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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education The Indonesian Journal of Occupational Safety and Health MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Indonesian Journal of Medicine CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Biomedicine and Clinical Sciences Deka in Medicine
Didi Candradikusuma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Jurnal Kedokteran Brawijaya

 1 
Terapi ARV Meningkatkan Kadar IL-17 Serum pada Pasien HIV Wahyudi, Hendrik; Candradikusuma, Didi; B, Niniek Budiarti; Ismanoe, Gatoet
Jurnal Kedokteran Brawijaya Vol 27, No 4 (2013)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.47 KB) | DOI: 10.21776/ub.jkb.2013.027.04.8

Abstract

Penurunan jumlah atau fungsi Th-17 mempengaruhi produksi IL-17 sehingga virus HIV lebih mudah mengalami replikasi. Pemberiaan ARV yang dapat menekan replikasi virus HIV diharapkan dapat memperbaiki produksi IL-17 dan menyebabkan pulihnya fungsi Th-17. Penelitian dilakukan untuk mengetahui rerata kadar IL-17 serum pada pasien HIV sebelum dan setelah 3 bulan mendapat terapi ARV. Survei pre dan post tes dilakukan pada  pasien infeksi HIV yang baru terdiagnosa di RSU Dr. Saiful Anwar-Malang. Diagnosa HIV berdasarkan  kriteria WHO, dan IL-17 serum diukur dengan metode ELISA. Hitung limfosit T-CD4 absolut menggunakan metode flowcytometry. Analisa statistik yang digunakan untuk komparasi numerik  adalah uji t berpasangan dan  analisa korelasi menggunakan uji Spearman. Kadar IL-17 serum penderita HIV sebelum dan sesudah 3 bulan mendapat terapi ARV adalah 44,17±12,56 pg/mL dan 52,91±9,90 pg/mL (p=0,005). Hitung sel limfosit T-CD4 absolut  sebelum dan sesudah 3 bulan mendapat terapi ARV adalah 69,41±95,06 cells/mL dan 180,72±73,15 cells/mL (p=0,000). Kadar IL-17 serum didapatkan tidak berkorelasi dengan hitung sel T-CD4 absolut (p=0,914, r=-0,024). Dapat disimpulkan kadar IL-17 serum dan CD4 penderita HIV setelah 3 bulan mendapat terapi ARV lebih tinggi dibandingkan sebelum mendapat terapi ARV, namun, kadar IL-17 tidak berhubungan dengan hitung sel limfosit T-CD4.Kata Kunci: CD4, infeksi HIV, IL-17 serum, Th-17
The Role of Plasma Osmolarity in the Mortality of Patients with Covid-19 Indiastari, Dewi; Candradikusuma, Didi; Sutanto, Heri; Budiarti, Niniek; Samsu, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.12

Abstract

Covid-19 (Coronavirus disease 2019) is a new infectious disease that attacks the respiratory tract and is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), causing multiorgan failure, often requiring temporary support such as the use of a ventilator or hemodialysis equipment. This condition is related to an imbalance in fluid distribution associated with changes in osmolarity or hyperosmolarity. This research aims to explain the role of plasma osmolarity in Covid-19 patients at dr. Saiful Anwar Hospital, Malang, in patient outcomes, especially death outcomes. The sample for this study was 205 medical records of Covid-19 patients, recorded from September 2021 to May 2022. This study used a retrospective cohort design to describe plasma osmolarity in Covid-19 patients and the outcome of hospitalized patients. There were 205 patient data obtained, with 85 patients dying aged <65 years. Sixty-eight patients of Covid-19 with comorbidities (DM, HT, AKI, CKD, combination) died. There was no difference in plasma osmolarity for living and deceased patients. Repeated plasma osmolarity (retest) had a good degree of accuracy in predicting the outcome of Covid-19 patients, where sensitivity was 71.3% and specificity was 73.4% at a cut-off value of 277.32mOsm/L. The repeat plasma osmolarity value of ≥277.32 had a PPV value of 75%, while plasma osmolarity <277.32 had an NPV value of 69.3%. The OR value was 6.77, meaning that Covid-19 patients with repeated plasma osmolarity levels ≥277.32 would have 6.77 times the risk of mortality compared to Covid-19 patients with repeated plasma osmolarity levels <277.32.
The Role of Plasma Osmolarity in the Mortality of Patients with Covid-19 Indiastari, Dewi; Candradikusuma, Didi; Sutanto, Heri; Budiarti, Niniek; Samsu, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.12

Abstract

Covid-19 (Coronavirus disease 2019) is a new infectious disease that attacks the respiratory tract and is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), causing multiorgan failure, often requiring temporary support such as the use of a ventilator or hemodialysis equipment. This condition is related to an imbalance in fluid distribution associated with changes in osmolarity or hyperosmolarity. This research aims to explain the role of plasma osmolarity in Covid-19 patients at dr. Saiful Anwar Hospital, Malang, in patient outcomes, especially death outcomes. The sample for this study was 205 medical records of Covid-19 patients, recorded from September 2021 to May 2022. This study used a retrospective cohort design to describe plasma osmolarity in Covid-19 patients and the outcome of hospitalized patients. There were 205 patient data obtained, with 85 patients dying aged <65 years. Sixty-eight patients of Covid-19 with comorbidities (DM, HT, AKI, CKD, combination) died. There was no difference in plasma osmolarity for living and deceased patients. Repeated plasma osmolarity (retest) had a good degree of accuracy in predicting the outcome of Covid-19 patients, where sensitivity was 71.3% and specificity was 73.4% at a cut-off value of 277.32mOsm/L. The repeat plasma osmolarity value of ≥277.32 had a PPV value of 75%, while plasma osmolarity <277.32 had an NPV value of 69.3%. The OR value was 6.77, meaning that Covid-19 patients with repeated plasma osmolarity levels ≥277.32 would have 6.77 times the risk of mortality compared to Covid-19 patients with repeated plasma osmolarity levels <277.32.
Co-Authors Abellia, Gaby Agustina Tri Endharti Al-Rasyid, Harun Amalia, Dinda Antariksa, Genta Asmiragani, Syaifullah Badrul Munir, Badrul Bagus Hermansyah Burhan, Niniek Chozin, Iin Noor Dewi Indiastari Dwi Budi Santoso Dwi, Pratiwi Suryanti Dwikarlina, Intan Eko Arisetijono Erma Sulistyaningsih Evatta, Arde Fathoni, Alfan Fatma, Endah Gatoet Ismanoe Hendrik Wahyudi Heri Sutanto Heri, Sutanto Hidayat Sujuti Indiastari, Dewi Kristyana, Septian Loeki Enggar Fitri Machlusil Husna, Machlusil Milanitalia Gadys Rosandy Natasia, Septalisa Niniek Budiarti Niniek Budiarti B Nur Samsu Purbasari, Bethasiwi Rendy Wijaya Rosandy, Milanitalia Rosandy, Milanitalia Gadys Samsul Arifin Santoso, Dimas Shahdevi Nandar Kurniawan, Shahdevi Nandar Sinta Silvia Sri Budhi Rianawati, Sri Budhi Tri Wahju Astuti, Tri Wahju Tuda, Josef Sem Berth Umar Zein Widodo Mardi Santoso, Widodo Mardi Winoto, Eden Suryoiman Yudha, Nyoman Satvika Dharma Yulia Rusmayanti, Mega