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Amalia, Annora Rizky
Politeknik Indonusa Surakarta
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UJI KONSENTRASI HAMBAT MINIMUM (KHM) MINYAK ATSIRI ADAS (FOENICULUM VULGARE MILL.) TERHADAP PERTUMBUHAN BAKTERI PROPIONIBACTERIUM ACNES DENGAN METODE SUMURAN Amalia, Annora Rizky
Jurnal Review Pendidikan dan Pengajaran Vol. 7 No. 3 (2024): Vol. 7 No. 3 (2024): Volume 7 No 3 Tahun 2024 (Special Issue)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v7i3.32115

Abstract

Jerawat (acne vulgaris) merupakan suatu kondisi inflamasi yang secara umum terjadi pada bagian organ kulit. Jerawat dapat disebabkan oleh bakteri Staphylococcus aureus, Propionibacterium acnes dan Staphylococcus epidermidis. Penelitian ini bertujuan untuk mengetahui aktivitas minyak atsiri adas (foeniculum vulgare mill.) terhadap pertumbuhan bakteri propionibacterium acnes. Pengujian aktivitas antibakteri dilakukan menggunakan metode difusi agar dengan cara sumuran pada variasi konsentrasi 2%, 4%, 6% dan 8% . Kontrol positif yang digunakan pada penelitian ini adalah klindamisin dan kontrol negatif menggunakan DMSO 10%. Hasil uji daya hambat yang diperoleh dari pengujian minyak adas pada konsentrasi 2% memiliki daya hambat rata-rata 7,5mm, konsentrasi 4% memiliki daya hambat rata-rata 12 mm, konsentrasi 6% memiliki daya hambat rata-rata 17 mm, dan pada konsentrasi 8% memiliki daya hambat rata-rata 19 mm. Kontrol positif klindamisin memiliki daya hambat sebesar 14 mm maka disimpulkan bahwa Konsentrasi Hambat Minimum (KHM) minyak atsiri adas terhadap bakteri jerawat yaitu Propionibacterium acnes pada konsentrasi 2% dengan diameter zona hambat sebesar 7,5 mm.
COST OF ILLNESS STROKE TREATMENT: A SYSTEMATIC REVIEW Izzah, Raihana Nurul; Alia, Dina Fatma; Amalia, Annora Rizky; Sari, Yunita Dian Permata
Medical Journal of Nusantara Vol. 5 No. 1 (2026): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v5i1.1957

Abstract

Cardiovascular disease remains the leading cause of death worldwide, with stroke playing a significant role in increasing morbidity, mortality, and the global economic burden. This study aimed to systematically review the cost of illness and health expenditure associated with stroke across different countries. A systematic review was conducted using PubMed, ScienceDirect, and Springer databases for articles published between 2021 and 2026, following PRISMA guidelines. Studies included in the criteria were original research that reported direct and/or indirect costs due to stroke, both in primary health care facilities and in hospitals. Data extraction, screening, and quality assessment were performed using the CHEERS checklist. A total of 13 studies met the inclusion criteria. The findings showed that most studies (76%) applied the Cost Of Illness (COI) approach, while the rest used Health Expenditure (HE) methods. Direct medical costs, particularly those from inpatient care, constitute the largest component of stroke-related expenditures. Cost estimates show considerable variation between countries, with expenditures tending to be higher in high-income countries than in middle-income countries. Clinical severity, length of hospital stay, stroke subtype, and sociodemographic factors were identified as key determinants influencing total costs. Indirect cost components such as lost productivity and premature death also contribute significantly, but their reporting has not been consistent across studies. In conclusion, stroke imposes a substantial and heterogeneous economic burden influenced by methodological approaches, perspectives, and healthcare system differences. Comprehensive evaluation including both direct and indirect costs is essential to support effective health policy and resource allocation.
Evaluation of Potential Antihypertensive Drug Interactions in Hospitalized Patients: A Retrospective Study Based on Medical Records Annora rizky amalia; Alfina Nurrahman; Bella Anggreyani Yusuf
Jurnal Surya Medika (JSM) Vol. 12 No. 1 (2026): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v12i1.13410

Abstract

Hypertension is a chronic disease that requires long-term treatment. The concomitant use of multiple medications in hospitalized patients may increase the risk of potential drug interactions, which can affect treatment effectiveness and patient safety. This study aimed to evaluate potential antihypertensive drug interactions in hospitalized patients based on medical record data. A descriptive study with a retrospective design was conducted by reviewing the medical records of patients with hypertension at a regional public hospital in Central Java. The samples were selected using purposive sampling according to the predetermined inclusion and exclusion criteria. Potential drug interactions were analyzed based on the combinations of medications prescribed during hospitalization. The results showed that 85 patients (70.83%) had potential drug interactions, with a total of 208 interaction events, of which 155 (74.52%) involved antihypertensive drugs. The most frequent potential interaction occurred between amlodipine and Santagesik, accounting for 20 events (9.62%). Most interactions were classified as significant (77.40%) and were predominantly pharmacokinetic in mechanism (79.81%). Potential antihypertensive drug interactions remain common among hospitalized patients, highlighting the importance of regular therapy evaluation and medication monitoring to improve treatment safety and effectiveness.
Uji Potensi Fraksi n-Heksan Daun Keji Besi (Hemigraphis repanda L.) Sebagai Antibakteri Terhadap Escherichia Coli dan Bacillus Cereus Beserta Penentuan Konsentrasi Hambat Minimum (KHM) Alfina Nurrahman; Rahmat Hidayat; Annora Rizky Amalia
Journal of Health, Medical, and Psychological Studies Vol 1 No 2 (2025): December: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/29v9p164

Abstract

This study aimed to evaluate the antibacterial potential of the n-hexane fraction of Keji Besi leaves (Hemigraphis repanda L.) against Escherichia coli and Bacillus cereus, as well as to determine its Minimum Inhibitory Concentration (MIC). Keji Besi leaves were extracted by maceration using 96% ethanol, followed by liquid–liquid fractionation with n-hexane. The antibacterial activity was assessed using the disc diffusion method, while MIC values were determined using the broth dilution method. Phytochemical screening revealed that the n-hexane fraction predominantly contained steroid and triterpenoid compounds. The disc diffusion assay showed that the n-hexane fraction exhibited stronger inhibitory activity against B. cereus than E. coli, with the largest inhibition zone observed at an 80% concentration. MIC determination indicated that the MIC value for B. cereus was 40% (w/v), whereas E. coli required a higher concentration of 80% (w/v) to inhibit bacterial growth. These findings suggest that the n-hexane fraction of Keji Besi leaves demonstrates selective antibacterial activity, particularly against Gram-positive bacteria. Therefore, this fraction has promising potential to be developed as a natural antibacterial agent, especially for infections caused by Gram-positive pathogens.
Co-Authors Alfina Nurrahman Alfina Nurrahman Alia, Dina Fatma Andany Oktamia Ningtyas Hartoyo Ardhia Intan Cahyani Arief, Khunaisa Ariska Rahmawati Utami Bella Anggreyani Yusuf Deny Balita Wulandari Dewi Weni Sari Diyan Sakti Purwanto Ela Fransisca Christa S Izzah, Raihana Nurul Kharisma Jayak Pratama Muhammad Dani Riano Muhammad Firdaus Nafisah, Umi Natasya Maya Isabella Rahmat Hidayat Riyan Setiyanto Riyan Setiyanto Sari, Dewi Weni Siski Nautika Dewi Vania Santika Putri Yunita Dian Permata Sari Zulaika Febru Zalsabila