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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Masyarakat Jurnal Kesehatan Andalas GIZI INDONESIA Journal Of Holistic Nursing Science Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) South East Asia Nursing Research Ina Kidney Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Pena Medika : Jurnal Kesehatan
Shofa Chasani
Nefrologi-Hipertensi Division, Master Program of Biomedical Science, Medical Faculty of UNDIP
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Ina Kidney

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Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Association Between Intradialysis Hypotension and Interdialytic Weight Gain in Deceased Hemodialysis Patients at Banyumas Regional General Hospital Poernomo, Gigih Rahmandanu; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa; Alatas, Haidar
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.178

Abstract

Background: Intradialytic hypotension (IDH) occurs in 5-40 percent of chronic kidney disease (CKD) with hemodialysis patients, it is associated with increased cardiovascular events and mortality. High Interdialytic Weight Gain (IDWG) requires higher ultrafiltration, increases the incidence of IDH, associated with a worse prognosis, patients with a history of diabetes are at higher risk. Objective: This study aimed to assess the association between IDWG and the occurrence of IDH in deceased patients undergoing hemodialysis, with a particular focus on the differences between diabetic and non-diabetic patients Methods: A retrospective study was conducted for one year at Banyumas Regional General Hospital, involving deceased hemodialysis patients. IDWG was calculated as the average of the last three hemodialysis sessions. Patients were further categorized based on their history of diabetes. Results: Among 37 deceased hemodialysis patients, 56.8% experienced IDH, including 50% of those with diabetes mellitus. IDWG was normally distributed (p = 0.283) and showed a weak but statistically significant correlation with IDH (r = 0.333, p = 0.044). Logistic regression indicated that each 1% increase in IDWG was associated with an 8% increase in the predicted probability of IDH. Diabetic status did not significantly modify this association (p = 0.772). Conclusion: Higher IDWG was associated with increased incidence of IDH in deceased hemodialysis patients, independent of diabetic status.
The Effect of Hemodialysis Adequacy on Inflammatory Status in Stage 5 Chronic Kidney Disease Patients Winarto, Dedi; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2025): Volume 2 No. 2, August 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.183

Abstract

Background: Chronic Kidney Disease (CKD) is a critical global health issue, particularly Stage 5 CKD, where kidney function is severely impaired. Hemodialysis, essential for managing such patients, aims to remove waste and excess fluids. Chronic inflammation, common among CKD5-HD patients, heightens cardiovascular risks and worsens quality of life. Hemodialysis adequacy, measured by the Kt/V ratio, plays a vital role in outcomes, yet its relationship with inflammatory markers, such as Hs-CRP, albumin, and TIBC, remains unclear. Objective: This study aimed to evaluate the relationship between hemodialysis adequacy, as reflected by Kt/V values, and inflammatory markers such as c-reactive protein (CRP), albumin, and total iron binding capacity (TIBC) in CKD stage 5 patients undergoing hemodialysis, providing insights into optimizing dialysis protocols to mitigate inflammation. Methods: A cross-sectional study of 45 CKD5-HD patients assessed Kt/V values and inflammatory markers (Hs-CRP, albumin, TIBC). Data were analyzed using Shapiro-Wilk, Independent t-tests, or Mann-Whitney U tests based on data distribution. Results: The mean Kt/V value was 1.31 ± 0.21. Lower Kt/V values were significantly associated with elevated Hs-CRP levels (p = 0.018). No significant differences in Kt/V values were observed concerning albumin (p = 0.546) or TIBC (p = 0.523). Correlations between Hs-CRP and albumin or TIBC were non-significant (p = 1.000). Conclusion: Adequate hemodialysis, reflected in optimal Kt/V values, is crucial for reducing systemic inflammation marked by Hs-CRP. Albumin and TIBC levels showed no significant association, underscoring the multifactorial nature of inflammation in CKD5 patients.
Co-Authors - Anggorowati Alatas, Haidar Ari Yulistianingsih Arinawati, Arinawati Arwanto, Arwedi Dwi Lestari Partiningrum Eka Sakti Wahyuningtyas Himawan, Fatchurozak Ikawati, Kartika Joko Wahyu Wibowo Lestariningsih Lestariningsih Lusito, Lusito Makarim, Fadhli Rizal Mohammad Sulchan Nurani, Ayudyah Oktaviarini, Eka Perdhana, Langgeng Poernomo, Gigih Rahmandanu Ragil Saptaningtyas, Ragil Rosiah, Rosiah Rudy Handoyo, Rudy Siti Nuraini Suharyo Hadisaputro Sulchan, M Sulchan, M Tanti Ajoe Kesoema, Tanti Ajoe Taufik Maryusman Taufiqurrachman Nasihun Untung Sujianto Wahju Ratna Martiningsih Wahyu Hidayati wibowo, subur Winarto, Dedi Yekti, Murwani Yunie Armiyati