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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Science and Technology Molecular and Cellular Biomedical Sciences (MCBS) Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy
Yuni Elsa Hadisaputri
Departemen Biologi Farmasi - Fakultas Farmasi - Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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AKTIVITAS ANTIKANKER FAMILI MYRTACEAE Hesti Renggana; Yuni Elsa Hadisaputri; Anas Subarnas
Jurnal Ilmiah Farmako Bahari Vol 9, No 2 (2018): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.66 KB) | DOI: 10.52434/jfb.v9i2.506

Abstract

Tanaman adalah sumber dari berbagai metabolit sekunder, yang sering digunakan dalam aktivitas antikanker. Menemukan obat antikanker baru dari sumber herbal lebih penting baik dalam biologi maupun kegiatan farmakologis. Oleh karena itu, tujuan dari review artikel ini adalah untuk mengidentifikasi agen antikanker dari 6 tanaman yang memiliki aktivitas antikanker dari famili myrtaceae. Dari data literatur famili myrtaceae yang memiliki aktivitas sebagai anti kanker diantaranya Callistemon citrinus (Curtis) skeel , Syzygium aromaticum L., Psidium guajava L. , Myrcia bella Cambess, Rhodomyrtus tomentosa (Aiton) Hassk, dan Syzygium cumini L. Kata kunci : anti kanker, myrtaceae
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition W. Wahyuni; Ajeng Diantini; Mohammad Ghozali; Anas Subarnas; Euis Julaeha; Riezki Amalia; Adryan Fristiohady; Andini Sundowo; Sofa Fajriah; Yuni Elsa Hadisaputri; Raden Maya Febrianti; Fauzia Azzahra; Agung W.M. Yodha; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i2.50547

Abstract

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.
Effect of Combination Herbal Plants Extracts on Diabetes Mellitus Semesta, Cleopatra Diva; Putri, Refitha Nurul; Hadisaputri, Yuni Elsa
Indonesian Journal of Biological Pharmacy Vol 3, No 3 (2023): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v3i3.47737

Abstract

Diabetes is a non-communicable disease with metabolic dysfunction characterized by high glucose levels due to damage to pancreatic β cells so that insulin cannot be secreted normally by the body. Diabetes mellitus cannot be cured, but it can only be controlled with appropriate treatment. Most of the available synthetic antidiabetic treatments have serious side effects and are quite expensive. Therefore, traditional herbal medicine is an alternative which is used for some people in maintaining normal blood sugar levels. The use of herbal therapy with a combination of plant extracts has the potential to be more effective in lowering blood sugar when compared to single plant extracts. The aim of this article review is that to compile and provide a scientific overview of the various studies which have been conducted previously regarding the effectiveness of combinations of herbal plant extracts in diabetes mellitus. A comprehensive literature study was conducted by using various electronic search databases with the keyword “Combination of antidiabetic extracts” and 30 international research journals which were combined into review articles were obtained which shows that combinations of plant extracts proved to be more effective in lowering blood glucose levels compared to single herbal plant extracts.
Tinjauan Pustaka : Optimasi Metode Budidaya Spons Demospongiae dan Bakteri Simbionnya Rozanah, Aida; Larasati, Ananda Oktafiani; Putri, Rizky Indah Febrianingsih Suddin; Hadisaputri, Yuni Elsa
Indonesian Journal of Biological Pharmacy Vol 3, No 1 (2023): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v3i1.39865

Abstract

Sumber Daya Alam berupa spons khususnya kelas Demospongiae memiliki jumlah yang banyak danberpotensi dalam mengembangkan berbagai bidang terutama bioteknologi. Maka dari itu, perludilakukan budidaya spons agar dapat mempertahankan keseimbangan alam dan ketersediaannya.Budidaya spons merupakan upaya memperbanyak spons dalam jumlah yang banyak dengan waktuyang relatif singkat. Diantara pertimbangan untuk menentukan optimasi metode adalah kedalamanserta substrat yang digunakan. Spons dapat bersimbiosis dengan bakteri. Simbiosis tersebut dapatmenghasilkan senyawa metabolit baru yang memiliki potensi aktivitas farmakologis khususnya dibidangfarmasi.
Potency of Peripheral Blood- and Umbilical Cord Blood-derived Dendritic Cells and Their Secretomes as Vaccines for Cancer Haifa, Rima; Sartika, Cynthia Retna; Faried, Ahmad; Hadisaputri, Yuni Elsa; Chouw, Angliana; Wijaya, Andi; Barliana, Melisa Intan
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.358

Abstract

Dendritic cell (DC) vaccines, as immunotherapy agents, can gather up and transport cancer-related antigens to T lymphocytes, activating anti-tumor effector responses. After being activated by DC, cytotoxic T lymphocyte cells (CTL) will secrete the cytolytic granzyme B that can effectively induce rapid apoptosis of target cells. On the other hand, DC also secrete several cytokines and a large number of exosomes, which together operate as a whole antigen-presenting entity. The efficacy of the vaccine’s treatment may be affected by the sources used for DC vaccines. Umbilical cord blood (UCB) from healthy donors can be employed when autologous cancer patient’s peripheral blood (PB) cannot be used as a source for isolating DC due to genetic abnormalities. Comparing UCB to other sources, there is a painless method of collecting sources as opposed to PB, which necessitates a venipuncture or leukapheresis procedure to isolate the blood. Many studies related to the use of PB-DC have been carried out, but research on potential comparisons between PB-DC and UCB-DC is still very limited. In this review, the potential of PB- and UCB-derived DC and their secretomes for cancer will be discussed.Keywords: dendritic cells, vaccines, umbilical cord blood, peripheral blood
Kajian Literatur: Potensi Ekstrak Tumbuhan sebagai Agen Fotoprotektif untuk Sediaan Tabir Surya Buwana, Sakanti Nabilah Bratandari; Hadisaputri, Yuni Elsa
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v4i2.55976

Abstract

Kajian literatur yang bertujuan untuk mengetahui tumbuhan yang memiliki berpotensi untuk menjadi agen fotoprotektif pada sediaan tabir surya dilihat dari aktivitas antioksidan dan aktivitas fotoprotektifnya.
Phytochemical Screening And Antioxidant Activity Test of Lupun Root (Poikilospermum suaveolens (Blume) Merr) from South of Borneo Mardiana, Lia; Milanda, Tiana; Hadisaputri, Yuni Elsa; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51350

Abstract

Lupun root is the local name for Poikilospermum suaveolens (Blume) Merr. in the Aranio region, South of Borneo, Indonesia. P.suaveolens is a medicinal plant traditionally used to treat various ailments and to enhance the body’s immune function. This study aimed to investigate the secondary metabolites and antioxidant capacity of the ethanol extract derived from the root of Lupun (P. suaveolens). Samples were collected from Aranio, South Borneo. Extraction was performed by maceration using 96% ethanol. The analysis included phytochemical screening and evaluation of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay measured by a UV-Vis spectrophotometer. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and phenolic compounds in the Lupun root extract. The antioxidant assay showed an IC50 value of 20.44 µg/mL, indicating strong antioxidant potential of the ethanol extract. These results highlight the plant’s promise as a candidate for pharmaceutical development.
Co-Authors Adryan Fristiohady Agung W.M. Yodha Ahmad Faried Anas Subarnas Anas Subarnas ANDI WIJAYA Andini Sundowo Angliana Chouw, Angliana Anis Yohana Chaerunisaa, Anis Yohana ANISA ROSDIANA Buwana, Sakanti Nabilah Bratandari CHIKA AULIA AFINA Cynthia Retna Sartika, Cynthia Retna DIANTINI, AJENG - Euis Julaeha Fauzia Azzahra, Fauzia FITRAH SYAFIRA PUTRI Haifa, Rima HANUN NABILA Hasna Nur Syahidah Hesti Renggana I. Sahidin Indah Pertiwi Iyan Sopyan Larasati, Ananda Oktafiani Mardiana, Lia MARITA ISTI WULANDARI Melisa Intan Barliana, Melisa Intan Mohammad Ghozali NONI CAHYANA Novaliana Devianti Sagita Putri, Refitha Nurul Putri, Rizky Indah Febrianingsih Suddin Raden Maya Febrianti Restu Amelia Apriyandi Riezki Amalia Rozanah, Aida Semesta, Cleopatra Diva Sofa Fajriah TIANA MILANDA W. Wahyuni