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All Journal Jurnal Biologi Tropis Oto Rhino Laryngologica Indonesiana Asian Australasian Neuro and Health Science Journal (AANHS-J) Narra J
Zahara, Devira
Faculty Of Medicine Universitas Sumatera Utara/H.Adam Malik General Hospital, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Relationship Between Cigarette Smoke Exposure and Laryngeal Histopathology in Rattus novergicus Rats Nasution, Erizal Salam Putra; Herwanto, H. R. Yusa; Zahara, Devira; Aliandri, Aliandri; Lubis, Yuliani M.; Ashar, Taufik; Chrestella, Jessy
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10804

Abstract

Smoking can cause health problems for both active and passive smokers because the toxic substances contained in it cause health problems, especially in the larynx, one of which is laryngeal cancer. Animal studies have shown histopathological changes in mice exposed to cigarette smoke, including increased immune cells and focal inflammation in these mice. The study aims to determine the relationship between cigarette smoke and the number of inflammatory cells, edema, hyperplasia, and dysplasia after exposure to cigarette smoke for 120 minutes in histopathological sampling at observations of 0, 10, 20, 30 and 40 days. This study used a true experimental design model with a post-test only group laboratory experimental design. The results of the study found a significant difference in the number of lymphocytes before and after exposure to cigarette smoke with p = 0.043. There was no significant change in the number of macrophages with p = 0.406 and eosinophils with p = 0.119. There were no histopathological changes, namely edema (p = 0.06), dysplasia (p = 0.126) and hyperplasia (p = 0.960). In conclusion, there is a relationship between cigarette smoke exposure and laryngeal histopathology in Rattus novergicus Rats.
Factors Associated with Nasal Mucociliary Clearance Time in Elderly Nursing Home Residents Baros, Wan Andre Nugraha Baros; Munir, Delfitri; Zahara, Devira; Nursiah, Siti; Farhat, Farhat; Ashar, Taufik
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i2.12407

Abstract

The mucociliary transport system is an essential defense mechanism of the nasal cavity that helps remove pathogens, allergens, and particles. Impairment of this system may prolong mucociliary clearance time (MCT) and increase susceptibility to infection. Aging and systemic conditions may influence mucociliary function. This study aimed to evaluate the association between age, gender, diabetes mellitus, hypertension, and smoking history with nasal mucociliary clearance time in elderly individuals. An analytical cross-sectional study was conducted in a nursing home in Medan over three months. A total of 40 elderly participants were included. Nasal mucociliary clearance time was measured using the saccharin test. Data were analyzed using the Chi-square test. The mean mucociliary clearance time was 16.45 minutes. A significant association was found between age and MCT, as well as between gender and MCT, with males showing better clearance time than females. No significant associations were observed between MCT and diabetes mellitus, hypertension, or smoking history. Age and gender are significantly associated with nasal mucociliary clearance time in the elderly, while diabetes mellitus, hypertension, and smoking history are not. These findings suggest that physiological aging and gender-related differences may influence nasal defense mechanisms, highlighting the importance of considering these factors in respiratory health assessment in the elderly.
Aerobic, Anaerobic, Fungal, and Antimicrobial Sensitivity Patterns in CSOM Patients Rahman, Nico Chairuar; Zahara, Devira; Rambe, Andrina Yunita Murni; Asroel, Harry Agustaf; Farhat, Farhat
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i2.12408

Abstract

Chronic Suppurative Otitis Media (CSOM) remains a major global health problem, particularly in low- and middle-income populations. Variations in microbial etiology and antimicrobial susceptibility patterns necessitate periodic evaluation to support appropriate treatment. Objective: To describe the aerobic, anaerobic, and fungal microorganisms associated with CSOM and their antimicrobial susceptibility patterns. This descriptive cross-sectional study included 24 middle ear swab specimens collected from patients with CSOM. Specimens were transported using Amies agar transport medium and cultured on appropriate media. Microorganisms were identified through macroscopic and microscopic examinations and confirmed using the VITEK® 2 Compact system. Antimicrobial susceptibility testing was also performed. Most patients were male and presented with benign CSOM. Pseudomonas aeruginosa was the most common aerobic isolate (6 specimens). Fusobacterium necrophorum and Prevotella disiens were the predominant anaerobic bacteria, while Aspergillus spp. was the most frequently identified fungal pathogen in both benign and malignant CSOM. Amikacin and gentamicin showed the highest antimicrobial sensitivity among the bacterial isolates. Pseudomonas aeruginosa, Fusobacterium necrophorum, Prevotella disiens, and Aspergillus spp. were the predominant microorganisms identified in CSOM. The high sensitivity of amikacin and gentamicin supports their continued use as therapeutic options, guided by microbiological and susceptibility testing.
Co-Authors Abdul Rachman Saragih Adrian Joshua Velaro Agus Multazar Aliandri Aliandri Aliandri, Aliandri Amin, Mustafa M. Ardinata, Dedi - Askaroellah Aboet Baros, Wan Andre Nugraha Baros Bintang Y.M. Sinaga, Bintang Y.M. Chrestella, Jessy Delfitri Munir Farhat, Farhat Ferryan Sofyan Fitri, Aida Harahap, Pahala Hanafi Harry Agustaf Asroel Herwanto, H R Yusa Herwanto, H. R. Yusa Herwanto, R. Yusa Kananda, Vive Lubis, Yuliani M Lubis, Yuliani M. Nasution, Andi Imam Buchari Nasution, Erizal Salam Putra Nasution, Nurhalimah Nursiah, Siti Rahman, Nico Chairuar Rambe, Andrina YM. Rambe, Andrina Yunita Murni Sara Yosephine Aruan Simanjuntak, Saurma O S Simanjutak, Yohana Situmorang, Yessi Debora Taufik Ashar Ulfa, Loriana Wardani, Retno S.