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All Journal Adi Widya : Jurnal Pengabdian Masyarakat Pharmasipha Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Jurnal Farmasi Jurnal Ilmiah Pendidikan Dasar (JIPDAS) Media Farmasi Indonesia Organisms: Journal of Biosciences jurnal Ilmu Sosial
Siti Aisiyah
Teknik Sipil Politeknik Negeri Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Optimasi Formula Tablet Floating Nifedipin Menggunakan HPMC K15M, PVP K-30 dan Avicel PH 102 dengan Metode Simplex Lattice Design Aisiyah, Siti; Fudholi, Achmad; Rohman, Abdul
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Nifedipine is a drug with a small solubility in water, a consequence, in order to obtain the desired drug release, the solubility of nifedipine should be increased by the addition of PVPK-30.This study was aimed to know the effect of HPMC K15M, PVP K-30 on the release of nifedipin, and Avicel PH 102 on the floating lag time of nifedipine floating tablet, and to find out the proportion of each ingredient to produce the optimum formula of nifedipin floating tablet. The study was conducted using Simplex Lattice Design (SLD) with 3 components i.e. HPMC K15M, PVPK-30 andAvicel PH 102 in order to obtain 14 formulas. The optimization parameter consists of absorption tablet, floating lagtime, C360 and DE360. The four parameters were analyzed using Design Expert7.1.3 software to determine the optimum formula. The optimum formula was obtained by determining the desired target for each parameter. The absorption was selected in maximum target, floating lag time was selected in minimum target, C360 targeted at number 54 and DE360 targeted at number 40. HPMC K15M at the highest concentration affected the smallest release of nifedipin, the highest PVP K-30 concentration affected the most of nifedipin release, where as high concentration Avicel PH 102 had a small affected reduce in floating lag time of nifedipin floating tablet. The composition of the optimum formula is as follows: 80mg HPMC K15M, 97mg PVPK-30 and 45mg Avicel PH 102. The results of tablet absorption, C360 and DE360 did not differ significantly; floating lag time gave significantly different results to obtain from software. The release kinetics of all formulas fit order 1, which indicated that the drug release occurred through a diffusion mechanism.
Pengaruh Pemberian Sediaan Creambath Ekstrak Daun Kembang Sepatu (Hibiscus Rosa-Sinensis) pada Pertumbuhan Rambut Kelinci (New Zealand) Widyastuti, Lita; Ningsih, Dwi; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Hibiscus rosa-sinensis is contains flavonoids, saponins and polyphenols that play a role in accelerating the growth of hair.This research aims to know the influence of the variation of concentration of ethanol extracts of hibiscus leaves in preparation creambath against rabbit hair growth. Of ethanol extracts of hibiscus leaves are obtained with the method remaseration using ethanol 70%. Creambath preparation made in 4 formula with the concentration of the extract of hibiscus in 10%, 15%, 20% and a negative control. Applied to the backs of rabbits that had been shaved and then given the preparations-2 times a day for 15 days. To test the activity of rabbit hair growth by measuring the length of the hair and rabbit hair, weight and physical test performed which include odor, color, pH, spread power, power protection, the ability to say, type, viscosity and stability of creams, creambath. Physical quality test data, weight, and hair is analyzed with the Saphiro-Wilk, then using ANOVA and Post Hoc Tests. The results showed that preparations creambath hibiscus leaves ethanol extract with a concentration of 10%, 15%, and 20% have good physical stability. The higher the concentration of the extract in preparations creambath hair growth activity differences produce rabbits. The results views of the parameter weights and lengths of hair, but not yet as effective as comparison control formula that delivers results-effective against the growth of rabbit hair creambath is with a concentration of 20%.
Pengaruh Matriks Pektin dan HPMC K15M Terhadap Daya Mengapung dan Mengembang serta Disolusi pada Tablet Floating Verapamil HCl dengan Metode Factorial Design Ayuk Armadani , Valentina; Aisiyah, Siti; Kuncahyo, Ilham
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Verapamil HCl is Calcium Channel blocker (CCB) used to treat hypertension and angina pectoris. Verapamil HCl has a bioavailability of 10-20% and half-life of 4 hours so it can be made gastroretentive preparations for defending drug therapy concentration. This study was purposed to know the effect of pectin and HPMC K15M on floatation behaviour, swelling and drug released of verapamil HCl floating tablet. This study used four varying matrix concentrations of pectin and HPMC K15M with direct compression method then evaluated physical properties of powders and tablets. Effects and interactions between pectin and HPMC K15M were given by factorial design method using software Design Expert®. Matrix of pectin and HPMC K15M gave effects to floatation behaviour, swelling and drud released of verapamil HCl floating tablet. HPMC K15M was dominant influenced about decreased floating lag time and increased floating time. Increased of HPMC K15M and pectin could be decreased initial burst and drug released rate but increased swelling. Pectin and HPMC K15M (1,5:1) combination had the fastest of floating lag time, the longest time of floating time, the greatest of swelling and followed zero order.
Optimasi Karbopol dan Gliserin pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Wahyu Aji Pangestu, Rochmadani; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of the Non Steroid Anti-Inflamatory Drug (NSAID) that serves as the treatment of pain or inflammation. Ibuprofen is a part of biopharmaceutical classification system (BCS) class II drug with the characteristics of low solubility and high permeability. Solid dispersion may increase solubility. Ibuprofen has a variety of side effects so it need to be made into other routes of administration such as topical. This study was conducted to understand the effect of combinations of carbopol as the gelling agent and glycerin as a penetration enhancer compound to the physical quality and the release of active substances also to determine the optimum formula. This study used simplex lattice design method with two factors which is carbopol and glycerin in formula 1 ; formula 2 ; formula 3 in sequence 100%:0% ; 50%:50% ; 0%:100%. The solid dispersion was made by the melting method, then was tested with FTIR and then was made into a solid dispersion gel of ibuprofen-PEG 6000. The release of substance was tested using franz diffusion cell through a cellophane membrane, then the optimum formula was determined based on the counterplot from Design Expert 10.0.1 trial version with critical parameters of adhesion, viscosity, and penetration of substance. The result of the study showed that carbopol and glycerin affecting the physical quality and the release of a drug in a gel. Glycerin has more impact to the release of the drug. The proportion of carbopol 1,011% and glycerin 7,389% produce the optimum formula with the most excellent physical quality and the release of the drug.
Optimasi Tween 80 dan Etanol pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Jonathan Suneidesis Alpons, Gabriel; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of Non Steroid Anti-Inflamatory Drug (NSAID) that used as treatment of pain or inflammatory. Solid dispersion method may improve the solubility of ibuprofen. Ibuprofen was made into a gel product to overcome the side effect. Addition of an enhancer in a gel may increase the penetration of an active substance. The purpose of this study is to understand the effect of tween 80 and ethanol as an enhancer to penetration and drug release of ibuprofen in gel, the effect to physical quality of gel, and to obtain the optimum formula of the combination of enhancer. This study used simplex lattice design with two factor which is tween 80 and ethanol in gel product formula 1; formula 2; and formula 3 in sequence 100%:0%; 50%:50%; 0%:100%. Solid dispersion of ibuprofen-PEG 6000 was made with melting method and tested with FT-IR before made into gel product. Penetration test is done by using Franz diffusion cell with selofan membrane and the determination of the optimum formula obtained based on counterplot from optimization with design expert 10.0.01 trial version with the parameters of the critical level is viscosity and penetration substanced. The results showed the combination of tween 80 and ethanol could affect viscosity and penetration of active substance, tween 80 had a greater effect than ethanol. The proportion of tween 80 4.681% and ethanol 16.319% produces the optimum formula with the most optimum viscosity, adhesion, and drug penetration
Formulasi Mouthwash Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) dengan Variasi Konsentrasi Gliserin sebagai Antibakteri Terhadap Streptococcus mutans ATCC 25175 Maharani, Novita; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Dental caries is a major disease in problems in the oral cavity especially in the teeth. The main cause of dental caries is the bacterium Streptococcus mutans which is a normal inhabitant of the oral cavity. Dental caries can be overcome using a mouthwash preparation containing antibacterial substances. Pineapple skin (Ananas comosus (L.) Merr) is one of the plants that contains substances that have antibacterial activity. The purpose of this study was to determine the physical quality and stability, and activity antibacterial of mouthwash pineapple skin extract. Pineapple skin extract was made in three mouthwash formulations using various concentrations of glycerin 5%, 10%, and 15%. Mouthwash were tested for physical quality and stability. Antibacterial activity test against Streptococcus mutans ATCC 25175 using the well method. The data obtained are presented in the form of tables and graphs processed with SPSS ver22 with the Paired T-Test method for testing viscosity and testing pH and ANOVA for measuring the diameter of the inhibition zone. The results showed that mouthwash preparations in all formulas with organoleptic physical qualities, viscosity, and stability produced good preparations, while in testing the physical quality of the pH did not meet the pH requirements of mouthwash preparations because of the influence of pineapple skin extract (Ananas comosus (L.) Merr). In testing the antibacterial activity of mouthwash, the diameter of the inhibition zone was obtained the base 0 mm; F1 11.08 mm; F2 13.08 mm; F3 15.08 mm; and control positive 16,75 mm.
Penentuan Nilai SPF pada Serum Fraksi Etil Asetat Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdarifa L.) Nopiyanti, Vivin; Harjanti, Reslely; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/0c0qrh09

Abstract

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values ​​F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations.
Pengaruh Konsentrasi Asam Stearat Terhadap Mutu Fisik Losion Ekstrak Daun Nangka (Arthocarpus heterophyllus) Sebagai Antioksidan Sava Agasta, Natasya; Aisiyah, Siti; Ponco Rahayu, Mamik
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/6mfph141

Abstract

Jackfruit leaf extract was developed into a lotion preparation to increase skin moisture and prevent the skin from being exposed to free radicals. The purpose of this study was to determine the effect of variations in stearic acid base on physical quality, differences in antioxidant activity in jackfruit leaf extract and preparations, best formula that can provide antioxidant activity. Jackfruit leaf extract was obtained by maceration using 70% ethanol and then formulated with a concentration of 6% jackfruit leaf extract and variations in stearic acid base 2%, 3%, and 4%. This study used the DPPH method to determine antioxidant activity and ANOVA for statistical analysis. This study obtained the IC50 value of jackfruit leaf extract of 64.5616 ppm. The IC50 value of jackfruit leaf extract and lotion was different due to the presence of additional ingredients in the lotion. The best formula from this research, formula has the best physical quality value, with the IC50 value of the extract in the formula 70.6862 ppm and the IC50 value of the base in the formula 1179.3357 ppm.
OPTIMASI SEDIAAN GUMMY CANDY PARASETAMOL DENGAN VARIASI KONSENTRASI GELATIN DAN GLISERIN MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN Nisa, Zaitun; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/35yaf041

Abstract

Paracetamol gummy candy is a chewy candy that is composed of a mixture of sweeteners and hydrocolloid components containing paracetamol and is designed to crumble and melt on the tongue. This study aims to see the effect of variations in the concentration of gelatin and glycerin on the physical quality of paracetamol gummy candy preparations, and to determine the best concentration of gelatin and glycerin to obtain paracetamol gummy candy preparations with optimum physical properties. Preparation of the preparation using the casting method and using 8 formula designs from Design Expert Simplex Lattice Design with a ratio of gelatin and glycerin concentrations. The results of the physical quality test with the critical parameters of elasticity and moisture content were analyzed using the Simplex Lattice Design method. This method can be used to optimize the dosage formula in various variations in the amount of material composition, so as to produce the optimum formula with the expected physical characteristics. The results showed that gelatin had more effect on elasticity and glycerin had more effect on the water content of paracetamol gummy candy. The proportions of gelatin 998,723 mg and glycerin 51.277 mg resulted in the optimum formula with the best elasticity and water content of gummy candy paracetamol.
FORMULASI DAN UJI ANTIJAMUR Candida albicans KRIM EKSTRAK RIMPANG KENCUR (Kaempferiae galanga Linn.) DENGAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Irawan, Ira; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 2 (2023): Jurnal Farmasi (Journal of Pharmacy), October 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/qzxj1g27

Abstract

The active compounds contained in the rhizome of kencur (Kaempferia galanga Linn.) include alkaloids, flavonoids, and tannins which are used as antifungals. This study aims to determine the effect of variations of stearic acid and triethanolamine on the physical quality and stability of cream preparations and their activity against Candida albicans ATCC 10231 and cream formulation formulas with the best physical quality and have antifungal activity. Kencur rhizome extract was obtained by maceration using 70% ethanol and formulated with an extract concentration of 12% and variations of stearic acid and triethanolamine with a ratio of (10:7, 13:5, 16:3). The formulation of the cream preparation was carried out by mixing the oil phase and the water phase and then physical quality was carried out including organoleptic tests, homogeneity, spreadability, adhesion, pH, viscosity, and Cycling test. This study used the disc diffusion method to determine antifungal activity and one way ANOVA for statistical analysis. The results showed that the diameter of the extract inhibition zone was 13.17 mm. Variations of stearic acid and triethanolamine affect the physical quality and antifungal activity of cream preparations. Cream preparations have antifungal activity against Candida albicans ATCC 10231. The best formula is formula 1 with variations of stearic acid : triethanolamine (10:7) which has the best physical quality, with an inhibition zone diameter of 13.00 mm which is strong in inhibiting fungal growth.
Co-Authors Abdul Rohman Achmad Fudholi Ahmad Fawaid Ainayya, Qurrotu Aisah, Nazmi Aprilia, Iza Ferdina Ayuk Armadani , Valentina Budi Budi Desi Purwaningsih Dwi Ningsih, Dwi Dzulhija, Aleyda Freshananda Ed-Dally, Ahmad Wildanun Najin Fani, Della violita Beauty Firdaus, Alifia Sabila Freshananda Dzulhija, Aleyda Husnul Khatimah Ilham Kuncahyo, Ilham Irawan, Ira Jonathan Suneidesis Alpons, Gabriel Khummayroh, Lutfia Maharani, Novita Muttaqin, Khoirul Nabila D, Putri Nisa, Zaitun Nuraini Harmastuti Nurhaini, Siti Ponco Rahayu, Mamik Pradana, Arsita Pradana, Arsitya Rahmatulloh, Ahmad Miftahul Iqbal Reslely Harjanti Salamah , Wichda ‘Ainis Salsabillah, Amalia Nuriski Sava Agasta, Natasya Suhartinah, Suhartinah Titik Sunarni Turahman, Taufik Vivin Nopiyanti Wahyu Aji Pangestu, Rochmadani Widyastuti, Lita Wulandari, Destik Zulmin, Lana Farhan Alafy