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All Journal JURNAL GIZI INDONESIA The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Plastik Rekonstruksi Jurnal Respirasi (JR) World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Archives of The Medicine and Case Reports Jurnal Ilmu Kesehatan Indonesia (JIKSI) Majalah Anestesia & Critical Care (MACC) Tarumanagara Medical Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Nurul Ratna Mutu Manikam
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Medical nutrition therapy in hospitalized patients with pemphigus vulgaris Bintari Anindhita; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 7 No. 01 (2023): Volume 07 Issue 1, August 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/10.25220/WNJ.V07.i1.0004

Abstract

Dysphagia due to involvement of the oral, pharyngolaryngeal, and esophageal mucosa and increased catabolism due to epidermal shedding can contribute to a decline in nutritional status in pemphigus vulgaris (PV) patients. On the other hand, decreased lean body mass is associated with immune system impairment, increased risk of infection, and delayed wound healing in PV patients, therefore, nutritional screening and assessment are necessary. Medical nutritional therapy in PV patients aims to overcome the metabolic response to the insults, prevent further malnutrition, modulate the immune system, and accelerate wound healing process. An aggressive nutritional support to minimize protein loss during the phase of mucocutaneous lesion healing is needed in patients with PV. Aside from macronutrient adequacy, micronutrients including vitamin A supplementation can be considered to accelerate wound healing process. Medical nutritional therapy including provision of adequate macronutrients, micronutrients, addressing dehydration and electrolyte imbalances should be the cornerstone of multidisciplinary treatment in PV patients.
Perioperative nutrition : ERAS special group discussion Luciana B Sutanto; Nurul Ratna Mutu Manikam; Adianto Nugroho
World Nutrition Journal Vol. 7 No. S1 (2023): Selected conference proceedings of the Nutri Symposium 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/V07.S1.0016

Abstract

Nutrition is one of the vital role in improving the healing and recovery after surgery, either preoperative (before surgery), intraoperative (during surgery), or postoperative (after surgery). The Enhanced Recovery After Surgery (ERAS) Society has published a multidisciplinary approach to perioperative care aimed at achieved early recovery for patients undergoing major surgery.
SUPLEMENTASI ASAM FOLAT PRAKONSEPSI DALAM PENCEGAHAN BIBIR SUMBING : EVIDENCE - BASED CASE REPORT Amelia Jessica; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.117

Abstract

Bibir sumbing merupakan kelainan bawaan yang sering dijumpai pada bayi baru lahir, terutama di negara berkembang. Faktor risikonya antara lain paparan terhadap rokok dan bahan kimia, konsumsi alkohol, serta asupan mikronutrien yang tidak memadai selama kehamilan. Dosis suplementasi asam folat yang lebih tinggi pada masa prakonsepsi berhubungan dengan penurunan risiko bibir sumbing. Tujuan: Mengetahui hubungan antara suplementasi asam folat prakonsepsi dengan risiko terjadinya bibir sumbing. Metode: Pencarian literatur dilakukan dengan advanced searching pada Pubmed, Cochrane Library, Scopus, dan ProQuest dengan kriteria eligibilitas yang ditentukan oleh penulis. Hasil: Studi systematic review-meta analisis oleh Jayarajan, et al. (2019) menjelaskan bahwa terdapat hubungan kuat antara suplementasi asam folat dosis tinggi dengan bibir sumbing. Studi kasus-kontrol yang menilai hubungan suplementasi asam folat prakonsepsi dengan penurunan risiko bibir sumbing dilakukan oleh 2 peneliti. Penelitian Xu W, et al. (2021) menjelaskan bahwa suplementasi asam folat prakonsepsi menurunkan risiko bibir sumbing (aOR = 0,52, 95% CI 0,30-0,90), sedangkan penelitian Mendonca VJ, et al. (2019) menjelaskan bahwa untuk mendapatkan efek samping pada 1 pasien diperlukan 71 pasien dengan suplementasi asam folat selama 1 tahun. Kesimpulan: Berdasarkan dua penelitian didapatkan hasil bahwa suplementasi asam folat prakonsepsi dapat menurunkan risiko bibir sumbing, namun diperlukan penelitian lebih lanjut.
The Effect of Probiotics on Radiation Enteritis in Endometrial Cancer Patients Undergoing Radiotherapy Godong, Bernardine; Ratna Mutumanikam, Nurul; Sunardi, Diana
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.551

Abstract

Introduction: Radiation enteritis is damage to the small and large intestines caused by radiation therapy for regional cancer treatment. The incidence is around 90% in patients undergoing radiation in the pelvic and abdominal regions. This study aimed to report the effect of probiotics on radiation enteritis in endometrial cancer patients. Case presentation: A 57-year-old morbidly obese woman diagnosed with endometrial cancer underwent chemoradiation therapy. On the 21st out of 25 radiation sessions and the 2nd chemotherapy session, the patient visited the nutrition clinic at the Radiation Oncology Therapy Center with a complaint of diarrhea for the past 5 days. The diarrhea occurred approximately 10 times a day, with each bowel movement being approximately 50 ml and yellow in color. The patient was then treated with anti-diarrheal therapy, probiotics (Lactobacillus acidophilus, Bifidobacterium longum, and Streptococcus thermophilus) 2 times a day, zinc 20 mg once a day, and prescribed a low-fat and lactose-free diet. After monitoring on the 21st day, the frequency of liquid bowel movements decreased to 2 times a day, and the appetite improved. Conclusion: Patients with radiation enteritis who are given probiotics may experience a reduction in symptoms of acute diarrhea. Direct administration of probiotics increases beneficial bacteria in the digestive tract.
The Role of Branched-Chain Amino Acids and Eicosapentaenoic Acid in Improving Body Composition and Functional Capacity in Nasopharyngeal Carcinoma Patients with Cancer Cachexia: A Case Report K.N, Beta Novianti; Krisadelfa Sutanto; Nurul Ratna Mutu Manikam
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.596

Abstract

Introduction: Cancer cachexia is a debilitating syndrome characterized by involuntary weight loss, muscle wasting, and functional decline, negatively impacting quality of life and survival. Nutritional interventions, including branched-chain amino acids (BCAAs) and eicosapentaenoic acid (EPA), have shown promise in ameliorating cachexia. This case report illustrates the potential benefits of these nutrients in a patient with nasopharyngeal carcinoma. Case presentation: A 65-year-old female presented with severe fatigue, dysphagia, and significant weight loss (11 kg in 6 months) secondary to nasopharyngeal carcinoma (T1N3Mx, stage IV). She was diagnosed with cancer cachexia and severe malnutrition. Nutritional therapy included enteral nutrition with 1.5-2 g/kgBW/day protein, 11-12 g/day BCAAs, and 1-2 g/day EPA. Conclusion: This case report suggests that a nutritional approach combining high protein, BCAAs, and EPA may improve body composition and functional capacity in patients with cancer cachexia. Further research is warranted to confirm these findings in larger studies.
Olive Oil and Vegetable Extract in Modified Hospital Enteral Formula Improves Glycemic Variability in Critically-Ill Diabetic Ketoacidosis Obese Patient: A Case Report Anindhita, Bintari; Singal, Anna Maurina; Wardhani, Wahyu Ika; Manikam, Nurul Ratna Mutu; Aditianingsih, Dita
Majalah Anestesia & Critical Care Vol 42 No 1 (2024): Februari
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v42i1.315

Abstract

Background: Severe hyperglycemia in diabetic ketoacidosis may elevate pro inflammatory cytokines, oxidative stress, and metabolic disruptions, impacting the nutritional status of critically ill patients. Diabetes-specific formula (DSF) administration is linked to favorable glycemic control, but research on the role of modified hospital enteral formulas in diabetic critical illness is lacking. Case Description: An obese 29-year-old male at risk of malnutrition, presented to the emergency room with decreased level of consciousness due to metabolic encephalopathy, diabetic ketoacidosis due to suspected type 1 diabetes mellitus, hypertension, and acute kidney injury. Medical nutritional therapy was provided via enteral route according to recent ESPEN, ASPEN and ADA recommendation. The administered enteral formula was a modified hospital-based enteral formula, consisting of a special kidney hospital-based enteral formula mixed with olive oil as source of monounsaturated fatty acid (MUFA) and vegetables as source of fibers. During the first week of hospitalization, the patient’s coefficient of variation (%CoV) of glycemic variability ranged between 17–61%, in addition, at the beginning of the second week of treatment there was also an increase in glycemic variability to 53%. This could be influenced by several factors. However, improvement in glycemic variability was observed in the following days. This improvement was in line with the gradual increase in MUFA and fiber intake, which reached its highest intake during the second week of hospitalization. Conclusion: Hospital-based enteral formula modified with olive oil and vegetable extract can be made to resemble the nutrients composition of diabetes specific formula and has a favorable effect on glycemic variability.
Validity test of the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria compared with the American Society for Parenteral and Enteral Nutrition (ASPEN) criteria in inpatients at Dr. Cipto Mangunkusumo hospital: A cross-sectional study Oentiono, Oki Yonatan; Manikam, Nurul Ratna Mutu
World Nutrition Journal Vol. 8 No. i1 (2024): Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0008

Abstract

Background: Malnutrition experienced by numerous inpatients is linked to various complications. The Global Leadership Initiative on Malnutrition (GLIM), which established the latest malnutrition criteria, recommends a two-step methodology for diagnosing malnutrition in adult inpatients. This study aims to evaluate the validity of the GLIM criteria for the diagnosis of malnutrition in hospitalized patients at Cipto Mangunkusomo Hospital Jakarta by comparing them with the ASPEN criteria. Methods: This cross-sectional study was conducted at Cipto Mangunkusomo Hospital, Jakarta. Secondary data was taken from 100 inpatients from October 2021 to February 2022 selected by consecutive sampling technique. The diagnosis of malnutrition in the patients applied the ASPEN and GLIM criteria. Furthermore, data were analyzed using Cohen's Kappa and chi-square tests. Results: Of 100 inpatients, 63% were diagnosed with malnutrition according to the GLIM diagnostic criteria. Meanwhile, 48% of them were found to be malnourished according to the ASPEN criteria. The GLIM criteria have a specificity of 69.2%, a sensitivity of 97.9%, a PPV of 74.6%, and an NPV of 97.3%. Conclusion: The GLIM diagnostic criteria are valid as an instrument for diagnosing malnutrition but require further research to assess the severity of malnutrition.
Effect of vitamin D3 supplementation on serum 25 (OH)D Levels, hand grip strength, blood sugar levels, and cognitive function in the elderly Probosari, Enny; Subagio, Hertanto Wahyu; Winarni, Tri Indah; Nugroho, Heri; Manikam, Nurul Ratna Mutu
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 1 (2024): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.1.79-87

Abstract

ABSTRACTBackground: The aging process in the elderly can be caused by a decrease in vitamin D precursors and reduced Vitamin D levels due to impaired absorption of Vitamin D. Vitamin D plays a role in cognitive function, acts as an immunomodulator affecting blood glucose levels, promotes muscle atrophy, and affects the intranuclear VDR concentration and gene expression of VDR.Objectives: To determine the effect of vitamin D3 supplementation on Serum 25(OH)D levels, hand grip strength, blood sugar levels, and cognitive function in the elderly.Materials and Methods: This study used a quasi-experimental pre-posttest control group design with a total of 60 subjects included and divided into two groups. The treatment group received vitamin D3 at a dosage of 1000 IU/day for three months, while the control group was given a placebo. Blood serum levels were used to obtained serum 25(OH)D and blood sugar level. Hand grip strength values were measured by a hand grip dynamometer, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) Questionnaire. The data was analyzed using the Wilcoxon test, and the bivariate analysis was performed using the Mann-Whitney test.Results: Most subjects were between 60 and 92 years old and had a vitamin D deficiency. Significant (P<0,05) differences were observed in serum 25(OH)D levels, blood sugar levels, and cognitive function following the intervention. The differences in serum 25(OH)D levels were 8,50±6,17, blood sugar levels were -21,68±25,88, and cognitive function was 2,23±3,05. Additionally, hand grip strength increased after the intervention (mean=0,42±4,66) but was not statistically significant (P=0,633).Conclusion: There is an improvement in cognitive function and a decrease in blood glucose levels, along with an increase in 25(OH)D levels after three months of vitamin D supplementation. However, hand grip strength did not significantly increase after supplementation.Keywords: Vitamin D3 Supplementation; serum 25(OH)D; hand grip strength; blood sugar level; cognitive function; elderly.
Increased Nutrition Intake from Day 1 to Day 7 and Its Correlation with LOS in The Burn Unit of Dr. Cipto Mangunkusumo Hospital Jakarta Sinaga, Wina; Nurul Ratna Mutu Manikam; Aditya Wardhana; Nandita Melati Putri; Lily Indriani Octovia; Akhmad Noviandi Syarif
Jurnal Plastik Rekonstruksi Vol. 9 No. 2 (2022): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v9i2.339

Abstract

Introduction : Burn patients as well as the critically ill experience strong oxidative stress, an intense inflammatory response, and a prolonged months-long hypermetabolic and catabolic response that affect nutritional requirements. This study aimed to investigate the nutrition intake in the acute phase from day 1 to day 7 and the correlation with length of stay (LOS) in burn patients in Dr. Cipto Mangunkusumo General Hospital.Method : This cross-sectional study was conducted from January to December 2020 in the Burn Unit of Dr. Cipto Mangunkusumo General Hospital. Research subjects were burns patients who were willing to take part in this research and met the research criteria. The characteristics data included gender, age, burn area, cause of burns, body mass index, and intake analysis were obtained from medical records and were analyzed using Spearman’s correlation and linear regression.Result : A total of 68 subjects were included in this study. There was an increase in energy intake from day 1 to day 7 of 10.81 + 12.73 Kcal/kgBW. There was a significant negative weak correlation between energy changes from day-1 to day-7 and length of stay (r = -0.25, p = 0.03).Conclusion: The higher energy increases within 7 days of treatment, the shorter the LOS of burn patients. Further research is still needed to assess the components that influence nutrition intake and how they impact the clinical outcome of burn patients.
The Role of Eicosapentaenoic Acid Supplementation on Muscle Mass in Malnutrition Patients with Squamous Cell Carcinoma of the Tongue: Case Report Kirana, Annisa Nurul; Sunardi, Diana; Manikam, Nurul Ratna Mutu; Rasyid, Nurhayati M
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.195

Abstract

The Indonesian prevalence of lip and oral cavity cancer in 2020 was 14,913, with 5,780 new cases. Head and neck cancer patients are very vulnerable to malnutrition; about 50% are malnourished, and 80% experience unwanted weight loss. Studies showed a significant effect of EPA as an anti-inflammatory substance. A 56-year-old female patient with a diagnosis of tongue squamous cell carcinoma (SCC) presents with the tumor removed along with some teeth. She is experiencing difficulty chewing food and had a weight loss of 8 kg (17%) in the last six months. The patient's muscle mass was 25.5% (low). Patients were given protein intake in the 1.1-1.8 g/kgbw/day range and EPA supplementation of 1.1 g/day. After one month, the BIA measurement showed that her muscle mass had increased to 26.2% and was in the normal category. Omega 3, especially EPA, improved body weight and lean body mass in cancer patients by modulating circulating inflammatory markers, demonstrating an inhibitory effect on inflammatory parameters related to muscle atrophy and lipolysis.Adequate protein intake and supplementation of 1.1 g/day EPA increased muscle mass in malnourished patients and enhanced the effectiveness of cancer therapy.
Co-Authors Adianto Nugroho Adityo Wibowo Akhmad Noviandi Syarif Amelia Jessica Anindhita, Bintari Astutik, Erni Badralany, Felianty Basalamah, Tarafainy Bintari Anindhita Budi Rahayu Diana Sunardi Dita Aditianingsih Dwirini Retno Gunarti Enny Probosari Fadilla, Chusnul Farapti Farapti Fariz, Nurwidya Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Godong, Bernardine Hajar, Siti Sarah Heri Nugroho Hertanto Wahyu Subagio Hidayat, Astriliana Febrianawati Inge Permadhi K.N, Beta Novianti Katya Saphira Kirana, Annisa Nurul Krisadelfa Sutanto Krisadelfa Sutanto Lily Indriani Octovia Luciana B Sutanto Marcia Kumala Marvin Marino Meilianawati Meilianawati Metta Satyani Muchtaruddin Mansyur Mulyana Mulyana Nandita Melati Putri Neni Sawitri Ninik Mudjihartini Oentiono, Oki Yonatan Oki Yonatan Oentiono Puspasari, Devi Rasyid, Nurhayati M Rizka Hanifa Singal, Anna Maurina Tri Indah Winarni Wahyu Ika Wardhani Wahyu Ika Wardhani Wardhana, Aditya Wiji Lestari Wina Sinaga Yohannessa Wulandari