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All Journal VALENSI Jurnal Sains dan Seni ITS IPTEK The Journal for Technology and Science Abdimas Journal of Mathematical and Fundamental Sciences Indonesian Journal of Tropical and Infectious Disease Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Chemistry Akta Kimia Indonesia ASEAN Journal of Chemical Engineering Indonesian Journal of Applied Research (IJAR) Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Sewagati International Journal of Cell and Biomedical Science
Fahimah Martak
Institut Teknologi Sepuluh Nopember
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Peningkatan Kompetensi Guru SMA Yapita Surabaya Melalui Pelatihan Pembuatan Modul Praktikum yang Linear dengan Kurikulum Agus Wahyudi; Fahimah Martak; Yulfi Zetra; Wahyu Prasetyo Utomo; Zjahra Vianita Nugraheni
Sewagati Vol 3 No 3 (2019)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.824 KB)

Abstract

Kebanyakan sekolah-sekolah, terutama sekolah swasta di daerah pinggiran, tidak melakukan proses pembelajaran di laboratorium dengan proporsi yang baik untuk pelajaran kimia. Beberapa alasan yang diutarakan antara lain adalah alat laboratorium yang terbatas, bahan kimia yang susah di dapat dan terbatasnya dana untuk melakukan praktikum. Penyusunan modul praktikum untuk guru-guru ini merupakan salah satu solusi untuk mengatasi masalah diatas. Di dalam modul praktikum tersebut berisi tentang praktikum-praktikum kimia sederhana dengan peralatan dan bahan sederhana yang dapat diperoleh dengan mudah di pasaran, yang dapat dilakukan di SMA dan tentunya disesuaikan dengan kurikulum yang berlaku. Bahan-bahan yang digunakan juga dapat diperoleh dengan mudah di sekitar kita dan harganya juga terjangkau. Dengan adanya modul praktikum ini, diharapkan sekolah-sekolah, khususnya SMA swasta di daerah pinggiran, tetap dapat melaksanakan praktikum kimia di laboratoriumnya. Diharapkan juga para siswa mempunyai pengalaman praktikum di laboratorium sehingga mereka mempunyai bekal saat melanjutkan pendidikan di Perguruan Tinggi. Selain itu, dengan adanya modul praktikum ini, diharapkan pola pikir siswa tentang pelajaran kimia menjadi pelajaran yang menarik karena berbasis ekspermen di Laboratorium.
Synthesis and Antidiabetic Evaluation of N’-Benzylidenebenzohydrazide Derivatives by In Silico Studies Yusuf Syaril Alam; Pratiwi Pudjiastuti; Saipul Maulana; Nur Rahmayanti Afifah; Fahimah Martak; Arif Fadlan; Tutik Sri Wahyuni; Syukri Arief
Indonesian Journal of Chemistry Vol 23, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.82073

Abstract

Two new of N’-benzylidenebenzohydrazide (NBB) derivatives were successfully synthesized and yielded 50–58%. FTIR, ESI-MS, 1H-NMR and 13C-NMR were used to investigate the characteristic of NBB derivates. The structure and relationship of NBB derivatives into α-glucosidase and α-amylase as good targets for diabetes treatment were evaluated using in silico screening. Molecular Mechanics-Poisson Boltzmann/Generalized Born Surface Area (MM-PB/GBSA) was used to calculate the free binding energy (ΔGbind (MM-GBSA)) of NBB to α-glucosidase and α-amylase receptors showed that the results of −0.45 and −20.79 kcal/mol respectively. In the ortho position, NBB derivatives exhibited electron donating groups (EDG like -OCH3, -OH and -Cl with binding free energies of −21.94, −6.71 and 21.94, respectively, and acarbose, a native ligand energy of 32.62 kcal/mol. In addition, the binding free energy of N-2-(-OCH3, -OH and -Cl)-NBB to the α-amylase receptor showed the number of −39.33, −43.96, −42.81, respectively and −46.51 kcal/mol in comparing with a native ligand. As a result, it was found that all the NBB derivatives were able to interact with several amino acids in the α-glucosidase cavity as well as the native ones, including Ala281, Asp282, and Asp616.  NBB and native ligand showed similar interaction between α-amylase with Gly110 amino acid residue.
SYNTHESIS OF METAL-ORGANIC (COMPLEXES) COMPOUNDS COPPER(II)-IMIDAZOLE FOR ANTIVIRAL HIV CANDIDATE Sucipto, Teguh Hari; Martak, Fahimah
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 1 (2016)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1015.057 KB) | DOI: 10.20473/ijtid.v6i1.1204

Abstract

The human immunodeficiency virus (HIV) is viruses known as rotaviruses. Potential target for therapeutic is reverse transcriptase (RT), possesses an RNA dependent DNA polymerase, DNA-dependent DNA polymerase and ribonuclease H fuctions. Imidazoles have high anti-HIV inhibitory activity, some derivates of imidazole reported drugs. 8-chloro-2,3-dihydroimidazole[1,2-b] [1,4,2]benzodithiazine-5,5-dioxides and 9-chloro-2,3,4-trihydropyri-mido[1,2-b][1,4,2]benzodithi-azine-6,6-dioxides. This compounds succesfully identified anti-HIV activity. Copper is a bio-essential element and copper complexes have been extensively utilized in metal mediated DNA cleavage for the generation of activated oxygen species. It has been reported that teraaza macrocyclic copper coordination compounds have anti-HIV activities. Studies have shown that these macrocyclic complexes can react with DNA in different binding fashions and exhibit effective nuclease activities. Complex compounds are compounds in which there is an atom that acts as the central atom and trotter group of molecules that can be either neutral or charged ions. Application a metal-organic (complex) compounds, especially copper metal and derivates of imidazole. So, in this study can explore new anti-HIV candidate.
ANTIVIRAL ACTIVITY OF COPPER(II)CHLORIDE DIHYDRATE AGAINST DENGUE VIRUS TYPE-2 IN VERO CELL Sucipto, Teguh Hari; Churrotin, Siti; Setyawati, Harsasi; Kotaki, Tomohiro; Martak, Fahimah; Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 4 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.829 KB) | DOI: 10.20473/ijtid.v6i4.3806

Abstract

Infection of dengue virus (DENV) was number of globally significant emerging pathogen. Antiviral dengue therapies ar importantly needed to control emerging dengue. Dengue virus (DENV) is mosquito-borne arboviruses responsible for causing acute systemic diseases and grievous health conditions in humans. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Copper and copper compounds have more effective in inactivation viruses, likes an influenza virus and human immunodeficiency virus (HIV). Purpose in this project was investigated of Copper(II)chloride Dihydrate antiviral compound were further tested for inhibitory effect on the replication of DENV-2 in cell culture. DENV replication was measures by Enzyme linked Immunosorbent Assay (ELISA) with selectivity index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for compound. The maximal inhibitory concentration (IC50) of Copper(II)chloride Dihydrate against dengue virus type-2 was 0.13 μg/ml. The cytotoxic concentration (CC50) of compound against Vero cell was 5.03 μg/ml. The SI values for Copper(II)chloride Dihydrate 38.69. Result of this study suggest that Copper(II)chloride Dihydrate demonstated significant anti-DENV-2 inhibitory activities and not toxic in the Vero cells. Copper mechanisms play an important role in the prevention of copper toxicity, exposure to excessive levels of copper can result in a number of adverse health effects, as a result increased reactive oxygen species and oxidative damage to lipid, DNA, and proteins have been observed in human cell culture models or clinical syndromes of severe copper deficiency and inhibition was attributed to released cupric ions which react with cysteine residues on the surface of the protease.
Effect of Zinc(II)-2,4,5-triphenyl-1H-imidazole Complex Against Replication DENV-2 in Vero Cell Sucipto, Teguh Hari; Wibrianto, Aswandi; Martak, Fahimah; Churrotin, Siti; Amarullah, Ilham Harlan; Setyawati, Harsasi; Wardhani, Puspa; Aryati, Aryati; Soegijanto, Soegeng
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11776

Abstract

Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. DENVs are transmitted to humans through female mosquitoes from Aedes aegypti and Aedes albopictus species. Indonesia is one of the largest countries in the world in dengue endemic regions worldwide. Dengue fever was occurred for the first time as an outbreak in Surabaya and Jakarta in 1968. Many efforts have been made to prevent and treat DENV infections, and clinical trials of a number of vaccines are currently underway. Antiviral testing of DENV is an important alternative for drug characterization and development. Complex compounds are formed as a result of metal and organic complex reactions. Complex compounds can be used as an anti-inflammatory, antimicrobial antifungal, antibacterial, antivirus. The Zn2+ ion can be used as an antiviral candidate. The purpose of this project was investigated Zinc(II)-2,4,5-triphenyl-1H-imidazole antiviral compound to be further tested for inhibitory effect on the replication of DENV-2 in cell culture. DENV replication was measured by antiviral activity assay and cytotoxicity assay. The inhibitory activity of Zinc(II)-2,4,5-triphenyl-1H-imidazole complex compound was determined by Viral ToxGloTM Assay. The cytotoxicity of Zinc(II)-2,4,5-triphenyl-1H-imidazole complex compound was determined by CellTiter96® AQuoeus assay. The inhibitory concentration (IC50) of Zinc(II)-2,4,5-triphenyl- 1H-imidazole against dengue virus type-2 was 34.42 μg/ml. The cytotoxic concentration (CC50) of compound against Vero cell was <100 μg/ml. The results of this study demonstrate the antidengue serotype 2 inhibitory activity of investigated Zinc(II)-2,4,5-triphenyl-1H-imidazole complex and its high toxicity in Vero cells. Further studies are not required before investigated Zinc(II)-2,4,5-triphenylimidazole can be applied in the treatment of DENV-2 infections
Trisindoline 5 Compound Inhibits Human Breast Cancer Stem Cell Formation by Downregulating the BCL-2 Gene Expression Fatoni, Muhammad; Salsabila, Yofinta I; Nurhayati, Awik P.D.; Ghaissani, Shabrina Syifa; Santoso, Mardi; Martak, Fahimah
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.19

Abstract

Background: Breast cancer cell's growth and survival are supported by breast cancer stem cells (bCSCs) mammosphere formation. bCSCs represent a subpopulation of undifferentiated cancer cells which associated with self-renewing abilities, tumor initiation, drug resistance, and metastasis. Overexpression of the B Cell Lymphoma 2 (BCL-2) family in many tumor cells contributes to apoptosis resistance. Trisindoline is an indole trimer alkaloid natural compound that provides a cytotoxic effect on cancer cells. A new modification of trisindoline has been synthesized into trisindoline 5 in 2021. Objective: This study purposed to investigate the effect of trisindoline 5 compounds against BCL-2 gene expression in bCSCs in vitro. Methods: The bCSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, the results showed that trisindoline 5 may decrease the expression of BCL-2 in MDA-MB-231 cells. Conclusion: This study concludes that trisindoline 5 could downregulate the antiapoptotic BCL-2 gene expression in bCSCs in vitro.
Upregulation of P53 Gene Expression on Breast Cancer Stem Cells Treated with Trisindoline 5 Compound Salsabila, Yofinta I; Azhaar, Nadia; Fatoni, Muhammad; Nurhayati, Awik P.D.; Ghaissani, Shabrina Syifa; Andifa, Vinda Aprilia Nurul; Santoso, Mardi; Martak, Fahimah
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.20

Abstract

Background: Cancer stem cells (CSCs) are the subpopulation of cancer cells that have been demonstrated as the cause of tumor formation. The most common cancer for women and the second leading cause of death in breast cancer. Numerous genes have been involved in breast cancers, including p53. In cancer cells, p53 as well-known as the tumor suppressor gene plays an important role in directing cells with DNA damage into apoptosis. Trisindolines are heterocyclic nitrogen compounds consisting of an isatin core bearing two indole moieties that provide cytotoxic effects on cancer cells. Recently research had led to the development of the new modification of trisindoline compound into trisindoline 5. Objective: This study aims to investigate the effect of trisindoline 5 compounds against p53 gene expression in CSCs MDA-MB-231 in vitro. Methods: CSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, trisindoline 5 increases the expression of p53 in CSCs MDA-MB-231. Conclusion: This study informed that trisindoline 5 could upregulate the expression of tumor suppressor gene p53 in CSCs MDA-MB-231 in vitro.
Co-Authors Abdul Halim Adi S Purnomo Adi Setyo Purnomo Adisya Salsabila Afninda Aryuni Widyanti Agung Nugroho Agus Wahyudi Agus Wahyudi Agus Wahyudi Agus Wahyudi Agus Wahyudi Ali Tajudin Moh Mohd Andifa, Vinda Aprilia Nurul Andika Putri Ningtyas Aryati Aryati Arynta Dharmayanti Aulia, Wulan Awik P.D. Nurhayati Ayu Widyasari Azhaar, Nadia Ceisar Andrian Putra Celvin Dicky Wahyudi Dewi Gita Anggraini Dicky Limanto Djulia Onggo Djulia Onggo Egar Pamela Eka Luthfi Septiani Endah Mutiara Marhaeni Putri Fadhil Adinata Fadlan, Arif Fanda Luvita Sari Fawait Afnani Ghaissani, Shabrina Syifa Gunawan, Triyanda Hamdan Dwi Rizqi Hamzah Fansuri Harsasi Setyawati Herdayanto S Putro Herdayanto Sulistyo Putro Iin Candrawati Iis Siti Jahro Ilham Harlan Amarullah Indana Madaniyah Tsani Irvan Adhin Cholilie Ismunandar Ismu Ismunandar Ismunandar M. Nadjib Mujahid M. Rachimoellah M. Rachimoellah Mardi Santoso muhammad fatoni, muhammad Mujahid, M. Nadjib Mujahid, Muhammad Nadjib Nuari Wahyu Dwi Cahyani Nugraheni, Zjahra Vianita Nur Rahmayanti Afifah Paramita Setyaningrum Pratiwi Pudjiastuti Putri, Endah Mutiara Marhaeni R.Y. Perry Burhan, R.Y. Perry Ramadhan, Zein Firdaus Refdinal Nawfa Saipul Maulana Salsabila, Yofinta I Sekarayu Dianing Putri Sigmatresna Wasatya Siti Churrotin, Siti Soegeng Soegijanto Sri Fatmawati Syafri Izzat Abidiy Syamsiar, Syamsiar Teguh Hari Sucipto, Teguh Hari Tia Ayu Christanti Tomohiro Kotaki, Tomohiro Tutik Sri Wahyuni Viqorul Ahmad Haryadi Wahyu Prasetyo Utomo Wardhani, Puspa Wibrianto, Aswandi Yuni Kurniati Yusuf Syahril Alam Yusuf Syaril Alam Zein Firdaus Ramadhan Zetra, Yulfi Zetra, Yulfi Zjahra Vianita Nugraheni