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All Journal Indonesian Journal of Urology The Indonesian Biomedical Journal Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Andalas obstetrics and gynecology journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Seroja Husada: Jurnal Kesehatan Masyarakat
Alvarino Alvarino
Department of Urology, Faculty of Medicine/Indonesia University, Cipto Mangunkusumo Hospital, Jakarta.
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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VALSARTAN TO ATTENUATE RENAL DAMAGE IN UNILATERAL URETERAL OBSTRUCTION Jusuf, Samycha; Alvarino, Alvarino
Indonesian Journal of Urology Vol 21 No 1 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i1.18

Abstract

Objective: This experimental study aims to observe the effect of valsartan to attenuate renal damage in unilateral ureteral obstruction. Material & method: Experimental study was performed using 30 wistar rats with unilateral ureteral obstruction achieved by ligation of the left ureter. Rats were divided into two groups, no treatment group and valsartan group. At the 14th day, evaluation was performed to compare interstitial fibrosis, hydropic degeneration, and tubular atrophy between the two groups using haematoxylin-eosin staining. Only rats surviving until at least the 7th day are included in the study. Results: From thirteen wistar rats in no treatment group, there were two with moderate interstitial fibrosis and eleven with mild interstitial fibrosis while all rats in valsartan group had mild interstitial fibrosis (p > 0.05). There is no significant difference on hydropic degeneration between no treatment and valsartan group (31.46 vs 33.67; p > 0.05). There is also no significant difference in tubular atrophy between the two groups (61.78 vs 62.07; p > 0.05). Conclusion: Valsartan therapy in antihypertensive dosage has no significant effect in to attenuate interstitial fibrosis, hydropic degeneration, and tubular atrophy in unilateral ureteral obstruction in wistar rats. Keywords: Unilateral ureteral obstruction, valsartan, interstitial fibrosis.
Hubungan Infeksi Cacing Soil Transmitted Helminth dengan Kejadian Alergi: Sebuah Tinjauan Literatur Sistematis Sutrisna, Betti Endang; Nurhayati, Nurhayati; Alvarino, Alvarino; Irawati, Nuzulia; Khaira, Fathiyyatul
ANATOMICA MEDICAL JOURNAL | AMJ Vol 7, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v7i3.19000

Abstract

Alergi adalah gangguan inflamasi yang umumnya disebabkan respon imun yang tidak tepat terhadap alergen lingkungan. Respon imun tubuh terhadap penyakit alergi mirip dengan respon tubuh host terhadap infeksi cacing. Tinjauan ini dilakukan untuk mengetahui hubungan infeksi soil transmitted helminth dengan kejadian alergi. Pencarian literatur dilakukan melalui database elektronik Pubmed dan Proques menggunakan kriteria inklusi dan eksklusi. Literatur terpilih dinilai kelayakannya menggunakan kuesioner The Joanna Broggs Institute (JBI checklist) yang disesuiakan dengan desain masing-masing literatur. Sebanyak 13 studi dimasukkan ke dalam tinjauan sistematis. Terdapat 7 artikel yang menjelaskan adanya hubungan negatif dimana infeksi soil transmitted helminth dapat memproteksi terhadap penyakit alergi. Terdapat 3 studi menunjukkan adanya hubungan positif antara dua variable tersebut atau infeksi soil transmitted helminth tidak bersifat proteksi terhadap penyakit alergi. Namun, terdapat 3 artikel yang menyatakan bahwa tidak terdapat hubungan antara infeksi soil transmitted helminth dengan kejadian alergi. Berdasarkan literatur yang didapatkan terdapat hasil yang bervariasi terkait dengan hubungan infeksi soil transmitted helminth dengan kejadian alergi, sebagian besar menunjukkan adanya hubungan negatif yang dipengaruhi oleh berbagai faktor.Kata kunci: infeksi soil transmitted helminth, alergi
Dampak Pandemi Coronavirus Disease 2019 (COVID-19) Terhadap Layanan Bedah Jantung di RSUP Dr. M. Djamil Padang Izzati, Ilham Yuma; Alvarino, Alvarino; Elfi, Eka Fithra
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 6 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Corona virus disease 2019 (COVID-19) merupakan new emerging disease disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) yang menyerang sistem pernapasan dan menimbulkan gejala ringan sampai berat. Pasien COVID-19 umumnya memiliki banyak komorbiditas, terutama penyakit jantung sebanyak 8%. Pandemi COVID-19 menyebabkan penurunan layanan bedah jantung. Tujuan penelitian ini untuk mengetahui dampak pandemi COVID-19 terhadap layanan bedah jantung. Penelitian ini merupakan studi observasional analitik dengan desain cross-sectional. Penelitian ini membandingkan layanan bedah jantung sebelum dan selama pandemi COVID-19 (Maret 2019-Februari 2020 dengan Maret 2020 - Desember 2021). Pengumpulan data dilakukan pada bulan November 2021 - Februari 2022. Teknik pengambilan sampel adalah total sampling. Analisis yang digunakan dalam penelitian ini adalah analisis univariat dan bivariat. Hasil dari data yang didapatkan 8 sampel sebelum pandemi dan 9 sampel selama pandemi. Didapatkan rerata usia pasien sebelum dan selama pandemi adalah 26,50 tahun dan 26,67 tahun, dengan sebagian besar adalah perempuan. Sebagian besar pasien memiliki komorbid, dengan seluruh pasien didiagnosis penyakit jantung kongenital dan menjalani tatalaksana korektif kongenital. Tidak didapatkan perbedaan yang signifikan antara pandemi dengan waktu layanan pra-operatif (p=0,114), intra-operatif (p=0,082) dan pasca-operatif (p=0,550). Kesimpulan, tidak didapatkan perbedaan waktu layanan pra-operatif, intra-operatif dan pasca-operatif pasien bedah jantung sebelum dan selama pandemi.
Karakteristik dan Faktor Risiko Bibir dan Langit-Langit Sumbing di RSUP Dr. M. Djamil Padang Periode 2018-2021 Ziqri, Muhammad Fathi Naufal; Saputra, Deddy; Usman, Elly; Alvarino, Alvarino; Rusjdi, Selfi Renita; Windasari, Noverika
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.998

Abstract

Latar Belakang: Sumbing bibir dan langit-langit merupakan salah satu malformasi orofasial yang paling sering terjadi yang meliputi isolated cleft lip, cleft lip with cleft palate, dan isolated cleft palate. Angka kejadian CL/P dipengaruhi oleh faktor etnis, ras, geografis, maupun jenis kelamin. Faktor-faktor risiko CL/P melingkupi usia ibu lanjut, merokok, konsumsi alkohol, dan defisiensi asam folat.. Objektif: Tujuan penelitian ini yakni untuk mengetahui karakteristik sumbing bibir dan langit-langit di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian deskriptif menggunakan rekam medis pasien sumbing bibir dan langit-langit di RSUP Dr. M. Djamil Padang pada tahun 2018-2021 serta wawancara dengan keluarga pasien. Penelitian ini dilakukan di bagian rekam medis RSUP Dr. M. Djamil Padang pada Maret-September tahun 2022. Teknik pengambilan sampel menggunakan total sampling. Analisis data menggunakan analisis univariat. Hasil: Hasil penelitian menunjukkan distribusi frekuensi celah bibir dan langit-langit terbanyak yakni 60,9% untuk cleft lip and palate. Celah bibir yang paling sering ditemukan yakni celah unilateral kiri dengan 36,8%. Jenis kelamin terbanyak adalah laki-laki dengan 51,1%. Terdapat 56% pasien yang berasal dari daerah luar Padang. Rata-rata usia saat labioplasty yakni 15,21 bulan dan palatoplasty yakni 30,14 bulan. Terdapat 79,3% dari kehamilan tidak berisiko. Distribusi frekuensi faktor risiko terbanyak yakni paparan asap rokok selama kehamilan trimester pertama dengan 80,4% Kesimpulan: Kesimpulan penelitian ini didapatkan cleft lip and palate terbanyak. Celah unilateral sisi kiri paling sering ditemukan. Laki-laki lebih banyak ditemukan dibandingkan perempuan. Faktor risiko paling banyak yakni paparan asap rokok dengan kemungkinan penyebab rendahnya kesadaran masyarakat terkait PHBS rumah tangga.
Semen Quality of Infertile Men and Correlation with Demographic Characterictics Iqbal, Muhammad; Karmia, Hudila Rifa; Alvarino, Alvarino
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.58-64.2022

Abstract

Objective: To analyze semen quality of infertile men and its correlation with demographics characteristics.Methods: This was an analytic observational study with cross-sectional retrospective study design on 92 infertile men. The study began in May 2021 to December 2021 in the Obstetrics and Gynecology Clinics at BMC Hospital Padang.Results:The correlation between age and marital duration was positively correlated (r= 0,558), with a weak correlation and there is statistically significant relationship between age and marital duration. Age and sperm concentration was positively correlated (r=0.048), with a weak correlation. Marital duration and sperm concentration was positively correlated (r=0.052), with a weak correlation. The correlation between age and progressive motility and non-progressive motility percentage were positively correlated (r = 0.009 and 0.035),with a weak correlation. The correlation between age and progressive immotile sperm percentage were negatively correlated (r = - 0,030),with a weak correlation.Conclusion: There was a positive correlation between age and sperm concentration, and progressive and non progressive motility with a weak correlation. There was a positive correlation between age and marital duration with a strong correlation. There was negative correlation between and sperm immotility with a weak correlation.Keywords:  male infertility, semen, age, marital duration
Lactococcus lactis D4 Decreases NF-κB and α-SMA in Rat Models of Obstructive Jaundice Suchitra, Avit; Alvarino, Alvarino; Darwin, Eryati; Harun, Harnavi; Rivai, Muhammad Iqbal; Sukma, Ade
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3384

Abstract

BACKGROUND: Obstructive jaundice, often due to choledocholithiasis or malignancies, leads to immune suppression, intestinal damage, and bacterial translocation, worsening outcomes. Some inflammatory mediators like nuclear factor kappa B (NF-κB), alpha-smooth muscle actin (α-SMA), and interleukin-6 (IL-6) are important in this process. Current treatments remain inadequate, highlighting the need for novel approaches. Probiotics, such as Lactococcus lactis D4 (LLD4), may help reduce inflammation and bacterial translocation, thus offering a potential therapeutic option. This study was conducted to evaluate the effects of LLD4 on NF-κB, α-SMA, and IL-6 in obstructive jaundice rat models.METHODS: This post-test randomized controlled study involved 15 male Wistar rats divided into three groups: sham, bile duct ligation (BDL), and BDL+LLD4 groups. The rats were maintained for 7–10 days, with the rats in BDL+LLD4 group received fermented milk containing LLD4 via gavage at a dose of 112 mg/20 gBW per day for 7 days. The expression levels of NF-κB, α-SMA, and IL-6 were analyzed using immunohistochemistry.RESULTS: Administration of LLD4 were able to significantly reduced NF-κB expression compared to the BDL group (40.20±21.276 vs. 53.60 ± 20.403) in obstructive jaundice rat models. Though not significant, BDL+LLD4 group showed lower α-SMA expression compared to BDL group (58.40±14.271 vs. 63.20±9.16). However, administration of LLD4 did not give any significant effect on IL-6 expression.CONCLUSION: LLD4 reduces inflammation in models of obstructive jaundice by lowering the NF-κB and α-SMA expression. This indicates that LLD4 might be potential as an adjunct therapy for reducing morbidity in obstructive jaundice cases.KEYWORDS: obstructive jaundice, bile duct ligation, Lactococcus lactis D4, NF-κB, α-SMA, IL-6
Lactococcus lactis D4 Has Potential Effect to Alleviate Inflammation and Reverse Dysbiosis in Colitis Rat Model Suswita, Rini; Alvarino, Alvarino; Darwin, Eryati; Jamsari, Jamsari
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2970

Abstract

BACKGROUND: Inflammatory bowel disease (IBD) is a prevalent chronic inflammatory disorder of the gastrointestinal tract that may lead to colorectal cancer if untreated. Several medications for IBD have adverse side effects. Thus, there are high interest for searching alternative treatment to treat IBD. Lactococcus lactis D4 isolated from dadih, a traditional fermented buffalo milk product, was investigated for the effect on gut inflammation and microbial composition in the colitis rat model.METHODS: Eighteen male Sprague-Dawley rats were divided into three groups; control rats, colitis-induced rats, and colitis-induced rats treated with L. lactis D4 isolate. The control group received water, while the colitis-induced rats were given azoxymethane (AOM) and dextran sodium sulphate (DSS). Rats’ feces were collected for the analysis of gut microbiota diversity by next-generation sequencing and for the measurement of transforming growth factor (TGF)-β, nuclear factor kappa-B (NF-κB), interleukin (IL)-6, and tumor necrosis factor (TNF)-α colonic expression using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).RESULTS: L. lactis D4 administration was able to reduce inflammation in colitis by decreasing IL-6 expression (0.87 vs. 0.73), while expression of TGF-β, NF-κB, and TNF-α were increased compared to the model group, suggesting a complex immunomodulatory effect. Gut microbiota sequencing revealed a similarity between the control and treatment groups, suggesting L. lactis D4 has great potential to ameliorate gut microbiota dysbiosis in colitis rats.CONCLUSION: L. lactis D4 has a beneficial effect in decreasing pro-inflammatory cytokines and is able to reserve dysbiosis in colitis rat model. Thus, L. lactis D4 might be used as a therapeutic agent for IBD.KEYWORDS: colitis, gut microbiota, inflammation, inflammatory bowel disease, Lactococcus lactis D4, probiotic, proinflammatory cytokines
Co-Authors Ade Sukma Ashal, Taufik Deddy Saputra Eka Fithra Elfi, Eka Fithra Eryati Darwin Etriyel Myh Fathiyyatul Khaira, Fathiyyatul Harun Harnavi Izzati, Ilham Yuma Jamsari Jamsari Karmia, Hudila Rifa Muhammad Iqbal Noverika Windasari Nurhayati Nurhayati Nuzulia Irawati Reza, Mohamad Rivai, Muhammad Iqbal Samycha Jusuf Selfi Renita Rusjdi Suchitra, Avit Suswita, Rini Sutrisna, Betti Endang Wahyuni, Febby Genta Zelly Dia Rofinda Ziqri, Muhammad Fathi Naufal