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All Journal JURNAL GIZI INDONESIA The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Plastik Rekonstruksi Jurnal Respirasi (JR) World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Archives of The Medicine and Case Reports Jurnal Ilmu Kesehatan Indonesia (JIKSI) Majalah Anestesia & Critical Care (MACC) Tarumanagara Medical Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Nurul Ratna Mutu Manikam
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Efek pemberian suplementasi vitamin D terhadap kejadian kekambuhan pasien inflammatory bowel disease: An evidence-based case report Hidayat, Astriliana Febrianawati; Manikam, Nurul Ratna Mutu
Tarumanagara Medical Journal Vol. 7 No. 1 (2025): TARUMANAGARA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/tmj.v7i1.34092

Abstract

Inflammatory Bowel Disease (IBD), yang mencakup Crohn’s Disease (CD) dan Ulcerative Colitis (UC), merupakan penyakit radang kronis saluran cerna yang dapat timbul berulang. Pasien IBD rentan mengalami defisiensi mikronutrien termasuk vitamin D akibat gangguan absorpsi, malnutrisi, dan peradangan kronis. Beberapa studi menunjukkan bahwa vitamin D mempunyai peran imunomodulator dan antiinflamasi yang berpotensi menurunkan angka kekambuhan IBD. Studi ini bertujuan untuk mengevaluasi efektivitas suplementasi vitamin D dalam menurunkan angka kekambuhan pada pasien dengan IBD melalui telaah bukti ilmiah terkini. Metode pencarian literatur dilakukan melalui basis data PubMed, CENTRAL, dan Google Scholar hingga Februari 2025. Artikel yang diseleksi meliputi studi uji klinis acak dan tinjauan sistematik/meta-analisis. Proses seleksi mengikuti alur PRISMA (preferred reporting items for systematic reviews and meta-analyses) dan dinilai menggunakan pedoman Oxford Centre for Evidence-Based Medicine. Studi ini didapatkan dua artikel memenuhi kriteria inklusi yaitu satu artikel meta-analisis dan satu artikel uji klinis acak. Kedua studi menunjukkan suplementasi vitamin D dapat menurunkan risiko kekambuhan klinis pada pasien IBD terutama signifikan pada pasien CD, bahkan pada pemberian dosis tinggi (2000 IU) dapat menurunkan kadar TNF-α dan meningkatkan kadar serum vitamin D, meskipun tidak signifikan terhadap semua penanda inflamasi setelah penyesuaian. Suplementasi vitamin D menunjukkan potensi dalam menurunkan kekambuhan dan meningkatkan kualitas hidup pasien IBD terutama pada pasien CD. Namun, dibutuhkan lebih banyak studi dengan metodologi yang seragam untuk menentukan dosis, durasi, dan rute pemberian optimal.
Effect of Omega-3 Supplementation on Psoriasis Severity: An Evidence-Based Case Report Basalamah, Tarafainy; Nurul Ratna Mutu Manikam
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 3 (2025): September 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i3.1599

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder often associated with significant morbidity and limited efficacy of conventional treatments, which may also cause adverse effects. Omega-3, with their anti-inflammatory and immunomodulatory properties, have been proposed as a potential adjunctive therapy for managing psoriasis. This evidence-based case report (EBCR) aims to evaluate the efficacy of omega-3 supplementation in improving clinical outcomes in patients with psoriasis. Objective: To determine the effect of omega-3 supplementation on changes in Psoriasis Area and Severity Index (PASI) scores in psoriasis patients. Methods: Literature search was conducted using advanced searching in three large databases: PubMed, Cochrane Library, and ProQuest. MeSH terms, advanced search and eligibility criteria were used for title and abstract screening after removing duplicates. Critical assessment tools and levels of evidence of the final articles are based on the Oxford Center for Evidence-Based Medicine. Results: Three systematic reviews and meta-analyses and one RCTs met the PICO and eligibility criteria that had been set. Three of the studies demonstrated a modest but statistically significant reduction in PASI scores with omega-3 PUFA supplementation, particularly when combined with conventional therapies. A study showed limited or non-significant effects when omega-3 was used alone. Conclusion: Omega-3 supplementation demonstrates a beneficial effect in reducing disease severity in patients with psoriasis, as evidenced by improvements in PASI scores.
EFFECTS OF VITAMIN D ADMINISTRATION FOR WOUND HEALING IN PATIENTS WITH DIABETIC FOOT ULCERS: EVIDENCE BASED CASE REPORT Badralany, Felianty; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.191

Abstract

Diabetes mellitus can cause microvascular and macrovascular complications. Diabetic foot ulcer is the complications that often occur in DM patients, which is as much as 10%-25%. In Indonesia, the incidence of diabetic foot ulcers is 12% and DM patients can be at risk of diabetic foot ulcers as much as 55.4%. The mortality rate that occurs as a result of diabetic foot ulcers can reach around 15-30%. Patients who have diabetic foot ulcers significantly decreased vitamin D levels. This study aims to determine the effectiveness of vitamin D supplementation for wound healing in diabetic foot ulcers.
Urinary PYD/Creatinine Ratio Has Negative Correlation to Serum 25(OH)D and Positive Correlation to Chronic Lead Exposure Index Hajar, Siti Sarah; Mudjihartini, Ninik; Manikam, Nurul Ratna Mutu; Mulyana, Mulyana; Mansyur, Muchtaruddin
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3174

Abstract

BACKGROUND: The burden of disease due to lead exposure continues to increase. Lead interferes with 25(OH)D hydroxylation and calcium transport, increasing osteoclastic activity and bone resorption. Pyridinoline crosslinks (PYD), as an indicator of bone damage, can be seen earlier compared to imaging changes. Therefore, it is necessary to determine the correlation between serum 25(OH)D levels and the urinary PYD/creatinine ratio in workers exposed to lead, since up to now, there are only limited studies related to it.METHODS: This cross-sectional study involved 104 workers exposed to lead, selected from parents whose children had blood lead levels above 10 µg/dL. Questionnaires and physical examination were performed to obtain characteristic data from subjects. Data regarding blood lead levels, serum 25(OH)D levels, urinary PYD levels, and urinary creatinine levels were also obtained from various laboratory methods.RESULTS: Most subjects (86.5%) had inadequate serum 25(OH)D. Median blood lead levels was 6.3 (1.2-35.5) µg/dL, chronic lead exposure index was 35.3 (1.2-535.8) years µg/dL, serum 25(OH)D levels was 22 (8-52) ng/mL, and urinary PYD/creatinine ratio was 5.3 (3.6-28.1)×10-6. There was a significant negative correlation between serum 25(OH)D levels and urinary PYD/creatinine ratio in workers exposed to lead. There was also a significant positive correlation between chronic lead exposure index and the urinary PYD/creatinine ratio.CONCLUSION: Since urinary PYD/creatinine ratio is correlated with serum chronic lead exposure index and serum 25(OH)D levels, it suggests that pyridinoline might be a potential biomarker to detect bone metabolism disorder due to the chronic lead exposure. Vitamin D adequacy is also an important factor in preventing bone metabolism disorder amidst chronic lead exposure.KEYWORDS: 25(OH)D, bone resorption, pyridinoline, lead, worker
Known facts: iron deficiency in Indonesia Manikam, Nurul Ratna Mutu
World Nutrition Journal Vol. 5 No. S1 (2021): Special Issue : The role and importance of iron
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S1.0001

Abstract

More than half cases of anemia are due to iron deficiency. Anemia is a major and global public health problem that affects maternal and child mortality, child cognitive development and eventually productivity. Infancy, adolescence, and pregnancy are particularly at risk. Indonesia is a low middle country with the prevalence of anemia as high as 48.9% in pregnant women and 38.5% in children under 5 years old. It is even higher among adolescents aged 12-18 years, especially in rural areas. Low income and level of education seem to also contribute to iron deficiency. Indonesia government aims to prevent anemia in young and pregnant women by providing iron pills. Still, the etiology of anemia in Indonesia is various and many elements are preventing Indonesia women to consume pills and/or iron-rich foods. We aim to review the prevalence, risk factors associated with iron deficiency especially among women of reproductive age in Indonesia, including the socio-determinant influence on iron deficiency. We will also discuss the management of iron deficiency in Indonesia in comparison with international guideline to identify the potential gaps.
Co-Authors Adianto Nugroho Adityo Wibowo Akhmad Noviandi Syarif Amelia Jessica Anindhita, Bintari Astutik, Erni Badralany, Felianty Basalamah, Tarafainy Bintari Anindhita Budi Rahayu Diana Sunardi Dita Aditianingsih Dwirini Retno Gunarti Enny Probosari Fadilla, Chusnul Farapti Farapti Fariz, Nurwidya Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Godong, Bernardine Hajar, Siti Sarah Heri Nugroho Hertanto Wahyu Subagio Hidayat, Astriliana Febrianawati Inge Permadhi K.N, Beta Novianti Katya Saphira Kirana, Annisa Nurul Krisadelfa Sutanto Krisadelfa Sutanto Lily Indriani Octovia Luciana B Sutanto Marcia Kumala Marvin Marino Meilianawati Meilianawati Metta Satyani Muchtaruddin Mansyur Mulyana Mulyana Nandita Melati Putri Neni Sawitri Ninik Mudjihartini Oentiono, Oki Yonatan Oki Yonatan Oentiono Puspasari, Devi Rasyid, Nurhayati M Rizka Hanifa Singal, Anna Maurina Tri Indah Winarni Wahyu Ika Wardhani Wahyu Ika Wardhani Wardhana, Aditya Wiji Lestari Wina Sinaga Yohannessa Wulandari