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All Journal Journal Of Vocational Health Studies Journal Health & Science : Gorontalo Journal Health and Science Community JURNAL MUTIARA KESEHATAN MASYARAKAT Jurnal Kesehatan Masyarakat dan Lingkungan Hidup Jurnal Scientia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences International Journal Of Science, Technology & Management (IJSTM) Archives of The Medicine and Case Reports Jurnal EduHealth Jurnal Ekonomi INTERNATIONAL JOURNAL OF CULTURAL AND SOCIAL SCIENCE Jurnal Multidisiplin Madani (MUDIMA) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) International Journal of Health and Pharmaceutical (IJHP) International Journal of Science and Environment Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan The International Journal of Medical Science and Health Research Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health
Ermi Girsang
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Journal : International Journal Of Science, Technology

 1 
Testing Of The Nephroprotective Effectiveness Of Sail Leaf (Syzygium Polyanthum (Wight.)Walp.) In DoxorubisinInduced Male Wistar Rat Dewi; Ali Nafiah Nasution; Ermi Girsang
International Journal of Science, Technology & Management Vol. 2 No. 6 (2021): November 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i6.372

Abstract

Cancer is one of the leading noncommunicable diseases leading to death worldwide. Cancer treatment has progressed but has side effects including nephrotoxic effects. The toxicity of doksorubisin has been widely known which is likely to be chained by the metabolic conversion of doxorubicin to doxorubicinol. The main mechanism of doxorubicinol toxicity occurs due to its interaction with iron and the formation of ROS that damages cell macromolecules. One of the plants that are widely used by the community to deal with various diseases and prevention is bay leaves. Bay leaves contain secondary metabolites that are antioxidant in nature. Antioxidants are needed to protect the body's cells from oxidative damage, preventing various degenerative diseases such as cancer, cardiovascular disease. The study aimed to determine the content of nephroprotective EEDS chemical compounds in phytochemical screening, EEDS characterization and EEDS nephroprotective activity in doxorubicin-induced mice based on uric acid, ureum and creatine levels. The study was experimentally laboratory using mice as test animals. The treatment group consisted of CMC-Na 0.5%, Nature E, EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB followed by administration of doxorubicin. The results showed phytochemicalally EEDS contains chemical compounds that are nephroprotective namely flavonoids, steroids / triterpenoids, saponins . EEDS has a water soluble sari content value of 21.64%, total ash content of 1.79%, water content of 9.98%. Ethanol soluble juice levels were 45.38% and acid insoluble ash levels were 0.39%. EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB can lower uric acid, ureum and cretinine levels and can picture the histopathology of doxorubicin-induced mouse kidneys with an effective dose of 500 mg/kgBB. It can be concluded that ethanol extract of bay leaves has nephroprotective activity.
Co-Authors Akmalul Habib Damanik Ali Nafiah Nasution Alvin Abrar Harahap Analita Khoironissa Anita Merry Cisca Arie - Vonikartika Ary Denggan Syahputra Lubis Asri Widiya Sitompul Asyrun Alkhairi Lubis Ayu Hasanah Panjaitan Benedictus Juve Bethania Nadi Ida Febrina Siagian Chiuman, Linda Clinton Antony Dennis Wijaya Depi Yunaspi Dewi Dhyta Nurhasanah Janas DIAN MELANI Diana Agustina Ritonga Disti Amanda Putri Djohan Djohan Dzil Fikri Erisman Hondro Eva Kristina Pelawi Fioni Fioni Firdha Muharraran Ginting, Chrismis Novalinda Gusbakti Gusbakti Hanjaya hardiansyah siregar Hariyento Halim Ibnu Rushd Ira Syaputri Irfan Aulia irza Haicha Pratama Jeri Yuliansyah Liani Br Ginting Liena M. Ridho Fitra Alamsya Maria Seri Arihta Marlinang I. Silalahi Martin Loodwyck Simanjuntak Maya Sari Mutia Maya Sari Mutiara Muhammad Agus Muljanto Muhammad Insan Andika Muhammad Nawal Hasya Nadia Zenni Andari Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Noni Rokaya Pasaribu Primanita Novi Andriati Putri Satriani Dachi Rakhmat Akbar Dinur Ramadhan Efendi Rapael Ginting Redo Widhio Mahatvavirya Ria Hartaty S. Shelly Hazlina Hararap Saprilliani . Sindy Zelvia SITI AMINAH Sri Lestari Nasution Sri Lestari Ramadhan Sri Lestari Ramadhani Sri Lestari Ramadhani Nasution Stefenie SURYANI Syaifullah Syaifullah Tan Suyono Tommy Adhi Wijaya Ulina Karo Karo Ulina Karo-karo Vijay Dhillon Waoziduhu Ndruru Welly Ria Utami Lubis Widya Pasca Amir Widyaningsih Oentari Widyaningsih Oentari Winda Tri Mutia Wiwin Dwi Handayani Wulan Dhari Yuliani Yuliani Zsa Zsa Ranty Bianca Saragih