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Uji Minyak Atsiri Daun Mengkudu (Morinda citrifolia L) terhadap Diameter Zona Hambat Staphylococcus aureus Wardani, Evi; Hariadi, Puspawan; Yuliana, Tri Puspita
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.25237

Abstract

Infeksi merupakan salah satu masalah kesehatan yang banyak disebabkan oleh virus, jamur, bakteri atau parasit. Bakteri Staphylococcus aureus merupakan bakteri penyebab infeksi pada manusia. Penggunaaan obat antibiotik dalam terapi infeksi yang tidak terkontrol dapat meningkatkan jumlah resistensi bakteri terhadap antibiotik, oleh karena itu perlu adanya terapi alternatif dari bahan alam yang memiliki potensi dalam menghambat pertumbuhan bakteri. Daun mengkudu (Morinda citrifolia L) merupakan salah satu tanaman yang dapat digunakan sebagai antibakteri dengan kandungan metabolit sekunder seperti flavonoid, alkaloid, saponin, steroid dan terpenoid. Tujuan penelitian ini untuk mengetahui pengaruh uji aktivitas minyak atsiri daun mengkudu terhadap pertumbuhan bakteri Staphylococcus aureus dan mengetahui konsentrasi optimum minyak atsiri daun mengkudu yang efektif dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Daun mengkudu diekstraksi secara destilasi dengan pelarut aquades. Destilat minyak atsiri daun mengkudu lalu diuji aktivitas antibakteri dengan menggunakan metode difusi kertas cakram dengan konsentrasi 15%, 25%, dan 35% (b/v). Kontrol positif yang digunakan yaitu ciprofloxacin dengan kontrol negatif DMSO. Hasil penelitian menunjukkan bahwa minyak atsiri daun mengkudu memiliki aktivitas antibakteri pada bakteri Staphylococcus aureus dibuktikan dengan adanya zona bening disekitar kertas cakram. Aktivitas antbakteri tertinggi yaitu pada konsentrasi 35%. Diketahui bahwa semakin tinggi konsentrasi yang digunakan hasil diameter zona hambat bakteri yang dihasilkan juga akan semakin besar.
Formulasi dan Evaluasi Sifat Fisik Sediaan Lulur Ekstrak Etanol Kulit Pisang Kepok (Musa paradisiaca L) Yuliana, Tri Puspita; Zulda, Nurul Fitri Erlinda
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26049

Abstract

Banana peel is the part of the banana that has not been used. A body scrub is a semi-solid preparation that functions to clean dirt on the face and dead skin cells. Banana peel one of any plants can be used as the basic of formulated cream cosmetics has flavonoid and tanin compound content, in acts as an moisturizer skin. This research aims to determine the formulation and evaluation of the physical preparation of kepok banana peel (Musa Paradisiaca L) ethanol extract scrub. The research method used was the laboratory experimental method. Evaluation of the scrub preparation includes organoleptic testing, homogeneity, spreadability testing, adhesion testing, pH testing and skin moisturizing power testing. The results showed that the preparation of the ethanol extract of kepok banana peel from both formulas had organoleptic results of F1 (semi-solid cream form, light brown color, typical aroma of kepok banana peel extract), F2 (semi-solid cream form, dark brown color, typical aroma of peel extract banana kepok), the homogeneity test of the preparation produces an even preparation when smeared on the surface of a glass object in all formulas, testing acidity or pH F1: 5.45 and F2 = 6.42. The spreading ability test results were at F1: 5.80 cm and F2: 5.44 cm. Testing ability of sticking time F1: 2.44 seconds and F2: 2.57 seconds. The skin moisturizing ability test before application showed an average of 23.6%, on day 5 an average of 36.5% and on day 10 an average of 48.5%. The conclusion is that the Kapok banana peel scrub formulation has physical properties that meet standards and is able to significantly moisturize the skin after 10 days of use. Statistical data shows that there is no significant difference in each formula with significance values ​​of 0.327, 0.265 and 0.294 (P<0.05).
Formulasi dan Uji Aktivitas Antibakteri Sediaan Mouthwash Fraksi Metanol Daun Seledri (Apium graveolens L.) terhadap Pertumbuhan Bakteri Streptococcus mutans Penyebab Karies Gigi Zulhijjati, Mirzalina; Yuliana, Tri Puspita; Fatmayanti, Baiq Risma; Oktresia, Erma Ewisa
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.31994

Abstract

Streptococcus mutans is a bacterium found in the human oral cavity and is the primary cause of tooth decay. The effects of Streptococcus mutans bacteria can be eliminated with mouthwash formulated with natural ingredients, one of which is celery leaves, which are known to have antibacterial properties against the growth of Streptococcus mutans. The purpose of this study was to determine the best concentration of a mouthwash formulation using the methanol fraction of celery leaves based on the results of the physical properties evaluation test and to determine the antibacterial activity of a mouthwash formulation using the methanol fraction of celery leaves in inhibiting the growth of Streptococcus mutans bacteria. This study was a quantitative study using a laboratory experimental method with a posttest-only control group design. This study is a quantitative study using a laboratory experiment method with a posttest-only control group design by observing the area of ​​the inhibition zone as the dependent variable. The area of ​​the inhibition zone of each formula was compared with the control using the ANOVA test. The results of the physical properties evaluation test, including ogrnanoleptic tests, pH tests, homogeneity tests, specific gravity tests, and cycling tests, met the requirements for good physical quality. The highest antibacterial activity results were found in formula III with a concentration of 1.5% celery leaf methanol fraction with an average inhibitory power of 23.63 mm with a Very Strong category.
Pengetahuan masyarakat dan pemanfaatan tanaman obat keluarga di desa toya aikmel utara Muhlisun Azim; Arief Rafsanjani; Tripuspita Yuliana; Puspawan Hariadi
Lentera Negeri Vol. 2 No. 1 (2021): Lentera Negeri
Publisher : Indonesian Institute For Counseling, Education and Therapy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/99330

Abstract

Family Medicinal Plants (TOGA) is an alternative in achieving GERMAS (Healthy Living Community Movement) as an effort to achieve traditional independent health. The success of the use of TOGA is strongly influenced by the level of public knowledge about the benefits of the type of medicinal plants which has been empirically investigated. The data obtained is qualitative data with descriptive approach analysis method. Data collection was carried out by conducting observations, interviews and technical training to the community in an effort to provide knowledge about TOGA and the creation of a TOGA demonstration plot. The results obtained from this activity are the emergence of public awareness of the use of home yard land for the manufacture of living pharmacies as an effort to achieve independent health and the emergence of public interest in the use of TOGA as a UMKM product in the form of packaged drink sachets as a pilot. The importance of public knowledge about TOGA is needed in supporting the success of achieving independent health and efforts to utilize local biological resources in initiating the manufacture of herbal plant-based UMKM products.
Formulation and Evaluation of the Physical Properties of Clay Mask Containing Ethanol Extract of Kenikir (Cosmos caudatus) Leaves Puspawan Hariadi; Rina Sri Apriani; Baiq Maylinda Gemantari; Tri Puspita Yuliana; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.19

Abstract

The demand for natural-based cosmetic products continues to increase due to their perceived safety and minimal side effects. Kenikir leaves (Cosmos caudatus Kunth) are known to contain active compounds such as flavonoids, tannins, and phenols, which have antioxidant potential and can be utilized in facial mask preparations. This study aims to formulate a clay mask preparation from the ethanol extract of kenikir leaves and evaluate its physical properties. The extract was obtained through maceration using 96% ethanol, and then formulated into three concentrations: F1 (0.5%), F2 (1%), and F3 (2%). The evaluation of the preparation included organoleptic tests, adhesion test, spreadability test, and pH measurement. The results showed that F1 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.3 cm. F2 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.2 cm. F3 had a pH of 6, adhesion time of 4.6 seconds, and spreadability of 5 cm. The evaluation results indicated that all clay mask formulations met the physical quality criteria for clay masks.