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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter The Journal of The Indonesian Medical Students´ Association Dental Journal (Majalah Kedokteran Gigi) YARSI Medical Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J International Journal of Public Health Excellence (IJPHE) Jurnal Natural The International Journal of Tropical Veterinary and Biomedical Research Narra X Al-Bahtsu: Jurnal Penelitian dan Pendidikan Islam
Zinatul Hayati
Syiah Kuala University
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : The Journal of The Indonesian Medical Students

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Role of Fasting on Enteroendokrin Cell Remodelling to Prevent Type 2 Diabetes Mellitus Harapan, Harapan; Fitri Jamil, Kurnia; Hayati, Zinatul; Muhammad, Iqbal
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Abstract

Hitherto, there was no study dedicated to analyze the effect of fasting associated enteroendocrine (EE) cell population remodelling on type 2 diabetes mellitus prevention. This article aimed at discussing the molecular and cellular mechanisms of fasting associated EE cell remodelling to type 2 diabetes mellitus prevention and estimating its effectiveness. It was shown that fasting could inhibit EE cell hyperplasia, thus decreased glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) production from K and L cells. Both hormones caused hyperinsulinemia -via enteroinsular axis- and obesity when they interacted with their respective receptors GIPR and GLP-1R in pancreatic beta cell and adipocyte. This would cause insulin resistance through PI-3 kinase and Cb1. Thus, the levels of GIP and GLP-1 are diabetic predisposition factors. Another study also revealed that EE cell remodelling due to fasting had effective target site on type 2 diabetes mellitus prevention - and was also more superior than GIP and GLP-1 analogs. Key words: type 2 diabetes mellitus, fasting, enteroendocrine cell, GIP, GLP-1
Co-Authors . Junaidi Abdillah Imron Nasution Ade Oktiviyari, Ade Azwar Azwar Basri A. Gani Basri Gani Boy M Bachtiar Cut Soraya Darniati . Diah, Muhammad Endang Winiati B Harapan Harapan I. Wayan T. Wibawan Iqbal Muhammad Ismail, Yulia S. Karmil, Teuku F. Kartini Hasballah KEUMALAHAYATI, MEUTIA Kurnia Fitri Jamil Maelani, Imelda Mahdani, Wilda Maulina, Novi Mawaddah Warahmah Mudatsir Mudatsir MULIANA, DESI Noratul Hafdhah Nurjannah Nurjannah Puspita, Ira PUTRI, FARAH DHITA ANISSA RAHMAWATI, CUT VIKA Ramadhana, Ika F. Ridwan, Azwar Santi Chismirina Saputra, Irwan Suhartono Syapal, Zulkarnain Usman, Said Yossadania, Asyriva Yusriadi, Teuku Zikra, Miftahul Zulkarnain Zulkarnain Zulkifli, Baidillah