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Hairrudin Hairrudin
Department Of Biochemistry, Faculty Of Medicine, University Of Jember, Jember, East Java, Indonesia, 68121
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Beras Analog dapat Mencegah Kerusakan Ginjal pada Tikus Induksi Kombinasi HFD dan STZ Hairrudin Hairrudin; Prajesiaji Praba Kumara; Rena Normasari
Indonesian Journal of Human Nutrition Vol. 8 No. 1 (2021)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2021.008.01.2

Abstract

Pengaturan diet pada diabetes mellitus (DM) dibutuhkan untuk mengendalikan kadar glukosa darah dan mencegah terjadinya komplikasi pada ginjal. Beras analog merupakan beras tiruan yang dibuat dari bahan pangan nonberas atau campuran dengan beras melalui teknik tertentu sehingga menyerupai beras. Beras analog diperkirakan dapat memperbaiki pengendalian kadar glukosa dan mencegah kerusakan ginjal karena memiliki kandungan serat dan resistant starch (RS) yang tinggi. Penelitian ini bertujuan untuk mengetahui efek beras analog dalam mencegah kerusakan ginjal pada tikus DM. Penelitian eksperimental ini menggunakan sampel ginjal tikus Wistar. Tikus dikelompokkan menjadi 4 kelompok (n=24), yaitu: kelompok kontrol (K0) dan tiga kelompok perlakuan (P). Kelompok K0 diberi pelet standar selama penelitian. Kelompok perlakuan diberi diet tinggi lemak selama 40 hari dan diiduksi streptozotocin (STZ) dosis 35 mg/kgBB pada hari ke-33. Hari ke-40 kelompok perlakuan dibagi menjadi 3 kelompok masing-masing diberi diet beras (PB), diet beras analog 1 (PBA1), dan diet beras analog 2 (PBA2) selama 3 minggu. Kerusakan ginjal diamati melalui gambaran histopatologi ginjal dan dinilai menggunakan sistem skoring berdasarkan tingkat glomerulosklerosis dan kerusakan tubulus. Hasil penelitian menunjukkan median skor glomerulosklerosis dan kerusakan tubulus pada K0=0,5 dan 1,0; PB=3,0 dan 4,0; PBA1=1,0 dan 2,5; PBA2=2,0 dan 3,0. Terdapat perbedaan signifikan (p<0,05) antara kelompok PB dengan PBA1 dan PBA2. Kesimpulannya adalah beras analog dapat mencegah kerusakan ginjal pada tikus DM
Evaluation of the Implementation of the Mining Safety Management System (SMKP) and Safety Culture in the Maintenance Department of PT Bumi Suksesindo Sukadi Sukadi; Isa Ma&#039;rufi; Hairrudin Hairrudin
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 2 (2023): August
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i2.2307

Abstract

Occupational accidents in Indonesia's Mineral and Coal (Minerba) mining sector are still quite high. In 2022, there were 11 of 93 cases of fatality accidents. Organizational factors that often become the basic cause of accidents are the non-optimal implementation of the work safety management system and the low level of Safety Culture. The mining safety management system (SMKP) has been implemented at PT Bumi Suksesindo, but the number of accidents was still high, namely 16 accidents in the Maintenance department in 2022. This study aims to evaluate the implementation of SMKP and the maturity level of OSH culture (safety culture) in the Maintenance department. This was an evaluation study with a descriptive approach. Data were collected using a questionnaire and document review. The number of samples was 140 of 214 population of field workers. A 5-point Likert scale was applied to analyze workers' perceptions of the implementation of SMKP. The causal factors were analyzed using Incident Cause Analysis Methodology (ICAM), while the evaluation of the Safety Culture level was performed through a frequency distribution based on the 5 levels of OSH culture in accordance with UK CoalJourney, namely Basic, Reactive, Planned, Proactive, Resilient. The implementation rate of the Mining Safety Management System (SMKP) in the Maintenance department of PT Bumi Suksesindo was 67%, which was included in the Good category. However, there were 16 occupational accident cases, and the organizational factor was the most common cause (45 findings). Furthermore, the OSH culture maturity level was 60.5%, included in the Resilient level. It can be concluded that the implementation of SMKP in the Maintenance department was still sub-optimal, and the OSH culture maturity level had not yet covered 100% of workers. Such a finding implies a high number of occupational accidents. It is necessary to supervise the implementation of the SMKP and plan an OSH culture improvement program by involving all workers to achieve the SMKP goal of preventing occupational accidents.
Correlation between Zinc Intake and Height of Children Aged 6-59 Months in Jelbuk and Sumberjambe Districts Eling Nurdianti; Hairrudin Hairrudin; Dwita Aryadina Rachmawati; Ancah Caesarina Novi Marchianti
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.42448

Abstract

Stunting is a nutritional problem that people around the world are facing. The World Health Organization (WHO) has determined Indonesia as one of the five stunting prevalence subregions in the Southeast Asia region. Zinc includes micro-nutrients that are important for the growth and development of children. The prevalence of zinc deficiency in children in Indonesia in 2006 was 36.1%. This study aims to determine the relationship between zinc intake and the length/height of children aged 6-59 months in the Districts of Jelbuk and Sumberjambe. This research is an analytic observational study with a cross-sectional design. The sample used was 119, derived from secondary data from previous studies. Zinc intake in children was obtained through 24-hour food recall data and then analyzed using nutrisurvey software, while body length/height is the maximum distance from the vertex to the soles of the feet. The study results were that 57.2% of the samples had insufficient zinc intake, with an average daily intake of 4.37 ± 2.35 mg, and as many as 60.5% had TB below normal. The data analysis showed a significant relationship between zinc intake and the length/height of children aged 6-59 months (p=0.001), with a reasonably strong relationship (r=0.295). This study concludes that there is a relationship between zinc intake and the length/height of children aged 6-59 months in the Jelbuk and Sumberjambe Districts. Keywords: Zinc, Stunted, Stunting
Determinant Analysis of Carpal Tunnel Syndrome and Phalen’s Test Examination of Tobacco Sorting Workers at Jember District Paulina Samuellia; Mei Syafriadi; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.43893

Abstract

Tobacco sorting officers in Jember Regency are still sorting tobacco leaves manually using hand muscles which can cause Musculo Skeletal Disorders (MSDs) complaints.One of the MSDs registered at the International Labor Organization (ILO) is Carpal Tunnel Syndrome (CTS) which is a disorder resulting from compression of the median nerve in the carpal tunnel at the wrist with the main symptom being tingling, pain radiating to the fingers which can be accompanied by numbness, weakness. muscles, stiffness, and possible muscle atrophy. This study aims to determine the factors associated with CTS supported by Phalen's test. This research is expected to provide information to workers and the public regarding health problems that can be experienced by tobacco sorting workers as well as being a consideration for increasing health insurance for these workers. This research was conducted using a cross-sectional survey design at PTPN A and PT B, Jember Regency with a sample calculation using the Slovin formula and obtained 246 respondents.The data analysis technique used was univariate SPSS analysis of frequency distribution, bivariate Chi Square analysis and SEM PLS multivariate analysis. research results show that education had an effect on the symptom severity scale, age had an influence on the symptom severity scale, age had an effect on the functional status scale and age had an influence on the Phalen's test. Conclusion:Age is the dominant factor affecting the symptom severity scale, functional status scale and Phalen's test. Keywords: CTS (Carpal Tunnel Syndrome), BCTQ (Boston Carpal Tunnel Questionnaire), SSS (Symptom Severity Scale), FSS (Functional Status Scale), Phalen's Test
ANALISIS FAKTOR RISIKO KEJADIAN ATRIAL FIBRILASI PADA PASIEN MITRAL STENOSIS DI RSD Dr. SOEBANDI JEMBER Hairrudin, Hairrudin; Triastiana Kurbaini, Feby; Wulandari, Pipiet
Jurnal Kesehatan Kusuma Husada Vol. 15 No. 2, Juli 2024
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34035/jk.v15i2.1308

Abstract

Mitral stenosis merupakan kelainan katup jantung dengan prevalensi yang masih tinggi di negara-negara berkembang seperti Indonesia. Penyakit ini menjadi penyebab tersering morbiditas dan mortalitas dini pada generasi muda di seluruh dunia. Salah satu komplikasi dari mitral stenosis adalah atrial fibrilasi yang dapat disebabkan oleh beberapa faktor risiko seperti, usia lanjut, dilatasi atrium sinistra, rendahnya nilai Left Ventricular Ejection Fraction (LVEF) dan Tricupsid Annular Plane Systolic Excursion (TAPSE), serta presentasi trombus. Penelitian ini bertujuan untuk menilai faktor risiko kejadian atrial fibrilasi pada pasien mitral stenosis. Penelitian ini menggunakan jenis analitik deskriptif dengan desain penelitian cross sectional. Sampel penelitian adalah seluruh pasien rawat jalan yang terdiagnosis mitral stenosis di Poli Jantung RSD dr. Soebandi Jember pada periode antara Januari 2022 - Januari 2024. Data variabel dianalisis menggunakan analisis univariat, bivariat (chi-square), dan multivariat (regresi logistik berganda). Jumlah sampel penelitian sebanyak 70 pasien, pasien mitral stenosis didominasi oleh wanita dan pasien berusia >40 tahun. Sebanyak 81% pasien mitral stenosis mengalami atrial fibrilasi. Dari enam variabel yang diteliti didapatkan bahwa derajat mitral stenosis (P = 0,005 ; OR = 12,744) dan usia >40 tahun (P = 0,012 ; OR = 15,835) memiliki hubungan yang signifikan terhadap kejadian atrial fibrilasi berdasarkan hasil uji bivariat dan multivariat. Dapat disimpulkan bahwa faktor risiko terkait kejadian atrial fibrilasi pada pasien mitral stenosis di RSD dr. Soebandi Jember adalah derajat mitral stenosis dan usia lanjut. Mitral stenosis is a heart valve disorder with a high prevalence in developing countries such as Indonesia. This disease is the most common cause of morbidity and premature mortality in young people throughout the world. One of the complications of mitral stenosis is atrial fibrillation, which can be caused by several risk factors such as advanced age, left atrial enlargement, low Left Ventricular Ejection Fraction (LVEF), and Tricupsid Annular Plane Systolic Excursion (TAPSE), as well as thrombus presentation. This study aims to assess the risk factors for atrial fibrillation in mitral stenosis patients. This research uses descriptive analytics with a cross-sectional research design. The research sample was all outpatients diagnosed with mitral stenosis at the Cardiac Polyclinic, RSD Dr. Soebandi Jember in the period between January 2022 - January 2024. Variable data was analyzed using univariate, bivariate (chi-square), and multivariate analysis (multiple logistic regression). The total research sample was 70 patients, with mitral stenosis patients being dominated by women and patients aged >40 years. As many as 81% of mitral stenosis patients experience atrial fibrillation. Of the six variables studied, it was found that the degree of mitral stenosis (P = 0.005; OR = 12.744) and age >40 years (P = 0.012; OR = 15.835) had a significant relationship with the incidence of atrial fibrillation based on the results of bivariate and multivariate tests. It can be concluded that the risk factors related to the incidence of atrial fibrillation in mitral stenosis patients at RSD Dr. Soebandi Jember is the degree of mitral stenosis and advanced age.
Identifikasi dan Konseling Pemakaian Alat Pelindung Diri pada Petani Gayasan B Desa Jenggawah Kabupaten Jember sugiyanta, sugiyanta; Hairrudin, Hairrudin; Efendi, Erfan; Febianti, zahrah; Sutejo, Ika Rahmawati; Septyawati, Ratna; Nurfahimi, Yudriani; Rayyan, Muhammad Isra Rafidin
Jurnal Pengabdian Pada Masyarakat Indonesia Vol 2 No 1 (2023): Februari: Jurnal Pengabdian Pada Masyarakat Indonesia
Publisher : Universitas Gajah Putih, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55542/jppmi.v2i1.240

Abstract

Indonesia merupakan negara Agraris dengan sektor pertanian menjadi salah satu kunci utama. Peningkatan produksi pertanian berkorelasi positif dengan penggunaan pestisida. Jika tidak bijak, pestisida menyebabkan berbagai masalah kesehatan. Untuk mencegah dan mengurangi efek buruk paparan pestisida, penting untuk menggunakan alat pelindung diri (APD) pada petani. Kegiatan ini bertujuan mengidentifikasi perilaku kepatuhan dan memberikan edukasi penggunaan APD untuk menghindari paparan pestisida. Kegiatan dilakukan melalui kerjasama FK Universitas Jember, pemerintah desa dan puskesmas Jenggawah. Kegiatan dilaksanakan di balai Dusun Gayasan B pada 18-19 Juni 2022, pukul 07.30-13.00 WIB. Jumlah sasaran dalam dua hari sebanyak 300 peserta. Tim pelaksana terdiri atas dosen, mahasiswa dan tenaga pendukung kegiatan, yang berjumlah 20 orang. Kegiatan terdiri atas pemeriksaan TTV, antropometri, anamnesis, identifikasi dan konseling mengenai penggunaan APD dilakukan oleh mahasiswa, dan konseling kesehatan dilakukan oleh dosen. Jumlah warga yang hadir dalam 2 hari mencapai 317 orang, dengan jumlah petani sebanyak 134 orang. 62 dari 134 petani menggunakan APD. Jenis APD yang sering digunakan oleh para petani adalah masker, baju lengan panjang dan sarung tangan. Melalui kegiatan ini diharapkan meningkatkan pengetahuan dan kesadaran petani terkait pentingnya APD, sehingga terbentuk masyarakat agrikultur yang sehat dan diharapkan visi Agromedis Fakultas Kedokteran Universitas Jember terimplementasi riil sebagai salah satu tri dharma perguruan tinggi.
Perbandingan Peningkatan Kadar Malondialdehid (MDA) Serum setelah Olahraga Pagi dan Malam Hari pada Orang Tidak Terlatih Mushab, Mushab; Hairrudin, Hairrudin; Abrori, Cholis
Jurnal Kesehatan Andalas Vol. 9 No. 2 (2020): Online June 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1312

Abstract

Olahraga mampu meningkatkan kadar radikal bebas dalam tubuh melalui beberapa mekanisme yaitu peningkatan aktivitas mitokondria, NADPH, dan XO serta inflamasi pada sel otot rangka yang mengakibatkan stimulasi aktivitas fagosit. Olahraga yang dilakukan pada malam hari memiliki beberapa mekanisme tambahan sehingga berpotensi menyebabkan peningkatan kadar radikal bebas lebih tinggi, yaitu faktor pencetus radikal bebas yang meningkat pada malam hari. Salah satu indikator untuk mengetahui kadar radikal bebas dalam tubuh yaitu malondialdehid (MDA). Tujuan: Menentukan perbandingan antara peningkatan kadar MDA serum setelah olahraga pada dan malam hari pada orang tidak terlatih. Penelitian ini merupakan uji klinis dengan pre dan post-test group design. Metode: Sampel berjumlah  20 mahasiswa Fakultas Kedokteran Universitas Jember yang tidak terlatih, masing-masing berperan ganda sebagai kelompok pagi (Kp) dan kelompok malam (Km) sehingga jumlah total sampel sebesar 40. Olahraga yang dilakukan berupa sepeda statis dengan intensitas 70-80% dari heart rate maksimal. Setelah satu minggu dilakukan croosing-over, yaitu sampel Kp dijadikan Km begitu pula sebaliknya. Pengukuran kadar MDA dilakukan sebelum dan setelah olahraga menggunakan metode TBARS. Peningkatan kadar MDA merupakan selisih dari kadar MDA setelah dan sebelum olahraga. Hasil: Peningkatan kadar MDA setelah olahraga pada pagi dan malam hari adalah 0,29±0,87 nmol/mL dan 1,13±1,2 nmol/mL. Hasil uji statistik menunjukkan ada perbedaan yang signifikan p=0,021 (p<0,05). Simpulan: Peningkatan kadar MDA setelah olahraga pada malam hari lebih tinggi dibandingkan dengan peningkatan kadar MDA setelah olahraga pada pagi hari pada orang yang tidak terlatih.Kata kunci: malondialdehid, olahraga, radikal bebas, TBARS
Hubungan Antara Nilai Neutrophil-to-Lymphocyte Ratio (NLR) dengan Kadar Procalcitonin (PCT) pada Pasien COVID-19 di Kabupaten Jember Rafida, Sofia Yusnur; Hairrudin, Hairrudin; Hasan, Muhammad
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1999

Abstract

The neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are biomarkers that represent inflammatory activity and immune status as predictors for the prognosis of COVID-19 patients. NLR values and PCT levels are positively correlated with the severity of COVID-19, but the relationship between the two biomarkers is unclear. Objectives: To analyzed the correlation between NLR values and PCT levels in COVID-19 patients in Jember Regency. Methods: This cross-sectional analytic observational study, conducted from March to April 2022, took data from 444 confirmed COVID-19 patients at the Jember Clinic Plantation Hospital. Secondary data were obtained from medical records of inpatients for the period January–December 2021. Results: The average NLR value was 8.58, while the average PCT level was 0.43 ng/mL. The results of the Spearman Correlation Analysis showed a positive correlation between NLR values and PCT levels in COVID-19 patients in the Jember Regency with a p-value = 0.00 and a moderate degree of correlation with an r count of 0.41. Conclusion: There is a positive correlation between NLR values and PCT levels for COVID-19 patients in Jember Regency. It is necessary to carry out routine NLR and PCT examinations to consider predictors of disease severity and prognosis in COVID-19 patients.Keywords:  COVID-19, NLR, PCT
Supplementation Of Analog Rice İn Combination With Metformin Prevent Myocardial Cell Death İn Type 2 Diabetuc Rats Muhammad, Andi; Firdaus, Jauhar; Rumastika, Nindya Shinta; Hairrudin, Hairrudin; Sakinah, Elly Nurus
International Journal of Health and Information System Vol. 3 No. 1 (2025): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v3i1.55

Abstract

Type 2 diabetes (T2D) is an urgent health issue that leads to one of the most significant cardiovascular complications worldwide, diabetic cardiomyopathy (DCM), which is associated with high morbidity and mortality. Chronic hyperglycemia and oxidative stress are major contributor for DCM. Analog rice based of MOCAF and corn starch is a functional food recommended as nutritional supplementation to replace staple foods in T2D patients. Analog rice has a high fiber content, high resistant starch and low glycemic index, which can help lower blood sugar levels and prevent DM complications. MOCAF in analog rice is also rich in phenolic compounds, which has potential effect of antioxidant. Metformin is the first line oral therapy for T2D. The present study investigates the potential effects of an analog rice diet in combination with metformin, for the development of DCM. Type 2 diabetic rats were induced by HFD/STZ method and was treated by analog rice and metformin for 4 weeks. Myocardial cell death measured by pyknotic nuclei percentage was analysed. The study result demonstrate that analog rice and metformin prevent the myocardial cell damage observed in type 2 diabetic animals, highlighting analog rice potential as adjuvant therapy, for treating DCM has no clinical significance than metformin therapy alone.
Comparison of lipid-lactate levels between brain abscesses and brain tumors through magnetic resonance spectroscopy examination Syafa, Nahdah Ardelia; Fatmawati, Heni; Putri, Komang Yunita Wiryaning; Hairrudin; Adji, Novan Krisno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art7

Abstract

Background: Intracranial masses are masses found in the intracranial space, such as brain abscesses and brain tumors. Magnetic Resonance Spectroscopy (MRS) examination is a noninvasive examination procedure with magnetic resonance regarding chemical composition or metabolites. One of the metabolites examined in MRS is lipid-lactate which will appear or increase if there are certain abnormalities such as in abscesses and brain tumors.Objective: This study analyzed the difference in lipid-lactate levels between brain abscess and brain tumor through MRS examination.Methods: This research adopted an observational analytic approach with a cross-sectional design. Samples in this study were brain abscess and brain tumor patients examined using MRI and MRS at Siloam Jember Hospital from June 2018 to October 2023. The sampling method employed encompassed a total sampling of 45 patients with 15 brain abscesses and 30 brain tumors. Results: The results of this study showed that the lipid-lactate levels of all brain abscess patients increased by 15 patients (100%), while in brain tumors, lipid-lactate levels increased by 19 patients (63.3%) and decreased by 11 patients (36.7%). The mean rank of lipid-lactate levels in brain abscesses was 14101,93 while in brain tumors was 6220,69. The statistical analysis results using the Mann-Whitney comparison test obtained a p-value of 0.008 (<0.05), meaning there is a significant difference.Conclusion: There is a significant difference in lipid-lactate levels in brain abscesses and brain tumors.
Co-Authors Adji, Novan Krisno Ahlulkemal, Mohammad Daffa Ancah Caesarina Novi Marchianti Andi Muhammad, Andi Anis Talitha Damarawati Anjani Putri Retnaninggalih Ari Setyo Rini Aris Prasetyo Azka Darajat Cholis Abrori Cholis Abrori, Cholis Darajat, Azka Davina Amalia Dewantari, Septiarina Putri Dina Helianti Dwita Aryadina Rachmawati Eling Nurdianti Elly Nurus Sakinah Elly Nurus Sakinah, Elly Nurus Erfan Efendi Fath Arina Fahma Fawziyah Putri Maulida Heni Fatmawati Ichlasul Mahdi Fardhani Ika Rahmawati Sutejo Isa Ma&#039;rufi Jauhar Firdaus Jauhar Firdaus Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Mei Syafriadi Monika Roosyidah Muhammad Hasan Muhammad Hasan Muhammad Rosyid Ridho Mushab Mushab Mushab, Mushab Nurfahimi, Yudriani Nurmaida, Eny Paulina Samuellia Pipiet Wulandari Prajesiaji Praba Kumara Purnomo, Farah Fadhila Nasywa Putri, Komang Yunita Wiryaning Putu Ratih Pradnyani Dewi Rafida, Sofia Yusnur Rayyan, Muhammad Isra Rafidin Rena Normasari Reny Ekawati Rumastika, Nindya Shinta Septyawati, Ratna Sofia Yusnur Rafida Sugiyanta Sugiyanta Sukadi Sukadi Supangat Supangat Syafa, Nahdah Ardelia Triastiana Kurbaini, Feby Yan Agus Achtiar Yulestrina Widiastuti Zahrah Febianti Zahrah Febianti Zahrox, Iin Fatimatus