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All Journal Medical Journal of Indonesia Indonesian Journal of Cardiology Sumatera Medical Journal SCRIPTA SCORE Scientific Medical Journal Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Raynaldo, Abdul Halim
Departemen Kardiologi Dan Kedokteran Vaskuler, Fakultas Kedokteran, Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Relationship between Coronary Artery Calcium Score (CACS) and Diastolic Dysfunction in Patients with Stable Coronary Heart Disease at Adam Malik General Hospital Medan Putra, Muhammad Hafiz Mahruzza; Hasan, Refli; Sitepu, Andika; Hasan, Harris; Ketaren, Andre Pasha; Andra, Cut Aryfa; Raynaldo, Abdul Halim; Ilyas, Kamal Kharrazi
Journal of Society Medicine Vol. 4 No. 6 (2025): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i6.221

Abstract

Introduction: Coronary artery calcium score (CACS) is a specific indicator of coronary atherosclerosis that plays a role in assessing the degree of calcification in atherosclerosis. Diastolic function is the first aspect of cardiac function to be impaired in ischemic heart disease. This study aims to determine the relationship between calcium scoring and diastolic dysfunction. Methods: This analytical observational study with cross-sectional design evaluated the relationship between coronary artery calcium score (CACS) and left ventricular diastolic function in patients with stable CAD. Data were collected retrospectively from medical records at RSUP H. Adam Malik Medan during Nov 2023-Nov 2024. CACS was assessed using coronary CT scan, while left ventricular diastolic function was measured by echocardiography. Data analysis used chi-square test, Mann-Whitney U test, and ROC curve analysis to evaluate CACS threshold in predicting diastolic dysfunction. Results: Among 158 analyzed samples, 113 patients had diastolic dysfunction. A calcium score ≥100 was found in 46.2% of patients, showing 1.318 times higher risk of diastolic dysfunction versus those with scores <100 (p = 0.006; 95% CI 1.083–1.605). ROC analysis showed CACS had moderate predictive ability for diastolic dysfunction with AUC of 0.647 (p = 0.004). A calcium score threshold of 45 had 65.5% sensitivity and 62.2% specificity in detecting diastolic dysfunction. Type 2 diabetes mellitus, urea, and creatinine levels were also significantly associated with diastolic dysfunction (p < 0.05). Conclusion: Calcium score shows a significant relationship with diastolic dysfunction in stable CAD patients and can predict diastolic dysfunction in patients undergoing coronary CT scan.
Indonesia-INTERASPIRE study: an Indonesian cross-sectional multicenter survey on cardiovascular secondary prevention in coronary heart disease Ambari, Ade Meidian; Hasan, Harris; Dwiputra, Bambang; Desandri, Dwita Rian; Hamdani, Rita; Krevani, Citra Kiki; Syaoqi, Muhammad; Ridwan, Muhammad; Anandini, Hesti; Fitra, Maha; Arso, Irsad Andi; Anggraeni, Vita Yanti; Hartopo, Anggoro Budi; Siregar, Yasmine Fitrina; Tjahjono, Cholid Tri; Tiksnadi, Badai Bhatara; Febrianora, Mega; Tarsidin, Najmi Fauzan; Arityanti, Dean; Qhabibi, Faqrizal Ria; Makes, Indira Kalyana; Susilowati, Eliana; Erwan, Nabila Erina; Hergaf, Indah Widyasari; Raynaldo, Abdul Halim
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257833

Abstract

BACKGROUND Cardiovascular disease (CVD) is projected to affect more than 23.3 million people by 2030. Therefore, CVD prevention strategies were established to decrease morbidity and mortality while enhancing overall well-being. The Joint European Societies (JES) guidelines on CVD prevention were developed to enhance preventive cardiology practices. This study aimed to evaluate the adherence to JES guidelines for cardiovascular prevention in routine clinical practice for secondary prevention. METHODS This multicenter cross-sectional study was conducted in 7 centers between August 2020 and June 2021. Patients under 80 years old who had undergone percutaneous transluminal coronary angioplasty, coronary artery bypass graft, percutaneous coronary intervention, or experienced acute coronary syndrome were identified from medical records and interviewed a year later. Descriptive statistics were used to calculate the occurrence of risk variables, medication use, and index events associated with low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c, and blood pressure (BP). RESULTS A total of 402 participants (13.9% female) were interviewed, and their medical records were reviewed. Among the study population, 74.4% had a smoking history, 35.4% had dyslipidemia, 33.1% did not meet the BP target, and only 28.4% achieved the LDL-C target. Additionally, less than half (43.8%) participated in physical activity for >150 min/week. Only 15.6% of the patients among the centers who had scored >8 for the guideline-based target score. CONCLUSIONS Most patients did not meet the guidelines for secondary prevention, primarily due to the high prevalence of dyslipidemia and physical inactivity, although some achieved the LDL-C target.
Patient-reported perceptions of life quality and longevity in chronic heart failure Lubis, Ahmad Feriansyah; Lubis, Anggia Chairuddin; Andra, Cut Aryfa; Raynaldo, Abdul Halim; Ardini, Tengku Winda; Haykal, Teuku Bob; Sarastri, Yuke
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.9

Abstract

BACKGROUND: Although heart failure therapy has advanced, many patients still experience functional limitations, which impact their quality of life. OBJECTIVES: To explore the factors influencing heart failure patients' preferences for quality of life and longevity. METHODS: This cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia. The study was conducted from April 2023 to October 2023. A total of 143 chronic heart failure patients were included using purposive sampling. Data were collected through interviews and the EuroQol five-dimension five-level questionnaire, EuroQol visual analogue scale, and the Time Trade-Off method. Statistical analysis was performed using multivariate logistic regression. RESULTS: Of the 143 patients, 66.4% preferred quality of life over longevity, and 47.3% were willing to trade two years of their lives for a better quality of life. The main factors associated with this preference were heart failure with reduced ejection fraction (OR: 3.554; 95% CI: 1.373 - 9.198; p: 0.009), diabetes mellitus (OR: 2.705; 95% CI: 1.108 - 6.602; p: 0.029), and lower visual analog scale scores (OR: 0.889; 95% CI: 0.848 - 0.932; p: 0.000). Our results also showed that patients in the longevity group had better ejection fractions, fewer rehospitalizations, and were less likely to have diabetes mellitus or chronic kidney failure compared to the quality of life group. CONCLUSION: The majority of heart failure patients choose quality of life over longevity, and this may be influenced by symptom burden and rehospitalization history. These findings emphasize the importance of patient-centered therapy focusing on symptom management and psychosocial support.
Perbandingan Penutupan Ventricular Septal Defect secara Transkateter dengan Pembedahan pada Anak: Telaah Sistematis dan Meta Analisis Ivander, Alvin; Adriansyah, Rizky; Tanjung, Ika Citra Dewi; Raynaldo, Abdul Halim
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v3i2.5412

Abstract

Background: Ventricular Septal Defect is a Congenital Heart Defect characterized by an opening in interventricular septum or more that happen because of intraventricular septum’s failure to fuse during fetal development. Ventricular Septal Defect itself is the most prevalent type of CHD found on pediatric patient and decreased their quality of life thus corrective treatment become important to ensure child healthy growth. Transcatheter procedure is expected as one of the alternative for corrective treatment which is better and safer compared to surgical closure of VSD corrective treatment. Objectives: This research aimed to observe the comparison of VSD closure between transcatheter compared to surgical closure. Methods: This research is a systematic review and meta-analysis compliant with PRISMA guidelines and analyzed using Review Manager 5.3. Discussion: This research identifies 1.991 journals however, only 10 journals fulfilled the inclusion criteria. The review founded that there is no significant difference between either transcatheter or surgical closure outcome (RR = 0,99) however the analysis founded that transcatheter method are much safer in term of complication event (RR =0,54), residual shunt event (RR = 0,56), and blood transfusion (RR=0,03) while also provide a much cheaper cost with faster procedure time, and hospitalization. Conclusion: The results of data analysis found that transcatheter procedure is safer, cheaper, and have a much faster speed in term of operation duration and hospital stay compared to surgical closure of VSD. Transcatheter procedure is recommended as treatment choice for corrective treatment of patient diagnosed with VSD. Keywords: Ventricular Septal Defect, transcatheter, surgical closure, child   Latar Belakang: Ventricular Septal Defect adalah Penyakit Jantung Bawaan yang ditandai dengan adanya satu lubang pada septum interventrikular atau lebih yang terjadi akibat kegagalan fusi septum intraventrikular saat perkembangan janin. VSD sendiri adalah jenis PJB yang paling sering timbul pada anak dan mengakibatkan penurunan kualitas hidup anak sehingga terapi korektif menjadi penting agar anak dapat tumbuh dengan baik. Prosedur transkateter diharapkan menjadi salah satu alternatif terapi korektif yang lebih baik dibandingan dengan pembedahan dalam pengobatan korektif VSD. Tujuan: Tujuan dari penelitian ini adalah untuk melihat perbandingan penutupan VSD secara transkateter dibandingkan dengan pembedahan. Metode: Penelitian ini merupakan telaah sistematik dan meta analisis yang patuh pada kaidah pedoman PRISMA lalu dianalisis menggunakan Review Manager 5.3. Pembahasan: Penelitian ini menemukan 1.991 jurnal namun hanya 10 jurnal yang memenuhi kriteria inklusi. Telaah tersebut menemukan bahwa tidak ada perbedaan signifikan antara luaran prosedur transkateter atau pembedahan (RR = 0,99) namun analisis yang dilakukan menemukan bahwa transkateter lebih aman dalam segi kejadian komplikasi (R = 0,54), kejadian pirau residual (RR = 0,56), dan transfusi darah (RR = 0,03) dan lebih murah dalam hal biaya serta lebih cepat baik prosedur maupun lama rawat inap. Kesimpulan: Hasil analisis ini menemukan bahwa prosedur transkateter lebih aman, murah, dan lebih cepat dalam hal prosedur serta lama rawat inap dibandingkan pembedahan. Prosedur transkateter direkomendasikan sebagai pilihan prosedur untuk pengobatan korektif VSD. Kata Kunci: Ventricular Septal Defect, transkateter, pembedahan, anak
Association of GWTG-HF Risk Score with Major Adverse Cardiovascular Events in Acute Heart Failure Patients: A Retrospective Study in a Tertiary Hospital in Indonesia Sumbayak, Novra Christy Grace; Hasan, Refli; Raynaldo, Abdul Halim; Haykal, Teuku Bob; Nasution, Ali Nafiah; Sarastri, Yuke
Journal of Society Medicine Vol. 4 No. 12 (2025): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i12.250

Abstract

Introduction: Heart failure (HF) affects approximately 64 million people globally, contributing to high mortality, morbidity, reduced quality of life, and substantial healthcare burden. Acute heart failure (AHF) requires urgent intervention and carries elevated risks of mortality and major adverse cardiovascular events (MACE). The Get With The Guidelines-Heart Failure (GWTG-HF) risk score, originally developed for predicting in-hospital mortality in HF patients, has shown potential in forecasting MACE in certain populations. However, its association with MACE in Indonesian AHF patients remains underexplored. Method: This retrospective observational cohort study included 319 AHF patients admitted to Adam Malik General Hospital, Medan, Indonesia, from January 2024 to March 2025. Patient characteristics, GWTG-HF scores, and in-hospital MACE were recorded. Statistical analyses involved receiver operating characteristic (ROC) curves and multivariate regression. Results: Patients had a mean age of 55 years, with 54.5% males. Median hospital stay was 5 days (range 1–47). Predominant features included acute decompensated HF (65.8%), infection as etiology (46.7%), HFrEF (52.0%), coronary heart disease (62.4%), and smoking (50.8%). In-hospital MACE occurred in 20.4% of patients, primarily mortality (18.8%), increasing with GWTG-HF risk categories (low: 8.1%; moderate: 17.4%; high: 36.7%). Age, systolic blood pressure, heart rate, sodium, and blood urea nitrogen significantly influenced MACE (p<0.05). The GWTG-HF score demonstrated good predictive performance for MACE (AUC 0.759, p<0.001; sensitivity 63.2%; specificity 78.1%). Conclusion: The GWTG-HF score is significantly associated with in-hospital MACE in Indonesian AHF patients, supporting its utility as a risk stratification tool to guide clinical decisions and optimize management.
Renal Function and Left Ventricular Ejection Fraction in Diabetic Patients with Acute Heart Failure Hutapea, Mery Natalia; Hasan, Refli; Raynaldo, Abdul Halim; Siregar, Abdullah Afif; Haykal, Teuku Bob; Sarastri, Yuke; Ardini, Tengku Winda; Ketaren, Andre Pasha; Purba, Joy Wulansari; Akbar, Nizam Zikri; Andra, Cut Aryfa
Sumatera Medical Journal Vol. 9 No. 1 (2026): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v9i1.22989

Abstract

Background: Acute heart failure (AHF) in patients with type 2 diabetes mellitus (T2DM) is frequently complicated by renal dysfunction, which may aggravate cardiac impairment. Serum creatinine may reflect this cardio–renal interaction, but its association with left ventricular ejection fraction (LVEF) in AHF patients with T2DM remains unclear. Objective: To investigate the correlation between serum creatinine and left ventricular ejection fraction (LVEF) in patients with acute heart failure (AHF) and type 2 diabetes mellitus (T2DM). Methods: A cross-sectional study of 52 hospitalized AHF patients with T2DM. Clinical data, serum creatinine, A1C, and echocardiographic LVEF (assessed by two independent consultants) were collected. Correlation and multivariable linear regression analyses were performed. Results: The patients were middle-aged and predominantly male. Mean LVEF was 33.2 ± 9.1%, and mean serum creatinine was 1.58 ± 0.31 mg/dL. Higher serum creatinine levels were strongly associated with lower LVEF. Glycemic status (A1C) and urea levels also showed negative associations with LVEF. After adjustment, serum creatinine and A1C remained independent predictors of reduced LVEF. Conclusion: In AHF patients with T2DM, higher serum creatinine and A1C levels are independently associated with reduced LVEF, underscoring the cardio-renal-metabolic interplay in this population and highlighting the need for integrated management strategies.
Co-Authors Akbar, Nizam Zikri Alsagaff, Mochamad Yusuf Ambari, Ade Meidian Anandini, Hesti Andra, Cut Aryfa Anggoro Budi Hartopo Anggraeni, Vita Yanti Ardini, Tengku Winda Arityanti, Dean Badai Bhatara Tiksnadi Batubara, Gio Justisia Chan, Muhammad Ikhsan Cholid Tri Tjahjono Desandri, Dwita Rian Dewita, Auliya Dwiputra, Bambang Erwan, Nabila Erina Febrianora, Mega Fitra, Maha Harris Hasan Hasan, Harris Hasan, Refli Hergaf, Indah Widyasari Hutapea, Mery Natalia Ilyas, Kamal Kharazzi Ilyas, Kamal Kharrazi Irsad Andi Arso, Irsad Andi Ivander, Alvin Ketaren, Andre Pasha Khaidirman, Sophia Khairina Krevani, Citra Kiki Lubis, Ahmad Feriansyah Lubis, Anggia Chairuddin Lubis, Dian Anindita Makes, Indira Kalyana Muhammad Ridwan Mukhtar, Zulfikri Napitupulu, Bertha Gabriella Nasution, Ali Nafiah Pase, Muhammad Aron Purba, Antonius Leonardo Purba, Joy Wulansari Putra, Muhammad Hafiz Mahruzza Qhabibi, Faqrizal Ria Ramzi, Defriyan Rejeki, Vidya Gilang Rina Artha, I Made Junior Rita Hamdani Rizky Adriansyah Sarastri, Yuke Siregar, Abdullah Afif Sitepu, Andika Sumbayak, Novra Christy Grace Sunanto Ng Susilowati, Eliana Syaoqi, Muhammad Tanjung, Ika Citra Dewi Tarigan, Stefanie Tarsidin, Najmi Fauzan Teuku Bob Haykal Wicaksono, Sony Hilal Yasmine Fitrina Siregar