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Vitamin D and Traumatic Brain Injury: A Systematic Review of Preclinical Evidence Jaslindo, Lieka Nugrahi; Sari, Widia; Dhuha, Alief; Handayani, Kurnia Maidarmi; Khudri, Ghaniyyatul Nugrahi; Maribeth, Annisa Lidra
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.2096

Abstract

Traumativ Brain Injury (TBI) triggers multiple secondary injury processes, such as inflammation, oxidative stress, apoptosis, BBB disruption, and impaired autophagy. These mechanisms contribute to progressive neuronal damage and functional decline. Vitamin D has emerged as a potential multi-target neuroprotective agent due to its regulatory roles in immune signaling, oxidative balance, neuronal survival, and autophagy pathways. This systematic review synthesized preclinical evidence evaluating the effects of Vitamin D supplementation in animal models of TBI. A comprehensive search of PubMed, OVID, and ProQuest identified six eligible studies. Across diverse dosing regimens and formulations, Vitamin D consistently improved key TBI outcomes. Reported benefits included reduced apoptosis, decreased neuroinflammation, attenuation of oxidative stress, preservation of BBB integrity, restoration of autophagy flux, and enhanced cognitive performance. Mechanistically, Vitamin D influenced several pathways, including Nrf2 activation, TLR4/MyD88/NF-κB suppression, mTOR and TRPM2 normalization, and improved microglial polarization. Although methodological quality varied, most studies demonstrated moderate rigor and supported the neuroprotective actions of Vitamin D. Heterogeneity in injury models, dosing strategies, and outcome measures limits direct comparison and highlights the need for standardized experimental approaches. Overall, current preclinical evidence indicates that Vitamin D confers robust neuroprotection following TBI. Further studies examining its mechanistic pathways, optimal therapeutic windows, and translational potential are warranted to inform future clinical applications.
Kualitas Tidur, Kecemasan, Tekanan Darah dan Hubungan pada Kejadian Hipertensi Lansia Bun Yurizali; Nurmaines Adhyka; Kurnia Maidarmi Handayani; Salsabila Maharani.S
Jurnal Kesehatan Vol 14 No 2 (2025): JURNAL KESEHATAN
Publisher : STIKES Ngesti Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46815/jk.v14i1.357

Abstract

Hypertension is a major health problem among the elderly, with rising prevalence. Sleep quality and anxiety contribute to blood pressure regulation, but their relationship is unclear. This study aims to analyze the relationship between sleep quality, anxiety, and blood pressure in hypertensive elderly patients at Puskesmas Air Dingin, Padang City. This study employed an analytical observational design with a cross-sectional approach. The sample included 42 hypertensive elderly patients registered at Puskesmas Air Dingin, selected by consecutive sampling. Data were analyzed using univariate and bivariate analyses, presented in frequency distribution, and processed with SPSS version 25.0. The results showed that most hypertensive elderly patients were aged 60-69 years (73.8%), with an equal gender distribution (50.0% male and female). The majority of respondents had poor sleep quality (83.3%) and mild anxiety (71.4%). No significant relationship emerged between sleep quality and systolic blood pressure (p=0.594), but a significant relationship was found between sleep quality and diastolic blood pressure (p=0.049). Additionally, anxiety was not associated with systolic (p=0.726) or diastolic blood pressure (p=0.647). In summary, poor sleep quality relates to higher diastolic blood pressure, while anxiety does not significantly correlate with blood pressure.
UPAYA PENCEGAHAN ANEMIA MELALUI EDUKASI ASUPAN NUTRISI DAN SUPLEMENTASI TABLET TAMBAH DARAH PADA REMAJA PEREMPUAN Annisa Lidra Maribeth; Widia Sari; Rialta Hamda; Ghaniyyatul Khudri; Kurnia Maidarmi Handayani
Jurnal Pengabdian Pendidikan Masyarakat (JPPM) Vol 6 No 1 (2025): Jurnal Pengabdian Pendidikan Masyarakat (JPPM), Vol 6 No 1 (Maret 2025)
Publisher : LPPM UNIVERSITAS MUHAMMADIYAH MUARA BUNGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52060/jppm.v6i1.2704

Abstract

Anemia is a common health problem worldwide, particularly among adolescent girls. This group is at high risk of anemia due to menstruation during adolescence, which leads to blood loss. Additionally, the increased need for iron in adolescent girls contributes to their vulnerability to anemia. Education about anemia and its prevention, as well as supplementation with iron tablets, is one solution to prevent and reduce the prevalence of anemia in females. Pesisir Selatan, a district in West Sumatra Province, recorded an increase in anemia prevalence in 2019. Based on this, it is necessary to provide education on anemia and its prevention to adolescent girls in the region. This counseling activity aimed to improve the knowledge and attitudes of adolescent girls regarding anemia. The activity consisted of pre-tests, counseling sessions, and post-tests. Counseling was conducted using lecture methods and interactive discussions with participants. Based on the evaluation of pre-test and post-test results, it was found that the counseling method was effective in increasing participants' knowledge. This was evidenced by a significant increase in participants' knowledge about anemia (p=0.004). The number of participants with good knowledge increased from 3 individuals (13.6%) to 7 individuals (31.8%), and none of the participants had poor knowledge after the counseling session. However, it was found that the counseling method did not significantly improve participants' attitudes towards anemia. In conclusion, although it did not affect participants' attitudes, the counseling method effectively enhanced their knowledge about anemia and is expected to help prevent anemia among adolescent girls
Enhancing caregivers’ knowledge through targeted health promotion: A study at TPA Adzkia Padang Annisa Lidra Maribeth; Ghaniyyatul Khudri; Rialta Hamda; Kurnia Maidarmi Handayani; Widia Sari
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol. 9 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jpm.v9i3.12407

Abstract

This study aimed to evaluate the effectiveness of health promotion activities for caregivers at the childcare center (TPA) Adzkia Padang. Health promotion sessions on PHBS (Clean and Healthy Living Behavior) and several health conditions including Chickenpox, Measles, Miliaria, and Diaper Dermatitis (CACAMINDER) were conducted. Participant knowledge levels were assessed using a questionnaire administered both before (pre-test) and after (post-test) the educational intervention. The distribution of knowledge levels and the scores from the pre-test and post-test were analyzed. Pre-test results indicated that 60% of participants had good knowledge, 40% had sufficient knowledge, and none had poor knowledge. Post-test results showed improvement, with 80% of participants demonstrating good knowledge and 20% having sufficient knowledge. No participants scored in the poor knowledge category. The maximum score increased from 11 to 12, while the minimum score remained constant at 8. The mean score also increased from 9 to 10. In conclusion, the health promotion activities significantly enhanced caregivers' knowledge of PHBS and various health conditions, as evidenced by improved post-test scores. These findings emphasize the importance of ongoing health education to empower caregivers with the knowledge necessary to promote and maintain toddler health.
Penyuluhan dan Skrining Tuberkulosis pada Anak di Panti Asuhan Ashabil Rayan Laura Zeffira; Kurnia Maidarmi Handayani; Febianne Eldrian; Mutiara Amonica
Abdika Sciena Vol 3 No 1 (2025): JURABDIKES Volume 3 No 1, Juni 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v3i1.235

Abstract

Tuberkulosis (TB) adalah penyakit menular yang masih menjadi masalah kesehatan global. Penyakit ini dapat ditemukan di semua usia termasuk anak. Indonesia menduduki peringkat kedua kasus TB terbanyak di dunia dengan perkiraan  1.060.000 kasus TB, dan sebanyak 110.881 kasus anak usia < 15 th pada tahun 2022. Kegiatan skrining sangat berguna untuk mendeteksi kasus TB secara dini serta mengurangi masalah penularan infeksi TB. Tujuan pengabdian masyarakat ini adalah untuk mendeteksi penularan TB anak terutama di wilayah panti asuhan Ashabil Rayan dengan sasaran seluruh anak yang bertempat tinggal di panti asuhan ashabil rayan dengan usia 5-14 tahun. Mengingat tingginya resiko penularan TB pada anak di asrama,  maka dilakukanlah penyuluhan serta skrining TB pada anak di wilayah panti asuhan Ashabil Rayan agar penyakit tuberkulosis dapat terdeteksi dan teratasi sejak dini.
DIFFERENCES BETWEEN FOREHEAD AND BACK OF THE HAND TEMPERATURE MEASUREMENTS USING NON-CONTACT INFRARED THERMOMETERS IN HEALTHY YOUNG ADULTS Rendri Bayu Hansah; Gusti Muhammad Dimas; Kurnia Maidarmi Handayani; Widia Sari; Annisa Lidra Maribeth; Lieka Nugrahi Jaslindo
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1848

Abstract

The COVID-19 pandemic necessitated the implementation of rapid, safe, and non-invasive body temperature screening methods to facilitate early identification of potentially infectious individuals. Non-contact infrared thermometers have therefore been widely adopted for this purpose. However, concerns have been raised regarding the accuracy of temperature measurements obtained from different anatomical sites, particularly in the context of increased reliance on alternative measurement locations such as the back of the hand (dorsum manus regio). This study aimed to compare body temperature measurements obtained from the forehead and dorsum manus using a non-contact infrared thermometer, with axillary temperature measured by a digital thermometer as a reference. An analytical observational study with repeated measures was conducted among 70 third-year medical students at Universitas Baiturrahmah. Temperature measurements were performed at the forehead, dorsum manus, and axilla, and participants were divided into control and intervention groups based on environmental measurement conditions. Repeated measures ANOVA revealed significant differences between forehead temperature and both dorsum manus and axillary temperatures, while no significant difference was observed between dorsum manus and axillary measurements. Independent t-tests showed no significant differences between control and intervention groups. These findings suggest that dorsum manus temperature measurements may approximate axillary values under stable conditions in healthy young adults, although caution is required when generalizing to other populations or clinical settings.