Article Per Year (5 Year)
p-Index From 2021 - 2026
0.983
P-Index
This Author published in this journals
All Journal Althea Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Muhammad Begawan Bestari
Division Of Gastroentero-hepatology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjajaran/Hasan Sadikin General Hospital, Bandung
Medicine & Pharmacology

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Correlation of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) with Liver Transient Elastography Results: An Evaluating Liver Fibrosis in Chronic Hepatitis B Patients Haryono, Haryono; Bestari, Muhammad Begawan; Agustanti, Nenny; Girawan, Dolvy; Wahyudi, Yudi; Abdurachman, Siti Aminah; Tjandrawati, Anna
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202312-22

Abstract

Background: Transient elastography (TE) is widely recognized as a reliable surrogate marker for grading the severity of liver fibrosis in chronic hepatitis B (CHB) patients. Mac-2 binding protein of glycosylation isomer (M2BPGi) is a novel non-invasive serum biomarker for liver fibrosis staging in various liver diseases, including CHB. This study aimed to evaluate the correlation of M2BPGi and liver stiffness (LS), as measured through TE, in predicting the degree of liver fibrosis in CHB patients.Methods: A cross-sectional study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, between September 2021 and January 2022. The study included patients diagnosed with chronic hepatitis B (CHB) based on clinical and biochemical assessments. All subjects underwent TE examination using Fibroscan®, and the M2BPGi levels were determined with an automated immunoassay analyzer HISCL-800, Sysmex, Japan. Statistical analysis was conducted using the Spearman rank correlation method, with a significance value of p0.05.Results: A total of 119 patients with chronic hepatitis B (CHB) were consecutively recruited (Male:Female = 66:53; median age: 43 years). The median M2BPGi level was 1.04 COI (range: 0.74–1.59), while the median liver stiffness (LS) was 7.3 kPa (range: 5.6–12.5). A moderate and statistically significant correlation was observed between M2BPGi and LS (r = 0.525; p 0.001). Median M2BPGi values by fibrosis stage were 0.89 COI for F0–F1, 0.88 for F2, 1.61 for F3, and 2.24 for F4 (p 0.001).Conclusion: This study revealed a moderate positive correlation between serum M2BPGi level and LS in CHB patients.
Co-Authors Achadiyani Ade Zuhrotun Agustanty, Nenny Ali Djumhana Ali Djumhana Amelia, Rachel Anna Tjandrawati Dewi, Sumartini Dolvy Girawan Dosmer Oloan Simarmata Eka Surya Nugraha Emmy Hermiyanti Pranggono Enny Rohmawaty Ghina Tsuraya Salsabila Budiman Guntur Darmawan Haryono - Haryono Haryono Hermin Aminah Usman Hesti Lina Wiraswati Jessica Cynthia Febryani Juke Roslia Saketi Juke Roslia Saketi Nenny Agustanti Nugraha, Irvan Pranggono, Emmy Hermiyanti Rachel Amelia Rasdianto, Devi Novianto Rini Hendriani Rosdianto, Aziiz Mardanarian Rudi Supriadi Saragih, Winda A. M. Savira Ekawardhani Simarmata, Dosmer Oloan Siti Aminah Abdurachman Siti Aminah Abdurachman Siti Aminah Abdurachman Siti Aminah Abdurachman Sri Suryanti Supriadi, Rudi Usman, Hermin A. Wijaya, Muhammad Palar Yelica Rachmat Yoga Windhu Wardhana Yudi Wahyudi Yudi Wahyudi Yudi Wahyudi Yudi Wahyudi