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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN e-GIGI JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro The Journal of Experimental Life Sciences (JELS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Jaringan Laboratorium Medis Medica Arteriana (Med-Art) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Desy Armalina
Department Of Anatomy And Histology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Association between Systole, Diastole, Sex, Age, Blood, and Urine Profile in Older Adults with Hypertension Desy Armalina; Neni Susilaningsih; Bambang Witjahjo; Ratna Damma Purnawati; Akhmad Ismail; Fanti Saktini
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 3 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i3.37060

Abstract

The main cardiovascular changes associated with aging included decreased heart rates, oxygen extraction, arterial stiffening, vasoconstriction, systolic blood pressure elevation, myocardial thickening, reduced diastolic filling rate, rhythmic rate changes, and action potential prolongation. Multifactorial risk can include the pathology of the diseased. This study aims to ascertain the relationship between systole, diastole, sex, age, blood, and urine profiles in an elderly with Hypertension. The logistic regression study found three significant associations between diastole systolic and leucocyte sedimentation with Hypertension. For the net study, various hormones are another pathological marker that can be included in hypertension screening  
HUBUNGAN ANTARA TERJADINYA BAKTERIAL VAGINOSIS DENGAN PENGGUNAAN KONTRASEPSI HORMONAL Salsabella Indriana P.; Widyawati Widyawati; Desy Armalina
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.487 KB) | DOI: 10.14710/dmj.v5i4.15941

Abstract

Latar belakang : Keputihan merupakan hal yang sering dialami oleh wanita usia subur di Indonesia. Keputihan dapat bersifat fisiologisa dan patologis. Keputihan patologis dapat disebabkan oleh banyak hal salah satunya bakterial vaginosis (BV). BV dapat disebabkan oleh beragam hal mulai dari penggunaan celana dalam yang terlalu ketat, kurang menjaga kebersihan daerah kemaluan, penggunaan kontrasepsi, dan sebagainya. Pada penelitian ini dilakukan analisa hubungan antara terjadinya bakterial vaginosis dengan penggunaan kontrasepsi hormonal.Metode : Penelitian ini adalah penelitian analitik korelatif dengan rancangan cross sectional dengan sampel 51 wanita pasien Puskesmas Mangkang usia 20-30tahun pengguna kontrasepsi hormonal. Data merupakan data primer dengan pemeriksaan sekret/duh vagina yang kemudian dicat dengan pengecatan gram dan dibaca di Laboratorium Ilmu Kesehatan Kulit dan Kelamin RS Kariadi. Analisis secara analitik korelatif menggunakan rancangan chi-square, dengan derajat kemaknaan p<0,05.Hasil penelitian : Kontrasepsi hormonal yang paling sering digunakan adalah jenis suntik (66.7%) kemudian disusul jenis pil (25.5%) dan yang terakhir adalah jenis implan (7,8%). Dari data tersebut didaptkan hasil p= 0,972 yang berarti tidak ada hubungan antara terjadinya bakterial vaginosis dengan penggunaan kontrasepsi hormonal.Kesimpulan : Kontrasepsi hormonal yang paling sering digunakan adalah jenis suntik (66.7%). Tidak terdapat hubungan antara kejadian bakterial vaginosis dengan penggunaan kontrasepsi hormonal.
The Effect of Moringa oleifera Extract on Histopathological of Mice Testes Exposed by Monosodium Glutamate Handoyo, Regenio Akira; Saraswati, Indah; Mochtar, Arufiadi Anityo; Armalina, Desy; Miranti, Ika Pawitra
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.37311

Abstract

Background: Monosodium glutamate (MSG) consumption in excess can have an impact on a man's fertility and lead to infertility. MSG has the potential to produce free radicals, which can harm cells. Antioxidants can fight off free radicals. Exogenous antioxidants are required to maintain equilibrium since there will be an imbalance if the body produces more free radicals than endogenous antioxidants. Exogenous antioxidants flavonoids are present in the leaves of the Moringa plant (Moringa oleifera L). It is thought that flavonoids have 4-5 times more antioxidant potential than vitamins. Objectives: To evaluate how moringa leaf extract affects the histopathological profile of MSG-exposed mouse testes. Methods: Only the posttest was used as a control group in this study. 25 male mice were used as the sample, and they were split up into five groups. The treatment group 1 (P1) received 6 g/day of MSG exposure + 300 mg/kg BW/day of moringa leaf extract, the treatment group 2 (P2) received 6 g/day of MSG exposure + 600 mg/kg BW/day of moringa leaf extract, and the treatment group 3 (P3) received 6 g/day of MSG exposure + 1200 mg/kg BW/day of moringa leaf extract. The control group (K-) received only standard feed. The mice were put to death after 30 days. The testes were removed for histological examination using hematoxylin-eosin staining, and the Johnsen scoring criteria were applied to their evaluation. Results: The data were not significant according to the Shapiro-Wilk test in the P3 group (MSG 6 g/day + Moringa Extract 1200 mg/kg BW/day). The Kruskal-Wallis test revealed that there was no significant difference between the seminiferous tubules according to the treatment group (p = 0.117). Conclusion: Moringa oleifera leaf extract protects the histopathological picture of the testes of male mice compared to the group given monosodium glutamate. 
Appropriate Slice for Microscopic of Hepar and Kidney Mice Fixed With BNF 10% Armalina, Desy; Elen, Mircha Restiana; Labai, Nikita Ferren
Medica Arteriana (Med-Art) Vol 6, No 2 (2024): Desember 2024
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.6.2.2024.43-49

Abstract

Background: Histological processing encompasses the steps of acquiring fresh tissue, preserving it through fixation to maintain its natural appearance, slicing it into thin sections, placing the sections on glass slides, and subsequently staining them. This enables the observation of various histological components within the tissue using a microscope. The objective of this study was to ascertain the microscopic characteristics of heparin preparations and the kidneys of mice (Mus musculus) through fixation using a formalin buffer solution.Method: This kind of research encompasses experimental research. The study employed a purposive sample methodology in its research design. This study concludes that preparations containing images provide a representative depic-tion of the cell nucleus, cytoplasm, and exhibit consistent coloration with different cutting thicknesses. The standard thickness for cutting the mice hepatic tissue using a microtome is 5 μm.Result: This thickness yields good microscopic results overall, with 25 field views from 5 preparations. The percentage of high-quality microscopic images obtained at this thickness is 100%. The statistical analysis revealed significant differences (p<0.05) between the 2 μm and 5 μm groups, as well as between the 5 μm and 8 μm groups. There was no statistically significant difference (p>0.05) observed between the 2 μm and 8 μm groups in terms of many aspects including structural, nucleolus, cytoplasm, color uniformity, and total structure scores.Conclusion: The optimum thickness in this research was 5 μm. Additional investigation is required to examine the microscopic characteristics of tissue samples by varying the duration of staining on the samples.
Histopathological changes in pregnant mice's hepar and kidney following exposure to kelor (Moringa oleifera) leaf extract Armalina, Desy; Susilaningsih, Neni; Saraswati, Indah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.145-151

Abstract

Background: Moringa provides extra dietary benefits. The immune system is significantly influenced by the nine necessary amino acids, calcium, iron, potassium, magnesium, zinc, and vitamins A, C, E, and B that are included in this food. Previous studies state that moringa causes liver and kidney damage. Another study found that moringa has an abortive effect.Objectives: This study aimed to determine how exposure to kelor (moringa oleifera) leaf extract affected the hepar and kidney in pregnant mice and found the secondary metabolite of the moringa leaves.Materials and Methods: An experimental laboratory design was conducted in 24 pregnant female Balb/c mice. They were randomized into four groups. Group K was not given anything. Group P1-P3 were given moringa leaf extract during pregnancy at days with a dose dose of 10, 20, and 30 mg in 10, 20, and 18 days, and termination was done to take the organs and make the tissue processing.Results: We found no dead mice and no aggression during the experiment. Significant statistics differed between the experimental group in the microscopic appearance of the kidney and hepar. This study found degeneration and inflammation in the hepar and kidney in the treatment group. Qualitative phytochemical tests on leaves contained alkaloids, flavonoids, phenolics, tannins, and steroids.Conclusion: The ethanol extract of Moringa leaf has shown a mild heparin and kidney effect compared to the control.
FAKTOR RISIKO KANKER PAYUDARA PADA WANITA USIA PRODUKTIF DI RSD K.R.M.T WONGSONEGORO SEMARANG dewi, nasywa laksita; Surati, Surati; Armalina, Desy
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 10 No. 1 (2025): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v10i1.3521

Abstract

Kanker payudara merupakan jenis kanker penyebab utama kematian pada wanita. Berdasarkan data Global Burner Of Cancer (GLOBOCAN) pada tahun 2020, terdapat 68.858 kasus baru di Indonesia dan lebih dari 22.000 kematian. Penyakit ini berkembang secara perlahan dengan berbagai faktor risiko seperti usia, usia menarche, usia melahirkan, penggunaan alat kontrasepsi hormonal, riwayat keluarga, kebiasaan merokok, gaya hidup dan obesitas. Penelitian ini bertujuan untuk mengetahui adanya faktor risiko kanker payudara pada wanita usia produktif (15–59 tahun) di RSD K.R.M.T Wongsonegoro Semarang. Pendekatan secara kualitatif dengan metode penelitian deskriptif berdasarkan pengumpulan data sekunder berupa catatan rekam medis di RSD K.R.M.T Wongsonegoro Semarang. Sampel yang diambil sebanyak 100 pasien kanker payudara. Hasil penelitian menunjukkan bahwa sebagian besar pasien berada dalam kelompok usia produktif (87%), mengalami menarche dini (< 12 tahun) sebesar (3%), riwayat melahirkan pada usia produktif (89%), menggunakan kontrasepsi hormonal (56%), seluruh pasien tidak memiliki kebiasaan merokok (100%), usia menarche dengan penggunaan alat kontrasepsi hormonal (67%) dan rentang usia produktif saat pertama terdiagnosa dengan penggunaan alat kontrasepsi hormonal (52%). Kesimpulan dari hasil penelitian ini faktor risiko usia saat terdiagnosis, usia melahirkan, serta penggunaan alat kontrasepsi hormonal menunjukkan adanya faktor risiko. Namun, tidak ditemukan adanya faktor risiko pada kebiasaan merokok dan usia menarche.
Mobile Phone Electromagnetic Waves and Pregnancy Outcomes: An Experimental Study in Mice Armalina, Desy; Susilaningsih , Neni; Sutanto, Heri; Sunarno, Sunarno
The Journal of Experimental Life Science Vol. 15 No. 3 (2025)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2025.015.03.06

Abstract

This study investigated the impact of mobile phone–derived electromagnetic wave (EMW) exposure on the uterus and progeny of pregnant Balb/c mice. Fourteen pregnant mice were randomly assigned to two groups (n=7 each). The control group (CG) was not exposed to EMW. In contrast, the experimental group (EG) was subjected to continuous exposure to EMW at a whole-body specific absorption rate (SAR) of 1.74 W.kg-1 for 24 hours daily from gestational day (GD) 1 to 19. On GD 20, all mice were euthanized, and body weight, oxidative stress biomarkers, and uterine histological parameters were assessed. Maternal body weight at termination showed a significant reduction in EG compared with CG (p < 0.05). However, differences in overall body weight gain, malondialdehyde (MDA), and superoxide dismutase (SOD) levels were not statistically significant (p > 0.05). Histological evaluation revealed marked alterations: endometrial scores were significantly higher in EG (3.32) than in CG (0.56) (p < 0.05), and myometrial scores were elevated in EG (1.72) versus CG (0.64). Endometrial thickness was reduced in EG (0.748 mm) compared with CG (1.470 mm) (p < 0.05), whereas myometrial thickness showed no significant difference. Continuous EMW exposure (24 h.day-1, GD1–GD19; SAR 1.74 W.kg-1) was associated with lower maternal weight at GD20, reduced litter size, higher endometrial/myometrial injury scores, and reduced endometrial thickness, while MDA and SOD differences were not statistically significant (p > 0.05). These findings warrant further studies to clarify the mechanisms involved without overstating the changes in oxidative biomarkers.
Opuntia cochenillifera Cream Accelerates Incision and Burn Wound Healing in Streptozotocin-Induced Diabetic Mice by Enhancing Fibroblast Indah Saraswati; Desy Armalina; Rivaldo Heru Setiawan; Najwan Muhammad Sinna; Sahila Nifa Arummaisya
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3824

Abstract

BACKGROUND: Diabetes mellitus (DM) often leads to chronic, slow-healing wounds due to impaired tissue regeneration and sustained inflammation, which can progress to diabetic ulcers. Opuntia cochenillifera has been reported to possess antioxidant and anti-inflammatory potential, making it a promising candidate for natural wound therapies. However, standardized topical formulations and in vivo evaluations are limited. This study was conducted to develop and assess the wound-healing effects of Opuntia cochenillifera cream in diabetic mice.METHODS: Forty-eight male Balb/C mice were randomly assigned to different groups: healthy control (HC), negative control (C−), positive control (C+), and treatment (T) groups. DM was induced by a single intraperitoneal injection of 180 mg/kgBW streptozotocin. After confirming hyperglycemia, incisions and burn wounds were created and monitored for 7 and 14 days. Wound healing was assessed macroscopically (incision length, width, and burn diameter) and microscopically (fibroblast proliferation and re-epithelialization). The formulated Opuntia cochenillifera cream was evaluated for pH, homogeneity, adhesion, and spreadability using standard topical formulation tests.RESULTS: The formulated cream exhibited good homogeneity, adhesion (4.97 s), spreadability (5.10 cm), and skin-compatible pH (6.44). Phytochemical analysis confirmed the presence of flavonoids, tannins, terpenoids and alkaloids. In vivo, Opuntia cochenillifera cream significantly accelerated wound closure and increased fibroblast proliferation compared to the C− group (p<0.05). Its effects were comparable to those of the standard treatment for burn wounds and superior for incision wounds, demonstrating enhanced fibroblast activity and more organized re-epithelialization.CONCLUSION: Opuntia cochenillifera cream effectively improves wound healing in diabetic mice through the enchantment fibroblast activity and organized re-epithelialization. These findings support the potential of this formulation as a natural topical therapy for diabetic wounds, warranting further mechanistic investigation.KEYWORDS: Opuntia cochenillifera, diabetic wound, wound healing, topical cream, phytochemical
Adverse effects of cell phone radiation on Purkinje cells of the cerebellum of pregnant Balb/c mice Armalina, Desy; Susilaningsih , Neni; Sutanto, Heri; Sunarno, Sunarno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art4

Abstract

Background: Pregnant women often use mobile phones for communication and health-related information. The World Health Organization (WHO) recommends minimizing mobile phone use during pregnancy to reduce maternal and child health risks. Electromagnetic waves (EMW) from cell phones can be absorbed by the brain and may affect neuronal function.Objective: This study aimed to evaluate the size, histology, and number of Purkinje cells in the cerebellum of pregnant mice exposed to cell phone EMW compared to unexposed controls.Methods: Fourteen pregnant Balb/c mice were randomly divided into exposed (EG) and control (CG) groups. The EG was exposed to an electromagnetic wave with a specific absorption rate (SAR) of 1.74 W/kg for 24 hours per day from gestation day 0 to 19. On day 20, cerebellar tissues were harvested and processed with hematoxylin–eosin (HE) staining for histological assessment.Results: The mean Purkinje cell size in the EG (0.069 ± 0.009 mm) was slightly smaller than in the CG (0.070 ± 0.007 mm), but this difference was not statistically significant (p = 0.741). However, the Purkinje cell count was significantly lower in the EG (6.160 ± 0.746) than in the CG (7.800 ± 0.764; p < 0.001), indicating that EMW exposure reduced Purkinje cell numbers.Conclusion: Exposure to cell phone EMW during pregnancy led to a significant reduction in Purkinje cell numbers in the cerebellum, while cell size remained unchanged. These findings suggest that prenatal exposure to EMW may negatively affect fetal cerebellar development. This underscores the need for pregnant women to be cautious with mobile phone use and highlights the importance of further research to clarify the risks to maternal and fetal health.
Mikroskopis Preparat Mus Musculus Jaringan Ginjal yang Dideparafinisasi dengan Minyak Zaitun pada Pengecatan Hematoxylin Eosin (HE) Ela Nur Pratiwi; Desy Armalina
Jaringan Laboratorium Medis Vol 3 No 1 (2021): Mei 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v3i1.8005

Abstract

Deparaffinization is a stage before the staining process to remove/dissolve paraffin so that the absorption of color in tissue preparations is maximized. Deparaffinization is usually carried out using xylol and toluol. Xylol has toxic effects including acute neurotoxicity, heart and kidney damage, hepatotoxicity, fatal blood dyscrasias, skin erythema, dry skin, peeling skin, and also has a carcinogenic effect. The toxicity effect of olive oil is lower than that of xylol. Oils that have non-polar properties can remove the remaining paraffin contained in the tissue. The purpose of this study was to determine the microscopic appearance of the kidney tissue preparations of mice deparaffinized with olive oil on hematoxylin eosin (HE) staining. The type of research used is experimental research which is analyzed with a descriptive approach. The results of the assessment of preparations deparaffinized with xylol in 80 visual fields obtained 100% good preparations and preparations deparaffinized with olive oil in 80 visual fields obtained 0% poor preparations, 11.3% poor preparations, and 88.7% good preparation. So it can be said that better results are found in the microscopic picture of the kidney preparations of mice (Mus musculus) deparaffinized with xylol.
Co-Authors Akhmad Ismail Akhmad Ismail Akhmad Ismail Akhmad Ismail Antari, Arlita Leniseptaria Ardiansyah Mahardika Ariyani, Bitha Astika Widy Utomo, Astika Widy Bambang Witjahjo Bambang Witjahjo Bambang Witjahjo Britya Maulidka Intar Luvilla Destia Afta Nugroho dewi, nasywa laksita Diah Ajeng Purbaningrum Ela Nur Pratiwi Elen, Mircha Restiana Eva Annisa Eva Annisaa Fadila Risang Ayu Faizah Fulyani Faizah Fulyani Fanti Saktini Fanti Saktini Fanti Saktini Farmaditya Eka Putra Mundhofir Ganesha Aji Pratama Handoyo, Regenio Akira Heri Sutanto Hermawan Istiadi Hermawan Istiadi Hermawan Istiadi Ika Pawitra Miranti Ika Pawitra Miranti Ina Marlina Indah Saraswati Indah Saraswati Indah Saraswati Labai, Nikita Ferren Mochtar, Arufiadi Anityo Muhammad Yudhistira Najwan Muhammad Sinna Neni Susilaningsih Neni Susilaningsih Noor Wijayahadi Okta Hardianti Putri Priscilla Jessica Purbaningrum, Diah A. Puspita Kusuma Dewi Puspita Kusuma Dewi Puspita Kusuma Dewi Rahma Athifah Amelia Ratna Damma Purnawati Ratna Damma Purnawati Ratna Damma Purnawati Ratna Damma Purnawati Riski Prihatningtias Riski Prihatningtias Rivaldo Heru Setiawan RR. Mahayu Dewi Ariani Sahila Nifa Arummaisya Salsabella Indriana P. Salwa Nabila Izzati Saputra, Aerio Rizqi Sherlin Mentary Farizha Sunarno Sunarno Surati Surati Susilaningsih , Neni Ullya Ullya Widyawati Widyawati