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All Journal Journal of Food and Pharmaceutical Science Techno (Jurnal Fakultas Teknik, Universitas Muhammadiyah Purwokerto) Proceeding Seminar LPPM UMP Tahun 2014 JURNAL PHARMASCIENCE PROSIDING SENATEK FAKULTAS TEKNIK UMP JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JRST (Jurnal Riset Sains dan Teknologi) Journal of Applied Science, Engineering, Technology, and Education Mattawang: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Molekul: Jurnal Ilmiah Kimia Media Farmasi Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia Indonesian Journal of Jamu
Alwani Hamad
University of Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Crude Drug Standardization, Formula Optimization, and Interaction Effects of a Five-Component Antioxidant Polyherbal Formulation Wardani, Tri Kusuma; Arianingsih, Elfa; Syarifah, Arini; Hamad, Alwani; Hartanti, Dwi
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.353

Abstract

A polyherbal formulation was developed from java tea (Orthosiphon aristatus (Blume) Miq.), turmeric (Curcuma longa L.), seed-under-leaf (Phyllanthus niruri L.), cinnamon (Cinnamomum verum J. Presl), and ginger (Zingiber officinale Roscoe). This study aimed to standardize crude drugs, optimize polyherbal formulations, and evaluate the interaction effect of the crude drug mixture. Standardization followed these methods and compared them with the Indonesian Herbal Pharmacopeia (IHP) standards. The crude drugs were mixed in 26 different ratios, and each formulation was extracted using the decoction method. The antioxidant activities of the extracts were evaluated using 2-diphenyl-2-picryl hydroxyl scavenging (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The optimum formula was obtained by antioxidant activity-based prediction using the simplex lattice design (SLD) method. The interaction effects of crude drug mixtures were determined using a statistical comparison method for the predicted and obtained antioxidant activities. Crude java tea, turmeric, cinnamon, and ginger were of good quality. The five-component formulation with optimum antioxidant activity consisted of java tea, turmeric, seed-under-leaf, cinnamon, and ginger crude drugs in a ratio of 20-20-40-10-10 with interaction effects of additive toward DPPH radical scavenging activity (7.05±0.94 µmol TE/g) and antagonistic toward FRAP (19.37±0.94 µmol TE/g). Formula 21 (mixture of java tea and seed-under-leaf crude drugs) showed the highest DPPH scavenging activity (6.39±0.16 µmol TE/g) with synergistic effects, while the synergistic, highest FRAP (23.74±0.03 µmol TE/g) was shown by Formula 13 (mixture of seed-under-leaf and ginger crude drugs). 
Crude Drugs Standardization, Total Flavonoid and Phenolic Content Profile, and Antimicrobial Activity of Red Ginger and Lemongrass Combination Puspitasari, Adinda; Hamad, Alwani; Hartanti, Dwi
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2008

Abstract

Baturraden people use a combination of red ginger rhizomes and lemongrass leaves for the treatment of masuk angin. This study aims to evaluate the quality profile of red ginger and lemongrass crude drug, total flavonoid content (TPC), total phenolic content (TFC), and the antimicrobial activities of their combination water extracts. The quality of both crude drugs was standardized to Indonesian Herbal Pharmacopeia (IHP). The TPC and TFC of red ginger and lemongrass combination in five different ratios were determined by standard UV-Vis spectrophotometry methods. The antimicrobial activity was evaluated using the microdilution method against patient-isolated multidrug-resistant (MDR) Staphylococcus aureus and Candida albicans. Lemongrass crude drugs were of good quality, while red ginger did not meet the acid-insoluble ash and volatile matter content requirements. The combination showed the highest TFC in a 75:25% ratio, while that of TPC was 50:50%. All combinations of lemongrass and red ginger extracts inhibited MDR Staphylococcus aureus and Candida albicans with a minimum inhibitory concentration (MIC) of 0.16 mg/ml. Candida albicans were more susceptible to the combination extracts. Red ginger rhizomes and lemongrass leaves 75:25% and 50:50% ratios showing comparable effects to the respective components. Hence, the combination of red ginger and lemongrass in 75:25 and 50:50% ratios potentially developed further for their masuk angin efficacy.
An Educational Intervention to Improve Knowledge of Local Medicinal Plants among Students Conducting Final Projects on Herbal Medicine Development Hartanti, Dwi; Utaminingrum, Wahyu; Zain, Dodi Siraj Mu'amar; Hamad, Alwani
Mattawang: Jurnal Pengabdian Masyarakat Vol. 6 No. 4 (2025)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.mattawang4404

Abstract

The diversity of medicinal plants found in Banyumas Regency has encouraged the Faculty of Pharmacy at Muhammadiyah University of Purwokerto to develop medicines from these natural ingredients actively. This is demonstrated through research projects, such as student final assignments, in this field. However, there are still many students from the Faculty of Pharmacy, UMP, who exhibit a gap between their high enthusiasm and limited in-depth knowledge of local medicinal plants, resulting in a weak scientific and cultural basis for their research in their final assignments. This community service activity aimed to enhance students’ knowledge and understanding of local medicinal plants, thereby supporting the quality and progress of their final assignments, which included topics related to herbal medicines. The method employed was a knowledge-refreshing program through education and hands-on practice. The activity involved 18 students (14 undergraduate and 4 postgraduate) and was conducted in July 2025. The stages included a pretest, education using leaflets and posters, field plant identification, and a Posttest. The program’s effectiveness was analyzed statistically using a T-test to compare the pretest and Posttest scores. The results indicated a highly significant increase in knowledge. The average Posttest scores (99.3 - 100.0) far exceeded the pretest scores (80.0 - 83.3), with a p-value < 0.05. This proves that the applied educational and practical methods were highly effective. A positive impact of this initiative was observed in the accelerated completion of final projects, where 7 students successfully defended their undergraduate theses with grades of A/A- and 4 other students completed their proposal seminars. In conclusion, this community service significantly improved students’ knowledge of local medicinal plants. The combined approach of visual education and field-based identification practice proved effective in equipping students with a solid understanding of their research subjects, which ultimately contributed directly to the timely and quality completion of their final assignments.
Co-Authors Abdul Haris Mulyadi Afifah, Dini Nur Andi Ghina Septhea, Andi Ghina Arianingsih, Elfa Asmiyenti Djaliasrin Djalil Charisma, Shintia Lintang Dwi Hartanti Eli Nurlaeli, Eli Endar Puspawiningtyas, Endar Fadlilah, Intan Nur Fitri Atyani, Fitri Ganda Kurniawan, Ganda Haryanto, Totok Haryo Wibisono Hasanah, Yeti Rusmiati Heru Sutopo Istifah Istifah, Istifah M. Gigih Panji Mahardika, M. Gigih Panji Ma'ruf, Anwar Magribi, Imam Maulana Naveed, Mubshair Neni Damajanti, Neni Nur Afifah Andriyani Nur Afifah Handayani, Nur Afifah Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Puspitasari, Adinda Putri, Regita Nanda Regawa Bayu Pamungkas Rinawati, Jeri Santosa, Arif Prashadi Suparman Suparman Syah Putri, Tina Syarifah, Arini Wahyu Utaminingrum Wardani, Tri Kusuma Wicaksana, Firman Yulianingsih, Nur Yulianti , Henti Zain, Dodi Siraj Mu'amar