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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia JOURNAL LA MEDIHEALTICO Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal MedScientiae Jurnal Kedokteran Meditek
Lili Legiawati
Department Of Dermatology & Venereology, Faculty Of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Markedly clinical improvement of papulopustular rosacea with multimodality therapeutic approach: a case report Priyanto, Mufqi Handaru; Wardani, Amanda Nandi; Legiawati, Lili; Sitohang, Irma Bernadette Simbolon; Suseno, Lis Surachmiati
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/85p5m842

Abstract

Introduction: Rosacea is a chronic inflammatory skin disease that mainly affects the central area of the face. There are four subtypes, and they may progress between subtypes or span multiple subtypes. Due to its long course of the disease, optimum treatments are needed to control the disease progression. Case: We reported rapid improvement of combining topical metronidazole, doxycycline, and light emitting diode for treating a patient with papulopustular rosacea in a 44-years-old woman, a week from the initial therapy. Discussion: Therapeutic approaches to rosacea mainly focus on controlling the symptoms with anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative or an adjuvant therapy to conventional treatment through their synergic mechanism between therapeutic modalities. Conclusions: This combination treatment may be effective for treating papulopustular rosacea without any side effects.
Inhibitor Transient Receptor Potential Vanilloid Type 1: Penggunaan Topikal pada Berbagai Dermatosis Muhammad, Parikesit; Paramitha Wibawa, Larisa; Keumala Budianti, Windy; Legiawati, Lili; Menaldi, Sri Linuwih; Rosdiana, Dewi Selvina
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3179

Abstract

Transient receptor potential vanilloid type 1 (TRPV1) plays an important role in the pathophysiology of pruritus and pain. TRPV1 inhibitors can reduce the sensation of itching and pain by blocking nociceptive signals from peripheral nerve fibers to the central nervous system. Topical TRPV1 inhibitors is also thought to improve skin barrier function. Therefore, TRPV1 inhibitors are considered as potential therapy in various dermatoses. Topical TRPV1 inhibitors that are currently being studied are asivatrep for atopic dermatitis and trans-4-tert-butylcyclohexanol for various dermatoses associated with sensitive skin. Further studies with better quality and longer duration are needed to assess the efficacy and safety profile of TRPV1 inhibitors.
Skrining pada Kanker Kulit Chairista, Inadia Putri; Paramitha, Larisa; Sampurna, Adhimukti T; Krisanti, RR Inge Ade; Wahyudi, Danang T; Hoemardani, Aida SD; Sujudi, Yufanti; Legiawati, Lili
Media Dermato-Venereologica Indonesiana Vol 51 No 3 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i3.423

Abstract

Tingginya insiden, prevalensi, morbiditas, dan mortalitas kanker kulit telah menjadi permasalahan kesehatan masyarakat di seluruh dunia. Skrining kanker kulit dilakukan sebagai salah satu upaya dalam mengurangi beban kanker kulit yang ditimbulkan. Skrining kanker kulit meliputi total body skin examination yang bersifat non-invasif, mudah, cepat, dan hemat biaya bila dibandingkan dengan skrining untuk kanker lainnya. Akan tetapi, efektivitas skrining kanker kulit pada tingkat populasi masih diperdebatkan. Tenaga kesehatan, khususnya dokter spesialis kulit berperan penting dalam pelayanan skrining kanker kulit. Pengetahuan lebih lanjut mengenai skrining kanker kulit, rekomendasi, dan berbagai teknik pendekatan diagnostik sangat diperlukan untuk memajukan program skrining kanker kulit. 
Herpes Zoster dengan Manifestasi Eritema Multiforme Bulosa pada Pasien Geriatri Imunokompromais: Laporan Kasus Halim, Dionisius Ivan Yonathan; Legiawati, Lili; Yusharyahya, Shannaz Nadia; Astriningrum, Rinadewi
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.531

Abstract

   Pendahuluan: Herpes zoster (HZ) merupakan sekumpulan gejala dan manifestasi klinis yang disebabkan oleh reaktivasi varicella-zoster virus (VZV). Faktor predisposisinya antara lain: usia lanjut, keadaan imunokompromi, obat imunosupresif, keganasan, stres psikologis, trauma, dan tindakan pembedahan. Manifestasinya bervariasi, namun manifestasi eritema multiforme (EM) bulosa jarang dilaporkan. Kasus: Seorang perempuan berusia 65 tahun mengeluhkan bercak gatal pada kedua lengan dan tungkai sejak 3 hari yang lalu. Pasien sedang menjalani kemoterapi atas indikasi kanker payudara metastasis tulang dengan multikomorbid. Pada pemeriksaan ditemukan lesi target tipikal EM yang beberapa berkembang menjadi EM bulosa. Terdapat riwayat demam. Pasien ditatalaksana dengan kortikosteroid serta terapi simptomatik. Satu minggu kemudian ditemukan lenting berkelompok di lengan kiri atas sampai ke leher kiri sesuai dermatom C4 dan C7 yang disertai rasa nyeri dan terbakar. Kortikosteroid dihentikan dan diobati dengan valasiklovir 3 x 1000 mg selama 10 hari dan terapi simptomatik. Setelah 2 minggu terdapat perbaikan klinis dan gejala. Diskusi: Kasus HZ aberans dengan manifestasi EM bulosa dapat terjadi pada individu dengan komorbid dan keadaan imunokompromi. Pada pasien ini terdapat usia lanjut riwayat kanker payudara, obat kemoterapi, serta komplikasi infeksi sekunder pasca tindakan pembedahan. Manifestasi HZ mirip dengan EM minor karena ditemukannya lesi target tipikal pada kedua ekstremitas tanpa lesi mukosa. Perubahan perjalanan penyakit menjadi vesikel berkelompok sesuai dermatom, kemungkinan HZ aberans lebih dipertimbangkan. Kesimpulan: Herpes zoster dapat menimbulkan manifestasi EM. Terapi dengan obat antiviral menunjukkan perbaikan baik klinis maupun gejala. Kemungkinan manifestasi EM pada HZ harus dipertimbangkan untuk diagnosis dini dan tatalaksana efektif.
Perbaikan Klinis Green Nail Syndrome yang Signifikan pada Lanjut Usia dengan Terapi Kombinasi: Sebuah Serial Kasus Marizki Ramadhani, Reinanda; Nadia Yusharyahya, Shannaz; Legiawati, Lili; Astriningrum, Rinadewi; Gunardi, Keiko Yolanda; Reshinta, Reisa
Jurnal Kedokteran Meditek Vol 31 No 2 (2025): MARCH
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i2.3383

Abstract

Introduction: Green nail syndrome is a common bacterial infection of the nails and is characterized by green discolouration of the nail plate caused by Pseudomonas aeruginosa. It frequently occurs in people who are exposed to constant water and due to mechanical trauma, especially in elderly patients. Case Illustration: We reported 2 cases treated with a combination therapy of oral ciprofloxacin, 1% acetic acid dressing, gentamicin ointment and showed a significant clinical improvement. There are two cases: a 67-year-old man and a 64-year-old woman complained of black-greenish discolouration on his right big toenail, which has been accompanied by changes in the shape of the nail for 3 months. Both patients have a history of frequent and prolonged contact with water—dermoscopy results in greenish-black discolouration in the nail plate.  The culture results of both patients, Pseudomonas aeruginosa was found. Combination treatment showed significant clinical improvement in both patients. Discussion: Dressing of 1% acetic acid was useful as an adjuvant to improve the ointment penetration, inhibiting the formation of Pseudomonas aeruginosa biofilms. Gentamicin and ciprofloxacin are effective against aerobic gram-negative bacterial infections, such as Pseudomonas aeruginosa. Conclusion: The use of ciprofloxacin is recommended, especially in elderly patients. Combination therapy with oral ciprofloxacin, 1% acetic acid dressing, and gentamicin ointment is an effective option for patients with green nail syndrome
MICRO AND NANO-AUTOLOGOUS FAT TRANSFER UNTUK TATA LAKSANA LIPODISTROFI WAJAH PADA LUPUS ERITEMATOSUS SISTEMIK Batubara, Irwan Saputra; Suseno, Lis Surachmiati; Sitohang, Irma Bernadette; Legiawati, Lili
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.404

Abstract

Introduction: Lipodystrophy in systemic lupus erythematosus (SLE) causes deformity and psychological problem for patients. The recommended treatment is autologous fat transfer (AFT) because of its effectiveness. Case: A 19-year-old woman with facial lipodystrophy due to SLE was treated with AFT. Fat tissue was aspirated from the lateral side of the left thigh and then processed into microfat and nanofat using the Luer-Lok connectors. The total volume of fat injected was 28 mL with a significant improvement of skin contour. She was satisfied with the results. There were no postoperative complications. She is still under monitoring for the next six months to assess AFT retention. Discussion: There are various modifications of the AFT technique to improve outcomes and avoid complications. Microfat aims to fill the volume loss, whereas nanofat is beneficial to improve skin contours. The main drawback of AFT is the unpredictable retention of fat volume. Patient factors, fat processing methods, and AFT technique play a role in post-AFT retention. Although extremely rare, fat embolization can occur during AFT which can be fatal. Injection with a blunt cannula, use of vasoconstrictors, and mapping of facial vascularization may reduce the risk of fat embolization. Conclusion: Autologous fat transfer is recommended for lipodystrophy because it is easy to perform, inexpensive, and non-immunogenic. Dermato-venereologists have an important role in the management of lipodystrophy due to SLE.
Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study Yusharyahya, Shannaz Nadia; Legiawati, Lili; Astriningrum, Rinadewi; Jonlean, Reganedgary; Andhira, Vega
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237092

Abstract

BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia. METHODS This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline. RESULTS 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden. CONCLUSIONS No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.
Telogen effluvium incidence in women wearing hijab compared to non-hijab: A cross-sectional study Sirait, Sondang Pandjaitan; Widaty, Sandra; Legiawati, Lili; Surachmiati Suseno, Lis; Krisanti, Roro Inge Ade; Budianti, Windy Keumala; Miranda, Eliza; Rihatmadja, Rahadi; Oktarina, Caroline; Pandelaki, Paulus Anung Anindita; Situmeang, Irhen
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Hair loss is a normal experience, but if the amount of hair loss exceeds what is considered normal, it will usually cause anxiety for the patient. In Indonesia, almost every Muslim woman wears a hijab. The hijab is one of many factors believed to cause hair loss. Telogen effluvium (TE) itself is a hair cycle disorder in which the anagen phase terminates prematurely, resulting in diffuse club hair loss without scarring, and TE itself has many risk factors. The purpose of this study was to determine the relationship between the incidence of TE in women who wear hijabs and those who do not. Methods: This cross-sectional study was conducted from August 2019 to April 2021 involving 188 healthy women aged 18 years and over who had not yet reached menopause. In the hijab group, it was determined that they should wear a minimum of 8 hours a day for at least 5 years. The test was carried out on hair that had not been washed using a trichogram, to look for hair characteristics in each group (hijab-wearing and non-hijab-wearing). Analysis of the data obtained was carried out using the Chi-square test and odds ratio. Results: Telogen effluvium was higher in subjects wearing hijab (26.8%) than in subjects who did not wear hijab (18.1%), (p-value 0.040, OR 2.036). Conclusion: There was a significant relationship between TE in women who wear hijab compared to those who do not. Further studies should be conducted in other populations with a larger sample size to confirm these results.
PITYRIASIS LICHENOIDES PASCA VAKSINASI mRNA COVID-19 Laurensia, Riani; Nadia Yusharyahya, Shannaz; Legiawati, Lili; Astriningrum, Rinadewi; Rihatmadja, Rahadi; Andrianus, Kenny
Media Dermato-Venereologica Indonesiana Vol 53 No 1 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i1.514

Abstract

   Pendahuluan: Pityriasis lichenoides (PL) merupakan spektrum kelainan kulit yang tumpang tindih secara klinis maupun histopatologis dengan dua bentuk utama yaitu pityriasis lichenoides et varioliformis acuta (PLEVA) dan pityriasis lichenoides chronica (PLC). Sekitar 20% PL terjadi pada anak-anak dan dewasa muda. Beberapa publikasi ilmiah melaporkan PL pascavaksinasi coronavirus disease (COVID-19). Kasus: Seorang laki-laki, 64 tahun didiagnosis PL, 4 hari pascavaksinasi COVID-19 booster pertama Pfizer® sejak 14 bulan lalu. Pemeriksaan dermoskopi ditemukan dotted vessels, yellowish-orange structureless area, vesicles with red background. Pemeriksaan laboratorium didapatkan peningkatan D-dimer 490 mG/L dan IgE 730 IU/ml. Pemeriksaan histopatologi kulit sesuai PLEVA, ditemukannya eosinofil dipertimbangkan sebagai hipersensitivitas vaksin. Perbaikan klinis signifikan tercapai dengan terapi metilprednisolon setara prednison 0.5 mg/kgBB dan doksisiklin selama 2 minggu. Diskusi: : Patogenesis PL disebabkan oleh peningkatan kompleks imun, deposit IgM, dan C3 pada vaskular taut dermo-epidermal, serta kumpulan sel sitotoksik pada dermis dan epidermis yang berkorelasi dengan hipersensitivitas tipe lambat terhadap bahan vaksin. Pemeriksaan histopatologi membantu menegakkan diagnosis. Terapi kortikosteroid dan doksisiklin memberikan respon terapi dan luaran klinis yang baik pada P. Simpulan: Kasus PL pascavaksinasi Pfizer® COVID-19, perbaikan klinis dengan terapi kortikosteroid dan doksisiklin, serta pentingnya mengawasi efek samping pascavaksinasi, pemeriksaan klinis dan evaluasi histopatologi penting dalam penegakan diagnosis.
Co-Authors Adistri, Kara Andhira, Vega Andrianus, Kenny Astriningrum, Rinadewi Barros, Terlinda Batubara, Irwan Bianti, Marsha Chairista, Inadia Putri Chandrakesuma, Vivianne Eliza Miranda Endi Novianto Evita H. Effendi Fauziah, Siti Nurani Fifi Mifta Huda Gunardi, Keiko Yolanda Halim, Dionisius Ivan Yonathan Hartanto, David Dwiadiputra Hoemardani, Aida SD Huda, Fifi Mifta Imelda Wihadi Indah Widyasari Irawan, Yudo Jonlean, Reganedgary Keumala Budianti, Windy Krisanti, Roro Inge Ade Krisanti, RR Inge Ade Kusmarinah Bramono Kusumawardhani, Dina Larisa Paramitha Laurensia, Riani Marizki Ramadhani, Reinanda Marsha Bianti Melody Febriana Andardewi Muhammad, Parikesit Nadia Yusharyahya, Shannaz Nadia, Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital Jakarta, Indonesia Shannaz, Yusharyahya Nugraheni Pasaribu, Uly Aanda Maria Oktarina, Caroline Pandelaki, Paulus Anung Anindita Priyanto, Mufqi Handaru Rahadi Rihatmadja Rahadi Rihatmadja Reshinta, Reisa Rheza, Agung Mohamad Rinadewi Astriningrum Rosdiana, Dewi Selvina Sampurna, Adhimukti T Sandra Widaty Shannaz Nadia Yusharyahya Sirait, Sondang Panjaitan Siskawati, Yulia Siti Nurani Fauziah Sitohang, Irma Bernadette Sitohang, Irma Bernadette Simbolon Situmeang, Irhen Sondang P Sirait Sri Adi Sularsito Sri Adi Sularsito Sri Adi Sularsito Sri L. Menaldi Sujudi, Yufanti Surachmiati Suseno, Lis Suseno, Lis Surachmiati Terlinda Barros Vivianne Chandrakesuma Wahyudi, Danang T Wardani, Amanda Nandi Widyasari, Indah Wihadi, Imelda Windy Keumala Budianti Wresti Indriatmi B. Makes Yudo Irawan Yudo Irawan