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All Journal Biology, Medicine, & Natural Product Chemistry Medical Laboratory Technology Journal Jurnal Berkala Kesehatan Meditory : The Journal of Medical Laboratory Window of Health : Jurnal Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Information : Jurnal Penelitian Jurnal Abdi Insani Jurnal Pengabdian Masyarakat Sasambo Ahmar Metakarya: Jurnal Pengabdian Masyarakat Molucca Medica Pakem : Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Sisthana Jurnal Masyarakat Madani Indonesia Jurnal Inovasi, Pemberdayaan dan Pengabdian Masyarakat Jurnal Cendekia Mengabdi Berinovasi dan Berkarya Karya Kesehatan Siwalima Poltekita: Jurnal Ilmu Kesehatan
Theosobia Grace Orno
Poltekkes Kemenkes Kendari
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Journal : Medical Laboratory Technology Journal

 1 
Correlation Between Onset of Diabetes Mellitus and Nitric Oxide Levels in Patient with Type 2 Diabetes Mellitus Theosobia Grace Orno; Mansyur Arif; Irfan Idris
Medical Laboratory Technology Journal Vol. 4 No. 1 (2018): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (930.985 KB) | DOI: 10.31964/mltj.v4i1.175

Abstract

Type 2 diabetes mellitus (DM) is associated with increased risk of endothelial dysfunction if it lasts a long time without control. This study aims to connect the Onset of Diabetes Mellitus (DM) with Nitric Oxide levels in patients of type 2 diabetes mellitus. The study used cross-sectional study method. The samples were 86 subjects, consisting of 38 subjects of Type 2 DM controlled and 48 subjects of Type 2 DM uncontrolled. The results of the Kruskal-Wallis statistical test showed no significant difference between the Onset of DM and Nitric Oxide levels in the categories of 4-6 years (19.4 ± 10.1), 7-9 years (17.3 ± 9.3) and 10-12 years (13.3 ± 8.5) (p=0.06). Furthermore, the Spearman correlation test revealed a negative correlation between the Onset of DM and Nitric Oxide level in patients with Type 2 DM with and without control (r =-0.217). The level of Nitric Oxide (NO) can consider as a predictor of long-term complication in patients with type 2 DM.
Correlation Analysis of Interleukin-6 on Blood Glucose in Prediabetes and Normal Glycemic Status Ratih Feraritra Danu Atmaja; Theosobia Grace Orno; Tuty Yuniarty; Handayani Malik
Medical Laboratory Technology Journal Vol. 9 No. 1 (2023): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v8i2.496

Abstract

Diabetes mellitus is a global health problem whose incidence rate continues to increase yearly. Most people with diabetes mellitus go through the prediabetes phase. Prediabetes is a condition where blood glucose levels are elevated but have not yet reached the criteria for diabetes mellitus. Low-grade chronic inflammation is one of the pathways known to interfere with insulin signalling that ultimately affects blood glucose levels. One of the most studied inflammatory pathways in the pathogenesis of diabetes mellitus is interleukin-6 (IL-6). This study aims to determine whether there were differences in IL-6 levels between groups of prediabetes subjects and normal subjects and to observe the correlation between IL-6 levels and blood glucose. This study is useful in providing additional scientific evidence on the development of diabetes mellitus, especially in blood glucose regulation through inflammatory pathways. The design of this study was analytic observational in 71 subjects with prediabetes or normal glycemic status. Prediabetes status was established based on fasting blood glucose levels and glucose levels 2 hours post oral glucose tolerance test. Subjects with fasting blood glucose levels> 125mg/ dl and who had a fever in the last week were excluded from the study. Interleukin 6 levels were measured based on the principle of enzyme-linked immunoassay. The correlation of interleukin 6 with glucose levels and other variables was analyzed using the spearmen test. The results showed that interleukin 6 levels did not differ between the prediabetes group and the normal group ((5.27 ± 2.55 pg/ml) vs (4.44 ± 2.46) respectively; (p=0.105)). There was no correlation between interleukin 6 level and fasting blood glucose level (r=0.014, p=0.908) and glucose level after the oral glucose tolerance test (r=-0.085, p=0.480). In this study, there was a significant correlation between body mass index with waist circumference (r=0.772, p=0.000) and glucose levels after the oral glucose tolerance test (r=0.240; p<0.001). Recommends the addition of anti-inflammatory cytokines and variable insulin to assess further the effect of the inflammatory process on the glucose metabolism of subjects in future studies.
Analysıs of Urınary Albumın and Urınary Synaptopodın Levels in Type 2 Dıabetes Mellıtus Subjects Afni Juhairia Laisouw; Liong Boy Kurniawan; Yuyun Widaningsih; Tenri Esa; Himawan Sanusi; Andi Alfian Zainuddin; Theosobia Grace Orno
Medical Laboratory Technology Journal Vol. 9 No. 1 (2023): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v8i2.514

Abstract

Hyperglycemia from diabetes mellitus affects many body organs and interferes with normal function. Kidney function decreased in approximately one-third of patients with diabetes mellitus before the development of albuminuria. The purpose of this study was to analyze differences in urine albumin and urine synaptopodin levels in type 2 diabetes mellitus (T2DM) and non-DM subjects, differences in urine synaptopodin levels in T2DM subjects with and without nephropathy, to analyze the correlation between urine albumin and urine synaptopodin in T2DM subjects and the cut-off analysis of sensitivity and specificity of urinary synaptopodin in diagnosing diabetic nephropathy. A sample of 60 subjects comprised 40 T2DM subjects and 20 non-DM subjects. Urinary synaptopodin levels were examined using the ELISA method, and albuminuria levels using the immunoturbidimetric method. Based on statistical analysis, the results showed that there were differences in urine albumin levels in T2DM and non-DM subjects (p*= < 0.001), there were differences in urine synaptopodin levels in T2DM and non-DM subjects (p*= < 0.001), there were no differences in urine synaptopodin levels with and without nephropathy in T2DM subjects (p*= 0.090), a relationship was found between urine albumin and urinary synaptopodin in T2DM subjects (p*= 0.048, r= 0.314) and the cut off of urinary synaptopodin in diagnosing nephropathy was ³0.39 ng/mL, sensitivity 64.7% and specificity 56.5%. We recommend further prospective studies with larger sample sizes to compare urinary synaptopodin levels and microalbuminuria (MAU) as markers for early detection of DN in T2DM subjects.
Co-Authors Afni Juhairia Laisouw Agnes Rantesalu Alfian Zainuddin Andi Alfian Zainuddin Anita Rosanty Anita Rosanty Anita Rosanty, Anita Aswiro Hasan Aswiro Hasan Atmaja, Ratih Feraritra Danu Banudi, La Dene Fries Sumah Devita Madiuw Elita Stephanie Lenderts Fauzi, Ahmad Zil Fonnie Esther Hasan Handayani Malik Hasan, Aswiro Hasan, Fonnie Esther Hasan, Zulfikar Ali Hikmawati Hikmawati Himawan Sanusi Husaini Umar Irfan Idris Julianti Isma Sari Jusni Ekasari Pelu Lenderts, Elita Stephanie Liong Boy Kurniawan Liong Boy Kurniawan Mansyur Arif Naningsih, Hasmia Nurahmi Nurahmi Nurmiaty, Nurmiaty Pattipeiluhu, Lisse Pelu, Jusni Ekasari Putra, Ahmat Rediansya Rahmat Kurniawan Ratih Feraritra Danu Atmaja Ratih Feraritra Danu Atmaja Rehena, Zasendy Reni Yunus Sanaky, Marisca Jenice Sari, Julianti Isma Sarita, Sultina Sinthia Rosanti Maelissa Sopacua, Dian Thiofany Supiati Supiati Supiati Supiati T. Iskandar Faisal Tahapary, Westy Teguh Fathurrahman, Teguh Tenri Esa Tuty Yuniarty Tuty Yuniarty Tuty Yuniarty Tuty yuniarty, Tuty Usman, Julianti Isma Sari Valensya Yeslin Tomasoa Vanny Leutualy Viere Allanled Siauta Yuyun Widaningsih Yuyun Widaningsih