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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Surya Medika PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) ALKIMIA : Jurnal Ilmu Kimia dan Terapan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Pharmacy Jurnal Farmasi dan Sains Indonesia (JFSI) INDRA: Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Lentera Negeri Sinteza Medical Sains : Jurnal Ilmiah Kefarmasian
Tri Puspita Yuliana
Universitas Hamzanwadi
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Formulasi Sediaan Masker Gel Peel-Off Kombinasi Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Cangkang Telur sebagai Anti Jerawat (Propionibacterium acnes) Yuliana, Tri Puspita; Kusumo, Rudy Harjo; Hariadi, Puspawan
Sinteza Vol. 3 No. 1 (2023): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.087 KB) | DOI: 10.29408/sinteza.v3i1.7585

Abstract

Jerawat (Acne Vulgaris) dan komedo merupakan penyakit kulit yang sering ditemui dan bukan merupakan jenis penyakit yang berbahaya. jerawat dapat mempengaruhi kepercayaan diri, timbul rasa cemas, bahkan depresi yang berujung menutup diri dari kegiatan dan lingkungan. Daun kelor mempunyai senyawa alkaloid, flavonoid, polifenol, dan saponin yang berpotensi sebagai antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri sediaan masker gel Peel Off  kombinasi ekstrak daun kelor (Moringa oleifera Lam.) Jenis penelitian yang digunakan adalah penelitian eksperimental laboratorik dengan menggunakan metode uji sumuran terhadap pertumbuhan bakteri P.acnes  menggunakan tiga reflikasi. kontrol positif Lea Gloria peel of mask, grup kontrol negatif sediaan masker gel peel of. Hasil pengamatan menunjukkan bahwa sediaan maskerp Peel off daun kelor (Moringa Oleifera L.)  kombinasi cangkang telur memiliki daya hambat terhadap pertumbuhan bakteri p.acne. parameter uji organoleptis, uji pH, uji daya lekat serta uji daya sebar memenuhi setandar SNI.
Uji Minyak Atsiri Daun Mengkudu (Morinda citrifolia L) terhadap Diameter Zona Hambat Staphylococcus aureus Wardani, Evi; Hariadi, Puspawan; Yuliana, Tri Puspita
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.25237

Abstract

Infeksi merupakan salah satu masalah kesehatan yang banyak disebabkan oleh virus, jamur, bakteri atau parasit. Bakteri Staphylococcus aureus merupakan bakteri penyebab infeksi pada manusia. Penggunaaan obat antibiotik dalam terapi infeksi yang tidak terkontrol dapat meningkatkan jumlah resistensi bakteri terhadap antibiotik, oleh karena itu perlu adanya terapi alternatif dari bahan alam yang memiliki potensi dalam menghambat pertumbuhan bakteri. Daun mengkudu (Morinda citrifolia L) merupakan salah satu tanaman yang dapat digunakan sebagai antibakteri dengan kandungan metabolit sekunder seperti flavonoid, alkaloid, saponin, steroid dan terpenoid. Tujuan penelitian ini untuk mengetahui pengaruh uji aktivitas minyak atsiri daun mengkudu terhadap pertumbuhan bakteri Staphylococcus aureus dan mengetahui konsentrasi optimum minyak atsiri daun mengkudu yang efektif dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Daun mengkudu diekstraksi secara destilasi dengan pelarut aquades. Destilat minyak atsiri daun mengkudu lalu diuji aktivitas antibakteri dengan menggunakan metode difusi kertas cakram dengan konsentrasi 15%, 25%, dan 35% (b/v). Kontrol positif yang digunakan yaitu ciprofloxacin dengan kontrol negatif DMSO. Hasil penelitian menunjukkan bahwa minyak atsiri daun mengkudu memiliki aktivitas antibakteri pada bakteri Staphylococcus aureus dibuktikan dengan adanya zona bening disekitar kertas cakram. Aktivitas antbakteri tertinggi yaitu pada konsentrasi 35%. Diketahui bahwa semakin tinggi konsentrasi yang digunakan hasil diameter zona hambat bakteri yang dihasilkan juga akan semakin besar.
Formulasi dan Evaluasi Sifat Fisik Sediaan Lulur Ekstrak Etanol Kulit Pisang Kepok (Musa paradisiaca L) Yuliana, Tri Puspita; Zulda, Nurul Fitri Erlinda
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26049

Abstract

Banana peel is the part of the banana that has not been used. A body scrub is a semi-solid preparation that functions to clean dirt on the face and dead skin cells. Banana peel one of any plants can be used as the basic of formulated cream cosmetics has flavonoid and tanin compound content, in acts as an moisturizer skin. This research aims to determine the formulation and evaluation of the physical preparation of kepok banana peel (Musa Paradisiaca L) ethanol extract scrub. The research method used was the laboratory experimental method. Evaluation of the scrub preparation includes organoleptic testing, homogeneity, spreadability testing, adhesion testing, pH testing and skin moisturizing power testing. The results showed that the preparation of the ethanol extract of kepok banana peel from both formulas had organoleptic results of F1 (semi-solid cream form, light brown color, typical aroma of kepok banana peel extract), F2 (semi-solid cream form, dark brown color, typical aroma of peel extract banana kepok), the homogeneity test of the preparation produces an even preparation when smeared on the surface of a glass object in all formulas, testing acidity or pH F1: 5.45 and F2 = 6.42. The spreading ability test results were at F1: 5.80 cm and F2: 5.44 cm. Testing ability of sticking time F1: 2.44 seconds and F2: 2.57 seconds. The skin moisturizing ability test before application showed an average of 23.6%, on day 5 an average of 36.5% and on day 10 an average of 48.5%. The conclusion is that the Kapok banana peel scrub formulation has physical properties that meet standards and is able to significantly moisturize the skin after 10 days of use. Statistical data shows that there is no significant difference in each formula with significance values ​​of 0.327, 0.265 and 0.294 (P<0.05).
Formulasi dan Uji Aktivitas Antibakteri Sediaan Mouthwash Fraksi Metanol Daun Seledri (Apium graveolens L.) terhadap Pertumbuhan Bakteri Streptococcus mutans Penyebab Karies Gigi Zulhijjati, Mirzalina; Yuliana, Tri Puspita; Fatmayanti, Baiq Risma; Oktresia, Erma Ewisa
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.31994

Abstract

Streptococcus mutans is a bacterium found in the human oral cavity and is the primary cause of tooth decay. The effects of Streptococcus mutans bacteria can be eliminated with mouthwash formulated with natural ingredients, one of which is celery leaves, which are known to have antibacterial properties against the growth of Streptococcus mutans. The purpose of this study was to determine the best concentration of a mouthwash formulation using the methanol fraction of celery leaves based on the results of the physical properties evaluation test and to determine the antibacterial activity of a mouthwash formulation using the methanol fraction of celery leaves in inhibiting the growth of Streptococcus mutans bacteria. This study was a quantitative study using a laboratory experimental method with a posttest-only control group design. This study is a quantitative study using a laboratory experiment method with a posttest-only control group design by observing the area of ​​the inhibition zone as the dependent variable. The area of ​​the inhibition zone of each formula was compared with the control using the ANOVA test. The results of the physical properties evaluation test, including ogrnanoleptic tests, pH tests, homogeneity tests, specific gravity tests, and cycling tests, met the requirements for good physical quality. The highest antibacterial activity results were found in formula III with a concentration of 1.5% celery leaf methanol fraction with an average inhibitory power of 23.63 mm with a Very Strong category.
Co-Authors Aditya Noviadi Rakhmatullah Arief Rafsanjani Aulia, Amanda Baiq Maylinda Gemantari Baiq Risma Fatmayanti Endang Darmawan Erma Ewisa Oktresia Ersi Arviana Ihsan Fitriwati Sovia Hamdi, Muhammad Irsyadul Hartini Haritani Hasratul Kusuma Kintoko Kintoko Kusumo, Djati Wulan Kusumo, Rudy Harjo Leny Ramadhan Minawati Minawati Minawati Minawati, Minawati Muhlisun Azim Muldiyana, Tya Novasari, Novasari Nurcholid Umam Kurniawan Pulhehe, Hasni Puspawan Hariadi Salsabila, Aulia Shakila, Shakila Sulistia Ardyati Ula, Fatin Bariatul Urmatul Waznah Wahyuningsih, Dahriah Fitri Wardani, Evi Wati, Ambar Yuli Nurullaili Efendi, Yuli Nurullaili Yuyun Febriani Zulda, Nurul Fitri Erlinda Zulhijjati, Mirzalina