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All Journal E-Jurnal Medika Udayana Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Journal of Maternal and Child Health Manuju : Malahayati Nursing Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Bidan Cerdas Biomolecular and Health Science Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat AKSONA Jurnal Sosial dan Sains Cerdika: Jurnal Ilmiah Indonesia Enrichment: Journal of Multidisciplinary Research and Development Jurnal Vokasi Keperawatan (JVK)
Isnin Anang Marhana
Departement Of Pulmonology And Respiration, Faculty Of Medicine, Univeristas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Faktor Jenis Kelamin dan Status Imunisasi terhadap Kejadian Pneumonia pada Balita di RSUD dr. Soedarso Zera Qurrota A'yuni; Lilis Sri Supiatun Mamesah; Isnin Anang Marhana
Jurnal Bidan Cerdas Vol. 4 No. 4 (2022)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jbc.v4i4.1635

Abstract

Introduction: The incidence of pneumonia in toddlers was recorded as the second highest case in the Pediatric Inpatient Room at the dr. Soedarso Regional General Hospital, West Borneo Province. Purpose: Analyzing the relationship between sex and immunization status on the incidence of pneumonia in toddlers at the dr. Soedarso Regional General Hospital, West Borneo Province. Methods: The study used a case control design with 31 cases and 31 controls. Sampling using a total sampling technique with a ratio of 1:1. The case group was toddlers diagnosed with pneumonia by the Patient Responsible Doctor who was recorded in the medical record. The control group was toddlers were not diagnosed with pneumonia by the Patient Responsible Doctor who was recorded in the medical record . This study used bivariate analysis. The statistical test is the Chi-Square Test. Results: The most data for toddlers is owned by toddlers with male sex (54.8%).Most of the data for toddlers is owned by toddlers with incomplete immunization status (82.3%). The results of the bivariate analysis showed that there was no significant correlation between sex and immunization status on the incidence of pneumonia in toddlers. Conclusion: There was no significant correlation between sex and immunization status on the incidence of pneumonia in toddlers at the dr. Soedarso Regional General Hospital, West Borneo Province. This research still needs further research to explore other factors that can cause pneumonia in toddlers.
The Impact of COVID-19 on Birth Weight during Pregnancy Arien Dwi Ajeng Adhe Safitri; Isnin Anang Marhana; Budi Prasetyo; Dominicus Husada; Erni Rosita Dewi
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.176-181

Abstract

Introduction: Coronavirus is a viral pathogen that can be transmitted through respiratory droplets, leading to severe infectious diseases. This study aimed to ascertain the influence of the COVID-19 pandemic on birth weight during pregnancy. Methods: This study used secondary data and a retrospective case-control approach for observational analysis. The case and control groups each had 153 samples. The case group was further separated into symptomatic and asymptomatic categories. Statistical analyses were performed to determine how COVID-19 infection in pregnant women affected birth weight. Fisher's exact test was used to evaluate data for the subgroups of asymptomatic and symptomatic individuals, while the Mann-Whitney test was used to compare the infection's impact. Results: Most participants were 21–35 years old (78.2%). The findings showed that 85% of pregnant COVID-19 patients were in their third trimester. Mothers diagnosed with COVID-19 had infants with birth weights of >4,000 grams (3.3%), 2,500–4,000 grams (43.1%), and <2,500 grams (53.6%). Birth weight distribution in women unaffected by COVID-19 was >4,000 grams (14.4%), 2,500–4,000 grams (67.3%), and <2,500 grams (18.3%). The Mann-Whitney statistical test was performed using SPSS. It yielded a p-value of 0.001, less than the significance level of 0.05, indicating a correlation between confirmed COVID-19 infection in pregnant women and birth weight. Conclusion: This study found that the presence of COVID-19 infection during pregnancy significantly affects infants' birth weight.
Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer Gondo Mastutik; Alphania Rahniayu; Isnin Anang Marhana; Mochamad Amin; Heru Fajar Trianto; Reny I’tishom
Folia Medica Indonesiana Vol. 59 No. 4 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v59i4.50477

Abstract

Highlights:1. In this study, new primers designed using the semi-nested polymerase chain reaction (PCR) method were utilized to identify MAGE-A11 and MAGE-A12 expressions in specimens collected from core biopsy, forcep biopsy, and bronchoalveolar lavage. 2. The histopathological analysis revealed positive expressions of MAGE-A11 and MAGE-A12 in specimens diagnosed with non-small cell lung cancer (NSCLC) as well as in specimens with no malignant cells. 3. This study provides evidence indicating that the detection of messenger ribonucleic acid (mRNA) of MAGE-A11 and MAGE-A12 by nested reverse transcription PCR can improve the accuracy of lung cancer diagnosis.   AbstractThe melanoma antigen gene (MAGE) belongs to the group of cancer-testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. The highly expressed MAGE-A subfamily in lung cancer may potentially be a diagnostic and prognostic biomarker. This study aimed to identify MAGE-A11 and MAGE-A12 expressions in lung tumors obtained from core biopsy, forceps biopsy, and bronchoalveolar lavage specimens. A cross-sectional observational study was conducted on 90 patients clinically diagnosed with lung tumors. These patients received core biopsy, forceps biopsy, and bronchoalveolar lavage interventions after ethical approval was obtained. The complementary deoxyribonucleic acid (cDNA) quality was assessed by the polymerase chain reaction (PCR) of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The assessment was performed to ascertain if all specimens exhibited positive PCR amplification of the GAPDH gene. MAGE-A11 and MAGE-A12 were identified through a semi-nested reverse transcription PCR. The positive results were detected by measuring the PCR products, with MAGE-A11 and MAGE-A12 at base pairs (bp) of 858 and 496 in the first and second rounds, respectively. The expressions of MAGE-A11 and MAGE-A12 were observed in 3 (3.33%) and 40 (44.44%) out of 90 specimens, respectively. The prevalence rate of non-small cell lung cancer (NSCLC) was 31.11% (28/90). Among these cases, 3.57% (1/28) showed the expression of MAGE-A11, while 32.14% (9/28) exhibited the expression of MAGE-A12. Sixty-two (68.89%) out of 90 patients were diagnosed with no tumor cell malignancy. Out of 62 cases, 2 (3.23%) exhibited the expression of MAGE-A11, while 31 (50%) demonstrated the expression of MAGE-A12. MAGE-A11 and MAGE-A12 were detected in NSCLC and certain specimens with a pathological diagnosis that indicated the absence of malignant cells. In conclusion, MAGE A11 and MAGE A12 have potential markers to improve the pathological diagnosis of lung cancer. Further investigation is necessary to explore the expression of MAGE-A in correlation with lung cancer progression. 
Hubungan Riwayat Penyakit Paru pada Ibu Hamil terhadap Kejadian BBLR di RSUD Dr. Soetomo Surabaya Risma Novalina Putri Zurohmi; Isnin Anang Marhana; Domincus Husada
Jurnal Vokasi Keperawatan (JVK) Vol. 7 No. 1 (2024): JUNI
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/jvk.v7i1.32009

Abstract

Masalah penyakit paru-paru perlu diperhatikan dikarenakan bisa menjadi salah satu penyakit yang mempersulit kondisi ibu hamil. Selama kehamilan, bagian paru-paru adalah organ tubuh yang dapat memberikan kontribusi penting di dalam tubuh terutama selama proses kehamilan berlangsung. Oleh sebab itu, bagian tubuh paru-paru jangan sampai dihiraukan ataupun disepelekan dari setiap permasalah yang timbul sehingga perlu adanya penelitian ini untuk menganalisis akibat buruk yang ditimbulkan dari penyakit paru-paru selama proses kehamilan berlangsung. Penelitian ini bertujuan untuk mengetahui hubungan riwayat penyakit paru pada ibu hamil terhadap kejadian BBLR di RSUD Dr. Soetomo. Penelitian ini menggunakan metode analitik observasional dengan desain pendekatan case control. Dalam penelitian ini sampel diambil di RSUD Dr. Soetomo dengan terbagi dalam kelompok kasus dan kelompok kontrol dengan adanya kriteria inklusi dan eksklusi di masing-masing kelompok kasus dan kontrol. Kriteria inklusi dari kelompok kasus bayi lahir dalam kondisi hidup, BBLN dan BBLR dan Ibu hamil dengan penyakit paru (Asma, Pneumonia dan Tuberkulosis) periode 2019-2023. Sedangkan untuk kriteria inklusi dari kelompok kontrol bayi lahir dalam kondisi hidup, BBLN dan BBLR dan Ibu hamil dengan tidak ada penyakit paru (Asma, Pneumonia dan Tuberkulosis) periode 2019-2023. Pemilihan sampling menggunakan probability sampling berupa simple random sampling. Instrumen penelitian ini menggunakan data sekunder berupa rekam medis dan  lembar pengumpulan data. Data dianalisis menggunakan uji Contingency Coefficient (C). Subyek sampel yang digunakan pada penelitian sebanyak 312 dengan perbandingan 1:1 dari kelompok kasus dan kelompok kontrol. Didapatkan dari 156 ibu hamil dengan riwayat penyakit paru (asma, pneumonia dan tuberkulosis) di RSUD Dr. Soetomo Surabaya ditemukan sebagian besar ibu melahirkan bayi dalam kondisi BBLR, yaitu sebanyak 109 (69.9%). Karakteristik dari kelompok kasus, rata-rata memiliki usia berisiko tinggi (<20 tahun dan > 35 tahun) dan memiliki kadar hemoglobin yang rendah. Hasil analisis bivariate menggunakan Contiqency Coefficient menunjukkan nilai yang didapatkan p<0.001 yang menunjukkan adanya hubungan bermakna antara ibu hamil yang memiliki riwayat penyakit paru (asma, pneumonia dan tuberkulosis) terhadap kejadian BBLR di RSUD Dr. Soetomo Surabaya. Terdapat ibu hamil dengan penyakit paru (asma, pneumonia dan tuberkulosis) di RSUD Dr. Soetomo dengan sebagian besar mempunyai riwayat penyakit paru (asma, pneumonia dan tuberkulosis) di RSUD Dr. Soetomo yang melahirkan bayi dalam kondisi Berat Badan Lahir Rendah (BBLR). Sehingga ada hubungan riwayat penyakit paru (asma, pneumonia dan tuberkulosis) pada ibu hamil terhadap kejadian BBLR di RSUD Dr. Soetomo.
KORELASI ANTARA AKTIVITAS ADENOSINE DEAMINASE (ADA) CAIRAN PLEURA DAN HASIL LEUKOSIT CAIRAN PLEURA PADA PENDERITA EFUSI PLEURA Patria Dewi, Pande Putu Ayu; Aryati, Aryati; Anniwati, Leonita; Marhana, Isnin Anang
E-Jurnal Medika Udayana Vol 12 No 3 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i03.P02

Abstract

Efusi pleura merupakan kumpulan cairan abnormal di ruang pleura. Diagnosis efusi pleura selain berdasarkan keluhan dan gejala klinis memerlukan berbagai pemeriksaan penunjang seperti radiografi, analisis cairan pleura. Adenosine deaminase merupakan enzim yang terlibat pada proses katabolisme purin. Enzim ini memegang peranan penting pada diferensiasi sel limfoid. Pemeriksaan aktivitas adenosine deaminase (ADA) telah lama digunakan sebagai penunjang diagnosis tuberkulosis karena cepat, murah, dan memiliki sensitivitas dan spesifisitas yang tinggi. Pemeriksaan analisis cairan pleura masih menjadi pemeriksaan utama pada penderita dengan efusi pleura untuk membantu penegakan diagnosis dan etiologi efusi pleura. Penelitian ini bertujuan untuk membandingkan aktivitas ADA cairan pleura dan hasil leukosit cairan pleura pada penderita efusi pleura. Jenis penelitian adalah penelitian observasional cross-sectional. Pemeriksaan aktivitas ADA dilakukan pada cairan pleura. Pemeriksaan aktivitas ADA dikerjakan dengan metode fotometri (cara Non Giusti) menggunakan reagen Diazyme dengan alat TMS 24i Premium. Pemeriksaan hitung sel leukosit menggunakan metode otomatis dengan prinsip flow cytometry menggunakan laser optic dengan alat Sysmex XN-1000. Subyek penelitian adalah 40 pasien efusi pleura dengan diagnosis keganasan, tuberkulosis, dan penyakit sistemik. Hasil analisis menunjukkan terdapat korelasi antara aktivitas ADA pada cairan pleura dan hitung sel leukosit untuk seluruh subyek penelitian (r = 0,495 dan p = 0,001). Korelasi antara aktivitas ADA pada cairan pleura dengan sel polimononuklear didapatkan r=0,521 dengan p = 0,001 sedangkan korelasi positif tidak bermakna ditunjukkan antara aktivitas ADA pada cairan pleura dengan sel mononuclear dengan r=0,228 dan p=0,157 Kata kunci. Adenosine deaminase, cairan pleura, leukosit
FOSTERING ASTHMA AWARENESS: COMMUNITY SERVICE IN THE OCCUPATIONAL SETTING OF MANGUHARJO LUNG HOSPITAL, EAST JAVA PROVINCE, MADIUN CITY Marhana, Isnin Anang; Rosyid, Alfian Nur; Duta, Garinda Alma
Edu Dharma Journal :Jurnal penelitian dan pengabdian masyarakat Vol 8, No 2 (2024): Edu Dharma Journal: Jurnal Penelitian Dan Pengabdian Masyarakat
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/edj.v8i2.826

Abstract

                                                ABSTRACTAsthma presents a global health challenge with high morbidity and potential mortality. Data from Manguharjo Lung Hospital in Madiun (2020-2022) show a consistent rise in asthma cases and related visits. Although asthma is incurable, its management aims to control and reduce attack frequency. Varied understandings of asthma complicate patient management and control. This community service initiative aims to enhance asthma knowledge and control among patients at Manguharjo Lung Hospital. Educational and health promotion methods were employed, assessed via pre- and post-test questionnaires. Results indicate a significant knowledge increase, with post-test scores substantially higher than pre-test scores. Initially, only 30% of participants scored high on the pre-test; this figure rose to 90% post-education. This study demonstrates that the asthma awareness program significantly improved patient knowledge. This psychosocial approach is expected to enable asthma patients to become health advocates within their community.                                          ABSTRAKAsma merupakan tantangan kesehatan global dengan tingkat morbiditas yang tinggi dan potensi mortalitas. Data dari Rumah Sakit Paru Manguharjo di Madiun (2020-2022) menunjukkan peningkatan kasus asma dan kunjungan terkait setiap tahun. Meskipun asma tidak dapat disembuhkan, pengelolaannya bertujuan untuk mengendalikan dan mengurangi frekuensi serangan. Pemahaman yang beragam tentang asma mempersulit pengelolaan dan pengendalian pasien. Studi pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan pengendalian asma di kalangan pasien di Rumah Sakit Paru Manguharjo. Metode edukasi dan promosi kesehatan digunakan, dengan penilaian melalui kuesioner pra-tes dan pasca-tes. Hasil menunjukkan peningkatan pengetahuan yang signifikan, dengan skor pasca-tes jauh lebih tinggi dibandingkan skor pra-tes. Awalnya, hanya 30% peserta yang mendapatkan skor tinggi pada pra-tes; angka ini meningkat menjadi 90% setelah edukasi. Studi ini menunjukkan bahwa program kesadaran asma secara signifikan meningkatkan pengetahuan pasien. Pendekatan psikososial ini diharapkan dapat memungkinkan pasien asma menjadi penggerak kesehatan dalam komunitas mereka.
LOW CD4 LYMPHOCYTE COUNT RELATED RISK TO Pneumocystis jiroveci PNEUMONIA IN HIV/AIDS PATIENTS FROM BRONCHOALVEOLAR LAVAGE SPECIMENS USING REAL TIME PCR DETECTION Widya, Alicia Margaretta; Mertaniasih, Ni Made; Kawilarang, Arthur Pohan; Marhana, Isnin Anang
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 6 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.955 KB) | DOI: 10.20473/ijtid.v6i6.6309

Abstract

HIV and opportunistic infections remain a big problem especially in developing country. Pneumocystis jiroveci pneumonia is a prevalent infection  in HIV infected patient with high mortality rate. Diagnosis of Pneumocystis jiroveci pneumonia is mainly based on clinical evidence. Microbiological diagnosis is quite challenging since this microorganism cannot be cultured and is mainly based on microscopic examination. Microscopic examination with special staining is still a gold standard diagnosis for P. jiroveci infection.The objectives of this study was to describe CD4 lymphocyte profile and establish microbiological diagnosis with recent molecular method in PJP suspected HIV positive patients. Fiberoptic bronchoscopy of HIV infected patients with lower respiratory tract infection in Dr. Soetomo general hospital Surabaya were performed to collect bronchoalveolar lavage specimens  from December 2016 to April 2017 for identification of Pneumocystis jiroveci using real time PCR assay. Positive samples were then evaluated for  microscopic examination with Gommori Methenamine Silver staining for comparison. Patient's CD4 lymphocyte count were gathered prior of admission. CD4 lymphocyte count from this study were very low with 61% of the patients were below 50 cells/ µL. There were five of  total thirteen patients (38,5%) with positive real time PCR assay (MSG gene)  and one patient was also positive with GMS staining showing characteristic cysts shape with dark centered area of P. jiroveci. Patient with positive microscopic examination showed no history of prophylactic therapy. Low CD4 lymphocyte count remains a strong risk factor of P. jiroveci pneumonia in HIV/AIDS patients. Real time PCR assay shows high value in detection of P. jiroveci regarding patient's prophylactic status.
The Clinical Outcome of COVID-19 Infection on Chronic Diabetic Complications Patients Wardani, Erlisa Pramodya; Tri Pudy Asmarawati; Isnin Anang Marhana; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 1 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i1.51748

Abstract

Introduction: COVID-19 is an infectious disease resulting from the SARS-CoV-2 virus. The virus targets the respiratory system and leads to a significant number of fatalities worldwide. Consequently, it was officially classified as a pandemic in 2020. The Covid varians is now being monitored by the World Health Organization. Diabetes mellitus is one of the disorders that might deteriorate following an infection. Diabetes mellitus and its associated comorbidities continue to pose a significant health challenge in Indonesia, while it is also a focus of concern of the Sustainable Development Goals (SDGs). The study was aimed to assess the risks and outcomes associated with COVID-19 infection and the long-term consequences of diabetes mellitus.Methods: This was a descriptive study using a retrospective design. Research data were taken from the medical records of patients confirmed positive for COVID-19 infection and also had chronic complications of diabetes mellitus who were treated at Dr Soetomo General Academic Hospital, Surabaya, Indonesia in 2021. There were 156 patients who met the criteria of this research.Results: There were 156 patients (97 males, 59 females). The average age of the patients was 58, while most of the patients (84%) died and the rest of the patients (16%) survived. Most of the patients with fatality (55.8%) were those with critical severity level and complications of microangiopathy, while the patients who survived (10.3%) were those with moderate severity level and complications of microangiopathy. Conclusion: COVID-19 patients with diabetes and comorbidities had a higher mortality rate than those who recovered, while most of the patients with fatality were those with significant COVID-19 and diabetic microangiopathy complications.
IL-10 Expression and Pulmonary Fibrosis in COVID-19 and Non-COVID-19: A Cross-sectional Study yasmin, dzakiyah; Anang Marhana, Isnin; Sandhika, Willy
Enrichment: Journal of Multidisciplinary Research and Development Vol. 2 No. 11 (2025): Enrichment: Journal of Multidisciplinary Research and Development
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/enrichment.v2i11.289

Abstract

Indonesia was declared the country with the highest number of COVID-19 cases in ASEAN, and East Java was the province with the highest confirmed case fatality rate (7.3%) in 2021. In the case of COVID-19, there was a drastic elevation of the anti-inflammatory cytokine IL-10. This study aimed to ensure the role of IL-10 against pulmonary fibrosis in COVID-19 and non-COVID-19 patients. This study is a cross-sectional (non-experimental) study. The study sample consisted of 40 lung tissue samples from COVID-19 and non-COVID-19 patients at Dr. Soetomo General Academic Hospital, Surabaya. The IL-10 antibody reagent (GTX632359, GeneTex) was used to assess IL-10 expression, and hematoxylin and eosin (H&E) were used to determine the degree of pulmonary fibrosis. For Spearman's correlation, the data were analyzed using Statistical Package for the Social Sciences (SPSS). The mean percentage of IL-10 expression in COVID-19 patients (40.07%) was higher than in non-COVID-19 patients (26.60%). However, the mean for the degree of pulmonary fibrosis score in non-COVID-19 patients (4.43) was higher than in COVID-19 patients (3.67). Furthermore, a negative correlation (p=0.000; r=-0.281) was found between the percentage of IL-10 expression and the degree of pulmonary fibrosis. The percentage of IL-10 expression in macrophage cells had a significant negative correlation with the degree of pulmonary fibrosis score.
HIGH FLOW NASAL CANUL (HFNC) SEBAGAI TERAPI OKSIGEN PADA KASUS GAGAL NAFAS TIPE 1 Nuswantoro, Yulian; Marhana, Isnin Anang; Hasan, Helmia; Baktiar, Arief
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 3 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penggunaan ventilasi mekanik invasif dapat meningkatkan morbiditas dan mortalitas terkait stres pulmonal dan pneumonia, serta mendorong penggunaan ventilasi non-invasif seperti High Flow Nasal Cannula (HFNC) sebagai terapi oksigen yang efektif pada gagal napas tipe 1. Studi ini bertujuan untuk menganalisis efektivitas HFNC dalam menangani gagal napas akut. Hasil penelitian menunjukkan bahwa HFNC mampu memberikan oksigen dengan konsentrasi tinggi dan aliran gas yang stabil, meningkatkan oksigenasi tanpa menimbulkan efek samping signifikan. HFNC juga terbukti meningkatkan kenyamanan pasien, mengurangi kebutuhan intubasi, dan memperbaiki hasil klinis secara keseluruhan. Kesimpulan dari penelitian ini adalah bahwa HFNC merupakan alternatif yang efektif dan aman dibandingkan dengan ventilasi mekanik invasif untuk pasien dengan gagal napas tipe 1. Kata kunci: gagal napas akut, high flow nasal cannula, terapi oksigen, ventilasi non-invasif DOI : 10.35990/mk.v8n3.p331-343
Co-Authors A’yuni, Zera Qurrota Adhari Ajipurnomo Alfian Nurfaizi Alphania Rahniayu Amelia Tantri Anggraeni Amir Sholeh Annisa Nurul Husna Anniwati, Leonita Anny Setijo Rahaju, Anny Setijo Arief Baktiar, Arief Arien Dwi Ajeng Adhe Safitri Aryati Aryati Aryati Aryati Asep Tri Handoko Asmarawati, Tri Pudy Bakhtiar, Arief Budi Prasetyo Desilia Atikawati Devy Trianne Putri Dhihintia Jiwangga Suta Winarno Domincus Husada Dominicus Husada Duta, Garinda Alma Dyah Erawati, Dyah Erni Rosita Dewi Ernila, Febe Fatih Nugraha Abdillah Fidiana Gatut Hardianto, Gatut Gondo Mastutik Hasan, Helmia Hermina Novida, Hermina Heru Fajar Trianto I Komang Rusgi Yandi I'tishom, Reny Izzati, Dwi Kawilarang, Arthur Pohan Kusmiati, Tutik Leonita Anniwati Lilis Sri Supiatun Mamesah Mochamad Amin Mohammad Yamin Sunaryo Suwandi Mokhammad Mukhlis Muhammad Rudy Chairudin Naomi Rahmasena Ni Made Mertaniasih Nurul Husna, Annisa Nuswantoro, Yulian Pande Putu Ayu Patria Dewi Patria Dewi, Pande Putu Ayu Paulus Sugianto Retna Dwi Puspitarini Risma Novalina Putri Zurohmi Rita Oktavia Harahap Rosyid, Alfian Nur Sari, Gadis Meinar Sheilla Matheos Supiatun.M, Lilis Sri Tuksin Jearanaiwitayakul Wardani, Erlisa Pramodya Widya, Alicia Margaretta Willy Sandhika yasmin, dzakiyah Yenny Kusmatuti Zera Qurrota A&#039;yuni