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All Journal E-Jurnal Medika Udayana Indonesian Journal of Tropical and Infectious Disease Journal of Maternal and Child Health Manuju : Malahayati Nursing Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Bidan Cerdas Biomolecular and Health Science Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat AKSONA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Sosial dan Sains Cerdika: Jurnal Ilmiah Indonesia Enrichment: Journal of Multidisciplinary Research and Development Jurnal Vokasi Keperawatan (JVK) Folia Medica Indonesiana
Isnin Anang Marhana
Departement Of Pulmonology And Respiration, Faculty Of Medicine, Univeristas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer Mastutik, Gondo; Rahniayu, Alphania; , Isnin Anang Marhana; Amin, Mochamad; Trianto, Heru Fajar; I'tishom, Reny
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. In this study, new primers designed using the semi-nested polymerase chain reaction (PCR) method were utilized to identify MAGE-A11 and MAGE-A12 expressions in specimens collected from core biopsy, forcep biopsy, and bronchoalveolar lavage. 2. The histopathological analysis revealed positive expressions of MAGE-A11 and MAGE-A12 in specimens diagnosed with non-small cell lung cancer (NSCLC) as well as in specimens with no malignant cells. 3. This study provides evidence indicating that the detection of messenger ribonucleic acid (mRNA) of MAGE-A11 and MAGE-A12 by nested reverse transcription PCR can improve the accuracy of lung cancer diagnosis. Abstract The melanoma antigen gene (MAGE) belongs to the group of cancer-testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. The highly expressed MAGE-A subfamily in lung cancer may potentially be a diagnostic and prognostic biomarker. This study aimed to identify MAGE-A11 and MAGE-A12 expressions in lung tumors obtained from core biopsy, forceps biopsy, and bronchoalveolar lavage specimens. A cross-sectional observational study was conducted on 90 patients clinically diagnosed with lung tumors. These patients received core biopsy, forceps biopsy, and bronchoalveolar lavage interventions after ethical approval was obtained. The complementary deoxyribonucleic acid (cDNA) quality was assessed by the polymerase chain reaction (PCR) of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The assessment was performed to ascertain if all specimens exhibited positive PCR amplification of the GAPDH gene. MAGE-A11 and MAGE-A12 were identified through a semi-nested reverse transcription PCR. The positive results were detected by measuring the PCR products, with MAGE-A11 and MAGE-A12 at base pairs (bp) of 858 and 496 in the first and second rounds, respectively. The expressions of MAGE-A11 and MAGE-A12 were observed in 3 (3.33%) and 40 (44.44%) out of 90 specimens, respectively. The prevalence rate of non-small cell lung cancer (NSCLC) was 31.11% (28/90). Among these cases, 3.57% (1/28) showed the expression of MAGE-A11, while 32.14% (9/28) exhibited the expression of MAGE-A12. Sixty-two (68.89%) out of 90 patients were diagnosed with no tumor cell malignancy. Out of 62 cases, 2 (3.23%) exhibited the expression of MAGE-A11, while 31 (50%) demonstrated the expression of MAGE-A12. MAGE-A11 and MAGE-A12 were detected in NSCLC and certain specimens with a pathological diagnosis that indicated the absence of malignant cells. In conclusion, MAGE A11 and MAGE A12 have potential markers to improve the pathological diagnosis of lung cancer. Further investigation is necessary to explore the expression of MAGE-A in correlation with lung cancer progression.
Predicting Prolonged Hospitalization in Pneumonia: The Role of Lung Injury Score Putri, Mayandra Alif Anggita; Marhana, Isnin Anang; Hakim, Arief Rakhman; Bakhtiar, Arief; Syafa'ah, Irmi
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.27-34

Abstract

Introduction: Pneumonia is a lung infection with a high prevalence and is associated with prolonged length of stay (LOS). An excessive LOS increases the risk of complications, while a short LOS may lead to inadequate treatment. The lung injury score (LIS), which assesses the severity of lung injury and respiratory dysfunction, is expected to be an accurate predictor of LOS in patients with pneumonia. This study aimed to determine the correlation between LIS and LOS in hospitalized patients with pneumonia. Methods: This retrospective cohort study included adult patients hospitalized at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, with a diagnosis of pneumonia between January and December 2023. The LIS component scores (chest X-ray findings, arterial partial pressure of oxygen-to-fractional inspired oxygen ratio, positive end-expiratory pressure (PEEP), and static lung compliance) were obtained from electronic medical records and used to calculate LIS values. The correlation between LIS and LOS was analyzed using the Spearman test, while the cut-off point was determined using receiver operating characteristic (ROC) curve analysis. Results: A total of 152 patients fulfilled the inclusion criteria. The mean LIS was 1.82±0.89, while the mean LOS was 10.23±6.27 days. A statistically significant correlation was found between LIS and LOS (p<0.001) with a correlation coefficient of 0.317. Receiver operating characteristic curve analysis identified the optimal LIS cut-off point for an LOS of 10 days as 1.75. Conclusion: There was a statistically significant correlation between LIS and LOS in patients with pneumonia. The LIS cut-off point of 1.75 for an LOS of 10 days was statistically significant.
Pengaruh Tradisi Perkawinan Adat Suku Lamaholot dan Dukungan Suami terhadap Kunjungan Antenatal Pertama Pada Ibu Hamil di Wilayah Puskesmas Waipukang Kabupaten Lembata – NTT Febe Ernila; Isnin Anang Marhana; Gatut Hardianto
Malahayati Nursing Journal Vol 6, No 4 (2024): Volume 6 Nomor 4 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i4.13611

Abstract

ABSTRAK Standar pelayanan antenatal terpadu dari Kementrian Kesehatan Republik Indonesia adalah kunjungan pertama antenatal pada usia kehamilan 12 minggu untuk skrining dan menangani faktor risiko kehamilan. Pencapaian kunjungan pertama antenatal pada ibu hamil di Puskesmas Waipukang terdapat kesenjangan yang cukup tinggi yaitu 52,6% dari target yang seharusnya dan merupakan cakupan terendah dikabupaten Lembata. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan kunjungan pertama antenatal pada ibu hamil di Puskesmas Waipukang Kabupaten Lembata – NTT diantaranya adalah tradisi pernikahan adat suku Lamaholot dan dukungan suami. Jenis penelitian analitik observasional dengan desain cross sectional  dan metode kuantitatif. Sampelnya adalah 70 ibu hamil yang berada dalam wilayah kerja Puskesmas Waipukang yang diambil dengan teknik consecutive sampling. Kunjungan pertama antenatal sebagai variabel terikat sedangkan variabel bebasnya adalah  tradisi dan dukungan suami. Instrumen penelitian menggunakan kuesioner. Analisis data menggunakan uji chi square dan uji regresi logistik berganda. Penelitian ini menemukan dari 70 responden 74,3% melakukan kunjungan pertama antenatal pada trimester I. Hasil analisis data didapatkan ada hubungan faktor tradisi dan dukungan suami dengan kunjungan pertama antenatal dimana nilai p0,05. Ada pengaruh tradisi dan dukungan suami terhadap kunjungan pertama antenatal pada ibu hamil di Puskesmas Waipukang Kabupaten Lembata – NTT sehingga layak untuk diperhatikan lebih mendalam dari lintas sektor terhadap tradisi yang berdampak negatife terhadap kunjungan pertama antenatal. Kata Kunci: Dukungan Suami, Tradisi, Suku Lamaholot, Kunjungan Pertama Antental  ABSTRACT The standard for integrated antenatal care from the Ministry of Health of the Republic of Indonesia is the first antenatal visit at 12 weeks' gestation for screening and treating pregnancy risk factors. There is a fairly high gap in the achievement of the first antenatal visit for pregnant women at the Waipukang Community Health Center, namely 52.6% of the target which should be and is the lowest coverage in Lembata Regency. This study aims to analyze factors related to the first antenatal visit for pregnant women at the Waipukang Community Health Center, Lembata Regency - NTT, including the traditional marriage traditions of the Lamaholot tribe and husband's support. This type of observational analytical research with a cross sectional design and quantitative methods. The sample was 70 pregnant women in the working area of the Waipukang Community Health Center, taken using consecutive sampling technique. The first antenatal visit is the dependent variable while the independent variables are tradition and husband's support. The research instrument used a questionnaire. Data analysis used the chi square test and multiple logistic regression test. This research found that of the 70 respondents, 74.3% had their first antenatal visit in the first trimester. The results of data analysis showed that there was a relationship between traditional factors and husband's support and the first antenatal visit, where the p value was 0.05. There is an influence of tradition and husband's support on the first antenatal visit for pregnant women at the Waipukang Community Health Center, Lembata Regency - NTT so it is worth paying more in-depth attention from across sectors to traditions that have a negative impact on the first antenatal visit. Keywords: Husband's Support, Tradition, Lamaholot Tribe, First Antenatal Visit
First bronchoscopy with cryobiopsy and argon plasma coagulation at Indonesia national referral hospital: Case series Maulidzy, Achmad Zaki; Marhana, Isnin Anang; Fatmawati, Farah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art10

Abstract

Cryobiopsy has emerged as a superior method for diagnostic endobronchial tissue sampling, offering more extensive and diagnostically valuable specimens than traditional techniques. Argon plasma coagulation (APC), a form of cryoablation, facilitates effective tumour resection and haemostasis with minimal complications. At Dr. Soetomo General Academic Hospital, conventional methods have predominantly been used for lung tumour sampling. These case reports introduced the novel application of cryobiopsy and APC in our institution, showcasing our expertise in advanced bronchoscopic techniques. We report on a 55-year-old male with a T3N1Mx stage IIIA left lung tumour and a 65-year-old male with a T4N2M1b stage IVA right lung cancer. Diagnoses were small-cell lung carcinoma and adenocarcinoma with wild-type EGFR mutation, respectively. Procedures were performed with minimal complications, demonstrating the effectiveness and safety of these techniques. These case reports underscored the potential of cryobiopsy and APC to enhance diagnostic accuracy and therapeutic outcomes, advancing pulmonary oncology care. These techniques provide superior diagnostic accuracy and therapeutic benefits with minimal complications. Our findings support the broader adoption of these advanced bronchoscopic interventions, particularly in settings where traditional methods may fall short.
Co-Authors A’yuni, Zera Qurrota Adhari Ajipurnomo Alfian Nurfaizi Alphania Rahniayu Amelia Tantri Anggraeni Amir Sholeh Annisa Nurul Husna Anniwati, Leonita Anny Setijo Rahaju, Anny Setijo Arief Baktiar, Arief Arien Dwi Ajeng Adhe Safitri Aryati Aryati Aryati Aryati Asep Tri Handoko Asmarawati, Tri Pudy Bakhtiar, Arief Budi Prasetyo Desilia Atikawati Devy Trianne Putri Dhihintia Jiwangga Suta Winarno Domincus Husada Dominicus Husada Duta, Garinda Alma Dyah Erawati, Dyah Erni Rosita Dewi Fatih Nugraha Abdillah Fatmawati, Farah Febe Ernila Fidiana Gatut Hardianto, Gatut Gondo Mastutik Hakim, Arief Rakhman Hasan, Helmia Hermina Novida, Hermina Heru Fajar Trianto I Komang Rusgi Yandi I'tishom, Reny Izzati, Dwi Kawilarang, Arthur Pohan Kusmiati, Tutik Leonita Anniwati Lilis Sri Supiatun Mamesah Maulidzy, Achmad Zaki MOCHAMAD AMIN Mochamad Amin Mohammad Yamin Sunaryo Suwandi Mokhammad Mukhlis Muhammad Rudy Chairudin Naomi Rahmasena Ni Made Mertaniasih Nurul Husna, Annisa Nuswantoro, Yulian Pande Putu Ayu Patria Dewi Patria Dewi, Pande Putu Ayu Paulus Sugianto Putri, Mayandra Alif Anggita Retna Dwi Puspitarini Risma Novalina Putri Zurohmi Rita Oktavia Harahap Rosyid, Alfian Nur Sari, Gadis Meinar Sheilla Matheos Supiatun.M, Lilis Sri Syafa'ah, Irmi Trianto, Heru Fajar Tuksin Jearanaiwitayakul Wardani, Erlisa Pramodya Widya, Alicia Margaretta Willy Sandhika yasmin, dzakiyah Yenny Kusmatuti Zera Qurrota A&#039;yuni