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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Biomedika Medfarm: Jurnal Farmasi dan Kesehatan Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Jurnal Kesehatan Farmasi Jurnal Sains dan Kesehatan
Fransiska Leviana
Fakultas Farmasi Universitas Setia Budi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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In Vitro Analysis of Anti-Inflammatory Activity of Lyotropic Liquid Crystal Nanoparticles from Echinacea purpurea Flower Extract Santianingtyas, Priscilla Sherly Ayu; Dzakwan, Muhammad; Leviana, Fransiska
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.555

Abstract

Inflammation serves as the body's defense mechanism in response to tissue damage caused by various factors. Echinacea contains flavonoids such as quercetin, kaempferol, and diosmetin, which exhibit significant anti-inflammatory properties by inhibiting inflammatory enzymes and reducing the production of proinflammatory mediators. This study aims to evaluate the anti-inflammatory effects of echinacea flower extract formulated as Lyotropic Liquid Crystal Nanoparticles (LLCN) and compare its efficacy with viscous echinacea flower extract and diclofenac sodium. Echinacea flower extract was produced using 70% ethanol solvent via ultrasonication. LLCNs were synthesized using a top-down approach and characterized based on particle size, zeta potential, stability, and absorption efficiency. Anti-inflammatory activity was assessed in vitro using 0.2% Bovine Serum Albumin (BSA) solution in Tris Buffer Saline (TBS), with diclofenac sodium as a positive control. The results showed that echinacea flower extract can be converted into LLCN with particle sizes ranging from 10 to 1000 nm. The LLCN formulation of echinacea flower extract showed stronger anti-inflammatory activity compared to the condensed extract, with activity recorded at 54,660 ppm, IC50 for LLCN at 21,823 ppm, and IC50 for diclofenac sodium at 19,984 ppm. Thus, echinacea flower extract LLCN has potential as a natural anti inflammatory agent, which shows higher efficacy compared to its condensed extract form. This indicates that LLCN technology not only improves the bioavailability, but also the effectiveness of the extract in inhibiting inflammation, thus LLCN has the potential to be applied more widely in the development of natural drugs for anti inflammatory therapy.
Co-Authors Ana Indrayanti Ana Indrayati Arsiaty Sumule Arum Triyas Wardani Dewi Putri Meirastuti Dwi Novita Eka Sari Dzakwan, Muhammad FITRI PUJIATI Hally Fazah Iyah I Nyoman Adi Putra Ilham Kuncahyo Kisrini Kisrini Louis Madalena Luvi Nurharisna Mamik Ponco Rahayu Muhammad Dzakwan Nadea Sherly Widya Putri Nadea Opstaria saptarini Prapita Sari Widayanti Priskila Wahyuningsih Rahmawati, Ismi Ratno Agung Samsumaharto Ratno Agung Samsumaharto Renata Tri Anggreany Rica Rica Rica Rica, Rica Santianingtyas, Priscilla Sherly Ayu Sari R Sari R, Sari Sri Agustiningsih Titik Sunarni Titik Sunarni Titik Sunarni Triana Hertiani Widyan Muchzadi Akbar Wiwin Herdwiani Wulandari, Destik Yolanda Yolanda Yolanda Yolanda, Yolanda Yudi Rinanto Zahra Zahra Zahra Zahra Zani Mariastuti