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All Journal Pharmaciana: Jurnal Kefarmasian Naturalis : Jurnal Penelitian Pengelolaan Sumberdaya Alam dan Lingkungan PENA SAINS Jurnal Kimia Riset Jurnal Ilmiah Kedokteran Wijaya Kusuma JPM (Jurnal Pemberdayaan Masyarakat) JCES (Journal of Character Education Society) EMBRIO : Jurnal Kebidanan Jurnal Surya Masyarakat JAST : Jurnal Aplikasi Sains dan Teknologi LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Health Information : Jurnal Penelitian Medicra (Journal of Medical Laboratory Science/Technology) Madaniya Jurnal Surya Masyarakat Jurnal Pengabdian Masyarakat dalam Kesehatan Medical Scope Journal (MSJ) Jurnal Abdimas Kartika Wijayakusuma Proceedings of The ICECRS Procedia of Social Sciences and Humanities Indonesian Journal of Community Diversity and Engagement Journal of Pharmaceutical and Sciences. International Journal Multidisciplinary Indonesian Journal Health Science and Medicine Academia Open
Jamilatur Rohmah
Prodi Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Sidoarjo
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Journal : academia open

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Toxicity Testing of Turi Putih Bark Extract on Mice Liver: Pengujian Toksisitas Ekstrak Kulit Batang Turi Putih pada Hati Mencit Mujemilatul Hasanah; Jamilatur Rohmah
Academia Open Vol. 8 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.5429

Abstract

General background the use of natural extracts in assessing toxicity has gained attention due to the growing interest in alternative medicine and natural products. Specific background Sesbania grandiflora, commonly known as turi putih, is a plant with potential medicinal properties, but its safety profile regarding hepatic toxicity remains inadequately explored. Knowledge gap while previous studies have examined various plants for their pharmacological effects, research specifically focusing on the hepatotoxicity of turi putih extract is lacking. Aims this study aims to evaluate the toxicity of ethanol extract from the bark of Sesbania grandiflora on liver function, as measured by SGOT and SGPT levels, in Mus musculus. Results showed no mortality or toxic symptoms in the mice exposed to the extract. Macroscopic examination of the liver indicated normal color, consistency, and shape. Statistical analysis yielded p-values of 0.502 for liver weight, 0.226 for SGOT, and 0.366 for SGPT, indicating no significant effects from the treatment. Novelty this research contributes new insights into the safety profile of Sesbania grandiflora, demonstrating its non-toxic effects at the tested doses. Implications the findings suggest that the bark extract of turi putih may be safe for use, highlighting its potential in herbal medicine without adverse hepatic effects. Highlights: No observed toxicity or mortality in mice after exposure to the extract. Normal liver function indicated by SGOT and SGPT levels. Potential safety of turi putih bark extract for medicinal use. Keywords: Turi Putih, Hepatotoxicity, Sesbania grandiflora, Mice, Ethanol Extract
Toxicity of White Turi Stem Bark Extract on Mice: Toksisitas Ekstrak Kulit Batang Turi Putih pada Mencit Anisatus Shalihah Amalia; Jamilatur Rohmah
Academia Open Vol. 8 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.5432

Abstract

General background the use of traditional medicinal plants has gained attention due to their potential therapeutic benefits and safety. Specific background among these, Sesbania grandiflora (L.) Pers., commonly known as white turi, is recognized for its various bioactive compounds. However, there is a knowledge gap regarding the toxicity of its stem bark extract, particularly concerning its effects on vital organs such as the kidneys. Aims this study aims to evaluate the toxicity of white turi stem bark extract on mice by determining the LD50 and assessing kidney health through biochemical parameters such as Blood Urea Nitrogen (BUN) and creatinine levels.The results indicate no significant toxic symptoms or mortality in the treated mice, with macroscopic kidney observations showing reddish-brown coloration and a consistent texture resembling red kidney beans.Novelty this study provides novel insights into the safety profile of Sesbania grandiflora stem bark extract, suggesting that it does not pose significant renal toxicity. Implications these findings support its traditional use while encouraging further research into its pharmacological properties. Highlights: No significant toxic symptoms observed in treated mice. Macroscopic kidney analysis indicated no severe damage. Statistical results confirmed no renal toxicity at various extract doses. Keywords: Sesbania Grandiflora, Toxicity, LD50, Kidneys, Mice
High Dose Sesbania Grandiflora Extract Alters Rat Kidney Electrolytes based on Insights from Indonesia: Ekstrak Sesbania Grandiflora Dosis Tinggi Mengubah Elektrolit Ginjal Tikus berdasarkan Wawasan dari Indonesia Mokhamad Amirul Hidayat; Jamilatur Rohmah
Academia Open Vol. 9 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.7812

Abstract

This study investigates the acute toxicity of white turi flower extract (Sesbania grandiflora) on kidney electrolyte levels in rats (Rattus norvegicus). Conducted at Muhammadiyah University of Sidoarjo, male Wistar rats were divided into control and treatment groups, receiving 10,000, 15,000, and 20,000 mg/kgBW doses. Symptoms of toxicity included lethargy and hair loss, but no deaths occurred. Despite normal macroscopic kidney observations, sodium and potassium levels significantly increased with higher doses (p=0.000). These findings suggest that high doses of white turi flower extract can affect kidney electrolytes, indicating potential toxicity. Further research is needed to assess long-term safety for medicinal use. Highlights: 1. High doses increase sodium and potassium in rat kidneys.2. Symptoms: lethargy, hair loss, no fatalities.3. Requires further research for long-term safety. Keywords: Sesbania grandiflora, acute toxicity, kidney electrolytes, sodium, potassium
Sesbania grandiflora Extract Reduces ALP and GGT in Paracetamol Toxicity: Ekstrak Sesbania grandiflora Mengurangi ALP dan GGT pada Toksisitas Parasetamol Veronika Oktaruliawan; Jamilatur Rohmah
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.12413

Abstract

General Background: Oxidative stress generated by excessive free radicals contributes to hepatic injury, particularly during metabolism of hepatotoxic drugs. Specific Background: Paracetamol overdose produces the reactive metabolite N-acetyl-p-benzoquinone imine, which triggers lipid peroxidation and elevates liver enzymes such as Alkaline Phosphatase (ALP) and γ-Glutamyl Transferase (GGT). Sesbania grandiflora leaves contain bioactive compounds including flavonoids, alkaloids, and tannins with antioxidant properties. Knowledge Gap: Scientific evidence describing the biochemical response of ALP and GGT to Sesbania grandiflora leaf extract under paracetamol-induced hepatotoxic conditions remains limited. Aims: This study evaluated the biochemical changes in ALP and GGT levels and oxidative stress marker malondialdehyde (MDA) in male Wistar rats administered toxic paracetamol doses followed by graded Sesbania grandiflora leaf extract treatment. Results: Experimental randomized controlled laboratory research involving 28 rats demonstrated significant differences in MDA, ALP, and GGT values across treatment groups (p<0.05). Paracetamol administration elevated oxidative stress and liver enzyme parameters, while extract administration decreased MDA and reduced ALP and GGT levels. The 1000 mg/kg body weight dose produced enzyme values approaching physiological ranges. Novelty: This study presents combined biochemical evaluation of oxidative stress indicators and dual liver enzyme parameters following graded Sesbania grandiflora leaf extract administration in paracetamol-induced hepatic injury. Implications: Sesbania grandiflora leaf extract represents a potential natural hepatoprotective candidate with antioxidant activity relevant for managing drug-induced liver injury and supporting development of plant-based therapeutic agents. Highlights: Highest Administered Dose Returned Enzyme Biomarkers Close to Physiological Values. Antioxidant Administration Lowered Lipid Peroxidation Indicator Concentrations in Treated Animals. Statistical Analysis Confirmed Significant Biochemical Differences Between Intervention and Control Groups. Keywords: Sesbania Grandiflora; Hepatoprotection; Oxidative Stress; Alp; Gamma Glutamyl Transferase
Co-Authors Achmad Noerkhaerin Putra Aini, Latifatul Andika Aliviameita Anisatus Shalihah Amalia Anwar, Najih Arini Siti Wahyuningsih Aziza, Vidayatul Chylen Setiyo Rini Devi Arvindani Masyitha Eni Fariyatul Fahyuni Fadilah, Fitrian Nur FATMAWATI, RIRIN Fikih Putri Ayu Nabila Firdaus, Firyalita Sarah Fitria Ayu Prayekti, Rahmatika Fitria Eka Wulandari Fiya, Uus Ufita Furqonati, Lili Galuh Ratmana Hanum Handini, Hesti Dwi Hidayat, Mokhamad Amirul Ida Agustini Saidi Karlia Hedit Tiana Khusniyah, Nurul Liyaajul, Pratasyah Makrufah, Makrufah Margareta, Frida Amelia Marlina, Mariany Lambertine Martina, Shofie Fitria Miftahul Mushlih Miranda, Niken Anggita Mokhamad Amirul Hidayat Mujemilatul Hasanah Mukarromah, Rizka Aisya Novitasari, Fia NUR EFENDI Nurul Azizah Paramitha Amelia Kusumawardani Purwanti, Yanik Puspitasari Puspitasari Puspitasari Puspitasari Putra, Moh. Faris Yudiana Rafhani Rosyidah Rini, Chylen S. Rofidah, Luthfiyah Salsabila Widya Kirana Siroj, Muhammad Said Agil SITI CHOLIFAH Siti Cholifah Sofi Rahayu, Bella Tri Chahyani Rahmawati Putri Tri Linggo Wati Vanda Rezania Veronika Oktaruliawan Wakhidah, Kemil Widyaningrum, Leni Yuroh Yuli Astutik Zulfida Ainindiyah Putri Purwanto Zurrotul Ilmiyah