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All Journal Jurnal Kesehatan Lingkungan indonesia Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Ilmu Kesehatan Masyarakat Journal of Agromedicine and Medical Sciences Jurnal Manajemen Kesehatan Indonesia UNEJ e-Proceeding Health Notions Journal of Dentomaxillofacial Science Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Epidemiologi Kesehatan Komunitas Jurnal Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung Indonesian Journal of Community Health Nursing Indonesian Journal of Health Sciences Research and Development (IJHSRD) Jurnal Biosense AloHA International Journal of Health Advancement (AIJHA) Berkala Penelitian Hayati Muhammadiyah Journal of Geriatric TEKIBA : Jurnal Teknologi dan Pengabdian Masyarakat Indonesian Journal of Cancer Jurnal Ilmu Kesehatan Masyarakat Jurnal Kesehatan Amanah
Candra Bumi
Departement Of Epidemiology, Public Health Faculty, University Of Jember, Jember, Indonesia Of Jember University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : UNEJ e-Proceeding

 1 
The Effect of Bitter Melon Extract (Momordica charantia)in Inhibition of NFkB Activation in Leptin treated HUVECS Purwandhono, Azham; Bumi, Candra
UNEJ e-Proceeding Indonesian Protein Society (IPS), International Seminar and Workshop 2014
Publisher : UNEJ e-Proceeding

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Abstract

The obesityincreases the riskof morbidityandmortalityof type2diabetesandcardiovasculardisease. Leptin, an adipocytokine that regulate metabolic process, was increase in obesity. Hyperleptinemia activate the transcriptionfactorNuclearFactorKappaB(NF-kB), leading to the occurrence of inflammation. The chronic inflammation in vessels would cause the dysfunction of endothelial cell.Bitter melon (Momordica charantia) has beenused by many peoplefor the treatmentof diseases. Studies showthatbitter melon fruitcontainssaponins(charantins) andalkaloids. This study aimed toinvestigate the effect of bitter melon extract on the level of activated NF-κB. Cultured endothelial cell, HUVECs (Human Umbilical Vein Endothelial), is used for a model of endothelial cells. There are 5 groups: 1) HUVECs culture without leptin as negative control; 2) HUVECs culture with leptin as positive control; and 3 groups given various dosages of bitter melon (0.1 mg/ml; 0.05 mg/ml; 0.01 mg/ml; 0.005 mg/ml; 0.001 mg/ml) and Leptin. Leptin (500 ng/ml) is added on HUVECs to stimulate responds of endothelial cells mimicking obesity condition. Momordica charantiawere given 2 h before leptin treatment. The level of activated NF-KB was measured by ELISA. This study showed that leptin significantly induce NFkB activation and the treatment of bitter melon inhibit NFkB activation significantly (p<0.05). Keywords: Leptin, Endothel, bitter melon, NFkB
The Effect of Bitter Melon Extract (Momordica charantia)in Inhibition of NFkB Activation in Leptin treated HUVECS Azham Purwandhono; Candra Bumi
UNEJ e-Proceeding Indonesian Protein Society (IPS), International Seminar and Workshop 2014
Publisher : UPT Penerbitan Universitas Jember

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Abstract

The obesityincreases the riskof morbidityandmortalityof type2diabetesandcardiovasculardisease. Leptin, an adipocytokine that regulate metabolic process, was increase in obesity. Hyperleptinemia activate the transcriptionfactorNuclearFactorKappaB(NF-kB), leading to the occurrence of inflammation. The chronic inflammation in vessels would cause the dysfunction of endothelial cell.Bitter melon (Momordica charantia) has beenused by many peoplefor the treatmentof diseases. Studies showthatbitter melon fruitcontainssaponins(charantins) andalkaloids. This study aimed toinvestigate the effect of bitter melon extract on the level of activated NF-κB. Cultured endothelial cell, HUVECs (Human Umbilical Vein Endothelial), is used for a model of endothelial cells. There are 5 groups: 1) HUVECs culture without leptin as negative control; 2) HUVECs culture with leptin as positive control; and 3 groups given various dosages of bitter melon (0.1 mg/ml; 0.05 mg/ml; 0.01 mg/ml; 0.005 mg/ml; 0.001 mg/ml) and Leptin. Leptin (500 ng/ml) is added on HUVECs to stimulate responds of endothelial cells mimicking obesity condition. Momordica charantiawere given 2 h before leptin treatment. The level of activated NF-KB was measured by ELISA. This study showed that leptin significantly induce NFkB activation and the treatment of bitter melon inhibit NFkB activation significantly (p<0.05). Keywords: Leptin, Endothel, bitter melon, NFkB
Sosialiasi Pencegahan Penuaan Dini Pada Pekerja Perkebunan Desa Pakis Kecamatan Panti Kabupaten Jember 2022 Prasetyowati, Irma; Simanjuntak, Tri Damayanti; Bumi, Candra
UNEJ e-Proceeding 2023: Prosiding Kolokium Pengabdian kepada Masyarakat Fakultas Kesehatan Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Background: Premature Ageing can accelerate the emergence of degenerative diseases. Plantation workers or farmers are a group of workers who are very vulnerable to degenerative diseases and accidents in carrying out their work. This activity aims to socialize the prevention of premature aging among plantation workers. Method: This activity uses the counseling method with the target of plantation workers in Pakis Village, Panti District, Jember Regency. The stages of the activities start from the preparation, implementation, and evaluation of activities. The instrument used is a booklet. Results: The socialization contained definitions of premature aging and emerging degenerative diseases, CERDIK prevention, adherence to using personal protective equipment (PPE) while at work, hand washing with soap (CTPS) behavior, and increased knowledge and behavior paying attention to a healthy and balanced nutritional diet, especially foods that contain antioxidants. Participants actively participate through question and answer. Conclusion: socialization activities to increase the knowledge, understanding, and awareness of plantation workers are crucial to prevent premature aging and degenerative diseases.Keywords: prevention, premature aging, plantation workers
Co-Authors . Helen . Mulyani . Purwati Abdul Syakur Adistha Eka Noveyani Aditya Kurniawan Adji, Novan Krisno Ancah Caesarina Novi Marchianti Anita Dewi Prahastuti Sujoso Avita Amalina Azham Purwandhono Bayu Taruna Widjaja Putra Christyana Sandra Dedek Sutinbuk Desi S. Sari Desi Sandra Sari Dewi Rokhmah Diana Chusna Mufida ERMA SAFITRI Ernie Maduratna Farida Wahyu Ningtyias, Farida Wahyu Fedik A. Rantam Fedik Abdul Rantam Fiya Wadudah Fiya Wadudah FX Ady Soesetijo, FX Ady Hayyu Putri Utami Heni Fatmawati Ida Srisurani Wiji Astuti Iken Nafikadini Irma Prasetyowati Isa Marufi Kinanthi, Citra Anggun Krish Naufal Anugrah Robby Leersia Yusi Ratnawati Leersia Yusi Ratnawati Lulus Mualimin Mas’ud Hariadi Mentari Sekar Arum Mujayanah, Ani Rosa Putri Ayu Ni'mah, Ana Masfurotin Nuzula Irfa Nuriana Oktalia Juwita Ovika Maulida Artharini Priza Pandunata Putri, Komang Yunita Wiryaning R. Heru Prasetyo Rachmad Gusti Irwansyah Rifdatun Nurul Huwaidah Hasan Fahmi S.Pd. M Kes I Ketut Sudiana . Simanjuntak, Tri Damayanti Sri Wigati Mardi Suzanita Utama Syahputri, Siti Ananda Hardita Wafiroh, Nabila Yunib Hibatu Winarismasari, Khoirunnisa Yunita Yuliana Amelia Reza Mustofa Yuliana Mahdiyah DA Yuliana Mahdiyah DA Yulistiana Yulistiana Yusri, Khalisa Nurima