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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Pendidikan Matematika dan IPA AL KAUNIYAH Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Human Nutrition Biota Journal of Tropical Biodiversity and Biotechnology BERITA BIOLOGI Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Jurnal Mangifera Edu BioEksakta : Jurnal Ilmiah Biologi Unsoed Proceeding Biology Education Conference Berkala Penelitian Hayati Kaunia: Integration and Interconnection of Islam and Science Journal Kenanga : Journal of Biological sciences and Applied Biology Gunung Djati Conference Series Berkala Ilmiah Biologi Jurnal Kefarmasian Indonesia
Laksmindra Fitria
Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Veterinary Other

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Journal : Berkala Ilmiah Biologi

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Single-Dose Oral Toxicity Study of Chloroform Extract of Kaffir Lime (Citrus hystrix DC.) Leaves in Wistar Rats (Rattus norvegicus Berkenhout, 1769) Fitria, Laksmindra; Meidianing, Maura Indria; Sanjaya, Wilda Bunga Tina; Gunawan, Isma Cahya Putri
Berkala Ilmiah Biologi Vol 15 No 1 (2024)
Publisher : Fakultas Biologi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bib.v15i1.6227

Abstract

Leaves of kaffir lime (Citrus hystrix) are commonly used as a seasoning in various Indonesian and Southeast Asian dishes. Phytochemical studies reported various secondary metabolites that possess medicinal properties. Before exploring their potential as therapeutic agent, a series of toxicity studies must be conducted to assess the toxicity and safety levels. This research aimed to study the single-dose acute oral toxicity of chloroform extract of kaffir lime leaves (CECHL) in female Wistar rats (Rattus norvegicus) as experimental animals. The procedure followed OECD Test Guideline No.420 with the dose 2000 mg/kg bw for 14 days (Sighting study). Parameters consisted of mortality, clinical signs of sublethal effect based on changes in general appearance and daily activity/behavior, hematological profile, and blood clinical biochemistry. Neither mortality nor sublethal effects were found during the experiment. All blood parameter values (erythrocytes, leukocytes, thrombocytes, ALT, AST, creatinine, BUN, glucose, cholesterol, and triglycerides) were within reference interval, indicating that CECHL is not harmful to normal physiology. In conclusion, single-dose oral administration of CECHL is safe, no-observed-adverse-effect-level (NOAEL) at dose 2000 mg/kg bw or included in Category 5 based on the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).
Analisis Kulit Marmut sebagai Model Hewan dalam Penelitian Dermatologi dan Kedokteran Estetika Fitria, Laksmindra; Gunawan, Isma Cahya Putri
Berkala Ilmiah Biologi Vol 15 No 2 (2024)
Publisher : Fakultas Biologi Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bib.v15i2.10295

Abstract

Skin is the main barrier to protect against harmful environmental influences, one of which is ultraviolet radiation (UVR) which comes from sunlight. Therefore, skin damage due to UVR (photodamage) has gained prominence in dermatology and aesthetic medicine, especially in tropical countries. Guinea pig (GP) as tropical mammal is potential to serve as animal model for skin-related research due to the similarity of their coat pigmentation to that of humans. This research aims to study the skin condition and histomorphometric structure of GP skin with coat color variations. Samples consisted of six adult female GP with tricolor and tortoiseshell patterns. After neatly shaved in 2 x 2 cm2 area, skin condition is then evaluated using Skin Analyzer. Skin samples were processed into histological preparations using paraffin method with 10 % NBF as fixative and stained with Hematoxylin & Eosin (H&E) to measure the thickness of epidermis and dermis. Results demonstrated that skin moisture levels do not significantly differ between coat colors, higher levels of sebum and pigmentation correspond with darker coat colors, whereas lower levels of elasticity and collagen are associated with lighter coat colors. Histomorphometric examination showed that in tortoiseshell GP, the thickness of the epidermis and dermis increased with the coat color, but in tricolor GP, the thickness of epidermis and dermis varied. Furthermore, tortoiseshell GP have thicker epidermis and dermis than tricolor GP. It can be concluded that coat color affects the skin condition as well as the thickness of epidermis and dermis. Based on the pigmentation pattern, tortoiseshell GP is promoted as the most suitable animal model to represent tropical human skin.
Co-Authors Abdul Razaq Chasani Aditya K. Karim Aditya Krishar Karim Andreas S. Budi, Andreas S. Anggoro Chandra Yulistiyanto Annisa Ridhowati Annisa Ridhowati, Annisa Cannadianti, Nadhira Cut M. Tiraya, Cut M. Diaz Ayu Anjani Dini Anggraini, Dini Eko Agus Suyono Eko Agus Suyono Epa Yohana Toga Torop Erlitaningsih, Ucik Gerald, Jeremia Gunawan, Isma Cahya Putri Hartantyo, Rahadian Yudo Helen Eko Putro Indah Permata Sari Indah Riwantrisna Dewi Indira Diah Utami Intan Woro Prawesti Intan Woro Prawesti, Intan Woro Isma Cahya Putri Gunawan Kholidatus Silmi Kindi Adam Kindi Adam Kristiawati, Dian Lia Lavi Illiy Lukitowati, Fajar Mahroos, Rifda El Maura Indria Meidianing Mayumi Hersasanti Meidianing, Maura Indria Meliala, Andreanyta Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Sarto Mulyati Sarto Mulyati Sarto Mulyati Sarto Narwidina, Paramita Oktavia, Nurfitria Onny Nurrahman Marwayana Paul J. Kawatu Pricellita Nur’aivy Alvianti Putri Gunawan, Ismi Cahya Putri Nur Nur Aida Rachid, Ayu Aziza Ar Rahadian Yudo Rahadian Yudo Hartantyo Rahadian Yudo Hartantyo Rahadian Yudo Hartantyo Rosita Dwi Putri Suranto Rury Eprilurahman Sanjaya, Wilda Bunga Tina Septy Azizah Puspitasari Siswanto Slamet Widiyanto Slamet Widiyanto Sudesty, Shellya Puti Syifa’ Aulia Rahmah Tika Candra Dewi Wilda Bunga Tina Sanjaya Windah Dwi Nuraini Mappalotteng