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All Journal Medical Laboratory Technology Journal Jurnal Berkala Kesehatan Meditory : The Journal of Medical Laboratory Window of Health : Jurnal Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Information : Jurnal Penelitian Jurnal Pengabdian Masyarakat Sasambo Ahmar Metakarya: Jurnal Pengabdian Masyarakat Molucca Medica Pakem : Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Sisthana Jurnal Masyarakat Madani Indonesia Jurnal Inovasi, Pemberdayaan dan Pengabdian Masyarakat Jurnal Cendekia Mengabdi Berinovasi dan Berkarya Karya Kesehatan Siwalima Poltekita: Jurnal Ilmu Kesehatan
Theosobia Grace Orno
Poltekkes Kemenkes Kendari
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

 1 
INVITRO CITOTOXICITY ASSAYS OF SEAGRASS (Enhalus acoroides) METHANOL EXTRACT FROM SOROPIA COASTAL WATERS SOUTHEAST SULAWESI REGENCY Theosobia Grace Orno; Agnes Rantesalu
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 2 No 1 (2020): Laboratory Examinations Support in Medical Toxicology
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v2i1.1463

Abstract

The studies analysing the use of natural ingredients as an alternative treatment in the field of pharmacology are developing very rapidly. One of researches that is quite promising in the pharmaceutical industry is the application of marine materials. Marine materials that are frequently used consist of shellfish, algae, sponges and seagrass. Several studies on toxicity tests have shown that the methanol extract of seagrass (from species Enhalus acoroides) is more toxic than the other seagrass family. This study aims to test the toxicity level of Seagrass (E. acoroides) extract from Soropia coastal waters. The research method in this study was an experimental laboratory using E. acoroides Seagrass as a sample that was obtained from Soropia Coast, Konawe Regency, Southeast Sulawesi Province. The sample was extracted using methanol as a solvent by macerating it and was tested for its toxicity using the Brine Shrimp Lethality Test (BSLT) method. Toxicity test results showed that the samples with a concentration of 10 ppm, 100 ppm and 1000 ppm in leaves extracts produced an LC50 value of 404.88 ppm, while the stem and root extracts has a value of LC50 >1000 ppm. The test was continued with higher concentration of leaves extracts consisted of 250 ppm, 500 ppm, and 1000 ppm. The toxicity test showed an LC50 value of 0.7309; which means that it was very toxic. The methanol extract of Seagrass (E. Acoroides) is potential to be used for further analysis and anticancer formulations.
Analysis of Urine Podocalyxin in Type 2 Diabetes Mellitus Subjects With and Without Diabetic Nephropathy Jusni Ekasari Pelu; Liong Boy Kurniawan; Yuyun Widaningsih; Alfian Zainuddin; Husaini Umar; Nurahmi Nurahmi; Theosobia Grace Orno
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 5 No 1 (2023): Step up to strengthen the laboratory system and prepare for patients care
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v5i1.3933

Abstract

Type 2 diabetes mellitus is the most common cause of diabetes, consist from about 85% of cases. Diabetic nephropathy is a complication of diabetes mellitus in the kidneys which can end up as kidney failure. Podocalyxin (PDX) is a protein expressed in kidney podocytes that is involved in various cancers, and is also essential for kidney development. The research design was carried out using observational and cross-sectional analytic methods with total participants of 25 DM with diabetic nephropathy and 25 DM without diabetic nephropathy with a purposive probability sampling technique. This research conducted at the Endocrine Polyclinic, Clinical Pathology Laboratory, Hasanuddin University Medical Research Center (HUM-RC) Laboratory, Hasanuddin University Hospital, Makassar. The results showed that the urinary PDX level in DM subjects with nephropathy were 1.160 ng/mL and DM without nephropathy were 0.167 ng/mL (p<0.001), the urine albumin/creatinine ratio (ACR) of DM subjects with nephropathy were 644.74 mg/ g and DM without nephropathy of 10.071 mg/g (p<0.001) and the correlation test results of urine PDX and urine ACR in DM subjects with nephropathy (r=0.510; p=0.001). This study concluded that there was a significant difference between urinary PDX in DM with and without diabetic nephropathy, there was a significant difference between urine ACR levels in DM with and without diabetic nephropathy, and there was a relationship between urinary PDX levels and urine ACR in DM subjects with diabetic nephropathy.
Co-Authors Afni Juhairia Laisouw Agnes Rantesalu Ahmad Zil Fauzi Alfian Zainuddin Andi Alfian Zainuddin Anita Rosanty Anita Rosanty Aswiro Hasan Aswiro Hasan Atmaja, Ratih Feraritra Danu Banudi, La Dene Fries Sumah Devita Madiuw Elita Stephanie Lenderts Elita Stephanie Lenderts Fonnie Esther Hasan Fonnie Esther Hasan Handayani Malik Hasan, Aswiro Hasan, Fonnie Esther Hikmawati Hikmawati Himawan Sanusi Husaini Umar Irfan Idris Julianti Isma Sari Julianti Isma Sari Julianti Isma Sari Usman Jusni Ekasari Pelu Lenderts, Elita Stephanie Liong Boy Kurniawan Liong Boy Kurniawan Mansyur Arif Marisca Jenice Sanaky Naningsih, Hasmia Nurahmi Nurahmi Nurmiaty, Nurmiaty Pattipeiluhu, Lisse Pelu, Jusni Ekasari Rahmat Kurniawan Ratih Feraritra Danu Atmaja Ratih Feraritra Danu Atmaja Ratih Feraritra Danu Atmaja Rehena, Zasendy Reni Yunus Sarita, Sultina Sinthia Rosanti Maelissa Sopacua, Dian Thiofany Supiati Supiati Supiati Supiati T. Iskandar Faisal Tahapary, Westy Teguh Fathurrahman, Teguh Tenri Esa Tuty Yuniarty Tuty Yuniarty Tuty Yuniarty Tuty Yuniarty Tuty yuniarty, Tuty Usman, Julianti Isma Sari Valensya Yeslin Tomasoa Vanny Leutualy Viere Allanled Siauta Yuyun Widaningsih Yuyun Widaningsih