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All Journal Jurnal Biologi Tropis Oto Rhino Laryngologica Indonesiana Asian Australasian Neuro and Health Science Journal (AANHS-J) Narra J
Zahara, Devira
Faculty Of Medicine Universitas Sumatera Utara/H.Adam Malik General Hospital, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Osteoradionecrosis and cholesteatoma of external auditory canal in postradiotherapy nasopharyngeal carcinoma patien Devira Zahara; Agus Multazar
Oto Rhino Laryngologica Indonesiana Vol 43, No 1 (2013): Volume 43, No. 1 January - June 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.997 KB) | DOI: 10.32637/orli.v43i1.13

Abstract

Background: Osteoradionecrosis and cholesteatoma of the external auditory canal following external-beam radiotherapy as the treatment of nasopharyngeal carcinoma is a rarely found complication. Patients with external auditory canal cholesteatoma (EACC) typically present with chronic otorrhea and dull pain due to the local invasion of squamous tissue into the bony external audioty canal (EAC). Purpose: To remind ENT specialists and general practitioners about the risk osteoradionecrosis and cholesteatoma of external auditory canal in nasopharyngeal carcinoma patient after radioteraphy treatment. Case: We report a case of osteoradionecrosis andcholesteatoma of EAC in nasopharyngeal carcinoma (NPC) patient with complaint of a foul-smelling discharge from her right and left ears. Two years previously she had undergone external-beam radiotherapy to the neck as the treatment for nasopharyngeal carcinoma. Management: The cholesteatoma was removed microscopicaly on local anasthesia. After the cholesteatoma had been removed the right ear result of pure tone audiometry showed mild degree conductive hearing loss (27,7 dB), while the left ear within normal hearing threshold. Conclusion: Osteoradionecrosis and cholesteatoma of external auditory canal could develop as a complication ofradioteraphy in nasopharyngeal carcinoma patient. Keywords: osteoradionecrosis, cholesteatoma, radiotherapy, chronic otorrhea.ABSTRAKLatar belakang: Komplikasi osteoradionekrosis dan kolesteatoma pada liang telinga luar akibat radioterapi pada pengobatan karsinoma nasofaring sangat jarang terjadi. Pasien dengan kolesteatoma liang telinga luar biasanya datang dengan keluhan otore kronis dan nyeri akibat invasi dari jaringan skuamus ke tulang liang telinga luar. Tujuan: Memberi wawasan bagi dokter umum dan spesialis THT-KL tentang adanya risiko osteoradionekrosis dan kolesteatoma pada liang telinga luar akibat radioterapi pada penderita karsinoma nasofaring. Kasus: Dilaporkan satu kasus osteoradionekrosis dan kolesteatoma di liang telinga luar pada penderita karsinoma nasofaring dengan keluhan sekret telinga berbau busuk pada liang telinga kanan dan kiri.Dua tahun sebelumnya pasien tersebut mendapat radioterapi untuk pengobatan karsinoma nasofaring. Penatalaksanaan: Kolesteatoma diangkat secara mikroskopis dengan anestesi lokal. Pemeriksaan audiometri nada murni pascatindakan didapati tuli konduktif derajat ringan (27,7dB) pada telinga kanan sedangkan telinga kiri dalam batas normal. Kesimpulan: Radionekrosis dan kolestatoma liang telinga luar merupakan komplikasi terapi radiasi pada kasus karsinoma nasofaring.Kata kunci: osteoradionekrosis, kolesteatom, radioterapi, otore kronis.
Hubungan ekspresi Tumor Necrosis Factor Alpha (TNF-α) dengan destruksi tulang akibat kolesteatoma Sara Yosephine Aruan; Askaroellah Aboet; Devira Zahara; Aliandri Aliandri; Abdul Rachman Saragih
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1737.418 KB) | DOI: 10.32637/orli.v45i1.104

Abstract

Latar belakang: Kolesteatoma merupakan penyakit yang menyebabkan destruksi tulang dan  komplikasi yang berbahaya. Tumor Necrosis Factor Alpha (TNF-a) merupakan sitokin utama yang terlibatdalam proses tersebut. Tujuan: Mengetahui hubungan ekpresi TNF-a dengan destruksi tulang akibatkolesteatoma pada penderita Otitis Media Supuratif Kronis (OMSK)  tipe bahaya. Metode: Penelitian inimerupakan penelitian analitik dengan menggunakan cross sectional design. Pemeriksaan imunohistokimiadilakukan untuk menilai ekspresi TNF-a pada kolesteatoma. Hasil: Ekspresi TNF-a yang positif/overexpressionlebihbanyakpada kelompok destruksi tulang derajat sedang yaitu sebanyak 57,9%. Terdapathubunganyang bermakna antara ekspresi TNF-adengan derajat destruksitulang (p=0,001).Kesimpulan:Terdapathubungan antara ekspresi TNF-adengandestruksi tulang akibat kolesteatoma padapenderitaOMSKtipe bahaya. Kata kunci: TNF-a, Destruksi tulang, Kolesteatoma, OMSKABSTRACT Background: Cholesteatoma is a disease which promotes bone destruction resulting in potentially serious complication.  The Tumor Necrosis Factor Alpha (TNF-a) is one of the main cytokine involvedin this process. Purpose: To find out the relationship between TNF-a expression and bone destruction indangerous type of CSOM. Method: This is a cross sectional analytical research. Thirty cholesteatomasamples were observed by immunohistochemical  examination for  TNF-a expression. Result: We foundover-expression of TNF-a in the group with moderate bone destruction (57.9%). There was a significantdifference between TNF-a expression with the degree of bone destruction (p=0,001). Conclusion: Therewas an association between TNF-a expression with   bone destruction in dangerous type of CSOM. Keywords: TNF-a, Bone destruction, Cholesteatoma, CSOM
The correlation between earphone usage patterns with the incidence rate and severity of tinnitus Adrian Joshua Velaro; Devira Zahara
Oto Rhino Laryngologica Indonesiana Vol 51, No 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i2.432

Abstract

ABSTRACTBackground: Earphone nowadays is extensively used along with audiovisual technology development. The increased use of earphone can lead to tinnitus. Around 10- 20% of the adult population had experienced tinnitus during their life, and 0.5-2.5% affected their quality of life. Tinnitus in medical students could interfere in the teaching process which could can lead to decreased quality of medical students. Objective: To observe the correlation between the pattern of using earphone with the incidence of tinnitus, and to determine the severity of tinnitus among students of the Faculty of Medicine, Universitas Sumatera Utara, class 2017-2019 who used earphones. Method: This was an analytic study with cross-sectional design, using consecutive sampling technique. Result: Bivariate analysis between earphone use patterns and the incidence of tinnitus among the subjects obtained statistically significant results (p=0.017). Univariate analysis on 148 respondents showed a pattern of risky earphone use (64.2%) and 52 people with tinnitus (35.1%), and tinnitus severity with 52 participants based on Visual Analogue Scale was mild (55.8%) and based on Tinnitus Handicap Inventory Questionnaire was light (53.9%). In the pattern of earphone use, the results of the analysis of the frequency of using earphones for 3-4 days were (40.5%), the volume of earphone use was 60-80% (54.1%), the length of time using earphones >3 years was (65.5%), and the duration of using earphones <1 hour (38.5%). Conclusion: There was a correlation between the pattern of earphone use and the incidence of tinnitus among students at the Faculty of Medicine, Universitas Sumatera Utara, class 2017-2019.Keywords: earphone, tinnitus, Visual Analog Scale, Tinnitus Handicap Inventory QuestionnaireABSTRAKLatar belakang: Earphone saat ini sangat banyak digunakan seiring dengan perkembangan teknologi audiovisual. Prevalensi pengguna earphone pada remaja sekitar 83,6% dari 436 remaja. Penggunaan earphone yang berlebihan dapat menyebabkan tinitus. Statistik prevalensi dunia menunjukkan 30-40% populasi dewasa pernah mengalami tinnitus dalam hidupnya dan 0,5-2,5% kualitas hidupnya sangat terganggu oleh tinitus. Tinitus merupakan salah satu tanda penurunan fungsi pendengaran dan mampu menyebabkan penurunan performa kognitif. Tinitus pada mahasiswa kedokteran dapat mengganggu proses belajar mengajar sehingga dapat menurunkan kualitas mahasiswa kedokteran. Tujuan: Untuk mengetahui apakah terdapat hubungan pola penggunaan earphone dengan angka kejadian tinnitus serta tingkat keparahan tinitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara. Metode: Penelitian analitik dengan desain potong lintang dengan teknik pengambilan secara consecutive sampling. Pengukuran dilakukan dengan Visual Analog Scale (VAS) dan Tinitus Handicap Inventory Questionnaire (THI-Q). Hasil: Analisis bivariat antara pola penggunaan earphone dengan angka kejadian tinnitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara diperoleh hasil (p=0,017). Analisis univariat pada 148 responden menunjukkan pola penggunaan earphone berisiko sebanyak (64,2%) dan yang mengidap tinitus sebanyak 52 orang (35,1%), dan tingkat keparahan tinitus dengan jumlah responden 52 orang berdasarkan VAS adalah ringan (55,8%) dan berdasarkan THI-Q adalah ringan (53,9%). Pada pola penggunaan earphone diperoleh hasil analisis frekuensi penggunaan earphone 3-4 hari sebanyak (40,5%), volume penggunaan earphone 60-80% sebanyak (54,1%), lama penggunaan earphone >3 tahun sebanyak (65,5%), dan durasi penggunaan earphone <1 jam sebanyak (38,5%). Kesimpulan: Terdapat hubungan antara pola penggunaan earphone dengan angka kejadian tinitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara angkatan 2017-2019.Kata kunci: earphone, tinitus, Visual Analog Scale, Tinnitus Handicap Inventory Questionnaire
The correlation between earphone usage patterns with the incidence rate and severity of tinnitus Adrian Joshua Velaro; Devira Zahara
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i2.432

Abstract

ABSTRACTBackground: Earphone nowadays is extensively used along with audiovisual technology development. The increased use of earphone can lead to tinnitus. Around 10- 20% of the adult population had experienced tinnitus during their life, and 0.5-2.5% affected their quality of life. Tinnitus in medical students could interfere in the teaching process which could can lead to decreased quality of medical students. Objective: To observe the correlation between the pattern of using earphone with the incidence of tinnitus, and to determine the severity of tinnitus among students of the Faculty of Medicine, Universitas Sumatera Utara, class 2017-2019 who used earphones. Method: This was an analytic study with cross-sectional design, using consecutive sampling technique. Result: Bivariate analysis between earphone use patterns and the incidence of tinnitus among the subjects obtained statistically significant results (p=0.017). Univariate analysis on 148 respondents showed a pattern of risky earphone use (64.2%) and 52 people with tinnitus (35.1%), and tinnitus severity with 52 participants based on Visual Analogue Scale was mild (55.8%) and based on Tinnitus Handicap Inventory Questionnaire was light (53.9%). In the pattern of earphone use, the results of the analysis of the frequency of using earphones for 3-4 days were (40.5%), the volume of earphone use was 60-80% (54.1%), the length of time using earphones >3 years was (65.5%), and the duration of using earphones <1 hour (38.5%). Conclusion: There was a correlation between the pattern of earphone use and the incidence of tinnitus among students at the Faculty of Medicine, Universitas Sumatera Utara, class 2017-2019.Keywords: earphone, tinnitus, Visual Analog Scale, Tinnitus Handicap Inventory QuestionnaireABSTRAKLatar belakang: Earphone saat ini sangat banyak digunakan seiring dengan perkembangan teknologi audiovisual. Prevalensi pengguna earphone pada remaja sekitar 83,6% dari 436 remaja. Penggunaan earphone yang berlebihan dapat menyebabkan tinitus. Statistik prevalensi dunia menunjukkan 30-40% populasi dewasa pernah mengalami tinnitus dalam hidupnya dan 0,5-2,5% kualitas hidupnya sangat terganggu oleh tinitus. Tinitus merupakan salah satu tanda penurunan fungsi pendengaran dan mampu menyebabkan penurunan performa kognitif. Tinitus pada mahasiswa kedokteran dapat mengganggu proses belajar mengajar sehingga dapat menurunkan kualitas mahasiswa kedokteran. Tujuan: Untuk mengetahui apakah terdapat hubungan pola penggunaan earphone dengan angka kejadian tinnitus serta tingkat keparahan tinitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara. Metode: Penelitian analitik dengan desain potong lintang dengan teknik pengambilan secara consecutive sampling. Pengukuran dilakukan dengan Visual Analog Scale (VAS) dan Tinitus Handicap Inventory Questionnaire (THI-Q). Hasil: Analisis bivariat antara pola penggunaan earphone dengan angka kejadian tinnitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara diperoleh hasil (p=0,017). Analisis univariat pada 148 responden menunjukkan pola penggunaan earphone berisiko sebanyak (64,2%) dan yang mengidap tinitus sebanyak 52 orang (35,1%), dan tingkat keparahan tinitus dengan jumlah responden 52 orang berdasarkan VAS adalah ringan (55,8%) dan berdasarkan THI-Q adalah ringan (53,9%). Pada pola penggunaan earphone diperoleh hasil analisis frekuensi penggunaan earphone 3-4 hari sebanyak (40,5%), volume penggunaan earphone 60-80% sebanyak (54,1%), lama penggunaan earphone >3 tahun sebanyak (65,5%), dan durasi penggunaan earphone <1 jam sebanyak (38,5%). Kesimpulan: Terdapat hubungan antara pola penggunaan earphone dengan angka kejadian tinitus pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara angkatan 2017-2019.Kata kunci: earphone, tinitus, Visual Analog Scale, Tinnitus Handicap Inventory Questionnaire
Correlation of Tympanomastoidectomy Pathological Findings With Hearing Loss In Chronic Suppurative Otitis Media Patients Nasution, Nurhalimah; Zahara, Devira; Lubis, Yuliani M.; Harahap, Pahala Hanafi; Herwanto, H.R. Yusa; Ashar, Taufik
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.614

Abstract

Background: Patients with chronic suppurative otitis media (CSOM) often experience hearing loss from mild to very severe degrees. In addition, patients with CSOM often have intraoperative pathological findings. Aims of this study is to determine the correlation between intraoperative tympanomastoidectomy pathological findings with the type and degree of hearing loss using pure tone audiogram images in CSOM patients. Methods: This study is an analytic type study that uses a cross-sectional design. This research was conducted in three hospitals during October 2021 to December 2021. The sample size in this study was 37 patients who would undergo tympanomastodectomy surgery. Results: The most common pathological finding was granulation in 36 patients (97.3%) and followed by sclerotic in 31 patients (83.8%). The average patient had more than 2 pathological findings. Most of patients (78.4%) had conductive hearing loss and most of patients had moderate degree of hearing loss in 25 patients (67.6%). Based on type of hearing loss, there were significant associations with several pathological findings, namely cholesteatoma (p=0.003), defect ossicles (p=0.009), ossicular defects (p=0.001), facial nerve defects (p=0.009). In terms of the number of pathological findings, there was a significant correlation with hearing loss (p=0.004, r=0.467) and the degree of hearing loss (p=0.029, r=0.360). Conclusion: Among the pathological findings by type of hearing loss, a significant correlation was found.
Carpal Tunnel Syndrome Incidence In Teachers and Employees at SMP Negeri 1 Pematangsiantar Situmorang, Yessi Debora; Fitri, Aida; Zahara, Devira; Sinaga, Bintang Y.M.
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 6 No. 3 (2024): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhsj.v6i3.19200

Abstract

Background. Median nerve compression at the wrist (carpal tunnel syndrome) is the most common disorder affecting the median nerve and is the most common nerve compression syndrome. Problems usually arise from excessive hand use and work microtrauma. Objectives. To determine the incidence, severity, characteristics of respondents detected, and risk factors that allow for CTS. Methods. The study was an analytic-descriptive study with a cross-sectional approach. Using 70 samples of data from educators and employees at SMP Negeri 1 Pematangsiantar. Data were analyzed using univariate and bivariate analysis. Results. This study involved 70 educators and employees, 59 (84.3%) were found with the majority of respondents experiencing complaints with asymptomatic symptom severity 46 people (65.7%), mild 22 people (31.4%), and moderate 2 people (22.9%). Of the 59 respondents detected, 50 people (71.4%) had mild functional symptom status. The majority of respondents detected with CTS were female (74.6%) and were in the age range of 51-60 years (44%). Respondents detected with CTS had nutritional status type I obesity (34%). Of the 59 respondents detected with CTS, 54 people (91.5%) were educators who had a working duration of ≥8 hours a day (52.5%) and experienced complaints in the left hand (69.5%). Conclusion. Most predominantly female in the age range of 51-60 years who worked as educators with a working duration of ≥8 hours and the majority experienced complaints in the left hand. Keywords: Carpal tunnel syndrome, educators, incidence
Therapeutic potential of thymoquinone in regulating p63, claudin, and periostin in chronic rhinosinusitis with nasal polyps: An animal model study Ulfa, Loriana; Munir, Delfitri; Rambe, Andrina YM.; Farhat, Farhat; Wardani, Retno S.; Amin, Mustafa M.; Zahara, Devira; Ardinata, Dedi
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1728

Abstract

High recurrence rate and the necessity for repeated surgical interventions contribute to the chronicity and treatment-resistant nature of chronic rhinosinusitis with nasal polyps (CRSwNP). Thymoquinone, known for its protective effects on epithelial integrity, has not been previously explored in CRSwNP. The aim of this study was to investigate the therapeutic potential of thymoquinone to restore epithelial integrity by assessing p63 transcription factor and claudin protein expressions, as well as periostin mRNA expression in an animal model. An in vivo study using post-test-only control group design was conducted in which male Wistar rats were randomly assigned to three groups, each consisting of 10 animals: healthy group, CRSwNP group, and thymoquinone-treated group for three weeks. Immunohistochemistry was used to analyze the p63 and claudin protein expressions, while periostin mRNA expression was quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR). This study found that thymoquinone significantly reduced p63 transcription factor expression compared to the untreated CRSwNP group (p=0.009). Claudin protein expression was significantly higher in thymoquinone-treated group compared to CRSwNP group (p=0.007), indicating improved epithelial barrier function. Periostin mRNA expression showed no significant difference between healthy and thymoquinone-treated groups (p=0.564), but a significant decrease was observed in CRSwNP group compared to thymoquinone-treated group (p=0.000) and between the healthy and CRSwNP groups (p=0.002), suggesting attenuation of tissue remodeling and inflammation. In conclusion, thymoquinone could enhance sinonasal epithelial barrier integrity in CRSwNP by downregulating p63 transcription factor, upregulating claudin protein expression, and reducing periostin mRNA expression. These findings emphasize the potential of thymoquinone as a therapeutic agent to mitigate inflammation and tissue remodeling in CRSwNP, warranting further investigation as a novel treatment option.
The Association Between Allergic Rhinitis and Chronic Suppurative Otitis Media Simanjutak, Yohana; Zahara, Devira; Sofyan, Ferryan; Ashar, Taufik
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8880

Abstract

Tympanic membrane perforation and continuous discharge are hallmarks of chronic suppurative otitis media, a chronic inflammation of the middle ear. Through the malfunction of the Eustachian tube brought on by allergic inflammation, allergic rhinitis may contribute to the development of CSOM. This study aimed to analyze the relationship between allergic rhinitis and CSOM, identify common allergens, and assess the association between eosinophil levels and CSOM. A case-control study was conducted at RSUP H. Adam Malik and RS Murni Teguh Medan involving 72 participants: 36 CSOM patients and 36 healthy controls. Skin prick tests (SPT) and eosinophil counts were used to assess allergic status. Statistical analysis used Chi-square and Fisher’s exact test with significance set at p < 0.05. The results showed a significant association between allergic rhinitis and CSOM (p = 0.001; OR = 6.192). Common allergens found in CSOM patients were D. pteronyssinus (66.7%), D. farinae (63.9%), and cockroach (47.2%), with significant associations (p < 0.05). No significant relationship was found between allergic rhinitis and CSOM sides or type (p > 0.05). Elevated eosinophil levels were more common in the CSOM group but were not statistically significant (p = 0.624). In conclusion, allergic rhinitis is significantly associated with CSOM. Allergen screening is recommended for CSOM patients to improve diagnosis, treatment, and recurrence prevention.
Antibacterial Effect of Honey Against Pseudomonas aeruginosa in Chronic Suppurative Otitis Media Patients and ATCC Bacterial Strains in Vitro Nasution, Andi Imam Buchari; Zahara, Devira; Asroel, Harry Agustaf
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9604

Abstract

Pseudomonas aeruginosa and Staphylococcus aureus are common causative bacteria in Chronic Suppurative Otitis Media (CSOM). Honey, as a natural substance, has shown antibacterial activity. To evaluate the antibacterial effect of honey at different concentrations on P. aeruginosa (clinical isolates and ATCC 27852) and S. aureus (ATCC 29213) compared to ofloxacin. An experimental in vitro study using post-test only design was conducted. Bacterial isolates from CSOM patients and ATCC strains were exposed to honey at concentrations of 60%, 70%, 80%, 90%, and 100%. Zone of inhibition was measured using the agar diffusion method. Honey exhibited significant antibacterial activity against all tested bacteria. The highest inhibition zones were observed at 100% concentration. Ofloxacin showed greater inhibition than honey in general, but honey still demonstrated moderate to strong activity. Honey has potential as a natural antibacterial agent against P. aeruginosa and S. aureus, and may serve as an alternative or adjunct treatment for CSOM.
The Relationship Between Age and Comorbidities (Type 2 Diabetes Mellitus and Hypertension) and Hearing Loss in Women Over 40 Years of Age Simanjuntak, Saurma O S; Herwanto, H R Yusa; Lubis, Yuliani M; Zahara, Devira; Kananda, Vive; Ashar, Taufik
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9999

Abstract

Hearing loss is a public health problem that increases with age and can be exacerbated by comorbidities such as type 2 diabetes mellitus (DM) and hypertension. This study analyzed the relationship between age and comorbidities (DM type 2 and hypertension) on hearing loss in women over 40 years old. A cross-sectional analytical study of 34 women over 40 years old in Kotamatsum IV Village, Medan. Hearing examinations were performed using pure tone audiometry and otoacoustic emission (OAE). Statistical analysis was performed using the Chi-Square, Mann-Whitney, and Kruskal-Wallis tests. There was a significant relationship between age and the degree of hearing loss (p=0.047), with the majority of subjects aged >50 years experiencing mild deafness. However, no significant relationship was found between comorbidities of type 2 DM and/or hypertension on the degree, type of hearing loss, or OAE results (p>0.05). Age was significantly associated with the degree of hearing loss, while type 2 DM and hypertension did not show a significant relationship. Further research is needed considering disease duration and treatment adherence to further understand the contribution of comorbidities to hearing loss.
Co-Authors Abdul Rachman Saragih Adrian Joshua Velaro Agus Multazar Aliandri Aliandri Aliandri, Aliandri Amin, Mustafa M. Ardinata, Dedi - Askaroellah Aboet Bintang Y.M. Sinaga, Bintang Y.M. Chrestella, Jessy Delfitri Munir Farhat, Farhat Ferryan Sofyan Fitri, Aida Harahap, Pahala Hanafi Harry Agustaf Asroel Herwanto, H R Yusa Herwanto, H. R. Yusa Herwanto, R. Yusa Kananda, Vive Lubis, Yuliani M Lubis, Yuliani M. Nasution, Andi Imam Buchari Nasution, Erizal Salam Putra Nasution, Nurhalimah Rambe, Andrina YM. Sara Yosephine Aruan Simanjuntak, Saurma O S Simanjutak, Yohana Situmorang, Yessi Debora Taufik Ashar Ulfa, Loriana Wardani, Retno S.