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All Journal Majalah Kedokteran Bandung Jurnal Anestesi Perioperatif Bali Journal of Anesthesiology Majalah Anestesia dan Critical Care Jurnal Anestesi Obstetri Indonesia Interdisciplinary Social Studies Journal of Applied Nursing and Health Jurnal Neuroanestesi Indonesia Acta Medical and Health Sciences (AMHS)
Tatang Bisri
Departemen Anestesiologi dan Terapi Intensif Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Applied Nursing and Health

 1 
In-Silico Analysis of Costunolide and Dehydrocostuslactone Interactions with NAFLD-Related Proteins Pontjosudargo, Fransiska Ambarukmi; Priyadi, Hendri; Hermawanto, Agung; Bisri, Tatang
Journal of Applied Nursing and Health Vol. 7 No. 2 (2025): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v7i2.361

Abstract

Background: Non-alcoholic Fatty Liver Disease (NAFLD) is a growing health problem, but there is no standard drug for its treatment. Costunolide and dehydrocostuslactone are compounds found in Saussurea costus, exhibiting antioxidant activities that include anti-hepatotoxic, anti-inflammatory, and immunostimulant properties, which have been proven both in vivo and in vitro. This study aims to identify the bioactive ingredients of S. costus that affect NAFLD and explore its therapeutic targets through pharmacological networking.  Various tissue databases were utilised to obtain the bioactive material from S. costus and identify potential therapeutic targets for NAFLD. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to enrich the functions and molecular pathways of common targets. Methods: The analysis was conducted using a Structure-Activity Relationship (SAR) search to evaluate the biological potential of the studied compounds. The design of this study involved selecting costunolide and dehydrocostuslactone compounds as the subjects of analysis, with data collection conducted through public databases and relevant literature. SAR assessment was conducted using reporting standards, such as STITCH, to ensure transparency and reproducibility in the analysis. The score range used was 0-1, where the closer to 1, the better the value obtained. This process allows the identification of significant relationships between chemical structure and biological activity, as well as providing deeper insight into the potential of the compounds analysed. Thus, this method not only assesses the effectiveness of the compound but also provides a basis for further research in the development of therapy Results: The results of the Structure-Activity-Relationship (SAR) analysis were that the costunolide and dehydrocostuslactone compounds had scored <0.5 as a hepatoprotector and as a regulator of fat metabolism. The potential of these two compounds as TNF-alpha inhibitors and Interleukin-6 antagonists also shows a score <0.5. Conclusion: Costunolide and dehydrocostuslactone showed significant potential as anti-inflammatory agents and NF-κB transcription inhibitors. These findings indicate that both compounds may be promising candidates for NAFLD therapy, particularly through the mechanism of inhibition of the NF-κB transcription pathway. The implications of these results suggest the need for further studies to explore the efficacy and safety of these compounds in a clinical context, as well as their potential in the development of novel therapies for non-alcoholic fatty liver disease.
Co-Authors , Rizki , Suwarman - Irwan, - A. Himendra Wargahadibrata A. Muthalib Nawawi Agus Junaidi Aini, Quratul Akbar, Ieva B Alifahna, Muhammad Rezanda Andie Muhari Barzah, Andie Muhari Ardi Zulfariansyah Arief Kurniawan Bambang Suryono, Bambang Christanto, Sandhi Christanto, Sandhi christiana, monica Dedi Fitri Yadi Dewi Yulianti Bisri Diana C. Lalenoh, Diana C. Diana Lalenoh Erias, Muhammad Erwin Pradian Ezra Oktaliansah Firdaus, Riyadh Firdaus, Riyadh Fithrah, Bona Akhmad Fithrah, Bona Akhmad Fitri Sepviyanti Sumardi Giovanni, Cindy Giovanni, Cindy Hamzah, Hanzah Hermawanto, Agung Hindun Saadah, Hindun Ida Bagus Krisna Jaya Sutawan Ieva B. Akbar Ike Sri Redjeki Indrayani, Ratih Rizki Iwan Abdul Rachman Iwan Fuadi Jasa, Zafrullah Khany Kusuma Harimin, Kusuma Laksono, Buyung Hartiyo Lalenoh, Diana Christine Lalenoh, Diana Christine Limawan, Michaela Arshanty M. Dwi Satriyanto M. Erias Erlangga, M. Erias M. Sofyan Harahap Mariko Gunadi Martinus, Fardian Martinus, Fardian MM Rudi Prihatno, MM Rudi Muh. Rumli Ahmad Muhamad Adli Boesoirie, Muhamad Adli Muhammad Habibi Ningsih, Diana Fitria Ningsih, Diana Fitria Noer Rochmah, Elly Nugraha, Ade Aria Nugraha, Ade Aria Nuryanda, Dian Oetoro, Bambang J. Oetoro, Bambang J. Okatria, Ahmado Pontjosudargo, Fransiska Ambarukmi Priyadi, Hendri Putri, Andika C. Putu Pramana Suarjaya Radian Ahmad Halimi Rahmadsyah, Teuku Rahordjo, Sri Rasman, Marsudi Rasman, Marsudi Reza Widianto Sudjud Rose Mafiana Rovina Ruslami, Rovina Ruby Satria Nugraha Ruli Herman Sitanggang Saleh, Siti Chasnak Saleh, Siti Chasnak Saputra, Tengku Addi Saputra, Tengku Addi SATRIYAS ILYAS Septiani, Gusti Ayu Pitria Soefviana, Stefi Berlian Sri Rahardjo Stella, Angela Subekti, Bambang Eko Subekti, Bambang Eko Suryaningrat, IGB Susanto, Bahtiar Sutanto, Sigit Sutanto, Sigit Suwarman Suwarman, Suwarman Suwarman, S Suwarman, S Syafruddin Gaus Thayeb, Srilina Theresia C. Sipahutar Theresia Monica Rahardjo Uhud, Akhyar Nur Widiastuti, Monika - Wirawijaya, Dear Mohtar Wirawijaya, Dear Mohtar Wirawijaya Wullur, Caroline Wullur, Caroline Yunita Susanto Putri Zaka Anwary, Army