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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Jurnal Sains dan Teknologi Indonesian Journal of Pharmaceutical Science and Technology Chimica et Natura Acta Akta Kimia Indonesia Widyadari : Jurnal Pendidikan Jurnal Pengabdian UNDIKMA Hydrogen: Jurnal Kependidikan Kimia Journal Of World Science Emasains : Jurnal Edukasi Matematika dan Sains Jurnal Pengabdian Kepada Masyarakat Widya Mahadi Usadha
Agung Ari Chandra Wibawa
Program Studi Sarjana Farmasi Fakultas Farmasi Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Usadha

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Skrining Fitokimia Dan Efek Antikoagulan Eliksir Dari Ekstrak Buah Mengkudu (Morinda citrifolia L.) Pada Tikus Putih Santoso, Puguh; Putri, Noviana; Wibawa, Agung Ari Chandra
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13154

Abstract

The increasing prevalence of thrombosis as a manifestation of hemostatic dysfunction has prompted the search for safer and more accessible alternative anticoagulant agents. Morinda citrifolia L. (noni fruit) contains various bioactive compounds suspected to modulate blood coagulation pathways. This study aimed to evaluate the anticoagulant effectiveness of an elixir formulated from ethanolic extract of noni fruit on the bleeding time of male white rats (Rattus norvegicus). A post-test only randomized group design was employed, consisting of four treatment groups: negative control (aquadest), positive control (acetosal 80 mg), elixir at 40 mg/kgBW, and elixir at 80 mg/kgBW. The extract was prepared by ethanol maceration and then formulated into elixirs, followed by physical quality testing. Anticoagulant activity was assessed by measuring tail bleeding time. Results indicated that the elixir at 80 mg/kgBW significantly prolonged the bleeding time compared to other groups. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids as dominant constituents. The findings demonstrate that the noni fruit elixir possesses anticoagulant activity, with the higher dose yielding the most pronounced effect. This study concludes that Morinda citrifolia has strong potential to be developed as a natural anticoagulant in pharmaceutical applications.
Co-Authors Arandika, I Wayan Wisma Bagus Putra Manuaba, Ida Dewa Ayu Ika Pramitha Dewa Ayu Sri Handani I Made Dedy Ariawan I Made Dira Swantara I WAYAN SUDIARSA I Wayan Surya Rahadi Ketut Agus Adrianta Luh Nik Pradnya Anggi Manuntun Manurung Megawati, Fitria Ni Komang Ariati Ni Made Suaniti Ni Made Sukma Sanjiwani Ni Putu Ayu Mirah Mariati NI PUTU AYU MIRAH MARIATI Ni Wayan Trisna Dewi Nova Mahendra, Agung Nyoman Mantik Astawa, I P Purwanto Paramitha, Dewa Ayu Ika Pradnyandari, I Gusti Ayu Agung Ratih Pramana, I Made Wisnu Yoga Puguh Santoso puguh santoso, puguh Putri, Noviana Putu Era Sandhi Kusuma Yuda Rahadi, I Wayan Surya Samidya, Ni Wayan Rias Sanjiwani, Ni Made Sukma Sari, Ni Wayan Suryani Puspita Setya Cahyani, I Gusti Ayu Agung Dwita Vinanda, Ketut Adelia Wardana, I Made Wisnu