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All Journal JURNAL GIZI INDONESIA The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Plastik Rekonstruksi Jurnal Respirasi (JR) World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Archives of The Medicine and Case Reports Jurnal Ilmu Kesehatan Indonesia (JIKSI) Majalah Anestesia & Critical Care (MACC) Tarumanagara Medical Journal Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Nurul Ratna Mutu Manikam
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Correlation of Beta Carotene and Nutrition Status With Malondialdehyde Levels in Breastfeeding Mother Katya Saphira; Nurul Ratna Mutu Manikam; Dwirini Retno Gunarti
World Nutrition Journal Vol. 3 No. 1 (2019): Volume 03 Issue 1 Include Supplements Oral Presentation Abstracts of 14th Sympo
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i1.0011

Abstract

Background : Malondialdehyde (MDA), one of the products of polyunsaturated fatty acid (PUFA) peroxidation detected in breast milk (BM). MDA levels depicted BM’s oxidative status. BM oxidative balance could prevent oxidative stress in babies. MDA could be influenced by antioxidant food source such as beta carotene as well as body mass index (BMI).Objective: To analyze beta carotene intake and BMI and their correlation with BM MDA levels in nursing motherMethods: Eighty breastfeeding mothers who were 20–40 years old, came to Cilincing and Grogol Petamburan Public Health Centre February–April 2019 and had 1–6 months old babies were enrolled in this cross-sectional study. The BM was extracted in the next day. Mothers were asked to empty one of the breast 2 hours prior to extraction. Beta carotene intake was assessed using semi quantitative food frequency (SQ-FFQ). Body weight and height was measured on the first day. The BM MDA levels were assessed using thiobarbituric acid reactive substance (TBARS) assay. The correlation of beta carotene intake and MDA as well as BMI and MDA was assessed using Spearman test with level of significance of p<0.05.Results: Subject’s median age was 27 (20-35) years old, median BMI was 23.21 (15.25-39.55) kg/m2. Beta carotene’s median intake was 8039.8 (1697.7–34028) mg/day with 72.5% of the subjects were considered low intake. BM MDA level’s median was 1.953 (0.739-4.928) nmol/ml. Beta carotene intake (r = 0.247, p = 0.027) and BMI (r = 0.285, p = 0.010[DN4] ) had a weak correlation with BM MDA level.Conclusion: The beta carotene intake and the BMI of the subjects correlate significantly with the BM MDA level. It showed that the mother’s intake and body composition contribute to the oxidant level in BM, therefore influenced the level of oxidative stress transferred to the babies.
Body Mass Index And Survival Rate in Nasopharyngeal Cancer Patient: An Evidence-based Case Report Yohannessa Wulandari; Metta Satyani; Marvin Marino; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 3 No. 2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V03.i2.0005

Abstract

Introduction: Nasopharyngeal cancer is the most common type of head and neck cancer with prevalence of 6.2/100000 population. Recently, study of prognostic factors for nasopharyngeal cancer still becomes one of research focuses. Several studies have tried to find the relationship between nutritional status (body mass index/BMI) and nasopharyngeal cancer patients’ survival rate, but the results are still inconsistent.                    Objective: To find the relationship between nutritional status represented by BMI and nasopharyngeal cancer patients’ survival rate.Methods: Electronic literature searches were performed in Cochrane®, Scopus®, and Pubmed®. Mesh term and title/abstracts were screened based on inclusion and exclusion criteria before relevant journals were reviewed.Results: Two articles were selected based on the eligibility criteria and relevancy to the clinical question. In the study of Huang et al., the subject was nasopharyngeal cancer patient stage III and IV was included as subject of the study. In the study of Lin et al., nasopharyngeal cancer patient with metastases was also included. Patient with higher BMI has better survival rate than underweight BMI category.Conclusion: Increasing BMI in underweight cancer patient simproves nasopharyngeal cancer patient’ survival rate.
Effect of isoflavone consumptions on the recurrence and survival rate among breast cancer patients: an evidence-based case report Meilianawati Meilianawati; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 4 No. 1 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i1.0010

Abstract

Background: isoflavones possess both anti-estrogenic and estrogenic-like properties. Tempeh is a traditional dish from Indonesia which rich in isoflavone content. It remains controversial whether women diagnosed with breast cancer should be advised to avoid or increase the intake of food products that contain isoflavone to improve survival.Objective: to identify the association between post-diagnosis isoflavone food consumption with the recurrence and survival rate among women with breast cancer. Methods: the search was conducted with advanced searching on PubMed, Cochrane, Scopus, and ProQuest according to the clinical question. The screening of title and abstract using inclusion and exclusion criteria, filtering double, and reading full text led to six useful articles. The selected studies were critically appraised for validity, importance, and applicability.Results: five prospective cohort studies and one meta-analysis were found with comparable validity. Women at the high level of isoflavone intake (>10 mg/day) had a significant reduction in the risk of recurrence and mortality of breast cancer.Conclusion: isoflavone food intake is associated with better survival, low recurrence, and low mortality among breast cancer patients.   
Effect of vitamin D supplementation to prevent acute respiratory tract infection : an evidence-based case report Oki Yonatan Oentiono; Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 4 No. 1 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.i1.0002

Abstract

Background: One of the frequent health problems that regularly occurs in Indonesia, as a tropical country is an acute respiratory tract infection, including influenza. Since immunological benefit of vitamin D already proven, hypothetically, vitamin D can be used as protective agent to prevent influenza or other respiratory tract infections. Objective: This evidence-based case report was focused on the evaluation of protective ability of vitamin D supplementation to prevent influenza or other acute respiratory tract infections.Methods: Literature searching was conducted on PubMed data base and Cochrane Library using the related keyword combinations.Results: Two randomized-clinical trials (RCTs) and a meta-analysis study were fulfilled the eligibility criteria. Vitamin D supplementation did not reduce the incidence of influenza but reduce the incidence of non-influenza infection. High-dose vitamin D supplementation had no effect on the reduction of acute respiratory tract infection incidence. The meta-analysis concluded that vitamin D supplementation reduced the risk for acute respiratory tract infection and the stronger effects occurred on low-levels of vitamin D serum.Conclusion: Vitamin D supplementation may prevent acute respiratory tract infections, especially in subjects with low-levels of vitamin D serum.
Known facts: iron deficiency in Indonesia Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 5 No. S1 (2021): The role and importance of iron : A supplementary papers
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S1.0001

Abstract

More than half cases of anemia are due to iron deficiency. Anemia is a major and global public health problem that affects maternal and child mortality, child cognitive development and eventually productivity. Infancy, adolescence, and pregnancy are particularly at risk. Indonesia is a low middle country with the prevalence of anemia as high as 48.9% in pregnant women and 38.5% in children under 5 years old. It is even higher among adolescents aged 12-18 years, especially in rural areas. Low income and level of education seem to also contribute to iron deficiency. Indonesia government aims to prevent anemia in young and pregnant women by providing iron pills. Still, the etiology of anemia in Indonesia is various and many elements are preventing Indonesia women to consume pills and/or iron-rich foods. We aim to review the prevalence, risk factors associated with iron deficiency especially among women of reproductive age in Indonesia, including the socio-determinant influence on iron deficiency. We will also discuss the management of iron deficiency in Indonesia in comparison with international guideline to identify the potential gaps.
Vitamin D and immune responses: how much is too much? Nurul Ratna Mutu Manikam
World Nutrition Journal Vol. 5 No. S3 (2022): Selected conference proceedings of the Nutri Virtual Symposium 2021
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S3.0019

Abstract

Vitamin D is a sunshine vitamin that is widely known for bone health. The main source of vitamin D from exposure to ultraviolet B radiation, whereas only 20% from natural and fortified food. Recent studies concluded that vitamin D has a putative role in reducing the risk of viral respiratory infection by suppressing pro-inflammatory cytokines and delaying increasing anti-inflammatory cytokines response. Whereas, vitamin D regulates innate immunity through macrophage and dendrite cell activity as well as an adaptive immune response through lymphocyte T cells response.
The Role of Omega-3/Omega-6 Ratio on Appetite in Pulmonary Multidrug-Resistant Tuberculosis Patients Fattrias Handayani Jayaatmaja; Nurul Ratna Mutu Manikam; Inge Permadhi; Neni Sawitri; Budi Rahayu; Adityo Wibowo; Fariz Nurwidya
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.7-11

Abstract

Introduction: Tumour necrosis factor-alpha (TNF-α) levels, pro-inflammatory cytokines that suppress appetite, were discovered to be much higher in multidrug-resistant tuberculosis (MDR-TB) than in drug-sensitive TB. Research on the omega-3/omega-6 (êž·-3/êž·-6) polyunsaturated fatty acids (PUFAs) intake, which can support appetite in patients with MDR-TB, has never been performed. This study aimed to examine the relationship between êž·-3/êž·-6 PUFAs intake ratio and appetite mediated by TNF-α in pulmonary MDR-TB patients. Methods: This was a cross-sectional study conducted on 46 male and female adults with MDR-TB undergoing intensive phase therapy. Data were collected through questionnaires, 1x24 hours food recall, anthropometric measurements, 100 mm visual analogue appetite scale, and venous blood collection. Results: Correlation analysis used the Pearson and Spearman tests. The findings revealed the ratio of êž·-3/êž·-6 PUFAs intake of 0.11 ± 0.05, the median value of TNF-α 7.49(1.66-447.62) pg/mL, and an average appetite of 58.72 ± 26.7. There was no relationship between êž·-3/êž·-6 PUFAs intake ratio and TNF-α (r = 0.016; p = 0.91), likewise between êž·-3/êž·-6 PUFAs intake ratio with appetite (r = -0.1; p = 0.54), but there was a relationship between TNF-α and appetite (r = 0.031; p = 0.04). Conclusion: There was no relationship between êž·-3/êž·-6 PUFAs intake ratio and TNF-α and appetite in pulmonary MDR-TB patients. However, there was a relationship between TNF-α and appetite. This study is the first to determine the correlation between êž·-3/êž·-6 PUFAs intake ratio and appetite in pulmonary MDR-TB patients.
External validation test of body height estimation on outpatient radiotherapy clinic of Dr. Cipto Mangunkusumo General Hospital Wiji Lestari; Fiastuti Witjaksono; Nurul Ratna Mutu Manikam; Wahyu Ika Wardhani; Krisadelfa Sutanto
World Nutrition Journal Vol. 6 No. 2 (2023): Volume 06 Issue 2, February 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.i2.0007

Abstract

Background : Stature is required to calculate body mass index and determine the energy needs of patients in nutritional medical therapy. Difficulty was found to obtain stature data in patients who are unable to stand. Therefore, there are some height estimation formula to predict the actual height using knee height. This study aimed to validate the Chumlea formula on outpatient clinic of Dr. Cipto Mangunkusumo General Hospital, Indonesia. Methods : This cross-sectional study used 90 respondents selected by consecutive sampling. Actual height, knee height, age and gender data were collected. Estimated height using the three of Chumlea formula. Pearson correlation was used to see the correlation between actual height and estimated height. Paired t-test were used to determine the difference significance. Results : The average age of the subjects was 45±10 years old with actual height 157±10 cm, and knee height 48.8±3.5 cm. A strong positive correlation was found between actual height with all estimated height on male (p=0.000; r > 0.8) and female subjects (p=0.000; r > 0.6). However, comparison between actual height and estimated height showed no significant differences only in Chumlea L1 formula (p=0.087) and Chumlea L3 formula (p=0.824) on the male subjects. Conclusions : Chumlea L1 and Chumlea L3 formula was a valid fomulation for calculating the estimated body height in adult male patients. There was no valid Chumlea’s formulation to estimate body height in female patients.
EFEKTIVITAS SUPLEMENTASI VITAMIN K TERHADAP KONTROL GLIKEMIK PADA PASIEN DIABETES MELITUS TIPE 2: EVIDENCE BASED CASE REPORT Rizka Hanifa; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 5 No 2 (2022): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v5i2.112

Abstract

Latar belakang: Terdapat beberapa bukti penelitian prospektif observasional dan uji klinis yang menunjukkan penurunan risiko diabetes melitus (DM) dengan suplementasi vitamin K melalui perannya terhadap respon insulin, efek insulinotropik, dan modulasi vitamin K-dependent protein. Tujuan penelitian: Studi ini bertujuan untuk menelaah secara kritis mengenai efek suplementasi vitamin K terhadap kontrol glikemik pada pasien DM tipe 2. Metode: Pencarian literatur dilakukan pada 3 database yaitu PubMed, Cochrane dan Scopus. Literatur yang sesuai dengan PICO kemudian diseleksi berdasarkan kriteria eligibilitas dan dilakukan telaah kritis. Hasil: Terpilih 2 artikel dengan studi randomized controlled trial (RCT). Kedua artikel tersebut menunjukkan pengaruh yang signifikan setelah pemberian suplemen vitamin K terhadap status glikemik pada pasien DM tipe 2. Artikel pertama menunjukkan dengan pemberian kapsul MK-7 sebesar 200 μg/hari selama 12 minggu, nilai glukosa darah puasa (GDP) (MD=24,37; 95% IK: 3,37-45,37; p: 0,02) dan HbA1c (MD=1,23; 95% IK: 0,21-2,26; p: 0,01) secara signifikan lebih rendah pada kelompok MK-7 dibandingkan plasebo. Artikel kedua juga menunjukkan dengan memberikan MK-7 180 μg dua kali sehari selama 12 minggu, kadar GDP (effect size (ES)=−0,68; p-adjusted=0,031) dan HbA1c (ES=−0,36; p-adjusted=0,004) pada kelompok Mk-7 secara signifikan lebih rendah dibandingkan dengan plasebo. Kesimpulan: Kedua artikel menunjukkan hasil yang konsisten dalam menurunkan kadar GDP dan HbA1c. Studi dengan ruang lingkup terapi yang membahas topik ini masih terbatas, sehingga diperlukan studi selanjutnya untuk mengonfirmasi temuan ini dan untuk mendukung rekomendasi suplementasi vitamin K dalam regimen terapi pasien DM tipe 2. Kata kunci: vitamin K, diabetes, kontrol glikemik, glukosa darah puasa, HbA1c
THE EFFECTS OF CURCUMIN SUPPLEMENTATION ON GLYCAEMIC INDEX IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: AN EVIDENCE BASED CASE REPORT Marcia Kumala; Nurul Ratna Mutu Manikam
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.133

Abstract

Background: PCOS is the most common cause of infertility around the world. PCOS is associated with impaired glucose tolerance and higher tendency to develop type 2 diabetes. Curcumin, which is known for its anti-inflammatory, antioxidant, and antidiabetic properties, may show promising effect in regulating blood glucose. Objective: This study aims to evaluate the effect of curcumin supplementation on improving glycaemic profile in women with PCOS. Methods: Literature searching was conducted by advanced searching in Pubmed, Cochrane Library, Scopus, and ProQuest database using MeSH Terms combined with Title/Abstract. After removing duplicates, the literatures were screened based on the eligibility criteria. Critical appraisal and level of evidence of the selected literatures were determined based on Oxford Centre for Evidence-Based Medicine. Results: Two selected literatures were relevant to answer our clinical question. The first literature is a systematic review/meta-analysis study by Chien et al (2021) and the latter is a randomized controlled trial by Asan et al (2020). Both literatures show that curcumin supplementation is beneficial in improving glycaemic profile in PCOS patients. These effects were marked by lower fasting blood glucose, insulin level, and HOMA-IR in curcumin group compared to the control group. Conclusion: Curcumin supplementation for at least 6 weeks significantly improve glycaemic profile in women with PCOS. Curcumin supplementation is also considered safe and well tolerable. However, more studies are needed to investigate further regarding the long-term effects of curcumin supplementation. Keywords: curcumin, turmeric, polycystic ovarian syndrome, glycaemic profile
Co-Authors Adianto Nugroho Adityo Wibowo Akhmad Noviandi Syarif Amelia Jessica Anindhita, Bintari Astutik, Erni Badralany, Felianty Basalamah, Tarafainy Bintari Anindhita Budi Rahayu Diana Sunardi Dita Aditianingsih Dwirini Retno Gunarti Enny Probosari Fadilla, Chusnul Farapti Farapti Fariz, Nurwidya Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Godong, Bernardine Hajar, Siti Sarah Heri Nugroho Hertanto Wahyu Subagio Hidayat, Astriliana Febrianawati Inge Permadhi K.N, Beta Novianti Katya Saphira Kirana, Annisa Nurul Krisadelfa Sutanto Krisadelfa Sutanto Lily Indriani Octovia Luciana B Sutanto Marcia Kumala Marvin Marino Meilianawati Meilianawati Metta Satyani Muchtaruddin Mansyur Mulyana Mulyana Nandita Melati Putri Neni Sawitri Ninik Mudjihartini Oentiono, Oki Yonatan Oki Yonatan Oentiono Puspasari, Devi Rasyid, Nurhayati M Rizka Hanifa Singal, Anna Maurina Tri Indah Winarni Wahyu Ika Wardhani Wahyu Ika Wardhani Wardhana, Aditya Wiji Lestari Wina Sinaga Yohannessa Wulandari