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All Journal JURNAL GIZI INDONESIA The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Plastik Rekonstruksi Jurnal Respirasi (JR) World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Archives of The Medicine and Case Reports Jurnal Ilmu Kesehatan Indonesia (JIKSI) Majalah Anestesia & Critical Care (MACC) Tarumanagara Medical Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Nurul Ratna Mutu Manikam
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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SUPLEMENTASI ASAM FOLAT PRAKONSEPSI DALAM PENCEGAHAN BIBIR SUMBING : EVIDENCE - BASED CASE REPORT Amelia Jessica; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.117

Abstract

Bibir sumbing merupakan kelainan bawaan yang sering dijumpai pada bayi baru lahir, terutama di negara berkembang. Faktor risikonya antara lain paparan terhadap rokok dan bahan kimia, konsumsi alkohol, serta asupan mikronutrien yang tidak memadai selama kehamilan. Dosis suplementasi asam folat yang lebih tinggi pada masa prakonsepsi berhubungan dengan penurunan risiko bibir sumbing. Tujuan: Mengetahui hubungan antara suplementasi asam folat prakonsepsi dengan risiko terjadinya bibir sumbing. Metode: Pencarian literatur dilakukan dengan advanced searching pada Pubmed, Cochrane Library, Scopus, dan ProQuest dengan kriteria eligibilitas yang ditentukan oleh penulis. Hasil: Studi systematic review-meta analisis oleh Jayarajan, et al. (2019) menjelaskan bahwa terdapat hubungan kuat antara suplementasi asam folat dosis tinggi dengan bibir sumbing. Studi kasus-kontrol yang menilai hubungan suplementasi asam folat prakonsepsi dengan penurunan risiko bibir sumbing dilakukan oleh 2 peneliti. Penelitian Xu W, et al. (2021) menjelaskan bahwa suplementasi asam folat prakonsepsi menurunkan risiko bibir sumbing (aOR = 0,52, 95% CI 0,30-0,90), sedangkan penelitian Mendonca VJ, et al. (2019) menjelaskan bahwa untuk mendapatkan efek samping pada 1 pasien diperlukan 71 pasien dengan suplementasi asam folat selama 1 tahun. Kesimpulan: Berdasarkan dua penelitian didapatkan hasil bahwa suplementasi asam folat prakonsepsi dapat menurunkan risiko bibir sumbing, namun diperlukan penelitian lebih lanjut.
The Effect of Probiotics on Radiation Enteritis in Endometrial Cancer Patients Undergoing Radiotherapy Godong, Bernardine; Ratna Mutumanikam, Nurul; Sunardi, Diana
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.551

Abstract

Introduction: Radiation enteritis is damage to the small and large intestines caused by radiation therapy for regional cancer treatment. The incidence is around 90% in patients undergoing radiation in the pelvic and abdominal regions. This study aimed to report the effect of probiotics on radiation enteritis in endometrial cancer patients. Case presentation: A 57-year-old morbidly obese woman diagnosed with endometrial cancer underwent chemoradiation therapy. On the 21st out of 25 radiation sessions and the 2nd chemotherapy session, the patient visited the nutrition clinic at the Radiation Oncology Therapy Center with a complaint of diarrhea for the past 5 days. The diarrhea occurred approximately 10 times a day, with each bowel movement being approximately 50 ml and yellow in color. The patient was then treated with anti-diarrheal therapy, probiotics (Lactobacillus acidophilus, Bifidobacterium longum, and Streptococcus thermophilus) 2 times a day, zinc 20 mg once a day, and prescribed a low-fat and lactose-free diet. After monitoring on the 21st day, the frequency of liquid bowel movements decreased to 2 times a day, and the appetite improved. Conclusion: Patients with radiation enteritis who are given probiotics may experience a reduction in symptoms of acute diarrhea. Direct administration of probiotics increases beneficial bacteria in the digestive tract.
The Role of Branched-Chain Amino Acids and Eicosapentaenoic Acid in Improving Body Composition and Functional Capacity in Nasopharyngeal Carcinoma Patients with Cancer Cachexia: A Case Report K.N, Beta Novianti; Krisadelfa Sutanto; Nurul Ratna Mutu Manikam
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.596

Abstract

Introduction: Cancer cachexia is a debilitating syndrome characterized by involuntary weight loss, muscle wasting, and functional decline, negatively impacting quality of life and survival. Nutritional interventions, including branched-chain amino acids (BCAAs) and eicosapentaenoic acid (EPA), have shown promise in ameliorating cachexia. This case report illustrates the potential benefits of these nutrients in a patient with nasopharyngeal carcinoma. Case presentation: A 65-year-old female presented with severe fatigue, dysphagia, and significant weight loss (11 kg in 6 months) secondary to nasopharyngeal carcinoma (T1N3Mx, stage IV). She was diagnosed with cancer cachexia and severe malnutrition. Nutritional therapy included enteral nutrition with 1.5-2 g/kgBW/day protein, 11-12 g/day BCAAs, and 1-2 g/day EPA. Conclusion: This case report suggests that a nutritional approach combining high protein, BCAAs, and EPA may improve body composition and functional capacity in patients with cancer cachexia. Further research is warranted to confirm these findings in larger studies.
Olive Oil and Vegetable Extract in Modified Hospital Enteral Formula Improves Glycemic Variability in Critically-Ill Diabetic Ketoacidosis Obese Patient: A Case Report Anindhita, Bintari; Singal, Anna Maurina; Wardhani, Wahyu Ika; Manikam, Nurul Ratna Mutu; Aditianingsih, Dita
Majalah Anestesia & Critical Care Vol 42 No 1 (2024): Februari
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v42i1.315

Abstract

Background: Severe hyperglycemia in diabetic ketoacidosis may elevate pro inflammatory cytokines, oxidative stress, and metabolic disruptions, impacting the nutritional status of critically ill patients. Diabetes-specific formula (DSF) administration is linked to favorable glycemic control, but research on the role of modified hospital enteral formulas in diabetic critical illness is lacking. Case Description: An obese 29-year-old male at risk of malnutrition, presented to the emergency room with decreased level of consciousness due to metabolic encephalopathy, diabetic ketoacidosis due to suspected type 1 diabetes mellitus, hypertension, and acute kidney injury. Medical nutritional therapy was provided via enteral route according to recent ESPEN, ASPEN and ADA recommendation. The administered enteral formula was a modified hospital-based enteral formula, consisting of a special kidney hospital-based enteral formula mixed with olive oil as source of monounsaturated fatty acid (MUFA) and vegetables as source of fibers. During the first week of hospitalization, the patient’s coefficient of variation (%CoV) of glycemic variability ranged between 17–61%, in addition, at the beginning of the second week of treatment there was also an increase in glycemic variability to 53%. This could be influenced by several factors. However, improvement in glycemic variability was observed in the following days. This improvement was in line with the gradual increase in MUFA and fiber intake, which reached its highest intake during the second week of hospitalization. Conclusion: Hospital-based enteral formula modified with olive oil and vegetable extract can be made to resemble the nutrients composition of diabetes specific formula and has a favorable effect on glycemic variability.
Effect of vitamin D3 supplementation on serum 25 (OH)D Levels, hand grip strength, blood sugar levels, and cognitive function in the elderly Probosari, Enny; Subagio, Hertanto Wahyu; Winarni, Tri Indah; Nugroho, Heri; Manikam, Nurul Ratna Mutu
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 1 (2024): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.1.79-87

Abstract

ABSTRACTBackground: The aging process in the elderly can be caused by a decrease in vitamin D precursors and reduced Vitamin D levels due to impaired absorption of Vitamin D. Vitamin D plays a role in cognitive function, acts as an immunomodulator affecting blood glucose levels, promotes muscle atrophy, and affects the intranuclear VDR concentration and gene expression of VDR.Objectives: To determine the effect of vitamin D3 supplementation on Serum 25(OH)D levels, hand grip strength, blood sugar levels, and cognitive function in the elderly.Materials and Methods: This study used a quasi-experimental pre-posttest control group design with a total of 60 subjects included and divided into two groups. The treatment group received vitamin D3 at a dosage of 1000 IU/day for three months, while the control group was given a placebo. Blood serum levels were used to obtained serum 25(OH)D and blood sugar level. Hand grip strength values were measured by a hand grip dynamometer, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) Questionnaire. The data was analyzed using the Wilcoxon test, and the bivariate analysis was performed using the Mann-Whitney test.Results: Most subjects were between 60 and 92 years old and had a vitamin D deficiency. Significant (P<0,05) differences were observed in serum 25(OH)D levels, blood sugar levels, and cognitive function following the intervention. The differences in serum 25(OH)D levels were 8,50±6,17, blood sugar levels were -21,68±25,88, and cognitive function was 2,23±3,05. Additionally, hand grip strength increased after the intervention (mean=0,42±4,66) but was not statistically significant (P=0,633).Conclusion: There is an improvement in cognitive function and a decrease in blood glucose levels, along with an increase in 25(OH)D levels after three months of vitamin D supplementation. However, hand grip strength did not significantly increase after supplementation.Keywords: Vitamin D3 Supplementation; serum 25(OH)D; hand grip strength; blood sugar level; cognitive function; elderly.
Increased Nutrition Intake from Day 1 to Day 7 and Its Correlation with LOS in The Burn Unit of Dr. Cipto Mangunkusumo Hospital Jakarta Sinaga, Wina; Nurul Ratna Mutu Manikam; Aditya Wardhana; Nandita Melati Putri; Lily Indriani Octovia; Akhmad Noviandi Syarif
Jurnal Plastik Rekonstruksi Vol. 9 No. 2 (2022): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v9i2.339

Abstract

Introduction : Burn patients as well as the critically ill experience strong oxidative stress, an intense inflammatory response, and a prolonged months-long hypermetabolic and catabolic response that affect nutritional requirements. This study aimed to investigate the nutrition intake in the acute phase from day 1 to day 7 and the correlation with length of stay (LOS) in burn patients in Dr. Cipto Mangunkusumo General Hospital.Method : This cross-sectional study was conducted from January to December 2020 in the Burn Unit of Dr. Cipto Mangunkusumo General Hospital. Research subjects were burns patients who were willing to take part in this research and met the research criteria. The characteristics data included gender, age, burn area, cause of burns, body mass index, and intake analysis were obtained from medical records and were analyzed using Spearman’s correlation and linear regression.Result : A total of 68 subjects were included in this study. There was an increase in energy intake from day 1 to day 7 of 10.81 + 12.73 Kcal/kgBW. There was a significant negative weak correlation between energy changes from day-1 to day-7 and length of stay (r = -0.25, p = 0.03).Conclusion: The higher energy increases within 7 days of treatment, the shorter the LOS of burn patients. Further research is still needed to assess the components that influence nutrition intake and how they impact the clinical outcome of burn patients.
The Role of Eicosapentaenoic Acid Supplementation on Muscle Mass in Malnutrition Patients with Squamous Cell Carcinoma of the Tongue: Case Report Kirana, Annisa Nurul; Sunardi, Diana; Manikam, Nurul Ratna Mutu; Rasyid, Nurhayati M
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.195

Abstract

The Indonesian prevalence of lip and oral cavity cancer in 2020 was 14,913, with 5,780 new cases. Head and neck cancer patients are very vulnerable to malnutrition; about 50% are malnourished, and 80% experience unwanted weight loss. Studies showed a significant effect of EPA as an anti-inflammatory substance. A 56-year-old female patient with a diagnosis of tongue squamous cell carcinoma (SCC) presents with the tumor removed along with some teeth. She is experiencing difficulty chewing food and had a weight loss of 8 kg (17%) in the last six months. The patient's muscle mass was 25.5% (low). Patients were given protein intake in the 1.1-1.8 g/kgbw/day range and EPA supplementation of 1.1 g/day. After one month, the BIA measurement showed that her muscle mass had increased to 26.2% and was in the normal category. Omega 3, especially EPA, improved body weight and lean body mass in cancer patients by modulating circulating inflammatory markers, demonstrating an inhibitory effect on inflammatory parameters related to muscle atrophy and lipolysis.Adequate protein intake and supplementation of 1.1 g/day EPA increased muscle mass in malnourished patients and enhanced the effectiveness of cancer therapy.
SCREEN TIME ON WEEKDAY AND WEEKEND AMONG HEALTH COLLEGE STUDENTS AND THE CORRELATION TO NUTRITIONAL STATUS Farapti, Farapti; Puspasari, Devi; Astutik, Erni; Fadilla, Chusnul; Nurul Ratna Mutu Manikam
The Indonesian Journal of Public Health Vol. 20 No. 1 (2025): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v20i1.2025.107-119

Abstract

Introduction: The prevalence of obesity in Indonesia reached 21.8% in 2018 and increased by 6.4% compared to 2013. Low physical activity is known as a risk factor of obesity. College students’ activities are closely related to use of screen time. Aims: To identify the activities of screen time for assignments and non-assignments on weekdays and weekends among college student and analyze its relationship with body mass index (BMI).  Methods: This study was conducted in 2018 with a cross sectional design among undergraduate students at the Faculty of Public Health, Universitas Airlangga, Indonesia, conducted in 2018. The screen time questionnaire was adapted from Sedentary Behavior Questionnaire. The correlation between screen time duration and BMI was analysed by Spearman test. Results: The female subjects were dominant (81.1%) and 28.4% of subjects as overweight-obese. The screen time duration in non-assignment activity on weekends has a positive correlation with the nutritional status of health college students (p 0.000, r 0.49), particularly duration of social networking sites and listening to music were more significant in obese than normal. The use of smartphones takes a high part, approximately 4 hours 20 minutes both on weekdays and on weekends. Conclusion: The screen time duration in non-assignment activity on weekend was associated to nutritional status of health college students. Health college students are encouraged to reduce screen time for non-assignment activities on weekends and to use wisely several smartphone applications or social networking sites to control body weight and achieve a balanced nutritional status.
Efek pemberian suplementasi vitamin D terhadap kejadian kekambuhan pasien inflammatory bowel disease: An evidence-based case report Hidayat, Astriliana Febrianawati; Manikam, Nurul Ratna Mutu
Tarumanagara Medical Journal Vol. 7 No. 1 (2025): TARUMANAGARA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/tmj.v7i1.34092

Abstract

Inflammatory Bowel Disease (IBD), yang mencakup Crohn’s Disease (CD) dan Ulcerative Colitis (UC), merupakan penyakit radang kronis saluran cerna yang dapat timbul berulang. Pasien IBD rentan mengalami defisiensi mikronutrien termasuk vitamin D akibat gangguan absorpsi, malnutrisi, dan peradangan kronis. Beberapa studi menunjukkan bahwa vitamin D mempunyai peran imunomodulator dan antiinflamasi yang berpotensi menurunkan angka kekambuhan IBD. Studi ini bertujuan untuk mengevaluasi efektivitas suplementasi vitamin D dalam menurunkan angka kekambuhan pada pasien dengan IBD melalui telaah bukti ilmiah terkini. Metode pencarian literatur dilakukan melalui basis data PubMed, CENTRAL, dan Google Scholar hingga Februari 2025. Artikel yang diseleksi meliputi studi uji klinis acak dan tinjauan sistematik/meta-analisis. Proses seleksi mengikuti alur PRISMA (preferred reporting items for systematic reviews and meta-analyses) dan dinilai menggunakan pedoman Oxford Centre for Evidence-Based Medicine. Studi ini didapatkan dua artikel memenuhi kriteria inklusi yaitu satu artikel meta-analisis dan satu artikel uji klinis acak. Kedua studi menunjukkan suplementasi vitamin D dapat menurunkan risiko kekambuhan klinis pada pasien IBD terutama signifikan pada pasien CD, bahkan pada pemberian dosis tinggi (2000 IU) dapat menurunkan kadar TNF-α dan meningkatkan kadar serum vitamin D, meskipun tidak signifikan terhadap semua penanda inflamasi setelah penyesuaian. Suplementasi vitamin D menunjukkan potensi dalam menurunkan kekambuhan dan meningkatkan kualitas hidup pasien IBD terutama pada pasien CD. Namun, dibutuhkan lebih banyak studi dengan metodologi yang seragam untuk menentukan dosis, durasi, dan rute pemberian optimal.
Effect of Omega-3 Supplementation on Psoriasis Severity: An Evidence-Based Case Report Basalamah, Tarafainy; Nurul Ratna Mutu Manikam
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 3 (2025): September 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i3.1599

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder often associated with significant morbidity and limited efficacy of conventional treatments, which may also cause adverse effects. Omega-3, with their anti-inflammatory and immunomodulatory properties, have been proposed as a potential adjunctive therapy for managing psoriasis. This evidence-based case report (EBCR) aims to evaluate the efficacy of omega-3 supplementation in improving clinical outcomes in patients with psoriasis. Objective: To determine the effect of omega-3 supplementation on changes in Psoriasis Area and Severity Index (PASI) scores in psoriasis patients. Methods: Literature search was conducted using advanced searching in three large databases: PubMed, Cochrane Library, and ProQuest. MeSH terms, advanced search and eligibility criteria were used for title and abstract screening after removing duplicates. Critical assessment tools and levels of evidence of the final articles are based on the Oxford Center for Evidence-Based Medicine. Results: Three systematic reviews and meta-analyses and one RCTs met the PICO and eligibility criteria that had been set. Three of the studies demonstrated a modest but statistically significant reduction in PASI scores with omega-3 PUFA supplementation, particularly when combined with conventional therapies. A study showed limited or non-significant effects when omega-3 was used alone. Conclusion: Omega-3 supplementation demonstrates a beneficial effect in reducing disease severity in patients with psoriasis, as evidenced by improvements in PASI scores.
Co-Authors Adianto Nugroho Adityo Wibowo Akhmad Noviandi Syarif Amelia Jessica Anindhita, Bintari Astutik, Erni Badralany, Felianty Basalamah, Tarafainy Budi Rahayu Diana Sunardi Dita Aditianingsih Dwirini Retno Gunarti Enny Probosari Fadilla, Chusnul Farapti Farapti Fariz, Nurwidya Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Godong, Bernardine Hajar, Siti Sarah Heri Nugroho Hertanto Wahyu Subagio Hidayat, Astriliana Febrianawati Inge Permadhi K.N, Beta Novianti Katya Saphira Kirana, Annisa Nurul Krisadelfa Sutanto Krisadelfa Sutanto Lily Indriani Octovia Luciana B Sutanto Marcia Kumala Marvin Marino Meilianawati Meilianawati Metta Satyani Muchtaruddin Mansyur Mulyana Mulyana Neni Sawitri Ninik Mudjihartini Oki Yonatan Oentiono Puspasari, Devi Putri, Nandita Melati Rasyid, Nurhayati M Rizka Hanifa Singal, Anna Maurina Tri Indah Winarni Wahyu Ika Wardhani Wahyu Ika Wardhani Wardhana, Aditya Wiji Lestari Wina Sinaga Yohannessa Wulandari