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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JOURNAL LA MEDIHEALTICO eJournal Kedokteran Indonesia Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal MedScientiae Jurnal Kedokteran Meditek
Lili Legiawati
Department Of Dermatology & Venereology, Faculty Of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Centella asiatica : alternative dry skin therapy in type 2 diabetes mellitus Lili Legiawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 3 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.061 KB) | DOI: 10.19106/JMedSci005303202108

Abstract

Diabetes mellitus (DM) in Indonesia has rapidly increased during recent years. World Health Organization (WHO) predicted that in 2030, Indonesia would be ranked fourth for the largest DM patients in the world. As the disease progresses, uncontrolled type 2 DM (T2DM) results in dry skin as the most prevalent skin disorder. Despite the prevalence and morbidities that lead to infection, ulcer, gangrene that can lead to amputation when insufficiently treated, dry skin in T2DM has limited therapeutic options. Currently, available therapies for dry skin in T2DM have not considered factors of hyperglycemia and hyperinsulinemia, which disturb skin homeostasis. Nonetheless, in T2DM, there are neuropathy and biostructural changes of the skin which induce dry skin. Alternative herbal medicine, Centella asiatica is getting well-known nowadays because of its vast amount of benefits. Centella asiatica has been studied for its antioxidant, antidiabetic, anti-inflammation, antiglycation, and neuroprotective activities. Furtherly, these properties may display benefits when introduced to T2DM dry skin therapy. The previous clinical study had shown that topical C. asiatica improved dry skin. This clinical study was also supported by in vitro studies. Currently, pharmacological profile studies of C. asiatica including dosage, toxicity, and safety have been available. This article aimed to review the current literature on the potential of C. asiatica as an alternative to treat dry skin in T2DM.
Development of a Questionnaire Evaluating the Knowledge, Attitude, and Practice on Geriatric Dermatology among Elderly Caregivers Shannaz Nadia Yusharyahya; Valdi Ven Japranata; Christine Lieana; Lili Legiawati; Rinadewi Astriningrum; Wresti Indriatmi
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.228.228-37

Abstract

Information concerning the extent of knowledge, attitude, and practice of elderly caregivers about dermatological care are still limited. This present study aimed to develop a tool with decent validity and reliability to delineate such profiles. A questionnaire was designed by geriatric dermatology experts, followed by content validation and reliability tests using Aiken’s V coefficient, Kuder-Richardson Formula 20 (KR-20) or Cronbach’s α, and Pearson’s correlation. The developed instrument was tested on elderly caregivers, before and after education. Obtained data were analyzed using appropriate inferential statistics. We found that the Aiken’s V coefficient for each item was ≥0.70; KR-20 in knowledge section was 0.81; Cronbach’s α in attitude and practice section were 0.81 and 0.80, respectively; and Pearson’s correlation in all sections was above 0.80. Significant disparities were observed in the initial knowledge (p=0.005) and attitude (p=0.020) based on academic levels. In addition, overall scores generally increased upon education (p<0.001). Therefore, the questionnaire is valid and reliable for assessing elderly caregivers' competencies in geriatric dermatology of which could be improved by education.
Characteristic of Skin Diseases in Two Public Boarding Schools Occupantsin West Java 2018 Sandra Widaty; Joses Saputra; Novita Suprapto; Joanne Natasha; Mochamad H Azis; Dewi Lestarini; Lili Legiawati; Lis Surachmiati; Yudo Irawan
eJournal Kedokteran Indonesia Vol 11, No. 1 - April 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.217.14

Abstract

Skin diseases are among the most common diseases found in developing countries, and it is very commonly encountered especially in children living in groups. This study aimed to identify the ten most common skin diseases in two public boarding schools in West Java and the environmental factors that influence them. This study was part of large scabies and pediculosis study in two public boarding schools on 2018 in West Java. Diagnosis was made through history taking and physical examination using Deskabâ instrument. The results showed that 93% of children had skin diseases. Skin diseases were found to be higher in girls (94.5%) than in boys (91.1%), but no significant differences (p= 0.08) were obtained. The most common skin diseases were pediculosis (50.14%), scabies (40.51%), dermatitis (8.15%), dermatophytosis (6.6%), insect bite hypersensitivity (6.18%), post-inflammatory hypo/hyperpigmentation (4.92%), acne vulgaris (3.51%), miliaria (3.37%), xerosis cutis (2.25%), and folliculitis (1.83%). Some environmental factors might influence the incidence of infectious skin diseases in public boarding schools, such as open-space areas, the number of bedrooms, and the number of individuals occupying each bedroom.
Atypical mycobacterial infection mimicking carbuncle in an elderly patient: A case report Barros, Terlinda; Legiawati, Lili; Yusharyahya, Shannaz Nadia; Sularsito, Sri Adi; Wihadi, Imelda
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Atypical mycobacterium infection occurs under certain skin conditions, namely the disruption of skin integrity and mucous membranes accompanied by the reduction of cellular immunity. However, atypical mycobacterial infection in elderly patients is rarely reported. Case: A 64 years old male patient, complained of red lumps on the upper-backfor a month, accompanied by mild fever and minimal pain. Three months before, the patient had accupuncture on the neck and upper back. Physical examination showed multiple miliar to lenticular sized papules and pustules on an erythematous-violaceus base with hard and immobile palpable nodes and infiltrate. After clinical and laboratory workup, the patient was diagnosed withcarbuncle with Candida spp colonization. The treatment consisted of systemicantibiotics and topical antifungals. There was no clinical improvement after 3 weeks. Histopathology and laboratory results suggested atypical mycobacterium infection. Discussion: Atypical mycobacterium infection should be considered in elderly patients with skin and soft tissue infections that show no clinical improvement tostandard therapy.
Atopic dermatitis in the elderly Irawan, Yudo; Rihatmadja, Rahadi; Legiawati, Lili; Yusharyahya, Shannaz Nadia; Sularsito, Sri Adi
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Atopic dermatitis (AD) is a recurrent skin inflammation accompanied by itching. The incidence of AD is increasing worldwide. AD, which persists until elderly or with an onset during elderly, is known as senile AD. It has different prevalence and clinical features from other AD stages. Senile atopic dermatitis affects males more than females, which is different from other stages of AD. Skin manifestation of senile AD is similar with the adult stage of Hanifin-Rajka criteria, but can be atypical. The typical feature of senile AD is eczematous dermatitis around a free-lesion fossa. Other common clinical manifestations are erythroderma and non- specific chronic dermatitis. In the management of senile AD, changes related to aging process should be considered. Management of senile AD is complex, involves combined pharmacological treatment consists of topical and systemic agents, and non pharmacological aspects. Appropriate treatment considering effectiveness and safety will improve the quality of life of patients with senile AD.
Atypical mycobacterial infection resembles sporotrichosis in elderly patient Fauziah, Siti Nurani; Legiawati, Lili; Sularsito, Sri Adi; Yusharyahya, Shannaz Nadia; Rihatmadja, Rahadi; Sirait, Sondang P.; Huda, Fifi Mifta; Widyasari, Indah
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Atypical mycobacterial (AM) infection is caused by Mycobacterium species other than M.tuberculosis. AM skin infection has clinical manifestations that resemble M. tuberculosis infection and deep fungal infection. Laboratory workup is necessary to confirm the diagnosis. An 83-year old female came with a painful lump and swelling on her right lower extremity since three months before admission. Physical examination revealed a plaque consisting, of multiple erythematous and hyperpigmented papules and nodules, diffuse erythematous lesion, and shallow ulcers partially covered with pus and crust. Histopathological features showed tuberculoid granuloma. Direct test and periodic acid-Schiff (PAS) staining of the skin biopsy found no fungal element nor acid-fast bacilli (AFB). Culture and polymerase chain reaction (PCR)of M. tuberculosis were negative. The working diagnosis was atypical mycobacterial infection and treatment with 450 mg rifampicin and 100 mg minocycline daily were administered accordingly. In two months observation following the treatment, the pain was no longer exist, the ulcers were completely healed, and some nodules were in the process of healing Among other Mycobacterium spp, M.marinum is the most common cause of AM infrections. Clinical manifestation of M. marinum infection may present as solitary or multiple nodules on the hands, feet, elbows and knees with sporotrichoid spreading  patern. The diagnosis of AM was established based on clinical and laboratory examination. The diagnosis was also confirmed by good clinical response to minocycline and rifampicin.
Photodermatoses in Children Fauziah, Siti Nurani; Indriatmi, Wresti; Legiawati, Lili
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Photodermatoses cover the skin’s abnormal reactions to sunlight, usually to its ultraviolet (UV) component or visible light. Etiologically, photodermatoses can be classified into 4 categories:  (1) immunologically mediated photodermatoses (idiopathic photodermatoses); (2) drug- or chemical-induced photosensitivity; (3) hereditary photodermatoses; and (4) photoaggravated dermatoses. The incidence of photodermatoses in the pediatric population is much lower than in adults, Polymorphous light eruption (PMLE) is the most common form of photodermatoses in children, followed by erythropoietic protoporphyria. Early diagnosis and investigations should be performed to avoid long-term complications. Photoprotection is the mainstay of photodermatoses management, including use of physical protection and sunscreen.
Efficacy of low level laser therapy in the treatment of postherpetic neuralgia Legiawati, Lili; Bianti, Marsha
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) and defined as pain that persists for more than 90 days after the onset of HZ rash. The chronic pain of PHN is debilitating and often associated with significant morbidity. It is a neuropathic pain and manifests as allodynia, hyperalgesia, or spontaneous pain. Although it is not considered to be life-threatening, sometime HZ is inadequately treated and may result in more severe PHN. Various treatment protocols for PHN are available; however, the result remains unsatisfactorily. The use of low level laser therapy (LLLT) in pain management is relatively new and is used with increasing frequency in the management of chronic pain. Aim: To assess the efficacy of low level laser therapy in the treatment of postherpetic neuralgia. Methods: Articles were searched through Pubmed/ MEDLINE, Cochrane, and Google scholar. Two randomized-controlled trials by Kemmotsu et al. and Moore et al. were obtained and critically appraised. Results: Based on the appraisal, studies by Kemmotsu et al. and Moore et al. are considered valid, important, and applicable. The results demonstrated a significant reduction in PHN intensity following a course of LLLT (p< 0.05). Conclusion: There is a statistically significant difference between the involvement of LLLT in PHN patients and without involvement of LLLT. LLLT is a noninvasive, painless, and safe method of treatment and may be recommended as an early intervention for pain therapy of PHN.
Narrowband ultraviolet B phototherapy combined with topical treatment for vitiligo in 2 geriatric patients Astriningrum, Rinadewi; Legiawati, Lili; Chandrakesuma, Vivianne; Nadia, Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia – Dr. Ci
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Narrowband ultraviolet B (NB-UVB) become the mainstay of widespread vitiligo therapy due to its great efficacy and safety compared with other modalities. The use of NB-UVB for vitiligo has been widely studied in adult patients, while studies on geriatric patients specifically are still very limited. This report aims to show the immediate response after the initial treatment, side effects of therapy, and other problems that were encountered during therapy in two geriatric patients with vitiligo who have been followed up for more than 12 months. Case Illustration: We reported two geriatric patients with vitiligo treated with NB-UVB phototherapy combined with topical treatment for more than 12 months. The first patient was 68-year-old woman, with Fitzpatrick skin type IV, who had vitiligo on her face, both lower arms and hands, and both legs and feet. The second patient was a 61-year-old man with Fitzpatrick skin type IV who had generalized vitiligo. The first repigmentation occurred on the 5th session in the first patient and on the 6th session in the second patient, using a cumulative dose of 1223 mJ/cm2 and 1541 mJ/cm2, respectively. Discussion: After NB-UVB phototherapy, there was a great improvement on the face in both patients, followed by the trunk and legs. However, the duration of treatment needed to achieve homogeneous repigmentation is longer in geriatric patients than in the general population. Conclusion: NB-UVB was well tolerated and showed good clinical response to treat vitiligo in the elderly. However, little is known about the safety and efficacy of phototherapy in elderly patients with vitiligo.
Perkembangan Terapi Sistemik Pada Pruritus Melody Febriana Andardewi; Windy Keumala Budianti; Lili Legiawati; Yudo Irawan
Jurnal Kedokteran Meditek Vol 28 No 1 (2022): JANUARI-APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i1.2203

Abstract

Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi tersebut disebabkan oleh berbagai hal, misalnya penyakit kulit, penyakit sistemik, atau idiopatik, gangguan psikiatri, serta penyakit neurologis. Pruritus menjadi masalah kesehatan karena dapat memberi dampak negatif terhadap kualitas hidup pasien. Pendekatan tata laksana pruritus diberikan secara bertingkat mulai dari terapi dasar, terapi target, dan terapi simtomatik. Pada kasus pruritus kronik yang refrakter maupun pruritus tanpa sebab yang diketahui, terapi simtomatik berperan besar dan dapat diberikan pada pasien tersebut. Tata laksana pada pruritus kronik saat ini banyak diteliti seiring dengan ditemukan berbagai mekanisme yang mendasari terjadinya pruritus. Sesuai dengan patofisiologi dari pruritus, terapi sistemik yang dikembangkan menargetkan pada reseptor spesifik di sistem saraf dan sistem imunitas yang berperan pada jalur sinyal pruritus. Berbagai terapi terbaru yang masih diteliti dalam uji klinis menunjukkan hasil yang menjanjikan dan berpotensi menjadi pilihan terapi pada pasien dengan pruritus kronik.
Co-Authors Adistri, Kara Andhira, Vega Andira Hardjodipuro Hardjodipuro Barros, Terlinda Batubara, Irwan Bianti, Marsha Chairista, Inadia Putri Chandrakesuma, Vivianne Christine Lieana Devi Arofah Dewi Lestarini Eliza Miranda Endi Novianto Evita H. Effendi Eyleny Meisyah Fitri Fauziah, Siti Nurani Fifi Mifta Huda Gunardi, Keiko Yolanda Halim, Dionisius Ivan Yonathan Hanny Nilasari Hartanto, David Dwiadiputra Hoemardani, Aida SD Huda, Fifi Mifta Ika Anggraini Ilyas, Nabila Chalisya Imelda Wihadi Inadia Putri Chairista Indah Widyasari Irawan, Yudo Irma Bernadette Irma Bernadette Joanne Natasha Jonlean, Reganedgary Joses Saputra Krisanti, RR Inge Ade Kusmarinah Bramono Kusumawardhani, Dina Larisa Paramitha Lis Surachmiati Marizki Ramadhani, Reinanda Marsha Bianti Melody Febriana Andardewi Menaldi, Sri Linuwih Susetyo Wardhani Mochamad H Azis Muhammad, Parikesit Mutiara Ramadhiani Nadia Yusharyahya, Shannaz Natalia Rania Sutanto Novita Suprapto Nugraheni Pasaribu, Uly Aanda Maria Oktarina, Caroline Pandelaki, Paulus Anung Anindita Priyanto, Mufqi Handaru Puteri, Fathirah Rahmatiah Putu Martha Gerynda Sukma Rahadi Rihatmadja Rahadi Rihatmadja Randy Satria Nugraha Rusdy Reshinta, Reisa Rheza, Agung Mohamad Rinadewi Astriningrum Roro Inge Ade Krisanti Rosdiana, Dewi Selvina Sampurna, Adhimukti T Sandra Widaty Sarah Qanita Edwar Shannaz Nadia Yusharyahya Sirait, Sondang Panjaitan Siskawati, Yulia Siti Nurani Fauziah Sitohang, Irma Bernadette S. Situmeang, Irhen Sondang P Sirait Sondang P. Sirait Sri Adi Sularsito Sri Adi Sularsito Sri Adi Sularsito Sri L. Menaldi Sujudi, Yufanti Surachmiati Suseno, Lis Suseno, Lis Surachmiati Terlinda Barros Valdi Ven Japranata Vivianne Chandrakesuma Wahyudi, Danang T Wardani, Amanda Nandi Widyasari, Indah Wihadi, Imelda Windy Keumala Budianti Wresti Indriatmi B. Makes Yudo Irawan Yudo Irawan Yudo Irawan