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All Journal Buletin Veteriner Udayana Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Jurnal Kesehatan Andalas Indonesian Journal of Human Nutrition Journal of Agromedicine and Medical Sciences Pharmascience Jurnal Gizi Klinik Indonesia Poltekita : Jurnal Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) Jurnal Kesehatan Kusuma Husada JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Information System (IJHIS)
Hairrudin Hairrudin
Department Of Biochemistry, Faculty Of Medicine, University Of Jember, Jember, East Java, Indonesia, 68121
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Efektivitas Ekstrak Putri Malu (Mimosa pudica Linn.) sebagai Nefroprotektor pada Tikus Wistar yang Diinduksi Parasetamol Dosis Toksik Ari Setyo Rini; Hairrudin Hairrudin; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The ethanolic extract of Mimosa pudica Linn. was evaluated for its nefroprotective and antioxidant activity against paracetamol induced kidney toxicity in wistar rats. Liver damage was induced by administration of 1.350 mg paracetamol/kg body weight. The ethanolic extract of Mimosa pudica Linn. (400mg/kg, 600mg/kg, and 800 mg/kg) was administered orally to the rats for 6 days. Curcuma® was given as positive control. All of the test drugs were administered orally by suspending in 1% of Na CMC solution. The nefroprotective activity was assessed using the levels of BUN and creatinine serum. The result revealed that all doses of the extracts showed effective activity in inhibiting the increase of BUN and creatinine serum and the doses of 800 mg/kg showed the biggest percent value (9,4% of BUN level and 12,19% of creatinine level). The positive control group could prevent the increase of BUN and creatinine serum better when compared with the group of Mimosa pudica Linn.The result of the present study indicated that the ethanolic extract of Mimosa pudica Linn. significantly prevent the increase of the level BUN and creatinine serum in wistar rats induced with paracetamol toxic dose.Keywords: Antioxidant, nefrotoxic, Mimosa pudica, paracetamol, BUN, creatinine.  
‘Propolis’ Protective Effect to Prevent Oxidative Stress Caused by Strenous Physical Activity (Swimming Stress) Hairrudin Hairrudin
Jurnal ILMU DASAR Vol 10 No 2 (2009)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Abstract

Strenous physical activity may give not only a possitive impact but also the negative one. One of the factors that produce negative impact is the increasing formation of oxydant that may cause tissues’ damages. In this kind of circumstances, the oxydant could make damages to the various components in the body, it calls oxydative stress. The effect of the oxydant to the unsaturated fatty acid cause a chain reaction that will break the fatty acid to become different kinds of substances, such as malondialdehid (MDA). The MDA produced then released into the circulatory system, made the serum level of MDA increasing. The influence of propolis as antioxidant may be prevent this problem. This study is a laboratory experiment using posttest-only control group design.  The samples of the experiment are 3-month male white rat with average weight between 180-220 grams. These samples are divided to three groups: (1) control group (2) exposure group that have to do strenous activity (30 days swimming stress) and (3) exposure group that have to do strenous activity (30 days swimming stress) and given propolis, each group consists of eight rats. The result of the study showed a higher average serum MDA level in exposure group (89.63 nmol/mL) than the control group (42.38 nmol/ml) significantly (p = 0.000). The influence of propolis could prevent oxidative stress wich was indicated by lower average serum MDA level (32.35 nmol/ml) significanly (p = 0.000).
Effect Artificial Rice Diet Administration to Coronary Artery Histopathology of Rat Model Type 2 DM Monika Roosyidah; Erfan Efendi; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6165

Abstract

The most common macrovascular complication of type 2 DM’s patiens is coronary artery disease caused by coronary artery stricture or spasm or both of them. The atherosclerosis process in coronary artery can be seen through coronary artery histopathology of rat. DM can be controlled so that the complication can be prevented, for example by controlling diet. Artificial rice with high fiber is one of breakthrough for DM patients diet. The purpose of this research is to know about the effects of artificial rice diet administration to coronary artery histopathology of rat model type 2 DM. Rats are divided to four groups consist of control normal group given standart feeding, PBA1;PBA2;PBB group are inducted by high fat diet and low dose STZ so that they become rat model type 2 DM. Since PBA1 is feeded by formula 1 artificial rice, PBA1 is feeded by formula 2 artificial rice and PBB is feeded by common rice. Rats are terminated and their hearts are taken away to make histopathology object and their coronary artery are seen under light microscope. Histopathology images are based on foam cell formed. Kruskal-Wallis’s result shows that p= 0,046 (p<0,05), so that there is a significant difference between groups.Keywords : DM, atherosclerosis, foam cell, coronary artery histopathology
The Relationship between Exposure Tobacco Smoke in Pregnant Women with Perinatal Death in Jember Regency Reny Ekawati; Supangat Supangat; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.9610

Abstract

Perinatal death is an indicator of the success implementing a country's health services. Perinatal death rate in Indonesia in 2012 was 26/1000 live births. In 2017 there were 225 cases of infant mortality from 34,669 births in Jember Regency. Perinatal death is influenced by maternal, infant, health services and the living environment. The environmental conditions of the residence can be affected by cigarette smoke. The aim of this study was to determine the relationship of exposure tobacco smoke in pregnant women with perinatal death in Jember Regency and to find out the main source of exposure tobacco smoke in pregnant women in Jember Regency. Type of research is analytic observation with case control study design. The sampling technique is consecutive sampling. The study sample was mothers who had a dead baby in the perinatal period (perinatal death) who resided in the Jember regency on the birth of January-December 2017. The sample size was 30 for each group. Collected data was carried out by univariate analysis and bivariate analysis using the chi-square test and fisher exact test if the chi-square test requirements were not met. Results of univariate analysis in this study showed that 89.47% of the main sources of exposure tobacco smoke originated from home and 73.68% from husbands. Results of the chi-square test between exposure tobacco smoke with perinatal death p value 0.579 (p> 0.05). Confounding variables that had no significant difference between the case and control groups were parity (p = 0.116, p> 0.05), education (p = 0.083, p> 0.05), birth distance (p = 0.26, p> 0.05), and birth attendants (p = 0.492, p> 0.05). Based on the results of these studies it can be concluded that exposure tobacco smoke in pregnant women is not associated with perinatal death and the main source of exposure tobacco smoke in pregnant women comes from home and at most from husbands. Keywords: exposure tobacco smoke, pregnant women, perinatal death
The Comparison of Bay Leaf and Celery Leaf Infusion Effect on Decreasing LDL Level in Dyslipidemic Wistar Rats Model Anjani Putri Retnaninggalih; Erfan Efendi; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 1 No 1 (2015)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was concluded that bay leaf and celery leaf infusion could reduce the LDL level in dyslipidemic wistar rat but there was no difference on the capability of the two different leafs on reducing LDL level. Keywords: dyslipidemia, LDL, bay leaf, celery leaf, wistar rats  
Effect of Cigarette Smoke Exposure Status on Pregnant Women as Passive Smokers with Birth Weight in Arjasa Health Center, Jember Regency Anis Talitha Damarawati; Dwita Aryadina Rachmawati; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.9650

Abstract

In Indonesia, there are around 65.6 million women and 43 million children exposed to cigarette smoke and thus act as passive smokers. If pregnant women act as passive smokers, then it can increase the risk of pregnancy complications, including LBW. Babies with LBW are one of the public health problems that must be considered because LBW is a major predictor of infant mortality, especially in the first month of life. The purpose of this study was to determine the effect of exposure to cigarette smoke on pregnant women as passive smokers on the incidence of LBW in Arjasa Health Center, Jember Regency. This type of research uses an observational analytic method with a retrospective case control study design. The sample of this study amounted to 60 people. The bivariate analysis using the chi square test stated that there was a significant relationship between exposure to 2x3 cigarette smoke (p = 0.031), exposure to 2x2 cigarette smoke (p = 0.030; OR = 4) and age of pregnant women (p = 0.033; OR = 5.2) with birth weight at Arjasa Community Health Center, Jember Regency. While the results of bivariate analysis using the chi square test stated that there was no significant relationship between jobs (p = 0.422; OR = 1.78), history of parity (0.784; OR = 1.3), and ANC frequency (p = 1,000; OR = 1.17). the results of multiple logistic regression analysis revealed that there was a significant effect between exposure to cigarette smoke (p = 0.050; OR = 3.39) and age (p = 0.037; OR = 4.6) on birth weight at Arjasa Health Center, Jember Regency. The conclusion of this study is that exposure to cigarette smoke has a significant relationship with birth weight and age is the most influential risk factor for birth weight in Arjasa Health Center, Jember Regency. Keywords: Birth weight, LBW, cigarette smoke exposure
Hepatoprotector Effect of Coconut Water (Cocos nucifera L.) and Folic Acid to the Liver Histopathological Desccription of Pregnant Wistar Female Rats (Rattus norvegicus) Induced by Carbamate Muhammad Rosyid Ridho; Aris Prasetyo; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.10758

Abstract

Abstract Carbamate is an insecticide with a working mechanism that inhibits the enzyme acetylcholineestrase (AChE). Obstacles to AChE will cause the formation of excessive free radicals in the body causing oxidative stress and causing lipid peroxidation in body cells, including hepatocyte cells in the liver. Pregnant women have a change in detoxification activity in the liver due to exposure to xenobiotic substances during pregnancy causing a decrease in cytochrome P450 1A2 (CYP1A2) which will cause an increase in free radicals and can damage liver cells. Coconut water contains antioxidants that can neutralize free radicals in the body. While folic acid can encourage improvement in morphology of liver cells. The purpose of this study was to determine the hepatoprotector effect of coconut water and folic acid on the histopathology of the liver of pregnant female wistar rats induced by carbamate. The design of this study is true experimental with a post test only control group design. The sampling method used is simple random sampling. The number of samples in this study were 28 rats divided into 4 groups K (aquades), P1 (carbamate), P2 (carbamate and coconut water), and P3 (carbamate and folic acid). At the end of the study rat liver was taken to then become histological preparations. The One Way ANOVA test results showed a significant difference between groups compared (p <0.05). Post hoc LSD test results showed that group P1 had damaged liver histopathology, there were significant differences with group K and P3 (p <0.05), but there were no significant differences when compared with group P2 (p = 0.826). Meanwhile, the P3 group had significant differences when compared with all groups (p <0.05). The conclusion of this study is that giving coconut water cannot prevent liver damage due to carbamate induction, while folic acid has been shown to prevent liver damage due to carbamate induction, from liver histopathology. Keywords: carbamate, coconut water, folic acid, liver histopathology
Efek kandungan serat beras analog terhadap ekspresi GLUT4 otot rangka tikus diabetes Azka Darajat; Elly Nurus Sakinah; Hairrudin Hairrudin
Jurnal Gizi Klinik Indonesia Vol 16, No 1 (2019): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1070.355 KB) | DOI: 10.22146/ijcn.31806

Abstract

Effect of analog rice’s fiber on skeletal muscles GLUT4 expression in diabetic rats Background: Disruption of glucose transportation in skeletal muscle through GLUT4 becomes a problem in diabetes. Analog rice that had been modified by adding dietary fiber could improve the expression of GLUT4.Objective: This study aims to know the effect of dietary fiber toward GLUT4 expression and to know the dietary fiber percentage in analog rice.Method: The research type is true experimental with post-test only group design. The samples consist of 24 male Wistar rats that are group into 4 groups (n=6 each group). Three groups were induced by giving a high-fat diet for 40 days and streptozotocin (STZ) 35 mg/kg BW was given at 33th day and one group was not induced. After the blood glucose level exceeded 135 mg/dl, the treatment was given. After 3 weeks, the rats were terminated and quadriceps femoris muscle tissue was taken for immunohistochemistry examination using rat GLUT4 polyclonal antibody. GLUT4 expression was quantified using an immunoreactive score (IRS-GLUT4). The data were analyzed using the Kruskal-Wallis test and Spearman test.Results: Statistical analyses showed that there were significant differences between groups with a moderate positive correlation (correlation coefficient=0,651; p=0,003).Conclusion: Dietary fiber in analog rice could improve skeletal muscle GLUT4 expression in Wistar rat diabetic model.
MANAJEMEN INTERVENSI NYERI PADA PLANTAR FASCIITIS: LAPORAN KASUS Erfan Efendi; Hairrudin Hairrudin; Sugiyanta Sugiyanta; Zahrah Febianti; Ika Rahmawati Sutejo
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 5 No 3 (2022): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Plantar fasciitis memiliki manifestasi klinis nyeri tumit yang disebabkan oleh peradangan pada plantar fascia. Penderita nyeri akut yang berkembang menjadi kronis tidak hanya menimbulkan masalah medis, melainkan juga masalah individu serta sosial. Penanganan nyeri kronis dengan manajemen intervensi berkembang sangat cepat dalam kurun waktu beberapa tahun terakhir. Seorang perempuan berusia 57 tahun datang ke rumah sakit dengan keluhan nyeri pada telapak kaki kiri sejak kurang lebih 4 bulan yang lalu. Nyeri terutama dikeluhkan saat bangun tidur pagi dan dipakai berjalan. Anamnesis dan pemeriksaan fisik lebih lanjut mengarahkan pada diagnosis plantar fasciitis. Manajemen intervensi nyeri dilakukan dengan memblok nervus tibialis posterior untuk mengurangi rasa nyeri pada daerah telapak kaki bagian medial dan lateral. Selanjutnya, pasien mendapat injeksi lokal proloterapi kombinasi lidokain dan dextrose pada plantar fascia. Tindakan dilakukan dengan panduan ultrasonografi (USG). Follow up dilakukan setelah 2 minggu. Penderita menyatakan perbaikan dengan tidak adanya nyeri, serta dapat melakukan kegiatan sehari-hari secara optimal. DOI : 10.35990/mk.v5n3.p321-331
Hubungan Antara Nilai Neutrophil-to-Lymphocyte Ratio (NLR) dengan Kadar Procalcitonin (PCT) pada Pasien COVID-19 di Kabupaten Jember Sofia Yusnur Rafida; Hairrudin Hairrudin; Muhammad Hasan
Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1999

Abstract

The neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are biomarkers that represent inflammatory activity and immune status as predictors for the prognosis of COVID-19 patients. NLR values and PCT levels are positively correlated with the severity of COVID-19, but the relationship between the two biomarkers is unclear. Objectives: To analyzed the correlation between NLR values and PCT levels in COVID-19 patients in Jember Regency. Methods: This cross-sectional analytic observational study, conducted from March to April 2022, took data from 444 confirmed COVID-19 patients at the Jember Clinic Plantation Hospital. Secondary data were obtained from medical records of inpatients for the period January–December 2021. Results: The average NLR value was 8.58, while the average PCT level was 0.43 ng/mL. The results of the Spearman Correlation Analysis showed a positive correlation between NLR values and PCT levels in COVID-19 patients in the Jember Regency with a p-value = 0.00 and a moderate degree of correlation with an r count of 0.41. Conclusion: There is a positive correlation between NLR values and PCT levels for COVID-19 patients in Jember Regency. It is necessary to carry out routine NLR and PCT examinations to consider predictors of disease severity and prognosis in COVID-19 patients.Keywords:  COVID-19, NLR, PCT
Co-Authors Ahlulkemal, Mohammad Daffa Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Anis Talitha Damarawati Anjani Putri Retnaninggalih Anjani Putri Retnaninggalih, Anjani Putri Ari Setyo Rini Aris Prasetyo Azka Darajat Cholis Abrori Cholis Abrori, Cholis Darajat, Azka Davina Amalia Dewantari, Septiarina Putri Dina Helianti Dwita Aryadina Rachmawati Eling Nurdianti Elly Nurus Sakinah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fath Arina Fahma Fawziyah Putri Maulida Heni Fatmawati Ichlasul Mahdi Fardhani Ika Rahmawati Sutejo Isa Ma&#039;rufi Jauhar Firdaus Jauhar Firdaus Komang Yunita Wiryaning Putri Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Mei Syafriadi Monika Roosyidah Muhammad Hasan Muhammad Hasan Muhammad Rosyid Ridho Mushab Mushab Mushab, Mushab Nahdah Ardelia Syafa Novan Krisno Adji Nurfahimi, Yudriani Nurmaida, Eny Paulina Samuellia Pipiet Wulandari Prajesiaji Praba Kumara Purnomo, Farah Fadhila Nasywa Putu Ratih Pradnyani Dewi Rafida, Sofia Yusnur Rayyan, Muhammad Isra Rafidin Rena Normasari Reny Ekawati Rumastika, Nindya Shinta Septyawati, Ratna Sofia Yusnur Rafida Sugiyanta Sugiyanta Sukadi Sukadi Supangat Supangat Triastiana Kurbaini, Feby Yan Agus Achtiar Yulestrina Widiastuti Zahrah Febianti Zahrah Febianti Zahrox, Iin Fatimatus