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All Journal Journal of Food and Pharmaceutical Science Techno (Jurnal Fakultas Teknik, Universitas Muhammadiyah Purwokerto) Proceeding Seminar LPPM UMP Tahun 2014 JURNAL PHARMASCIENCE PROSIDING SENATEK FAKULTAS TEKNIK UMP JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JRST (Jurnal Riset Sains dan Teknologi) Journal of Applied Science, Engineering, Technology, and Education Mattawang: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Molekul: Jurnal Ilmiah Kimia Media Farmasi Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu
Alwani Hamad
University of Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Crude Drug Standardization, Formula Optimization, and Interaction Effects of a Five-Component Antioxidant Polyherbal Formulation Wardani, Tri Kusuma; Arianingsih, Elfa; Syarifah, Arini; Hamad, Alwani; Hartanti, Dwi
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.353

Abstract

A polyherbal formulation was developed from java tea (Orthosiphon aristatus (Blume) Miq.), turmeric (Curcuma longa L.), seed-under-leaf (Phyllanthus niruri L.), cinnamon (Cinnamomum verum J. Presl), and ginger (Zingiber officinale Roscoe). This study aimed to standardize crude drugs, optimize polyherbal formulations, and evaluate the interaction effect of the crude drug mixture. Standardization followed these methods and compared them with the Indonesian Herbal Pharmacopeia (IHP) standards. The crude drugs were mixed in 26 different ratios, and each formulation was extracted using the decoction method. The antioxidant activities of the extracts were evaluated using 2-diphenyl-2-picryl hydroxyl scavenging (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The optimum formula was obtained by antioxidant activity-based prediction using the simplex lattice design (SLD) method. The interaction effects of crude drug mixtures were determined using a statistical comparison method for the predicted and obtained antioxidant activities. Crude java tea, turmeric, cinnamon, and ginger were of good quality. The five-component formulation with optimum antioxidant activity consisted of java tea, turmeric, seed-under-leaf, cinnamon, and ginger crude drugs in a ratio of 20-20-40-10-10 with interaction effects of additive toward DPPH radical scavenging activity (7.05±0.94 µmol TE/g) and antagonistic toward FRAP (19.37±0.94 µmol TE/g). Formula 21 (mixture of java tea and seed-under-leaf crude drugs) showed the highest DPPH scavenging activity (6.39±0.16 µmol TE/g) with synergistic effects, while the synergistic, highest FRAP (23.74±0.03 µmol TE/g) was shown by Formula 13 (mixture of seed-under-leaf and ginger crude drugs). 
Co-Authors Abdul Haris Mulyadi Afifah, Dini Nur Andi Ghina Septhea, Andi Ghina Arianingsih, Elfa Asmiyenti Djaliasrin Djalil Charisma, Shintia Lintang Dwi Hartanti Eli Nurlaeli, Eli Endar Puspawiningtyas, Endar Fadlilah, Intan Nur Fitri Atyani, Fitri Ganda Kurniawan, Ganda Haryanto, Totok Haryo Wibisono Hasanah, Yeti Rusmiati Heru Sutopo Istifah Istifah, Istifah M. Gigih Panji Mahardika, M. Gigih Panji Ma'ruf, Anwar Magribi, Imam Maulana Naveed, Mubshair Neni Damajanti, Neni Nur Afifah Andriyani Nur Afifah Handayani, Nur Afifah Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Puspitasari, Adinda Putri, Regita Nanda Regawa Bayu Pamungkas Rinawati, Jeri Santosa, Arif Prashadi Suparman Suparman Syah Putri, Tina Syarifah, Arini Wardani, Tri Kusuma Wicaksana, Firman Yulianingsih, Nur Yulianti , Henti