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Hubungan Pemilih Makanan dan Citra Tubuh dengan Status Gizi pada Remaja Putri SMA Negeri 2 Palu Alda Asran; Lilik Sofiatus Solikhah; Hardianti Hardianti
Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi Vol. 3 No. 2 (2025): Antigen : Jurnal Kesehatan Masyarakat dan Ilmu Gizi
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/antigen.v3i2.686

Abstract

Adolescent girls are susceptible to nutritional and psychological problems due to changes during puberty. Selective eating behavior and negative body image perceptions may affect nutritional intake, potentially leading to eating disorders and mental health issues. This study aimed to examine the relationship between food selectivity and body image with nutritional status in adolescent girls. A quantitative, cross-sectional design was used, involving 89 purposively sampled female adolescents aged 15–19 years from a population of 790. Anthropometric measurements were conducted using a microtoise and a digital scale, and data were analyzed using the chi-square test. Results showed that 17.5% of participants were undernourished. There was no significant association between food selectivity and nutritional status (p = 0.454), but a significant association was found between negative body image and abnormal nutritional status (p = 0.001). In conclusion, body image is significantly associated with nutritional status, whereas food selectivity is not, among adolescent girls at SMA Negeri 2 Palu.  
Efektivitas Antikonvulsan Glodokan Tiang (Polyathia longifolia) pada Hewan Uji Mencit yang Diinduksi Strikinin Haryanto Haryanto; Nur Fadila Rustam; Nur Amalinda; Hardianti Hardianti; Fitrinaya Fitrinaya; Nur Halisah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1669

Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. This condition can significantly impact the quality of life of sufferers, making the development of effective and safe anticonvulsant therapies a priority in pharmacological research. This study aimed to evaluate the effectiveness of various anticonvulsant drugs, including herbal candidates, in a mouse model (Mus musculus) using acute and subchronic test protocols. Seizures were induced by administering strychnine, a glycine receptor antagonist that triggers excessive neuronal excitability. Parameters observed included seizure onset (the time from strychnine administration to the onset of the first seizure) and deadtime (the time of survival after a seizure). The study involved six treatment groups: a negative control (Na-CMC), four conventional drug groups (phenytoin, diazepam, pregabalin, and gabapentin), and one herbal candidate group made from Polyalthia longifolia (glodokan tiang). The results showed that most treatment groups were able to delay seizure onset and significantly prolong deadtime compared to the negative control. Statistical analysis using ANOVA yielded a p-value <0.05, indicating a significant difference between groups. The herbal candidate Polyalthia longifolia showed promising anticonvulsant potential, although it did not fully match the effectiveness of conventional drugs such as phenytoin or diazepam. The negative control (Na-CMC) showed the fastest onset and shortest survival time, reflecting the absence of a protective effect against seizures. This study emphasizes the importance of further testing using chronic protocols and evaluating additional parameters such as plasma drug concentrations and neurological side effect profiles. The obtained data are expected to form the basis for the development of anticonvulsant therapies based on a combination of modern drugs and natural ingredients, with the hope of producing safer, more effective treatment alternatives, and potentially reducing dependence on long-term synthetic drugs.