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All Journal Buletin Veteriner Udayana Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Jurnal Kesehatan Andalas Indonesian Journal of Human Nutrition Journal of Agromedicine and Medical Sciences Pharmascience Jurnal Gizi Klinik Indonesia Poltekita : Jurnal Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) Jurnal Kesehatan Kusuma Husada JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Information System (IJHIS)
Hairrudin Hairrudin
Department Of Biochemistry, Faculty Of Medicine, University Of Jember, Jember, East Java, Indonesia, 68121
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Beras Analog dapat Mencegah Kerusakan Ginjal pada Tikus Induksi Kombinasi HFD dan STZ Hairrudin Hairrudin; Prajesiaji Praba Kumara; Rena Normasari
Indonesian Journal of Human Nutrition Vol. 8 No. 1 (2021)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2021.008.01.2

Abstract

Pengaturan diet pada diabetes mellitus (DM) dibutuhkan untuk mengendalikan kadar glukosa darah dan mencegah terjadinya komplikasi pada ginjal. Beras analog merupakan beras tiruan yang dibuat dari bahan pangan nonberas atau campuran dengan beras melalui teknik tertentu sehingga menyerupai beras. Beras analog diperkirakan dapat memperbaiki pengendalian kadar glukosa dan mencegah kerusakan ginjal karena memiliki kandungan serat dan resistant starch (RS) yang tinggi. Penelitian ini bertujuan untuk mengetahui efek beras analog dalam mencegah kerusakan ginjal pada tikus DM. Penelitian eksperimental ini menggunakan sampel ginjal tikus Wistar. Tikus dikelompokkan menjadi 4 kelompok (n=24), yaitu: kelompok kontrol (K0) dan tiga kelompok perlakuan (P). Kelompok K0 diberi pelet standar selama penelitian. Kelompok perlakuan diberi diet tinggi lemak selama 40 hari dan diiduksi streptozotocin (STZ) dosis 35 mg/kgBB pada hari ke-33. Hari ke-40 kelompok perlakuan dibagi menjadi 3 kelompok masing-masing diberi diet beras (PB), diet beras analog 1 (PBA1), dan diet beras analog 2 (PBA2) selama 3 minggu. Kerusakan ginjal diamati melalui gambaran histopatologi ginjal dan dinilai menggunakan sistem skoring berdasarkan tingkat glomerulosklerosis dan kerusakan tubulus. Hasil penelitian menunjukkan median skor glomerulosklerosis dan kerusakan tubulus pada K0=0,5 dan 1,0; PB=3,0 dan 4,0; PBA1=1,0 dan 2,5; PBA2=2,0 dan 3,0. Terdapat perbedaan signifikan (p<0,05) antara kelompok PB dengan PBA1 dan PBA2. Kesimpulannya adalah beras analog dapat mencegah kerusakan ginjal pada tikus DM
Efek Neem Gum Terhadap Kadar Glukosa Darah Tikus yang Diinduksi Streptozotosin Ichlasul Mahdi Fardhani; Jauhar Firdaus; Zahrah Febianti; Hairrudin Hairrudin; Cholis Abrori; Elly Nurus Sakinah
Buletin Veteriner Udayana Vol. 15 No. 5 October 2023
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2023.v15.i05.p35

Abstract

Pharmacological therapy for diabetes, which is primarily made up of chemicals, still causes a lot of side effects. The numerous side effects of pharmacological therapy for diabetes have generated innovations in alternative diabetes therapies using ingredients derived from nature. One of the natural ingredients with an anti-hyperglycemia effect is neem gum (NG), or the sap of the neem plant (Azadirachta indica). The aim of this study was to determine the effect of NG on the reduction of blood glucose levels. Moreover, this study had six groups, including a normal control group and groups with doses of 0, 3.75, 7.5, 15, and 30 grams/kgBW. The results showed that NG reduced blood glucose levels in diabetic rats. The paired t-test showed a significant reduction in blood glucose in all groups administered NG except for the dose 3.75 group (P<0.05). The minimum and maximum effective doses of NG were calculated using the quadratic regression test with the equation y = 1.059x2–46.576x+408. With a target blood glucose level of between 80 and 126 mg/dL, the minimum and maximum effective doses of NG were obtained in the range of 12–15 mg/dL. This study concluded that administering NG to diabetic rats can reduce blood glucose levels. Phytochemical studies and research are needed with serial examinations using the effective dose range of neem gum.
Evaluation of the Implementation of the Mining Safety Management System (SMKP) and Safety Culture in the Maintenance Department of PT Bumi Suksesindo Sukadi Sukadi; Isa Ma&#039;rufi; Hairrudin Hairrudin
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 2 (2023): August
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i2.2307

Abstract

Occupational accidents in Indonesia's Mineral and Coal (Minerba) mining sector are still quite high. In 2022, there were 11 of 93 cases of fatality accidents. Organizational factors that often become the basic cause of accidents are the non-optimal implementation of the work safety management system and the low level of Safety Culture. The mining safety management system (SMKP) has been implemented at PT Bumi Suksesindo, but the number of accidents was still high, namely 16 accidents in the Maintenance department in 2022. This study aims to evaluate the implementation of SMKP and the maturity level of OSH culture (safety culture) in the Maintenance department. This was an evaluation study with a descriptive approach. Data were collected using a questionnaire and document review. The number of samples was 140 of 214 population of field workers. A 5-point Likert scale was applied to analyze workers' perceptions of the implementation of SMKP. The causal factors were analyzed using Incident Cause Analysis Methodology (ICAM), while the evaluation of the Safety Culture level was performed through a frequency distribution based on the 5 levels of OSH culture in accordance with UK CoalJourney, namely Basic, Reactive, Planned, Proactive, Resilient. The implementation rate of the Mining Safety Management System (SMKP) in the Maintenance department of PT Bumi Suksesindo was 67%, which was included in the Good category. However, there were 16 occupational accident cases, and the organizational factor was the most common cause (45 findings). Furthermore, the OSH culture maturity level was 60.5%, included in the Resilient level. It can be concluded that the implementation of SMKP in the Maintenance department was still sub-optimal, and the OSH culture maturity level had not yet covered 100% of workers. Such a finding implies a high number of occupational accidents. It is necessary to supervise the implementation of the SMKP and plan an OSH culture improvement program by involving all workers to achieve the SMKP goal of preventing occupational accidents.
Correlation between Zinc Intake and Height of Children Aged 6-59 Months in Jelbuk and Sumberjambe Districts Eling Nurdianti; Hairrudin Hairrudin; Dwita Aryadina Rachmawati; Ancah Caesarina Novi Marchianti
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.42448

Abstract

Stunting is a nutritional problem that people around the world are facing. The World Health Organization (WHO) has determined Indonesia as one of the five stunting prevalence subregions in the Southeast Asia region. Zinc includes micro-nutrients that are important for the growth and development of children. The prevalence of zinc deficiency in children in Indonesia in 2006 was 36.1%. This study aims to determine the relationship between zinc intake and the length/height of children aged 6-59 months in the Districts of Jelbuk and Sumberjambe. This research is an analytic observational study with a cross-sectional design. The sample used was 119, derived from secondary data from previous studies. Zinc intake in children was obtained through 24-hour food recall data and then analyzed using nutrisurvey software, while body length/height is the maximum distance from the vertex to the soles of the feet. The study results were that 57.2% of the samples had insufficient zinc intake, with an average daily intake of 4.37 ± 2.35 mg, and as many as 60.5% had TB below normal. The data analysis showed a significant relationship between zinc intake and the length/height of children aged 6-59 months (p=0.001), with a reasonably strong relationship (r=0.295). This study concludes that there is a relationship between zinc intake and the length/height of children aged 6-59 months in the Jelbuk and Sumberjambe Districts. Keywords: Zinc, Stunted, Stunting
Determinant Analysis of Carpal Tunnel Syndrome and Phalen’s Test Examination of Tobacco Sorting Workers at Jember District Paulina Samuellia; Mei Syafriadi; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.43893

Abstract

Tobacco sorting officers in Jember Regency are still sorting tobacco leaves manually using hand muscles which can cause Musculo Skeletal Disorders (MSDs) complaints.One of the MSDs registered at the International Labor Organization (ILO) is Carpal Tunnel Syndrome (CTS) which is a disorder resulting from compression of the median nerve in the carpal tunnel at the wrist with the main symptom being tingling, pain radiating to the fingers which can be accompanied by numbness, weakness. muscles, stiffness, and possible muscle atrophy. This study aims to determine the factors associated with CTS supported by Phalen's test. This research is expected to provide information to workers and the public regarding health problems that can be experienced by tobacco sorting workers as well as being a consideration for increasing health insurance for these workers. This research was conducted using a cross-sectional survey design at PTPN A and PT B, Jember Regency with a sample calculation using the Slovin formula and obtained 246 respondents.The data analysis technique used was univariate SPSS analysis of frequency distribution, bivariate Chi Square analysis and SEM PLS multivariate analysis. research results show that education had an effect on the symptom severity scale, age had an influence on the symptom severity scale, age had an effect on the functional status scale and age had an influence on the Phalen's test. Conclusion:Age is the dominant factor affecting the symptom severity scale, functional status scale and Phalen's test. Keywords: CTS (Carpal Tunnel Syndrome), BCTQ (Boston Carpal Tunnel Questionnaire), SSS (Symptom Severity Scale), FSS (Functional Status Scale), Phalen's Test
ANALISIS FAKTOR RISIKO KEJADIAN ATRIAL FIBRILASI PADA PASIEN MITRAL STENOSIS DI RSD Dr. SOEBANDI JEMBER Hairrudin, Hairrudin; Triastiana Kurbaini, Feby; Wulandari, Pipiet
Jurnal Kesehatan Kusuma Husada Vol. 15 No. 2, Juli 2024
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34035/jk.v15i2.1308

Abstract

Mitral stenosis merupakan kelainan katup jantung dengan prevalensi yang masih tinggi di negara-negara berkembang seperti Indonesia. Penyakit ini menjadi penyebab tersering morbiditas dan mortalitas dini pada generasi muda di seluruh dunia. Salah satu komplikasi dari mitral stenosis adalah atrial fibrilasi yang dapat disebabkan oleh beberapa faktor risiko seperti, usia lanjut, dilatasi atrium sinistra, rendahnya nilai Left Ventricular Ejection Fraction (LVEF) dan Tricupsid Annular Plane Systolic Excursion (TAPSE), serta presentasi trombus. Penelitian ini bertujuan untuk menilai faktor risiko kejadian atrial fibrilasi pada pasien mitral stenosis. Penelitian ini menggunakan jenis analitik deskriptif dengan desain penelitian cross sectional. Sampel penelitian adalah seluruh pasien rawat jalan yang terdiagnosis mitral stenosis di Poli Jantung RSD dr. Soebandi Jember pada periode antara Januari 2022 - Januari 2024. Data variabel dianalisis menggunakan analisis univariat, bivariat (chi-square), dan multivariat (regresi logistik berganda). Jumlah sampel penelitian sebanyak 70 pasien, pasien mitral stenosis didominasi oleh wanita dan pasien berusia >40 tahun. Sebanyak 81% pasien mitral stenosis mengalami atrial fibrilasi. Dari enam variabel yang diteliti didapatkan bahwa derajat mitral stenosis (P = 0,005 ; OR = 12,744) dan usia >40 tahun (P = 0,012 ; OR = 15,835) memiliki hubungan yang signifikan terhadap kejadian atrial fibrilasi berdasarkan hasil uji bivariat dan multivariat. Dapat disimpulkan bahwa faktor risiko terkait kejadian atrial fibrilasi pada pasien mitral stenosis di RSD dr. Soebandi Jember adalah derajat mitral stenosis dan usia lanjut. Mitral stenosis is a heart valve disorder with a high prevalence in developing countries such as Indonesia. This disease is the most common cause of morbidity and premature mortality in young people throughout the world. One of the complications of mitral stenosis is atrial fibrillation, which can be caused by several risk factors such as advanced age, left atrial enlargement, low Left Ventricular Ejection Fraction (LVEF), and Tricupsid Annular Plane Systolic Excursion (TAPSE), as well as thrombus presentation. This study aims to assess the risk factors for atrial fibrillation in mitral stenosis patients. This research uses descriptive analytics with a cross-sectional research design. The research sample was all outpatients diagnosed with mitral stenosis at the Cardiac Polyclinic, RSD Dr. Soebandi Jember in the period between January 2022 - January 2024. Variable data was analyzed using univariate, bivariate (chi-square), and multivariate analysis (multiple logistic regression). The total research sample was 70 patients, with mitral stenosis patients being dominated by women and patients aged >40 years. As many as 81% of mitral stenosis patients experience atrial fibrillation. Of the six variables studied, it was found that the degree of mitral stenosis (P = 0.005; OR = 12.744) and age >40 years (P = 0.012; OR = 15.835) had a significant relationship with the incidence of atrial fibrillation based on the results of bivariate and multivariate tests. It can be concluded that the risk factors related to the incidence of atrial fibrillation in mitral stenosis patients at RSD Dr. Soebandi Jember is the degree of mitral stenosis and advanced age.
Identifikasi dan Konseling Pemakaian Alat Pelindung Diri pada Petani Gayasan B Desa Jenggawah Kabupaten Jember sugiyanta, sugiyanta; Hairrudin, Hairrudin; Efendi, Erfan; Febianti, zahrah; Sutejo, Ika Rahmawati; Septyawati, Ratna; Nurfahimi, Yudriani; Rayyan, Muhammad Isra Rafidin
Jurnal Pengabdian Pada Masyarakat Indonesia Vol 2 No 1 (2023): Februari: Jurnal Pengabdian Pada Masyarakat Indonesia
Publisher : Universitas Gajah Putih, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55542/jppmi.v2i1.240

Abstract

Indonesia merupakan negara Agraris dengan sektor pertanian menjadi salah satu kunci utama. Peningkatan produksi pertanian berkorelasi positif dengan penggunaan pestisida. Jika tidak bijak, pestisida menyebabkan berbagai masalah kesehatan. Untuk mencegah dan mengurangi efek buruk paparan pestisida, penting untuk menggunakan alat pelindung diri (APD) pada petani. Kegiatan ini bertujuan mengidentifikasi perilaku kepatuhan dan memberikan edukasi penggunaan APD untuk menghindari paparan pestisida. Kegiatan dilakukan melalui kerjasama FK Universitas Jember, pemerintah desa dan puskesmas Jenggawah. Kegiatan dilaksanakan di balai Dusun Gayasan B pada 18-19 Juni 2022, pukul 07.30-13.00 WIB. Jumlah sasaran dalam dua hari sebanyak 300 peserta. Tim pelaksana terdiri atas dosen, mahasiswa dan tenaga pendukung kegiatan, yang berjumlah 20 orang. Kegiatan terdiri atas pemeriksaan TTV, antropometri, anamnesis, identifikasi dan konseling mengenai penggunaan APD dilakukan oleh mahasiswa, dan konseling kesehatan dilakukan oleh dosen. Jumlah warga yang hadir dalam 2 hari mencapai 317 orang, dengan jumlah petani sebanyak 134 orang. 62 dari 134 petani menggunakan APD. Jenis APD yang sering digunakan oleh para petani adalah masker, baju lengan panjang dan sarung tangan. Melalui kegiatan ini diharapkan meningkatkan pengetahuan dan kesadaran petani terkait pentingnya APD, sehingga terbentuk masyarakat agrikultur yang sehat dan diharapkan visi Agromedis Fakultas Kedokteran Universitas Jember terimplementasi riil sebagai salah satu tri dharma perguruan tinggi.
Analisis Efek Terapi Kombinasi Beras Analog dan Glimepirid terhadap Kadar MDA Pankreas pada Tikus Diabetes Melitus Tipe 2 Ahlulkemal, Mohammad Daffa; Hairrudin, Hairrudin; Nurmaida, Eny
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.18891

Abstract

Prevalensi dan insidensi diabetes melitus tipe 2 (DMT 2) di dunia terus meningkat. Penyakit ini ditandai dengan hiperglikemia yang memicu kondisi stres oksidatif. Salah satu terapi oral yang sering digunakan adalah glimepirid. Pengendalian hiperglikemia pada penderita DM Tipe 2 membutuhkan perubahan gaya hidup, misalnya dengan mengubah menu makanan pokok dari beras padi menjadi beras analog yang terbuat dari bahan baku modified cassava flour (MOCAF) dan jagung. Beras analog ini mengandung resistant startch dan serat yang tinggi sehingga indeks glikemiknya rendah, serta mengandung antioksidan senyawa fenolik dan β karoten. Penelitian ini bertujuan mengetahui efek terapi kombinasi beras analog dan glimepirid terhadap kadar MDA pankreas pada tikus DMT 2. Tikus Wistar sebanyak 24 ekor dibagi menjadi kelompok kontrol dan 3 kelompok perlakuan. Pada kelompok perlakuan diberikan diet tinggi lemak selama 17 hari dan diinduksi STZ pada hari ke-15. Pada hari ke-18 kelompok perlakuan dibagi menjadi 3 kelompok masing-masing diberikan pakan standar (KN), diberikan pakan standar dan glimepirid dengan dosis 0,1 mg/KgBB/hari (P1), diberikan pakan beras analog dan glimepirid 0,1 mg/KgBB/hari (P2). Perlakuan tersebut dilakukan selama 21 hari. Pengukuran kadar MDA pankreas menggunakan metode ELISA. Hasil penelitian adalah kadar MDA kelompok kontrol = 0,437; KN = 0,649; P1 = 0,384; P2 = 0,300. Terdapat perbedaan yang signifikan antara KN dan P2. Kesimpulannya adalah kombinasi glimepirid dan beras analog mampu menurunkan kadar MDA pankreas pada tikus DM Tipe 2. Kata Kunci: Diabetes Melitus Tipe 2, MDA Pankreas, Glimepirid, Beras Analog, MOCAF  The prevalence and incidence of type 2 diabetes mellitus (T2DM) in the world continues to increase. This disease is characterized by hyperglycemia, which triggers oxidative stress conditions. One oral therapy that is often used is glimepiride. Controlling hyperglycemia in T2DM sufferers requires lifestyle changes, for example, changing the staple food from rice to analog rice made from modified cassava flour (MOCAF) and corn. This analog rice contains resistant starch and high fiber, so the glycemic index is low. It has antioxidant phenolic compounds and β-carotene. This study aims to determine the effect of rice analog and glimepiride combination therapy on pancreatic MDA levels in T2DM mice. Twenty-four Wistar rats were divided into the control group and three treatment groups. The treatment group was given a high-fat diet for 17 days and induced by STZ on the 15th day. On the 18th day, the treatment group was divided into three groups, each given standard feed (KN), standard feed and glimepiride 0,1 mg/KgBW/day (P1), and analog rice feed and glimepiride 0,1 mg/KgBW/day (P2). This treatment was carried out for 21 days. Measurement of pancreatic MDA levels using the ELISA method. The results in this study were MDA level of control group=0.437; KN=0.649; P1=0.384; P2=0.300. There is a significant difference between KN and P2. Conclusion: The combination of glimepiride and rice analogs can reduce pancreatic MDA levels in T2DM rats.
Peningkatan Risiko Infeksi Genital pada Pengguna SGLT-2 Inhibitor Purnomo, Farah Fadhila Nasywa; Hairrudin, Hairrudin; Indreswari, Laksmi
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.18846

Abstract

SGLT-2 inhibitor merupakan salah satu terapi farmakologis oral yang diberikan pada pasien Diabetes Mellitus tipe 2. Risiko infeksi genitourinari pada pengguna SGLT-2 inhibitor masih belum jelas. Penelitian ini bertujuan untuk menganalisis risiko infeksi saluran genitourinari pada pasien diabetes melitus tipe 2 yang diterapi menggunakan sodium-glucose co-transporter-2 (SGLT-2) inhibitor. Metode penulisan menggunakan desain penelitian tinjauan sistematis (Systematic Review). Pencarian jurnal dilakukan pada basis data Pubmed Central, Science Direct dan Google Scholar (pencarian hingga 17 Mei 2023) lalu diseleksi menggunakan Flowchart PRISMA. Studi yang diseleksi menggunakan design studi cohort/observational studies yang dibandingkan dengan terapi nonSGLT-2 inhibitor. Analisis data menggunakan metaanalisis. Hasil penelitian didapatkan 10 jurnal yang ditinjau secara sistematis tetapi hanya 6 jurnal yang dipat di metaanalisis dikarenakan heterogenitas yang tinggi. Empat jurnal dengan outcome infeksi saluran kemih yang dimetaanalisis menunjukkan risiko tidak signifkan (RR 0,98 95%CI 0,85-1,14; p= 0,80; I2=57%). Dua jurnal dengan outcome infeksi genital yang dimetaanalisis menghasilkan risiko 2,3 kali lipat lebih tinggi dibanding non-SGLT-2 inhibitor(RR 2,32 95%CI 2,04-2,64; p<0,00001; I2=36%). Kesimpulannya terjadi peningkatan risiko infeksi genital pada pasien diabetes melitus tipe 2 yang diterapi menggunakan sodium-glucose co-transporter-2 (SGLT-2) inhibitor yang signifikan sedangkan peningkatan risiko infeksi saluran kemih tidak signifikan. Kata Kunci: Diabetes Melitus Tipe 2, Infeksi Genital, Infeksi Saluran Kemih, Antidiabetes, SGLT-2 Inhibitor SGLT-2 inhibitors are an oral pharmacological therapy given to patients with type 2 diabetes mellitus. The risk of genitourinary infections in SGLT-2 inhibitor users is still unclear. This study aims to analyze the risk of genitourinary tract infections in patients with type 2 diabetes mellitus treated with sodium-glucose co-transporter-2 (SGLT-2) inhibitors. The method uses a systematic review research design.. Journal searches were carried out on the Pubmed Central, Science Direct, and Google Scholar databases (search until 17 May 2023) and then selected using the PRISMA Flowchart. The selected studies used a cohort/observational study design compared to nonSGLT-2 inhibitor therapy. Data analysis using meta-analysis. The results showed that 10 journals were reviewed systematically, but only 6 journals were included in the meta-analysis due to high heterogeneity. Four journals with urinary tract infection outcomes that were meta-analyzed showed an insignificant risk (RR 0.98 95%CI 0.85-1.14; p= 0.80; I2=57%). Two journals with meta-analyzed outcomes of genital infections resulted in a 2.3-fold higher risk compared to non-SGLT-2 inhibitors (RR 2.32 95%CI 2.04-2.64; p<0.00001; I2=36%). In conclusion, there was a significant increase in risk for genital infections while it was not significant for urinary tract infections.
Comparison of lipid-lactate levels between brain abscesses and brain tumors through magnetic resonance spectroscopy examination Nahdah Ardelia Syafa; Heni Fatmawati; Komang Yunita Wiryaning Putri; Hairrudin; Novan Krisno Adji
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art7

Abstract

Background: Intracranial masses are masses found in the intracranial space, such as brain abscesses and brain tumors. Magnetic Resonance Spectroscopy (MRS) examination is a noninvasive examination procedure with magnetic resonance regarding chemical composition or metabolites. One of the metabolites examined in MRS is lipid-lactate which will appear or increase if there are certain abnormalities such as in abscesses and brain tumors.Objective: This study analyzed the difference in lipid-lactate levels between brain abscess and brain tumor through MRS examination.Methods: This research adopted an observational analytic approach with a cross-sectional design. Samples in this study were brain abscess and brain tumor patients examined using MRI and MRS at Siloam Jember Hospital from June 2018 to October 2023. The sampling method employed encompassed a total sampling of 45 patients with 15 brain abscesses and 30 brain tumors. Results: The results of this study showed that the lipid-lactate levels of all brain abscess patients increased by 15 patients (100%), while in brain tumors, lipid-lactate levels increased by 19 patients (63.3%) and decreased by 11 patients (36.7%). The mean rank of lipid-lactate levels in brain abscesses was 14101,93 while in brain tumors was 6220,69. The statistical analysis results using the Mann-Whitney comparison test obtained a p-value of 0.008 (<0.05), meaning there is a significant difference.Conclusion: There is a significant difference in lipid-lactate levels in brain abscesses and brain tumors.
Co-Authors Ahlulkemal, Mohammad Daffa Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Anis Talitha Damarawati Anjani Putri Retnaninggalih Anjani Putri Retnaninggalih, Anjani Putri Ari Setyo Rini Aris Prasetyo Azka Darajat Cholis Abrori Cholis Abrori, Cholis Darajat, Azka Davina Amalia Dewantari, Septiarina Putri Dina Helianti Dwita Aryadina Rachmawati Eling Nurdianti Elly Nurus Sakinah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fath Arina Fahma Fawziyah Putri Maulida Heni Fatmawati Ichlasul Mahdi Fardhani Ika Rahmawati Sutejo Isa Ma&#039;rufi Jauhar Firdaus Jauhar Firdaus Komang Yunita Wiryaning Putri Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Mei Syafriadi Monika Roosyidah Muhammad Hasan Muhammad Hasan Muhammad Rosyid Ridho Mushab Mushab Mushab, Mushab Nahdah Ardelia Syafa Novan Krisno Adji Nurfahimi, Yudriani Nurmaida, Eny Paulina Samuellia Pipiet Wulandari Prajesiaji Praba Kumara Purnomo, Farah Fadhila Nasywa Putu Ratih Pradnyani Dewi Rafida, Sofia Yusnur Rayyan, Muhammad Isra Rafidin Rena Normasari Reny Ekawati Rumastika, Nindya Shinta Septyawati, Ratna Sofia Yusnur Rafida Sugiyanta Sugiyanta Sukadi Sukadi Supangat Supangat Triastiana Kurbaini, Feby Yan Agus Achtiar Yulestrina Widiastuti Zahrah Febianti Zahrah Febianti Zahrox, Iin Fatimatus