Article Per Year (5 Year)
p-Index From 2021 - 2026
1.152
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Matematika & Sains Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Medicine and Health Jurnal Ilmu Kefarmasian Indonesia Current Research on Biosciences and Biotechnology Narra J
Irda Fidrianny
Departemen Farmasi, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
HEPATOPROTECTIVE ACTIVITY OF SAPONIN FRACTION OF OYONG SEED FLESH AND ITS COMBINATION AGAINST CCl4-INDUCED CHRONIC LIVER DAMAGE IN MALE WISTAR RAT Rachmawati, Heni; Y. Hartiadi, R. Leonny; Fidrianny, Irda; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (940.23 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-185

Abstract

Saponin fraction of seed flesh of Oyong (Luffaacutangula [L.]Roxb) has been investigated to have a hepatoprotective activity in rats with fibrotic chronic liver damage. This research was conducted to evaluate whether saponin fraction of Oyongseed flesh has a hepatoprotective activity in CCl4-induced acute liver damage. Hepatoprotective activity was determined by measuring the activity of liver enzymes (SGOT, SGPT, LDH), total nitrite/nitrate level, liver index and liver histology. Saponin fraction of Oyong flesh seeds 10mg/kg BW and meniran extract 400mg/kg BW alone showed hepatoprotective activity. Administration of saponin fraction 10mg/kb BB decreased SGPT and LDH significantly over untreated group. Group given meniran extract at dose of 200mg/kg BW showed decreased on LDH, while at dose of 400mg/kg BW decreased SGPT, SGOT, and LDH significantly. Hystological observation revealed any improvement in liver morphology especially after treated with saponin fraction 10mg/kg BWand meniran extract at dose of 400mg/kg BW. However, all groups treated with combination of saponin and meniran did not show improvement both at biochemical parameter and liver histology. In conclusion, saponin extract with dose of 10mg/kg BW and meniran extract at dose of 400mg/kg BW showed hepatoprotector activity. In contrast, combination of both did not show any hepatoprotective effect and it was suspected that they have antagonist effects.Key words:hepatoprotective, CCl4-induced liver fibrosis, Luffaacutangula, Phyllanthusniruri
ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF RED Psidium guajavaL. LEAVES GROWN IN MANOKO, LEMBANG - INDONESIA Fidrianny, Irda; Hartanti, Rika; Raveendaran, Narmmatha
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.492 KB) | DOI: 10.14499/indonesianjpharm23iss1pp36-40

Abstract

Psidium  guajava L.  (Myrtaceae)  is  a  well  known  plant  in Malaysia  and  Indonesia.  Its  leaves  extract  was  found  to  possess antidiarrhea,  antimicrobial,  hepatoprotective  and  antioxidant activities.  Objective  of  this  research  is  to  isolate  an  antioxidant subtance   from  Red Psidium  guajava L.  leaves.  The  crude  leaves was extracted using Soxhlet apparatus by gradual polarity of three different  solvents,  n-hexane,  ethyl  acetate  and  methanol. Antioxidant  activity  of  each  extract  was  tested  by  using  DPPH (2,2-diphenyl-1-picrylhydrazyl)  radical  scavenging  method.  Total phenol,  total  flavonoid  and  total  tannin  content  of  the  extracts were  also  measured.  Ethyl  acetate extract  was fractionated  using vacuum  liquid  chromato-graphy  for  fractionation.  Purification  was performed using TLC  preparative. Isolate then characterized using specific  spray  reagent,  UV-Vis  spectrophotometry  and  infrared spectrophotometry.  Crude  drug  of  Psidiumguajava contained flavonoid,  tannin,  quinone,  saponin  and  steroid/  triterpenoid. Antioxidant  activity  of  ethyl  acetate  extract  is  65.63%  with  total phenol  4.25%,  total  flavonoid  0.53%  and  total  tannin  1.16%. Antioxidant  compound N was  isolated  from  ethyl  acetate  extract.Antioxidant  compound N was  supposed  to  be   aglycone  flavone that has OH at C -4’, C-5 and C-7.Key words: Psidium guajava L. , antioxidant activity, ethyl acetate extract
Analysis of nicotine in various organs of male mice after inhalation of cigarette smoke Irda Fidrianny; IGNA Supradja; Andreanus A Soemardji
Indonesian Journal of Pharmacy Vol 15 No 4, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.457 KB) | DOI: 10.14499/indonesianjpharm0iss0pp207-210

Abstract

Nicotine is one of dangerous components in cigarette smoke, there for concentration of nicotin in organ quantitative in organs must be determined. Qualitative and quantitative thin layer chormatographic analysis of nicotine in various organs of male mice after inhalation of cigarette smoke has been carried out. Nicotine was extracted with chloroform in ammoniacal medium and determined by spectrophotodensitometry. The nicotine content in lung is higher than kidney and liver.Key words: nicotine, lung, kidney, liver, male mice
Co-Authors - Satrialdi . Elfahmi Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Amanda, Patricia Andreanus A Soemardji Andreanus A Soemardji Annisa Rahman Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Arsul, Muhammad Ikhlas Baitariza, Ardian Choirunnisa, Atina Rizkiya Darijanto, Sasanti Tarini Dinda Prasetya Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Ellis Siti Zahidah Fadhilah, Syifa Fitria, Alfiyani Fitriansyah, Sani Nurlaela Hartanti, Rika HENI RACHMAWATI I Ketut Adnyana IGNA Supradja Iwo, Maria I. Jessie Sofia Pamudji Jessie Sofia Pamudjie Jessie Sofia Pamudjie, Jessie Sofia Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kosasih Padmawinata Leonny Yulita Hartiadi Meutia Faradilla, Meutia Muhamad Insanu Muhamad Insanu Nia K Sari Pamudji, Jessie Sofia Patricia Amanda Pramastya, Hegar Prasetya, Dinda Prihantini, Malinda Raveendaran, Narmmatha Regiana, Zhafira Amalia Rika Hartati Rika Hartati Rizaldy, Defri Rizka Triani Ruslan, Komar Sasanti Tarini Darijanto Sasanti Tarini Darijanto Sasanti Tarini Darijanto, Sasanti Tarini Satrialdi, - Shelvi E. Suherman Shelvi E. Suherman, Shelvi E. Sienny Wijaya Siti Kusmardiyani Slamet Tuty Soediro Soetarno Sukandar, Elin Yulinah Sukrasno Tri Suciati Triani, Rizka Wijaya, Sienny Yohanes Andika Suharli Yundari, Yundari Yuniarto, Ari Zahidah, Ellis Siti