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All Journal PHARMACON CHEMISTRY PROGRESS Transmisi JPSE (Journal of Physical Science and Engineering) Briliant: Jurnal Riset dan Konseptual JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JURNAL PENDIDIKAN TAMBUSAI Jurnal Agritechno Jurnal Abdi Insani Community Empowerment Journal of Community Empowerment Borneo Journal of Pharmacy Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Journal of Social Sciences and Technology for Community Service
Hariyanto, Yuanita Amalia
Universitas Sam Ratulangi (Scopus ID: 57202791490)
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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STANDARISASI EKSTRAK MANGROVE Sonneratia ovata Backer. DARI DESA TONGKAINA, BUNAKEN, SULAWESI UTARA SEBAGAI BAHAN BAKU OBAT TOPIKAL Jaya Edy, Hosea; Parwanto, edy; Sudewi, Sri; Hariyanto, Yuanita Amalia
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.59468

Abstract

Mangrove merupakan tanaman yang tumbuh pada area pantai atau daerah pesisir, hingga membentuk ekosistem hutan mangrove. Mangrove memiliki kandungan metabolit sekunder yang sangat beragam dan sangat berpotensi sebagai bahan baku obat-obatan. Penelitian ini bertujuan melakukan identifikasi dan standarisasi ekstrak daun mangrove Sonneratia ovata Backer. yang dikoleksi dari desa Tongkaina, Sulawesi Utara. Metode standarisasi ekstrak dengan melakukan pengujian parameter spesifik dan parameter non-spesifik ekstrak serta pengujian sterilitas ekstrak etanol daun mangrove Sonneratia ovata Backer. dari desa Tongkaina. Nilai kadar sari ekstrak etanol terlarut air adalah 18,78 % dan nilai kadar sari ekstrak larut etanol adalah 25,44%. Nilai susut pengeringan dari ekstrak etanol daun S. ovata adalah 0,187 % dan nilai kadar air dalam ekstrak adalah 7,254 %. Nilai kadar abu ekstrak daun S. ovata adalah 3,940 % dan nilai kadar abu tidak larut asam adalah 0,410 %. Ekstrak etanol daun S. ovata bebas kontaminan mikroorganisme dan dapat dimanfaatkan sebagai bahan baku zat aktif sediaan topikal berbasis bahan alami.
Evaluation of Antioxidant Activity of Ethanol Extract from Phyllospongia lamellosa Obtained in Parentek Beach, Minahasa Regency Karunia Ritje Virginia Rintjap; Adithya Yudistira; Yuanita Amalia Hariyanto
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55294

Abstract

Sponges are one of the components of coral reef biota that are quite widespread. Almost 75% of the sponge species found in the waters are classes of Demospongiae. Asymmetrical in shape, demospongiae grow in various sizes from small to more than 2 meters. This study aims to determine the antioxidant activity of ethanol extract of Phyllospongia lamellosa obtained using DPPH method. The results of data analysis of % inhibition values are 20 ppm concentration (41.80%), 40 ppm concentration (43.78%), 60 ppm concentration (46.65%), 80 ppm concentration (47.25%), 100 ppm concentration (48.42%). This shows that the Phyllospongia lamellosa sponge sample obtained from Parentek Beach, Minahasa Regency has antioxidant effectiveness but is not active because the highest percent inhibition value at a concentration of 100 ppm is only 48.42%.
Antibacterial Efficay Test of Ethanol Extract of Yaki Areca Nut (Areca vestiaria) Against the Growth of Propionibacterium acnes, the Cause of Acne. Pabundu, Daniel; Simbala, Herny; Hariyanto, Yuanita Amalia
PHARMACON Vol. 13 No. 3 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55524

Abstract

A bacterial skin infection that is often experienced by everyone, especially in adolescence, is acne(Acne vulgaris). Acne is caused by the accumulation of excess oil in the skin, thus becoming a medium for bacterial growth, which causes acne. The use of natural antibiotics can be a therapeutic option in the treatment of acne. One of the plants that potentially has antbacterial activity is Pinang Yaki (Areca vestiaria). The purpose of this study was to determine the antibacterial activity of ethanol extract of areca nut fruit against the growth of Propionibacterium acnes that causes acne. The test of antibacterial activity of areca nut extract with the pitting method found that at a concentration of 10% the antibacterial activity was included in the weak group, 20% was included in the medium group, while those included in the strong group in inhibiting the growth of Propionibacterium acnes were extracts with concentrations of 40%, 60% and 80%..
Training on antibacterial liquid soap making from nipah leaf extract to support SDGs-3 good health and well being Yuanita Amalia Hariyanto; Aditya Lapu Kalua; Bukroanah Amir Makkau; Imam Jayanto
Community Empowerment Vol 9 No 12 (2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12570

Abstract

Wori Village, located in the buffer zone of the Likupang Tourism Special Economic Zone (KEK), requires development of both its natural and human resources. Natural resource optimization can be achieved through diversification, specifically by producing liquid soap from the nipah plant. Human resource development necessitates increased public awareness of skin health and personal hygiene. This Community Service aimed to educate the Wori Village community on personal hygiene and provide a practical solution for reducing skin diseases through the use of antibacterial liquid soap. The methodology comprised socialization, training, technology application, mentoring, evaluation, and plans for program sustainability. The resulting NIPALS soap met quality standards, exhibiting a pH of 7. Evaluation demonstrated a 96.7% increase in participants' knowledge of personal hygiene and soap-making (pre-test vs. post-test). Furthermore, 95.5% of participants expressed satisfaction with the soap (4.5% considered it average). Positive user experiences included a 97% absence of itching, 76.7% reporting a tightening effect, and 70% noting moisturization. These results, supported by positive hedonic test results, confirm the successful production of liquid soap by the participants.
PENINGKATAN KAPASITAS MASYARAKAT DALAM UPAYA PENCEGAHAN INFEKSI KULIT DAN PRODUKTIVITAS EKONOMI MELALUI PELATIHAN PEMBUATAN SABUN-VCO DI DESA MINAESA MINAHASA UTARA Hariyanto, Yuanita Amalia; Jayanti, Meilani; Lebang, Julianri Sari
Jurnal Abdi Insani Vol 12 No 1 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i1.2083

Abstract

Considering skin disorders can now spread through a variety of media, it is crucial for the public to understand skin health issues. Skin conditions are now among the most prevalent illnesses in coastal towns. People who live near the coast are more likely to experience skin health issues. Numerous elements, such as humidity, sun exposure, personal cleanliness, and water quality, contribute to this. The goal of this project is to teach the Minaesa Village community how to make liquid soap from VCO and to educate them about personal hygiene. On-the-job training is the approach used in the PKM. Direct field visits, identifying the partners' issues and requirements, offering solutions, conducting activities to satisfy the partners' needs, and evaluation are all part of this approach. The pH of the VCOLS soap manufactured is 7, which means that it satisfies quality criteria. According to the evaluation's findings, participants' knowledge increased by 86.5%. More than 82.2% of participants expressed pleasure with the VCOLS soap, according to the evaluation of the satisfaction questionnaire about the created soap, while 17.8% expressed no opinion. The findings of the perception survey of the VCOLS soap, on the other hand, indicate that no one itched after using it, 70% thought it was non-greasy, and 67.7% thought it was hydrating. The evaluation's findings indicate that participants' knowledge of skin care and soap-making methods has grown. According to the results of the perception questionnaire, participants have successfully produced liquid soap from VCO that satisfies quality standards. It is also envisaged that the expertise offered, particularly in the creation of liquid soap from VCO, can be further enhanced through the community service activities in Minaesa Village.
In Silico Analysis of the Antigastritis Activity of Gedi (Abelmoschus manihot) Flower Flavonoids on H2 Receptor Adikila, Gregorius Giani; Hariyanto, Yuanita Amalia; Tallei, Trina Ekawati; Suoth, Elly Juliana; Sudewi, Sri; Fatimawali, Fatimawali
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.7586

Abstract

Gastritis remains a highly prevalent health concern in Indonesia, underscoring a continuous demand for innovative therapeutic interventions. The flower of Abelmoschus manihot, commonly known as Gedi, has garnered interest for its potential antigastritis properties, specifically as an H2 antagonist, attributed to its rich flavonoid content. This study aimed to rigorously evaluate the H2 antagonist potential of A. manihot flowers using an in silico approach. Our research methodology involved assessing the physicochemical and pharmacokinetic profiles, alongside molecular docking simulations, of ten prominent flavonoid ligands identified in A. manihot flowers: quercetin, myricetin, myricetin-3-O-glucoside, myricetin-3'-O-glucoside, quercetin-3'-O-glucoside, hibifolin, isoquercetin, hyperoside, quercetin-3-O-robinobioside, and rutin. The analysis of physicochemical and pharmacokinetic properties encompassed Lipinski's Rule of Five and comprehensive ADMET predictions. Molecular docking simulations focused on evaluating binding energies and interactions with crucial H2 receptor residues: Asp98, Asp186, Val99, and Phe254. Among the ligands being assessed, quercetin demonstrated the most favorable physicochemical-pharmacokinetic characteristics and exhibited superior binding affinities and interactions in the molecular docking analysis. These findings collectively suggest that A. manihot flower holds significant promise as a natural source for antigastritis agents, specifically through its potential H2 antagonist activity, with quercetin emerging as a key contributing compound.
Analisis Struktur Kristal Kalsium Hidroksida dari Cangkang Bekicot sebagai Kandidat RAW Material Hidroksiapatit Berbasis Bahan Alam Mujiyanti, Tri; Hariyanto, Yuanita Amalia; Ananingtyas, Ratika Sekar Ajeng
BRILIANT: Jurnal Riset dan Konseptual Vol 6 No 4 (2021): Volume 6 Nomor 4, November 2021
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (580.323 KB) | DOI: 10.28926/briliant.v6i4.811

Abstract

Salah satu bahan alam yang melimpah di Indonesia dan tidak dipergunakan dengan maksimal adalah limbah cangkang bekicot. Penelitian sebelumnya melaporkan bahwa cangkang bekicot memiliki kandungan kalsium oksida sebesar 98,63%, sehingga memiliki potensi yang cukup baik dalam pemanfaatan sebagai biomaterial yaitu hidroksiapatit, dimana diketahui hidroksiapatit ini merupakan salah satu bahan dalam  implan tulang. Penelitian ini bertujuan menganalisis dan mengkarakterisasi kalsium hidroksida sebagai bahan raw material hidroksiapatit dari bahan limbah cangkang bekicot. Cangkang bekicot dikalsinasi untuk menghasikan CaO (Kalsium Oksida) dimana CaO akan berubah fasa menjadi Ca(OH)2 ketika direaksikan dengan air, dengan perlakuan kalsinasi suhu 10000 C dalam waktu 5 jam. Ca(OH)2 (Kalsium Hidroksida) akan di analisis dengan karakterisasi  XRD. Hasil analisis data XRD menggunakan metode scherrer yang menunjukan bahwa Kalsium Hidroksida memiliki rata - rata ukuran partikel sekitar 28 nm. Hasil penelitian menunjukan  bahwa sampel membentuk satu fasa kalsium hidroksida dengan kemurnian tinggi. Analisis rietica sampel Ca(OH)2  menunjukkan bahwa reaksi CaO dan air berhasil membentuk fasa Ca(OH)2 yang ditunjukkan dengan adanya sudut puncak difraksi dimana diperoleh puncak tertinggi pada sudut 2Ө = 34.200 sesuai dengan data model AMCSD code_0000116. Kristal yang terbentuk memiliki sel satuan a,b = 3,59122 Å dan c = 4,904649 Å parameter kisi α = b≠c, α = β = 900, γ= 1200 dengan space group P-3M1.
Karakterisasi Protein Total Konsentrat Daun Kelor (Moringa oleifera Lam) Menggunakan Spektrofotometer UV-VIS Hariyanto, Yuanita Amalia; Azis, Rosidi; Alam, Yuniar; Monica, Anindya Bella
BRILIANT: Jurnal Riset dan Konseptual Vol 7 No 1 (2022): Volume 7 Nomor 1, Februari 2022
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (782.82 KB) | DOI: 10.28926/briliant.v7i1.884

Abstract

Salah satu tumbuhan yang keberadaannya sangat melimpah di Indonesia dengan berbagai macam manfaatnya adalah daun kelor (Moringa oleifera Lam). Daun Moringa oleifera memiliki potensi sebagai bahan feed additives karena tersebar luas di wilayah Indonesia. Di Indonesia para peternak ruminansia sering menggunakan daun Moringa oleifera sebagai imbuhan pakan karena dipercaya dapat menghasilkan daging yang berkualitas tinggi. Penelitian ini bertujuan untuk menganalisis kandungan protein total yang ada dalam daun Moringa oleifera dengan menggunakan metode Bradford. Ekstraksi daun Moringa oleifera lalu di keringkan dengan suhu 30 oC – 35 oC dan di ayak menggunakan ayakan 200 mesh untuk diperoleh serbuk nano. Selanjutnya, disintesis konsentrat protein dengan tambahan akuades dan larutan Bradford untuk di ukur dengan spektrometer pada panjang gelombang ( λ ) 595 nm. Berdasarkan pengukuran menggunakan spektrofometer UV-Vis diperoleh kadar protein total untuk pengujian simplo, duplo, dan triplo sebagai berikut 9,009%, 9,689%, dan 9,495%.
Sintesis dan Karakterisasi Nanokomposit Hidroksiapatit/Tembaga Oksida Sebagai Antibakteri Escherchia coli Hariyanto, Yuanita Amalia; Hakim, M Helmi; Ananingtyas, Ratika Sekar Ajeng; Monica, Anindya Bella
BRILIANT: Jurnal Riset dan Konseptual Vol 7 No 2 (2022): Volume 7 Nomor 2, Mei 2022
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.358 KB) | DOI: 10.28926/briliant.v7i2.885

Abstract

Pengolahan limbah cangkang Achatina Fulica yang dimanfaatkan sebagai bahan dasar utama pembuatan hydroxyapatite (HAp). Dalam upaya  menjaga perfomanya, HAp dikompositkan dengan material yang memiliki kemampuan khusus yang sama dan biokompatibilitasnya sangat baik yaitu CuO. Setelah dilakukan komposit material, hasil dari sintesis tersebut dimasukkan ke tahap karakterisasi menggunakan XRD menunjukkan HAp muncul pada = 25,9o; 31,9o; 39,57o; 46,62o, 49,47o. Untuk puncak CuO terdeteksi pada 2-teta = 35,544o, 38,709o, 48,717o, 58,265, dan 61,526o. Selanjutnya, untuk data hasil FTIR menunjukkan terdeteksinya puncak Cu-O berada dalam kisaran 400 hingga 600 cm-1. Untuk puncak Hap terdeteksi gugus fungsi fosfat (PO43) pada kisaran 560, 618, 987, dan 1060 cm-1. Sedangkan fungsi karbonat (CO32-) pada kisaran 910 cm-1 dan 1630-1670 cm-1. Berdasarkan aktivitas antimikroba, pada nanokomposit Hap/CuO menunjukkan kemampuan yang baik dalam membunuh koloni bakteri yang sangat baik.
Peningkatan Nilai Guna Cangkang Kepiting sebagai Kitosan untuk Raw Material pada Pasta Gigi Herbal Hariyanto, Yuanita Amalia; Antasionasti, Irma; Jayanti, Meilani
BRILIANT: Jurnal Riset dan Konseptual Vol 8 No 3 (2023): Volume 8 Nomor 3, Agustus 2023
Publisher : Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/briliant.v8i3.1574

Abstract

Sejauh ini inovasi raw material pasta gigi herbal yang berasal dari limbah masih jarang dikembangkan, cangkang kepiting menjadi material yang berpotensi untuk menjadi bahan baku dalam pembuatan pasta gigi herbal. Tujuan penelitian ini yaitu mengembangkan limbah cangkang kepiting menjadi material yang memiliki nilai ekonomi. Penelitian ini dilakukan dengan ekstraksi dan sintesis sederhana. Karakterisasi XRD, FTIR, dan SEM-EDX digunakan untuk menganalisis kristalinitas, gugus fungsi, dan morfologi kitosan. Hasil analisis menunjukkan struktur kitosan membentuk kristalin yang ditunjukkan dengan terkonfirmasinya tiga puncak tajam pada 2-teta 19o, 26o, dan 29o. Hasil analisis puncak serapan FTIR menunjukkan terdeteksinya 5 gugus fungsi utama kitosan pada bilangan gelombang 3458 cm-1, 2895,15 cm-1, 1654,92 cm-1, 1587,42 cm-1, dan 1386,82 cm-1 adalah OH stretching, CH(CH3) bending, C=O (-NHCOCH3) stretching amida I, NH (-NHCOCH3) bending amida II, CH (-CH2) bending sym secara berturut-turut. Morfologi kitosan yang disintesis dari cangkang kepiting berpori, bergelombang, dan bentuknya tidak teratur serta unsur yang terkandung yaitu C, O, Ca, dan Si.
Co-Authors Abdulgani, Nayla Inayah Abdullah, Surya Sumantri Adikila, Gregorius Giani Adithya Yudistira Aditya Lapu Kalua Ahmad Taufiq Antasionasti, Irma ASARI Asviyatu Nisa' Azis, Rosidi Bakti, Andi Ikhtiar BUKROANAH AMIR MAKKAU DEBY AFRIANI MPILA Dzaki, Najwan Nafis Elly Suoth Fatimawali . Gusti, Indah Syaidina Hakim, M Helmi Herny E.I. Simbala Hidayatun Nasikhah Imam Jayanto Imam Jayanto Irma Antasionasti Ismail, Regita Reyne Jaya Edy, Hosea Jayanto, Imam Jesikha Sharen Salikode Julianri Sari Lebang Julianri Sari Lebang, Julianri Sari Jumriadi Karunia Ritje Virginia Rintjap Lahope, Juan Sebastian Sirjon Lapu Kalua, Aditya Lestari, Utami Sasmita Lianly Rompis Mahendra Kusuma Nugraha Meilani Jayanti Monica, Anindya Bella Muhammad Helmi Hakim Muhammad Setiawan Mujiyanti, Tri Pabundu, Daniel Parwanto, Edy Pricillia Esterlita Mintadoa Rahmawati, Dian Wahyu Ratika Sekar Ajeng Ananingtyas Rizal Musafa Medica Salsabila, Unik Hanifah Sri Sudewi Sri Sudewi, Sri Sumare, Chika Wanda Sunaryono Tri Mujiyanti TRINA EKAWATI TALLEI Turnip, Rama Ijon Yuniar Alam Yuniar Alam, Yuniar