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All Journal Buletin Veteriner Udayana Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Jurnal Kesehatan Andalas Indonesian Journal of Human Nutrition Journal of Agromedicine and Medical Sciences Pharmascience Jurnal Gizi Klinik Indonesia Poltekita : Jurnal Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) Jurnal Kesehatan Kusuma Husada JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Information System (IJHIS)
Hairrudin Hairrudin
Department Of Biochemistry, Faculty Of Medicine, University Of Jember, Jember, East Java, Indonesia, 68121
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Perbandingan Peningkatan Kadar Malondialdehid (MDA) Serum setelah Olahraga Pagi dan Malam Hari pada Orang Tidak Terlatih Mushab, Mushab; Hairrudin, Hairrudin; Abrori, Cholis
Andalas Journal of Health Vol. 9 No. 2 (2020): Online June 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1312

Abstract

Olahraga mampu meningkatkan kadar radikal bebas dalam tubuh melalui beberapa mekanisme yaitu peningkatan aktivitas mitokondria, NADPH, dan XO serta inflamasi pada sel otot rangka yang mengakibatkan stimulasi aktivitas fagosit. Olahraga yang dilakukan pada malam hari memiliki beberapa mekanisme tambahan sehingga berpotensi menyebabkan peningkatan kadar radikal bebas lebih tinggi, yaitu faktor pencetus radikal bebas yang meningkat pada malam hari. Salah satu indikator untuk mengetahui kadar radikal bebas dalam tubuh yaitu malondialdehid (MDA). Tujuan: Menentukan perbandingan antara peningkatan kadar MDA serum setelah olahraga pada dan malam hari pada orang tidak terlatih. Penelitian ini merupakan uji klinis dengan pre dan post-test group design. Metode: Sampel berjumlah  20 mahasiswa Fakultas Kedokteran Universitas Jember yang tidak terlatih, masing-masing berperan ganda sebagai kelompok pagi (Kp) dan kelompok malam (Km) sehingga jumlah total sampel sebesar 40. Olahraga yang dilakukan berupa sepeda statis dengan intensitas 70-80% dari heart rate maksimal. Setelah satu minggu dilakukan croosing-over, yaitu sampel Kp dijadikan Km begitu pula sebaliknya. Pengukuran kadar MDA dilakukan sebelum dan setelah olahraga menggunakan metode TBARS. Peningkatan kadar MDA merupakan selisih dari kadar MDA setelah dan sebelum olahraga. Hasil: Peningkatan kadar MDA setelah olahraga pada pagi dan malam hari adalah 0,29±0,87 nmol/mL dan 1,13±1,2 nmol/mL. Hasil uji statistik menunjukkan ada perbedaan yang signifikan p=0,021 (p<0,05). Simpulan: Peningkatan kadar MDA setelah olahraga pada malam hari lebih tinggi dibandingkan dengan peningkatan kadar MDA setelah olahraga pada pagi hari pada orang yang tidak terlatih.Kata kunci: malondialdehid, olahraga, radikal bebas, TBARS
Hubungan Antara Nilai Neutrophil-to-Lymphocyte Ratio (NLR) dengan Kadar Procalcitonin (PCT) pada Pasien COVID-19 di Kabupaten Jember Rafida, Sofia Yusnur; Hairrudin, Hairrudin; Hasan, Muhammad
Andalas Journal of Health Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1999

Abstract

The neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are biomarkers that represent inflammatory activity and immune status as predictors for the prognosis of COVID-19 patients. NLR values and PCT levels are positively correlated with the severity of COVID-19, but the relationship between the two biomarkers is unclear. Objectives: To analyzed the correlation between NLR values and PCT levels in COVID-19 patients in Jember Regency. Methods: This cross-sectional analytic observational study, conducted from March to April 2022, took data from 444 confirmed COVID-19 patients at the Jember Clinic Plantation Hospital. Secondary data were obtained from medical records of inpatients for the period January–December 2021. Results: The average NLR value was 8.58, while the average PCT level was 0.43 ng/mL. The results of the Spearman Correlation Analysis showed a positive correlation between NLR values and PCT levels in COVID-19 patients in the Jember Regency with a p-value = 0.00 and a moderate degree of correlation with an r count of 0.41. Conclusion: There is a positive correlation between NLR values and PCT levels for COVID-19 patients in Jember Regency. It is necessary to carry out routine NLR and PCT examinations to consider predictors of disease severity and prognosis in COVID-19 patients.Keywords:  COVID-19, NLR, PCT
Supplementation Of Analog Rice İn Combination With Metformin Prevent Myocardial Cell Death İn Type 2 Diabetuc Rats Muhammad, Andi; Firdaus, Jauhar; Rumastika, Nindya Shinta; Hairrudin, Hairrudin; Sakinah, Elly Nurus
International Journal of Health and Information System Vol. 3 No. 1 (2025): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v3i1.55

Abstract

Type 2 diabetes (T2D) is an urgent health issue that leads to one of the most significant cardiovascular complications worldwide, diabetic cardiomyopathy (DCM), which is associated with high morbidity and mortality. Chronic hyperglycemia and oxidative stress are major contributor for DCM. Analog rice based of MOCAF and corn starch is a functional food recommended as nutritional supplementation to replace staple foods in T2D patients. Analog rice has a high fiber content, high resistant starch and low glycemic index, which can help lower blood sugar levels and prevent DM complications. MOCAF in analog rice is also rich in phenolic compounds, which has potential effect of antioxidant. Metformin is the first line oral therapy for T2D. The present study investigates the potential effects of an analog rice diet in combination with metformin, for the development of DCM. Type 2 diabetic rats were induced by HFD/STZ method and was treated by analog rice and metformin for 4 weeks. Myocardial cell death measured by pyknotic nuclei percentage was analysed. The study result demonstrate that analog rice and metformin prevent the myocardial cell damage observed in type 2 diabetic animals, highlighting analog rice potential as adjuvant therapy, for treating DCM has no clinical significance than metformin therapy alone.
Co-Authors Ahlulkemal, Mohammad Daffa Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Anis Talitha Damarawati Anjani Putri Retnaninggalih Anjani Putri Retnaninggalih, Anjani Putri Ari Setyo Rini Aris Prasetyo Azka Darajat Cholis Abrori Cholis Abrori, Cholis Darajat, Azka Davina Amalia Dewantari, Septiarina Putri Dina Helianti Dwita Aryadina Rachmawati Eling Nurdianti Elly Nurus Sakinah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fath Arina Fahma Fawziyah Putri Maulida Heni Fatmawati Ichlasul Mahdi Fardhani Ika Rahmawati Sutejo Isa Ma&#039;rufi Jauhar Firdaus Jauhar Firdaus Komang Yunita Wiryaning Putri Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Mei Syafriadi Monika Roosyidah Muhammad Hasan Muhammad Hasan Muhammad Rosyid Ridho Mushab Mushab Mushab, Mushab Nahdah Ardelia Syafa Novan Krisno Adji Nurfahimi, Yudriani Nurmaida, Eny Paulina Samuellia Pipiet Wulandari Prajesiaji Praba Kumara Purnomo, Farah Fadhila Nasywa Putu Ratih Pradnyani Dewi Rafida, Sofia Yusnur Rayyan, Muhammad Isra Rafidin Rena Normasari Reny Ekawati Rumastika, Nindya Shinta Septyawati, Ratna Sofia Yusnur Rafida Sugiyanta Sugiyanta Sukadi Sukadi Supangat Supangat Triastiana Kurbaini, Feby Yan Agus Achtiar Yulestrina Widiastuti Zahrah Febianti Zahrah Febianti Zahrox, Iin Fatimatus