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All Journal Medical Journal of Indonesia Indonesian Journal of Cardiology Sumatera Medical Journal SCRIPTA SCORE Scientific Medical Journal Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Raynaldo, Abdul Halim
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran, Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : sumatera medical journal

 1 
Renal Function and Left Ventricular Ejection Fraction in Diabetic Patients with Acute Heart Failure Hutapea, Mery Natalia; Hasan, Refli; Raynaldo, Abdul Halim; Siregar, Abdullah Afif; Haykal, Teuku Bob; Sarastri, Yuke; Ardini, Tengku Winda; Ketaren, Andre Pasha; Purba, Joy Wulansari; Akbar, Nizam Zikri; Andra, Cut Aryfa
Sumatera Medical Journal Vol. 9 No. 1 (2026): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v9i1.22989

Abstract

Background: Acute heart failure (AHF) in patients with type 2 diabetes mellitus (T2DM) is frequently complicated by renal dysfunction, which may aggravate cardiac impairment. Serum creatinine may reflect this cardio–renal interaction, but its association with left ventricular ejection fraction (LVEF) in AHF patients with T2DM remains unclear. Objective: To investigate the correlation between serum creatinine and left ventricular ejection fraction (LVEF) in patients with acute heart failure (AHF) and type 2 diabetes mellitus (T2DM). Methods: A cross-sectional study of 52 hospitalized AHF patients with T2DM. Clinical data, serum creatinine, A1C, and echocardiographic LVEF (assessed by two independent consultants) were collected. Correlation and multivariable linear regression analyses were performed. Results: The patients were middle-aged and predominantly male. Mean LVEF was 33.2 ± 9.1%, and mean serum creatinine was 1.58 ± 0.31 mg/dL. Higher serum creatinine levels were strongly associated with lower LVEF. Glycemic status (A1C) and urea levels also showed negative associations with LVEF. After adjustment, serum creatinine and A1C remained independent predictors of reduced LVEF. Conclusion: In AHF patients with T2DM, higher serum creatinine and A1C levels are independently associated with reduced LVEF, underscoring the cardio-renal-metabolic interplay in this population and highlighting the need for integrated management strategies.
SYNTAX Score II as a Predictor of One-Year Major Adverse Cardiovascular Events in Patients with Chronic Coronary Syndrome and Type 2 Diabetes Mellitus Undergoing Percutaneous Coronary Intervention Elsa Tamara Saragih; Hasan, Harris; Raynaldo, Abdul Halim; Andra, Cut Aryfa; Haykal, Teuku Bob; Ilyas, Kamal Kharazzi
Sumatera Medical Journal Vol. 9 No. 2 (2026): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v9i2.23616

Abstract

Background: The severity of coronary atherosclerotic lesions is an important determinant of cardiovascular events in patients with CAD. The SS-II (SYNTAX-II) score, which integrates anatomical characteristics with clinical variables, provides improved prognostic value compared with anatomical scoring alone. Objective: To determine whether the SS-II predicts one-year MACE in CCS patients with T2DM who undergo PCI. Methods: This observational analytic study employed a retrospective cohort design including patients treated from June 2023 to August 2024. A total of 128 CCS patients with T2DM who underwent PCI were enrolled. Bivariate and multivariate analyses were performed to examine the association between the SS-II and MACE. One-year MACE-free survival was analyzed using Kaplan–Meier curves.  Results: MACE occurred more frequently among patients with high SS-II scores (22 [34.4%], P < 0.001). Mortality and acute heart failure were both significantly associated with the SS-II (P = 0.042 and P = 0.03, respectively). Patients with high scores had significantly lower one-year MACE-free survival. Conclusion: The SS-II is a valuable predictor of one-year MACE in CCS patients with T2DM undergoing PCI.
Co-Authors Akbar, Nizam Zikri Alsagaff, Mochamad Yusuf Ambari, Ade Meidian Anandini, Hesti Andra, Cut Aryfa Anggoro Budi Hartopo Anggraeni, Vita Yanti Ardini, Tengku Winda Arityanti, Dean Badai Bhatara Tiksnadi Batubara, Gio Justisia Chan, Muhammad Ikhsan Cholid Tri Tjahjono Desandri, Dwita Rian Dewita, Auliya Dwiputra, Bambang Elsa Tamara Saragih Erwan, Nabila Erina Febrianora, Mega Fitra, Maha Harris Hasan Hasan, Harris Hasan, Refli Hergaf, Indah Widyasari Hutapea, Mery Natalia Ilyas, Kamal Kharazzi Ilyas, Kamal Kharrazi Irsad Andi Arso, Irsad Andi Ivander, Alvin Ketaren, Andre Pasha Khaidirman, Sophia Khairina Krevani, Citra Kiki Lubis, Ahmad Feriansyah Lubis, Anggia Chairuddin Lubis, Dian Anindita Makes, Indira Kalyana Muhammad Ridwan Mukhtar, Zulfikri Napitupulu, Bertha Gabriella Nasution, Ali Nafiah Pase, Muhammad Aron Purba, Antonius Leonardo Purba, Joy Wulansari Putra, Muhammad Hafiz Mahruzza Qhabibi, Faqrizal Ria Ramzi, Defriyan Rejeki, Vidya Gilang Rina Artha, I Made Junior Rita Hamdani Rizky Adriansyah Sarastri, Yuke Siregar, Abdullah Afif Sitepu, Andika Sumbayak, Novra Christy Grace Sunanto Ng Susilowati, Eliana Syaoqi, Muhammad Tanjung, Ika Citra Dewi Tarigan, Stefanie Tarsidin, Najmi Fauzan Teuku Bob Haykal Wicaksono, Sony Hilal Yasmine Fitrina Siregar