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Molecular Docking on Kokosanolide A and C for Anticancer Activity Against Human Breast Cancer Cell MCF-7 Sri Purwani; Julita Nahar; Zulfikar Zulfikar; Nurlelasari Nurlelasari; Tri Mayanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.20534

Abstract

Kokosanolide A (1), from the seeds of Lansium domesticum Corr. cv Kokossan, has been shown strong cytotoxic activities (IC50 = 8.62 μg/mL) against MCF-7 breast cancer cells. The aim of this work was to study the molecular interactions of kokosanolide A and kokosanolide C with the Estrogen Receptor α (ERα) using computer-aided drug design approaches. Molecular docking using Autodock Vina (open-source software PyRx 0.8) was employed to explore the modes of binding of kokosanolide A (1) and kokosanolide C (2) with ERα. Compounds 1 and 2 showed strong bond-free energy (-8.8 kcal/mol and -8.7 kcal/mol) to ERα. These two compounds have a molecular mechanism to inhibit ERα in breast cancer cells.
Analisis Turunan dan Integral Fraksional Fungsi Pangkat Tiga dan Fungsi Eksponensial Muhamad Deni Johansyah; Julita Nahar; Farid H. Badruzzaman
Matematika Vol 16, No 2 (2017): Jurnal Matematika
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jmtm.v16i2.3357

Abstract

Abstrak. Ide dari konsep turunan fraksional adalah bagaimana menentukan turunan yang berorde suatu bilangan pecahan (fraksional) yaitu bilangan rasional atau bahkan bilangan real. Dalam makalah ini dikaji tentang definisi, teorema, dan karakteristik serta contoh turunan fraksional pada fungsi pangkat tiga dan fungsi eksponen yang dikembangkan oleh matematikawan Riemann dan Liouville. Metode penelitian yang ditempuh adalah melalui studi literatur primer, yaitu dengan mengembangkan teori yang telah dikerjakan peneliti terdahulu, sehingga metode tersebut dapat diterapkan untuk penyelesain masalah yang dapat diaplikasikan dan dikembangkan secara lebih luas. Hasil dari makalah ini berupa analisis dari turunan fraksional fungsi pangkat sederhana dan fungsi eksponensial.Keywords: turunan fraksional, fungsi pangkat tiga, fungsi eksponenAbstract. The idea of the fractional derivative concept is how to determine the derivation with fractional order, that is a rational number or even a real number. In this paper, we examine the definitions, theorems, and the characteristics as well as fractional derivatives example of the cubic and exponential functions in which developed by mathematician Riemann and Liouville. This research is done by primary literature review, that is by developing the theory that has been done by the previous researcher, so that the method of problem solving can be applied and developed widely. The results of this paper are the analysis of fractional derivatives from simple-order and exponential functions.Keywords: fractional derivatives, cubic functions, exponential functions
Supply Chain Management Planning for a Project Using the Fuzzy Logic and Crasing Program Method Elis Hertini; Julita Nahar
International Journal of Supply Chain Management Vol 9, No 4 (2020): International Journal of Supply Chain Management (IJSCM)
Publisher : International Journal of Supply Chain Management

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Abstract

Project management is a strategy that needs to be done in project planning and scheduling. With the preparation of a good project management, it can be estimated the time and cost needed to run the project, so as to minimize cost losses due to possible project lags. Project scheduling is one element of planning results, which can provide information about project schedules, plans and progress. Project time management can be arranged using the Critical Path Method (CPM) and Program Evaluation and Review Technique (PERT). One alternative to accelerate project completion (Crashing) is by adding project costs using the Crasing Program Method. To overcome the uncertainty of scheduling time and project costs in calculations Fuzzy Logic is used. From the results of using Fuzzy Logic, we estimate the time and cost needed to carry out the project, so as to minimize cost losses due to possible time delays in the project. The results of using Fuzzy Logic on CPM and PERT project schedule on a house renovation project in Ujungberung Indah Bandung housing complex, requires a longer completion time, but the probability of completion of the project is higher, the use of the Crasing Program Method results in faster project completion times and lower incremental costs.
Principal Component Analysis (PCA) of Phytoplankton Community Relations Based on Physical-Chemical Structures for Supply Chain Management in the Waters of the Bangka Bay Region of West Bay Julita Nahar; Elis Hertini
International Journal of Supply Chain Management Vol 9, No 4 (2020): International Journal of Supply Chain Management (IJSCM)
Publisher : International Journal of Supply Chain Management

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Abstract

Phytoplankton as one of the most important organisms in the territorial waters, which is the beginning of the food chain in a territorial waters. Phytoplankton have certain tolerance limits to physical-chemical factors so that they will form different community structures. The relationship between chemical physics parameters with phytoplankton communities in a territorial waters, can be used as an indicator of water quality. West Bangka Regency has considerable marine and fisheries resource potential, especially for marine aquaculture. So research on the structure of the phytoplankton community in relation to the physical-chemical parameters of seawater needs to be carried out to see indicators of fertility and availability of natural food in the waters that will be used as a marine aquaculture location. To find out the relationship between physico-chemical parameters and phytoplankton abundance, Principal Component Analysis (PCA) was used. Some physico-chemical parameters observed were temperature, brightness, pH, salinity, coated oxygen (DO), phosphate, nitrate, and ammonia. The results show the eigenvalues value of the main component 1 (PC1) represents about 41.78% of the diversity of data with its main identifying variable, namely temperature with a loading factor value of -0.885, brightness with a loading factor value of -0.8872 and salinity with a loading factor value of 0.824. For the main component 2 (PC2) represents about 28.16% of the diversity of data with its founder variable, pH with a loading factor value of -0.841. As for the main component 3 (PC3), it represents 18.67% of the diversity of data with its originating variable, Nitrate, with a loading factor value of -0,700. So that it can be formed into 3 clusters namely the first cluster is temperature and salinity, the second cluster is pH and nitrate and the third cluster is DO, phosphate, and ammonia.
Forecasting Of Production And Export Indonesian Pepper Commodities Using Smoothing Exponential And Holt Winter Methods Hapiz Jasman; Eman Lesmana; Julita Nahar
IJEBD (International Journal of Entrepreneurship and Business Development) Vol 4 No 2 (2021): March 2021
Publisher : LPPM of NAROTAMA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.144 KB) | DOI: 10.29138/ijebd.v4i2.1368

Abstract

Purpose: The last few years the contribution of Indonesian pepper in the world market has decreased and has been replaced by Vietnam. If in 2000 and a few years before Indonesia became the world’s main pepper exporter, since 2001 the position has been replaced by Vietnam. In 2006 Indonesia’s position fell back to number three the world was replaced by Brazil which was ranked second. In 2006 Indonesian exports outperformed brazil and returned to rank second. Based on data from the Directorate General of Plantations in 2015, the area under pepper in Indonesia tends to decrease from 2004 to 2015 with an average reduction of area of 3064.5 hectares per year. Based on data from the Directorate General of Plantation in 2015, the area of pepper in Indonesia tends to decline from 2004-2015 with an average reduction of 3,064.5 hectares per year. The occurrence of the deduction according to the Ministry of Agriculture (2013), among others, is caused by: (a) drought; (b) Pest and disease attacks, especially stem rot and jaundice; and (c) conversion of pepper into mining or other plantation land, such as oil palm, rubber or cocoa. Design/methodology/approach:. Methods used to predict the number of production and consumption of domestic and export of Indonesian pepper is Double exponential Smoothing Brown and the Smoothing exponential method of Holt-Winter. Research limitations/implications: This Paper discusses the predictions of production and domestic consumption and the export of Indonesian pepper.
PENERAPAN METODE DOUBLE EXPONENTIAL SMOOTHING UNTUK MERAMALKAN PRODUKSI DAN KONSUMSI DOMESTIK BERAS DI INDONESIA PUTRI NUR PRASETIA; ANITA TRISKA; JULITA NAHAR
E-Jurnal Matematika Vol 11 No 3 (2022)
Publisher : Mathematics Department, Faculty of Mathematics and Natural Sciences, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MTK.2022.v11.i03.p375

Abstract

Rice is one of the most important commodities in Indonesia since it is one of the staple foods.Therefore, it becomes one of Indonesian government concerns by setting a goal of 46,8 million tons of rice supply in 2024. Despite 29,67% of the population earns their living from agriculture, forestry, and fisheries, the domestic production of rice could not meet its demand many times. Hence, the forecasting of the production and domestic consumption of rice is needed to know whether the domestic production is able to meet the demand. In this study, the rice production and domestic consumption were forecasted using the Double Exponential Smoothing (DES) method. The DES was chosen due to the pattern of the data shows the trends without seasonality. The accuracy of the forecasting was measured by Mean Absolute Percentage Error (MAPE) and Durbin-Watson statistic test. The yielded forecasts showed that the production rate is lower than the domestic consumption’s so that it would not meet the demand. It was concluded that the DES suitable to be used to forecast production and domestic consumption of rice in Indonesia since its MAPE are 6,48% and 5,91%, respectively. Moreover, the Durbin-Watson statistic showed that there was no autocorrelations on the errors of both data.
Storm Eg Agent Profit and Loss Report in February 2022 Felix Daniel Budiman; Elis Hertini; Julita Nahar
International Journal of Research in Community Services Vol 3, No 4 (2022)
Publisher : Research Collaboration Community (RCC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46336/ijrcs.v3i4.362

Abstract

Financial statements are a fundamental thing in a company. One type of financial report is the income statement. The income statement is a report that provides information on the company's performance, which contains income and profit and loss expenses. This study aims to introduce good and simple income statements and understand financial statement analysis. This research uses quantitative methods by using vertical, horizontal and ratio financial analysis techniques. The result of this research is that the Storm egg agent records that the company's finances are in good condition based on the ratio analysis of gross profit margin and net profit margin. Based on the vertical and horizontal analysis, it was found that the company experienced profit growth from the first period to the second period.
Penerapan Metode Multidimensional Scaling dalam Pemetaan Sarana Kesehatan di Jawa Barat Julita Nahar
Jurnal Matematika Integratif Vol 12, No 1: April, 2016
Publisher : Department of Matematics, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.152 KB) | DOI: 10.24198/jmi.v12.n1.10283.43-50

Abstract

Upaya kesehatan dapat diwujudkan dalam suatu pelayanan kesehatan atau sarana kesehatan. Kesehatan sangat berarti untuk pembangunan kesejahteraan masyarakat Indonesia. Pelayanan kesehatan yang baik akan menciptakan masyarakat yang sehat diseluruh kawasan baik dipedesaan maupun perkotaan. Penelitian ini ditujukan untuk memetakan sarana kesehatan yang ada di kota-kota di Jawa Barat. Hasil analisis yang dilakukan dengan menggunakan analisis Multidimensional Scaling memperlihatkan bagaimana pengelompokan kota-kota di Jawa Barat berdasarkan sarana kesehatan yang dimilikinya, Dari hasil pemetaan terdapat tiga kelompok kota yang memiliki kemiripan antar anggotanya namun berbedadengan kelompok lainnya. Tiap kelompok yang terbentuk memiliki kemiripan karakteristik dari jumlah fasilitas sarana kesehatan..Kata Kunci : Multidimensional Scaling, pemetaan, sarana kesehatan
Forecasting Model of the Effect of Vaccination on the Number of Covid-19 Cases in West Java Province Nazihah, Nazihah; Nahar, Julita; Supian, Sudradjat
International Journal of Global Operations Research Vol. 4 No. 4 (2023): International Journal of Global Operations Research (IJGOR), Nopember 2023
Publisher : iora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47194/ijgor.v4i4.242

Abstract

COVID-19 adalah virus yang disebabkan oleh SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) dan pertama kali ditemukan di Wuhan, Hubei, China. Selain menggunakan masker dan melakukan social distancing, cara lain untuk mencegah paparan COVID-19 adalah dengan memberikan dosis vaksin COVID-19 lengkap, yang meliputi dosis pertama dan kedua dari vaksin yang sama, serta dosis booster tambahan untuk peningkatan dosis. kekebalan. Vaksinasi adalah suatu proses di dalam tubuh yang membuat seseorang menjadi sangat kebal atau terlindungi dari suatu penyakit, sehingga jika di kemudian hari terinfeksi penyakit tersebut, mereka tidak akan sakit atau hanya mengalami gejala ringan. Tujuan dari penelitian ini adalah membangun model peramalan untuk mengetahui dampak vaksinasi terhadap jumlah kasus COVID-19 di Provinsi Jawa Barat dan memprediksi jumlah kasus COVID-19 di Provinsi Jawa Barat dengan menggunakan metode regresi linier berganda. Data penelitian yang digunakan terdiri dari jumlah kasus COVID-19 dan penerima dosis vaksin pertama, kedua, dan booster dalam kurun waktu 13 Januari 2021 sampai dengan 22 Januari 2023. Data tersebut diperoleh dari situs resmi PT. Diskes Jabar dan Vaksin Kemkes. Hasil uji statistik dengan kadar alpha 5% menunjukkan bahwa diantara vaksin pertama, kedua, dan booster, hanya vaksin pertama dan kedua yang memberikan dampak signifikan, artinya ada pengaruh efektifitas vaksinasi terhadap jumlah kasus COVID-19. kasus di Provinsi Jawa Barat.
THE PLANNING FOR UPPER SHOES RAW MATERIAL INVENTORY USING THE MATERIAL REQUIREMENT PLANNING (MRP) METHOD (Case Study : PT X) Apriliza, Poppy; Supian, Sudradjat; Nahar, Julita
International Journal of Global Operations Research Vol. 4 No. 4 (2023): International Journal of Global Operations Research (IJGOR), Nopember 2023
Publisher : iora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47194/ijgor.v4i4.235

Abstract

The planning of raw material inventory is one of the essential factors in planning the order of the raw materials that can make a company maintain its production quality. The company’s policies can be implemented in various ways, such as in planning the raw materials inventory to avoid shortages and excesses of the raw materials supply. However, X Inc. has not implemented inventory planning properly, making the costs incurred by the company not optimal. Thus, Material Requirement Planning (MRP) will be used to determine the scheduling time and quantity of raw materials for ordering with lot sizing techniques. Lot sizing techniques provide solutions to determine the right quantity of raw material orders and minimum total inventory costs with techniques which are Lot for Lot (LFL), Least Unit Cost (LUC), Economic Order Quantity (EOQ), and Silver-Meal. Based on the calculation results, the four lot sizing techniques show that the LFL technique is the optimal technique compared to other techniques because it produces the minimum inventory cost of Rp566.015.685,05. Thus, the company can profit Rp13.295.563,75 compared to company policy.