaatkan sebagai biopestisida. DIantaranya adalah bunga kecombrang dan daun jambu biji yang dapat berfungsi sebagai larvasida. Tujuan dari penelitian ini adalah mengetahui efektivitas campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap mortalitas larva Aedes aegypti. Objek dalam penelitian ini adalah semua larva Aedes aegypti instar III yang berumur 3-4 hari Sampel total yang digunakan pada penelitian ini sebanyak 280 larva, yang di tentukan dengan teknik Purposive Sampling. Hasil penelitian menunjukkan ada pengaruh campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap kematian larva nyamuk Aedes aegypti. Semakin tinggi konsentrasi ekstrak bunga kecombrang dan daun jambu biji yang diberikan, semakin banyak pula terjadinya kematian pada larva Aedes aegypti. Angka kematian tertinggi sebesar 90% dengan label konsentrasi uji 5 pada konsentrasi 5000 ppm (komposisi 1250 ppm ekstrak bunga kecombrang dan 3.750 ppm ekstrak daun jambu biji). Hasil analisis probit menunjukkan nilai LC50 pada larva Aedes aegypti untuk formula campuran ekstrak bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidi guajava L.) adalah pada konsentrasi 2567,83 ppm
Papain-like Protease Peptides as Construction Material for the SARS-CoV-2 Vaccine Design Candidate: In-silico Study Mardianingrum, Richa; Pertiwi, Nur Ihsani; Rizkuloh, Lina Rahmawati; Ikram, Nur Kusaira Khairul; Ruswanto, Ruswanto
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.42748

Abstract

COVID-19 remains a major global health threat. In addition to implementing health protocols and consuming supplements, proactive prevention strategies are essential to limit the spread of the virus. One of the most promising approaches is the use of vaccines, particularly peptide-based vaccines, which are under active development. This study aimed to design a peptide vaccine derived from the SARS-CoV-2 papain-like protease (PLpro) and evaluate its interaction with key components of the human immune system, namely Toll-like receptor 3 (TLR3), major histocompatibility complex class I (MHC-I), and class II (MHC-II). The research employed an immunoinformatics approach utilizing NetCTL, IEDB Tepitool, PEP-FOLD3, trRosetta, HDOCK, GalaxyRefine2, and other molecular modeling tools. The designed vaccine construct was visualized in 3D using trRosetta and validated through ERRAT2, achieving a 100% quality score, indicating excellent structural integrity. The docking simulations demonstrated stable interactions between the vaccine and the immune receptors, suggesting strong immunogenic potential. In conclusion, the in silico-designed peptide vaccine based on SARS-CoV-2 PLpro shows promise in triggering immune responses through stable binding with TLR3, MHC-I, and MHC-II, highlighting its potential as a candidate for further experimental validation in COVID-19 vaccine development.
Co-Authors Anindita Trikusuma Pratita Anisa Dhea, Octavia Anna Yuliana, Anna Bachtiar, Kamiel Roesman Depa Sanjaya Elis Nurul Ikhlas Fathurohman, Mochamad Gina Septiani Agustien Hilman Fitriaji S P Ikram, Nur Kusaira Khairul Ira Rahmiyani Kamiel Roesman Bachtiar Kamiel Roesman Bachtiar Khofi Siti Mukhaufillah Marlia Singgih Nitya Nurul Fadilah Nofriyaldi, Ali Nurfadilah, Ratna Nurul Halimah Amimi Pertiwi, Nur Ihsani Richa Mardianingrum Risa Delpia Rofi, Uyep Muhamad Rosalina L.S, Fazrisa Ruswanto, Ruswanto Salsabila Adlina Salsabila, Adlina Selvia Maslamah Aan Septiani Agustien, Gina Slamet Ibrahim Srie Rezeki Nur Endah SUSANTI Susanti Susanti Susanti Susanti Windi Susi Indryani