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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik ALCHEMY Jurnal Penelitian Kimia Adi Widya : Jurnal Pengabdian Masyarakat Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika Cendekia Journal of Pharmacy Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Farmasi Jurnal Pengabdian kepada Masyarakat EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Parapemikir Jurnal Ilmiah Farmasi Advance Sustainable Science, Engineering and Technology (ASSET)
Siti Aisiyah
Program Studi S1 Farmasi, Universitas Setia Budi, Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Freeze-Dried Phycocyanin Microcapsules: Effect of Maltodextrin-Soy Protein Ratios on Encapsulation Efficiency and Particle Properties Siti Aisiyah; Ira Juliani Anwar; Dian Marlina; Ana Indrayati; Desi Purwaningsih
Advance Sustainable Science Engineering and Technology Vol. 8 No. 3 (2026): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v8i3.2759

Abstract

Natural pigments such as phycocyanin are highly sensitive to environmental conditions and therefore require stabilization to broaden their applications in functional products. This study aimed to evaluate the effect of varying ratios of maltodextrin and soy protein isolate (SPI) on the physical properties and encapsulation performance of freeze-dried phycocyanin microcapsules. Phycocyanin was extracted using phosphate buffer and encapsulated in three formulations with different maltodextrin–SPI proportions. The obtained microcapsules were characterized using UV–Vis spectrophotometry and particle size analysis (PSA) to determine encapsulation efficiency (EE), yield, moisture content, purity index, and particle size distribution. All experiments were performed in triplicate (n = 3), and data were analyzed using one-way ANOVA (p < 0.05). The formulation with a higher proportion of maltodextrin exhibited the best performance, achieving high EE (≈96%), low moisture content, and uniform particle size. These findings highlight that optimizing biopolymer combinations can enhance the quality and stability of phycocyanin microcapsules, demonstrating potential applications in functional food and pharmaceutical formulations.
PENGARUH KOMBINASI BAHAN PELICIN MAGNESIUM STEARAT DAN TALK DALAM PEMBUATAN TABLET GLIMEPIRID DENGAN TEKNIK PENCAMPURAN INTERAKTIF Ilham Kuncahyo; Siti Aisiyah; Shabrina Nindya Hutami; RR Sri Wulandari

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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v10i2.419

Abstract

Homogeneity is one of the primary challenges in the formulation of tablets containing low-dose drugs such as glimepiride. The interactive mixing technique, in which the drug is adhered to a host carrier, has been developed as an innovative approach to address this issue. One of the essential excipients required in tablet manufacturing is a lubricant. The use of micronized lubricants, namely magnesium stearate and talc, plays a critical role in determining the outcome of the compression process of interactive mixture tablets. This study aimed to investigate the effect of magnesium stearate and talc as lubricants on the physical quality and dissolution behavior of glimepiride interactive mixture tablets. Five formulations were prepared using different proportions of magnesium stearate and talc: F1 (magnesium stearate : talc) = 1,25 : 0,75; F2 = 0,5 : 1,5; F3 = 0,25 : 1,25; F4 = 1,5 : 0,5; and F5 = 1 : 1. The host carrier was prepared by mixing Avicel PH 101 and lactose in a 1:1 ratio, followed by granulation using polyvinylpyrrolidone (PVP) as a binder. The lubricants were then blended with the host particles onto which glimepiride had been adhered, and the mixture was subsequently compressed using the direct compression method. The resulting tablets were evaluated for physical quality parameters, including friability, hardness, disintegration time, and dissolution. The data obtained from each formulation were statistically analyzed using SPSS version 12.0. The results demonstrated that all five formulations met the homogeneity requirements, with coefficient of variation (CV) values of less than 5%. The combination of magnesium stearate and talc significantly affected the physical quality and dissolution behavior of glimepiride interactive mixture tablets. Formula 4, which contained the highest proportion of magnesium stearate and the lowest proportion of talc compared to F1, F2, F3, and F5, produced tablets with greater hardness, reduced friability, prolonged disintegration time, and a slower dissolution rate.
Co-Authors Ana Indrayati Desi Purwaningsih Dwi Ayunda Putri ELISABETH APRILIA Gregorius Prima Indra Budianto, Gregorius Prima Indra Husnul Khatimah Ilham Kuncahyo Ilham Kuncahyo, Ilham Ira Juliani Anwar Marlina, Dian Mega Novita Mimiek Murrukmihadi Muhamad Ansory, Hery Muhammad Dzakwan Noela Riski Riani Sumbung Nurfiana Rachmawati Padusitrada Padusitrada Pudiastuti R.S.P Rani Dewi Pratiwi Reslely Harjanti Rika Widyapranata RR Sri Wulandari Ryan Werytama Saputra Shabrina Nindya Hutami Suhartinah Suhartinah Suhartinah Suhartinah, Suhartinah Syamsul Arifin Takad Bagas Aji Prasetyo Titik Sunarni Valentina Ayuk Armadani Vivin Nopiyanti Wulandari, Destik Yari Mukti Wibowo Yunita Ayuningtyas Â