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Factors Related to Malnutrition in Children Under Five Years with Congenital Heart Disease Augiani, Amani Sakinah; Rahayuningsih, Sri Endah; Herawati, Dewi Marhaeni Diah
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Congenital heart disease (CHD) is the most frequent type of heart disease that occurs in children. Children with CHD are more vulnerable to suffer impaired nutritional status related to morbidity and mortality. The nutritional status, however, may not be influenced only by CHD, but also by other factors.. The study was conducted to identify factors related to malnutrition in children with CHDMethods: This cross-sectional study involved 86 children with CHD recruited from Dr. Hasan Sadikin General Hospital Bandung from October to November 2015. Data collected in this study were obtained by conducting anthropometric measurements, interviewed the parents (obstetric history, patientâs medical history and socioeonomic status) and from medical records (the type and time of CHD diagnosis, other diseases that accompanied the CHD). The collected data were presented by frequency distribution. Results: There were 46.5%Â patients who had nutritional disturbance. Malnutrition in males and patients with Tetralogy of Fallot were higher than other groups. Almost half patients with maternal history of passive smoking during pregnancy had nutritional disturbance. The most common disease found was diarrhea followed by lower respiratory infection. Percentage of normal children in low-income parents group was lower than the high-income group. Conclusions: Nearly half of patients have nutritional disturbance. Percentage of nutritional disturbance in male was higher compared to female. Active and passive smokers, Tetralogi Fallot, diarrhea, lower respiratory infection and lower incomeÂ were factors contributed to malnutrition. [AMJ.2017;4(1):111â7]DOI:Â 10.15850/amj.v4n1.1031

Familial Analysis of Patients with Hypertension in Jatinangor, West Java, Indonesia Hayati, Keumala; Sofiatin, Yulia; Rahayuningsih, Sri Endah; Roesli, Rully M.A.
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (740.112 KB)

Background: Hypertension is a disease that is influenced by genetic factors, although the single gene affecting the occurrence of the disease has not been yet discovered. Genetic analysis and familial analysis on hypertension are needed to be done but genetic analysis needs substantial fund, and familial analysis on hypertension has been never done in community. Besides sharing the genetic factors, family also shares similar environment and life style. Latest study showed that the association between genetic and environmental factors can affect the phenotype of chronic disease suchas hypertension. The study was aimed to explore the family history contribution of patients with hypertension in Jatinangor.Methods: This was a descriptive-quantitave study. The subjects were 283 hypertensive patients in Jatinangor with complete data of family history. The data was retrospectively obtained from secondary data of a previous study conducted in Community Health and Well-ness Study Center, Faculty of Medicine, Universitas Padjadjaran titled Epidemiology of Hypertension and Albuminuria in Jatinangor 2014. Familial analysis conducted in this study was modified trios analysis.Results: In this modified trios analysis, there was only 20% of total patients with hypertension who have history of hypertension in two generations of their family. The proportion of patients with hypertension who have history of hypertension in one generation of their family was greater. More than 45% from the total 283 patients with hypertension analyzed in this study have family history of hypertension.Conclusions: Familial analysis using modified trios analysis showed similar results with the study conducted using other genetical analysis.

Factors Related to Malnutrition in Children Under Five Years with Congenital Heart Disease Amani Sakinah Augiani; Sri Endah Rahayuningsih; Dewi Marhaeni Diah Herawati
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.947 KB)

Background: Congenital heart disease (CHD) is the most frequent type of heart disease that occurs in children. Children with CHD are more vulnerable to suffer impaired nutritional status related to morbidity and mortality. The nutritional status, however, may not be influenced only by CHD, but also by other factors.. The study was conducted to identify factors related to malnutrition in children with CHDMethods: This cross-sectional study involved 86 children with CHD recruited from Dr. Hasan Sadikin General Hospital Bandung from October to November 2015. Data collected in this study were obtained by conducting anthropometric measurements, interviewed the parents (obstetric history, patient’s medical history and socioeonomic status) and from medical records (the type and time of CHD diagnosis, other diseases that accompanied the CHD). The collected data were presented by frequency distribution. Results: There were 46.5% patients who had nutritional disturbance. Malnutrition in males and patients with Tetralogy of Fallot were higher than other groups. Almost half patients with maternal history of passive smoking during pregnancy had nutritional disturbance. The most common disease found was diarrhea followed by lower respiratory infection. Percentage of normal children in low-income parents group was lower than the high-income group. Conclusions: Nearly half of patients have nutritional disturbance. Percentage of nutritional disturbance in male was higher compared to female. Active and passive smokers, Tetralogi Fallot, diarrhea, lower respiratory infection and lower income were factors contributed to malnutrition. [AMJ.2017;4(1):111–7]DOI: 10.15850/amj.v4n1.1031

Congenital Heart Disease Characteristics in Low Birth Weight Infants at Dr. Hasan Sadikin General Hospital in 2010–2014 Villia Damayantie; Sri Endah Rahayuningsih; Irvan Afriandi
Althea Medical Journal Vol 6, No 3 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Congenital heart disease (CHD) is a multifactorial disease defined as an anomaly in the macroscopic structure of the heart that may cause functional disorders. The incidence of CHD is reported higher in infants with low birth weight (LBW) than the entire population of neonates. This study aimed to describe the characteristics of CHD in infants born with LBW.Methods: This was a retrospective descriptive study with a cross-sectional design, performed in October–November 2015. Data were obtained from medical records of inpatients infants at Dr. Hasan Sadikin General Hospital, Bandung in the period of 2010–2014. The data presented were the characteristics of CHD in LBW infants.Results: Of 364 LBW infants treated in the hospital within 5 years period, 21 infants (14 girls and 7 boys) were diagnosed as CHD, with birth weight group predominantly (n18; 85.7%) in the range of 1,500–2,499 gr. Non-cyanosis CHD was prevalent in 95.2% (n20),and patent ductus arteriosus (PDA)was found in 76.1% (n16). Comorbid conditions mostly found in this study were preterm birth (n17), sepsis (n10), and neonatal hyperbilirubinemia (n9).Conclusions: The most common type of CHD in low birth weight infants in Dr. Hasan Sadikin General Hospital is Patent Ductus Arteriosus. The presence of congenital heart disease should be considered in low birth weight infants, thus it is essential to perform screening for early recognition.

The Air Quality and Detection of Streptococcus pneumoniae in the Pediatric Ward of Dr. Hasan Sadikin Hospital Bandung Thiban Raj Manoraj; Yanti Mulyana; Sri Endah Rahayuningsih
Althea Medical Journal Vol 6, No 3 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Nosocomial infection can be acquired by inhalation of droplets from contaminated air. In children, nosocomial pneumonia is mainly caused by Streptococcus pneumoniae. This study aimed to explore the air quality level and to detect Streptococcus pneumonia in the air of the Pediatric Ward of Dr. Hasan Sadikin Hospital, Bandung. Methods: This was an observational descriptive study conducted in the Pediatric Ward of Dr. Hasan Sadikin Hospital in November 2012. The different number of modified tryptic soy agar (TSA) plates with 4% blood were exposed and placed in various rooms of the ward for 30 minutes between 12.00 pm to 1.00 pm at heights between 1.0m to 1.5m and according to the respectively room air volume. After exposure, these plates were then incubated for 48 hours at 35°C. The Colony Forming Units (CFU) on each plate was counted per Replicate Organism Detection and Counting (RODACTM). Detection of Streptococcus pneumonia was performed by detecting any round α-hemolytic colonies on the TSA plate, confirmed by Gram staining, optochin susceptibility test, and the bile solubility test. Result: The air quality in 13 rooms of the Pediatric Ward was generally poor ranging from 27.5 to 232.0 CFU/30 min, however, the concentration of microorganisms per cubic meter air was from 0.198 to 4.296 CFU/m3. Moreover, Streptococcus pneumoniae was not present in the air of the ward.Conclusions: Although Streptococcus pneumoniae has not been detected, the air quality in the Pediatric Ward of Dr. Hasan Sadikin Hospital, Bandung is generally poor. General precautions need to be enhanced to increase the air quality in the hospital.

Familial Analysis of Patients with Hypertension in Jatinangor, West Java, Indonesia Keumala Hayati; Yulia Sofiatin; Sri Endah Rahayuningsih; Rully M.A. Roesli
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (740.112 KB)

Background: Hypertension is a disease that is influenced by genetic factors, although the single gene affecting the occurrence of the disease has not been yet discovered. Genetic analysis and familial analysis on hypertension are needed to be done but genetic analysis needs substantial fund, and familial analysis on hypertension has been never done in community. Besides sharing the genetic factors, family also shares similar environment and life style. Latest study showed that the association between genetic and environmental factors can affect the phenotype of chronic disease suchas hypertension. The study was aimed to explore the family history contribution of patients with hypertension in Jatinangor.Methods: This was a descriptive-quantitave study. The subjects were 283 hypertensive patients in Jatinangor with complete data of family history. The data was retrospectively obtained from secondary data of a previous study conducted in Community Health and Well-ness Study Center, Faculty of Medicine, Universitas Padjadjaran titled Epidemiology of Hypertension and Albuminuria in Jatinangor 2014. Familial analysis conducted in this study was modified trios analysis.Results: In this modified trios analysis, there was only 20% of total patients with hypertension who have history of hypertension in two generations of their family. The proportion of patients with hypertension who have history of hypertension in one generation of their family was greater. More than 45% from the total 283 patients with hypertension analyzed in this study have family history of hypertension.Conclusions: Familial analysis using modified trios analysis showed similar results with the study conducted using other genetical analysis.

Early Left Ventricular Structural Changes With Preserved Function in Overweight and Obese Adolescents: A Speckle-Tracking Echocardiography Study Nurfandi, Wendi; Hafsah, Tisnasari; Rahayuningsih, Sri Endah; Apandi, Putria Rayani; Hakim, Dzulfikar Djalil Lukmanul; Ghrahani, Reni; Kuswiyanto, Rahmat Budi; Gurnida, Dida Akhmad
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4343

Background: Overweight and obesity in adolescents are associated with dyslipidemia and may contribute to early cardiovascular remodelling. Speckle-tracking echocardiography (STE) is a sensitive imaging technique capable of detecting early myocardial functional alterations before the onset of clinical symptoms. This study aimed to evaluate the correlation between cardiac chamber dimensions, left ventricular (LV) geometry and function, and lipid profiles in overweight and obese adolescents. Methods: A cross-sectional study was conducted from June to September 2023, involving 51 overweight and obese adolescents aged 15–18 years in Bandung, Indonesia. Anthropometric measurements, fasting lipid profiles (triglycerides, total cholesterol, LDL, HDL), and transthoracic echocardiography were obtained. LV dimensions, LV mass index (LVMI), ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS) were assessed. Associations were analyzed using Pearson correlation.Results: Participants were predominantly male (64.7%) with a mean age of 16.3±0.6 years. Overweight (47.1%) and obesity (52.9%) were almost equally distributed with a mean BMI of 29.6±4.1 kg/m². LVMI correlated negatively with total cholesterol (r=−0.356; p=0.005), HDL (r=−0.351; p=0.006), and LDL (r=−0.280; p=0.023). The LV posterior wall thickness and LV end-diastolic diameter were also inversely correlated with selected lipid parameters. Interventricular septal thickness in systole correlated positively with triglycerides (r=0.270; p=0.028). No significant correlations were found between lipid profiles and LV function parameters, including EF, FS, and GLS (p>0.05).Conclusions: In overweight and obese adolescents, lipid profiles are associated with early alterations in LV structural dimensions while LV systolic function remains preserved. These findings support the importance of early cardiovascular screening and lifestyle modification to reduce future cardiometabolic risk.

Reduced Left Ventricular Global Longitudinal Strain in Obese Adolescents Febrianda, Rilda Dwi; Hafsah, Tisnasari; Rahayuningsih, Sri Endah; Hakim, Dzulfikar Djalil Lukamnul; Kuswiyanto, Rahmat Budi; Apandi, Putria Rayani; Gurnida, Dida Akhmad
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4342

Background: Obesity in adolescents is associated with early cardiac structural and functional alterations that may progress to ventricular dysfunction later in life. Two-dimensional speckle-tracking echocardiography (2D STE) enables early identification of subclinical ventricular dysfunction. Nevertheless, its application in the adolescents remains limited. This study aimed to assess differences in left ventricular (LV) function among well-nourished, overweight, and obese adolescents using 2D STE.Methods: A cross-sectional study was conducted among adolescents aged 15–18 years from five senior high schools in Bandung, Indonesia between June and August 2023. Participants were randomly categorized into well-nourished, overweight, and obese groups. Transthoracic echocardiographic using M-mode and 2DSTE was performed to evaluate LV function, particularly global longitudinal strain (GLS). Statistical analyses were performed using SPSS with significance defined as p<0.05.Results: Sixty adolescents were included, 65% were male with a mean age of 16.4±0.6 years. Conventional echocardiography showed no significant differences in systolic or diastolic function among groups. However, obese adolescents demonstrated significantly greater LV posterior wall thickness and larger LV and right ventricular basal volumes compared with other groups. GLS analysis revealed significantly reduced LV deformation in obese group compared with overweight and well-nourished groups (–20.0±1.9 vs. –22.3±1.4 vs. –22.7±1.9, respectively; p<0.001).Conclusion: Reduced LV GLS detected by 2D STE indicates early subclinical myocardial dysfunction in obese adolescents despite normal conventional echocardiographic findings. Early cardiovascular screening and lifestyle interventions, including balanced nutrition and regular physical activity, may help reduce future cardiometabolic risk.

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