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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Biopropal Industri Jurnal Kimia Riset Jurnal Biologi Tropis ANNALES BOGORIENSES Narra J Makara Journal of Science Jurnal Sains Materi Indonesia Annales Bogorienses
Marissa Angelina
Pusat Penelitian Kimia-LIPI, Kawasan PUSPIPTEK Serpong 15314, Tangerang 15314
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antiviral Effect of Pterocarpus indicus Willd Leaves Extract Against Replication of Dengue Virus (DENV) In Vitro Dewi, Beti Ernawati; Angelina, Marissa; meilawati, lia; Hartati, Sri; Dewijanti, Indah Dwiatmi; Santi, Mei Ria; Desti, Hidayati; Sudiro, Mirawati
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (886.48 KB) | DOI: 10.11594/jtls.08.01.10

Abstract

Dengue hemorrhagic fever (DHF) is major public health problem in tropical and subtropical areas of the world with lack of approved vaccines and effective antiviral therapies. With no current treatment for illness attributed to dengue virus (DENV) infection other than supportive care, therapeutic strategies that use natural extract was developed. Indonesia have many plants that potential for antiviral drµgs such as Pterocarpus indicus Willd (P. indicus). The objective of this study was to determine the effect of P. indicus to inhibit DENV replication. We used a well-differentiated hepatocytes-derived cellular carcinoma cell line (Huh-7 it-1 cells) to determine and select antiviral activity. The toxicity effects were determined by MTT assay. Then, the suppression of DENV replication was determined by Focus assay. Dengue infected cells with DMSO were used as control. We found that crude extract (Pi), hexane (Pi.1) and ethyl acetate (Pi.2) extract showed strong inhibition with high selectivity index (SI) of 1,392; 285.36 and 168.56 respectively.  Sub fraction of Pi.1 and Pi.2 still showed strong inhibition with high SI.  Further sub-sub fraction of Pi.2 such as Pi.2.12 and Pi.2.12.1 still showed inhibition of DENV replication but there was reduction of SI value. The mechanism experiment of Pi.2.12, we found that Pi 2.12 more profound to inhibit in the post infection stage that entry or pre-infection. We conclude that the sub-fraction of Pi.2.12 has potential antiviral activity against DV infection in vitro. Further studies are still needed to investigate the pure compound of Pi.2.12 that inhibit and have advantages in the future as alternative for treatment of DENV infection.
Toxicity and Lethality Evaluations of Koordersiodendron pinnatum Leaves Methanolic Extract in DDY Mice Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah Dwiatmi; Angelina, Marissa; Fajriah, Sofa
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.10

Abstract

The study of toxic features of Koordersiodendron pinnatum is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of K. pinnatum in DDY mice. Animals were grouped into five: Group 1 was given 1 mL solution of 2.5% Tween 80 in a single oral dose; the remaining groups were orally given a single dose of 2, 4, 8 and 16 g/kg of K. pinnatum, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 2% of the male group, and no mortality within the female group. The extract is practically non toxic for both male and female (LD50>15 g/kg).
Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice Angelina, Marissa; Dewijanti, Indah D; S, Banjarnahor S D; megawati, Megawati; Yuliani, Tri
Journal of Tropical Life Science Vol 2, No 2 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

Isolation and Characterization Compounds From Hexane and Ethyl Acetate Fractions of Peperomia pellucida L. Hartati, Sri; Angelina, Marissa; Dewiyanti, Indah; Meilawati, Lia
Journal of Tropical Life Science Vol 5, No 3 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.05.03.02

Abstract

      Peperomia pellucida was used traditionally in Indonesia for health treatment: wounds, boils, pimples, abscesses, abdominal pain, colic, gout, kidney, rheumatic pain, fatigue headache, furuncles, conjunctivitis and anti dermatogenic and also for dengue treatment. The isolation compounds from hexane and ethyl acetate fractions of Peperomia pellucida L. are  conducted by maceration of the dry herbs sample with methanol and partition with hexane, ethyl acetate, butanol and water.The hexane and ethyl acetate fractions were fractionated by gravitation column chromatography and eluted successively with hexane, ethyl acetate and methanol by the gradient. The structure was elucidated base on spectroscopy data of NMR proton and carbon for one and two dimension, LC-MS and FT-IR. The isolation founded three compounds are stigmasterol, analogue of pheophytin and b-sitosterol-D-glucopyranoside.
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Co-Authors . Megawati A.A. Ketut Agung Cahyawan W Agustiyanti, Dian F. Agustiyanti, Dian Fitria Anak Agung Istri Sri Wiadnyani Andri Wardiana, Andri Antonius Herry Cahyana Aoki, Chie Beti Ernawati Dewi Desriani Desriani Desti, Hidayati Dewijanti, Indah Dwiatmi Dewijanti, Indah Dwiatmi Dwi Hilda Putri ERNAWATI ARIFIN GIRI-RACHMAN Ferry Iskandar Fibriani, Azzania HAK HOTTA Hariyatun, Hariyatun Indah D Dewijanti, Indah D Indah Dewiyanti, Indah Irdawati Irdawati Kamarisima, Kamarisima Kasiyati Kasiati Khoerunisah, Marya Salfia Lia Meilawati Megawati - Meitha, Karlia Meliana, Yenny Mirawati Sudiro Muchammad Irsyad, Muchammad Ningrum, Ratih A. Nugroho, Herjuno A. Nurfauziyah Permatasari, Fitri Aulia Popi Hadi Wisnuwardhani, Popi Hadi Priharto, Neil Putria, Devi Kasih RAHMANI, SILMI RATIH ASMANA NINGRUM S, Banjarnahor S D Santi, Mei Ria Saputra, Ziyan Saputri, Ariyanti Septiani, Popi Septiyanti, Melati Soedarmono, Pratiwi Sofa Fajriah Sofna D.S. Banjarnahor Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Sri Hartati Stephanie, Rebecca Taharuddin, Audrey Angelina Putri Tan, Marselina I. Tri Yuliani, Tri Triana Dewi, Rizna Wisnuwardhani, Popi H. Yamahoki, Nicholas Yana Rubiyana, Yana Zakri, Dwika Febriana