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All Journal Journals of Ners Community Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Biologi UMA (JIBIOMA) Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Sewagati: Jurnal Pengabdian Masyarakat Indonesia Jurnal Pengabdian Ilmu Kesehatan Jurnal Muara Medika dan Psikologi Klinis Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia
Siufui Hendrawan
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Penapisan Fitokimia, Fitur Antioksidan, dan Uji Toksisitas pada Ekstrak Metanol Kubis Ungu (Brassica oleracea var. capitata L.) Alvionica, Selina; Hendrawan, Siufui; Ferdinal, Frans
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 3 (2025): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i3.16405

Abstract

This study aims to analyze the phytochemical content, antioxidant properties and toxicity of methanolic extract of red cabbage originating from West Java, Indonesia. The study comprised in vitro assays, which included phytochemical screening, determination of total phenolic level, and antioxidant activity tests. The toxicity was tested using Brine Shrimp Lethality Test (BSLT). The screening results revealed the presence of various secondary metabolites in the extract. The total phenolic content of red cabbage was 29.8 mgGAE/g. The antioxidant potential was evaluated through the FRAP (Ferric Reducing Antioxidant Power) and ABTS (2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays, yielding IC50 values of 13.42 µg/mL and 21.28 µg/mL, respectively; both were classified as having a strong antioxidant activity. The BSLT toxicity test showed an LC50 value of 153.87 µg/mL. These findings suggest that red cabbage is rich in beneficial phytochemicals and acts a strong natural antioxidants source. Moreover, it demonstrates potential for future development as a standardized herbal medicine with antioxidant properties and an affordable price.
SKRINING FITOKIMIA DAN KAPASITAS TOTAL ANTIOKSIDAN EKSTRAK DAUN WALANG SANGIT (ERYNGIUM FOETIDUM) Gaofman, Brian Albert; Hendrawan, Siufui; Ferdinal, Frans
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25026

Abstract

Secara geografis Indonesia merupakan negara yang beriklim tropis dan memiliki keanekaragaman hayati, yang sudah lama digunakan sebagai tanaman herbal untuk menyembuhkan berbagai penyakit secara turun-temurun. Salah satunya daun walang sangit yang berasal dari Meksiko, Karibia, dan Amerika Tengah dan Selatan. Di Indonesia di yakini dapat mencegah penyakit saluran pencernaan namun belum banyak penelitian tentang tumbuhan tersebut. Tanaman ini dipercaya memiliki senyawa bioaktif yang dapat berfungsi sebagai antioksidan untuk mengatasi kondisi stres oksidatif sebagai dasar timbulnya penyakit. Serta memiliki kandungan senyawa kimia non-nutrien (fitokimia). Antioksidan dibutuhkan oleh tubuh untuk meredam radikal bebas yang ada di dalam maupun di luar tubuh akibat paparan lingkungan yang semakin memburuk terutama di Jakarta. Maka dari itu perlu diseimbangi dengan antioksidan eksogen. Salah satunya pada daun walang sangit. Tujuan penelitian adalah untuk menentukan kapasitas antioksidan dan kadar fenolik tumbuhan tersebut. Penelitian eksperimental ini bersifat in vitro mencakup uji fitokimia dan uji kapasitas antioksidan. Daun walang sangit dikeringkan dan diekstraksi dengan metode perkolasi menggunakan pelarut metanol. UV-Vis alat yang digunakan untuk mendapatkan data, selanjutnya diolah menggunakan Graphpad Prism v.7.0 La Jolla, California, USA. Ekstraksi daun walang sangit ditemukan kandungan fitokimia kecuali antosianin dan alkaloid dengan reagen Mayer. IC50 didapatkan pada metode DPPH, ABTS, dan FRAP sebesar  68,752 µg/mL, 25,557 µg/mL, dan 23,364 µg/mL dengan pembanding vitamin-C untuk DPPH, serta trolox untuk ABTS dan FRAP. Kadar fenolik total ekstrak daun walang sangit sebesar 966 µg/mL. Maka daun walang sangit dapat berfungsi sebagai antioksidan eksogen sedang, dibandingkan pembandingnya tetapi bersifat anti mitotik sehingga dapat dijadikan agen anti kanker.
Hubungan Penggunaan APD Dengan Infeksi Covid-19 Pada Bidan Di Sekertariat IBI Ranting Tigaraksa Zefiro Letius, Fairuz; Tirtasari, Silviana; Hendrawan, Siufui
Journals of Ners Community Vol 13 No 6 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i6.2399

Abstract

Coronavirus Disease (COVID-19) first reported in Wuhan, China On December 31, 2019. In January 2020, World Health Organization (WHO) declared COVID-19 as a global health emergency. Confirmed cases of COVID-19 in Indonesia until September 21, 2021, amounted to 4 million cases, with death rate of 140 thousand people. This study determine the correlation between the use of PPE with COVID-19 infection in midwives. Analytical research with a cross-sectional design. subjects of this study are midwives who actively treated patients and is an active members of Tigaraksa IBI branch who met inclusion and exclusion criteria totaling 153 respondents, data were collected on March 4, 2022. Average age of respondents was 29 years old. 69 respondents (45.1%) have an education level of D3 and 84 respondents (54.9%) have an education level of S1. The average work experience of each respondent is 6 years, the longest work experience is 32 years and the most recent is 1 year. majority of midwives implemented PPE. 129 out of all respondents (84.3%) implemented PPE and only 24 respondents (15.7%) did not. There were 99 respondents (64.7%) infected with COVID-19 and 54 respondents (35.3%) who were not infected. There were 13 respondents (54.2%) who did not use PPE and were not infected with COVID – 19 and 11 respondents (45.8%) who did not use PPE and were infected with COVID-19. 41 respondents (31.8%) use PPE and are not infected with COVID-19, and there were 88 respondents (68.2%) who use PPE and are infected with COVID-19. The relationship between the use of PPE with COVID-19 infection obtained a significant value of 0.061, there no relationship between the implementation of PPE and COVID-19 infection in midwives at the IBI Branch Tigaraksa secretariat
Gambaran Pengetahuan, Sikap Dan Perilaku Pentingnya APD Pada Tenaga Kesehatan Selama Pandemi Covid-19 Bayu Ifana, Shomadya; Tirtasari, Silviana; Hendrawan, Siufui
Journals of Ners Community Vol 13 No 6 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i6.2400

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which first appeared in Wuhan, China and was reported in December 2019. In early October 2021, it was reported According to the World Health Organization (WHO), there are approximately 233 million people in the world who have confirmed COVID-19, while the number of patients who died has been recorded at approximately 4 million people. This study was to describe the knowledge, attitudes, and behavior of the importance of PPE for health workers in hospitals. This research is a descriptive cross-sectional design. In this study, all health workers at Sunan Kudus Islamic Hospital who met the inclusion and exclusion criteria were 169 respondents. In the study, the average age of respondents was 35 years, 135 respondents (79.9%) were women and 34 respondents (20.1%) were men. The average length of work of respondents is 10 years, the longest working respondent is 30 years and the new one is 1 year. The majority who worked in the inpatient room were 109 respondents (64.5%), outpatient room 31 respondents (18%), intensive care room 8 respondents (4.7%), emergency room 21 respondents (12.4%). The picture of the majority of good knowledge on the importance of PPE 168 respondents (99.4%), less good one respondent (0.6%), good attitude towards the importance of PPE 167 respondents (98.8%), bad attitude 2 respondents (1,2 %), good behavior on the importance of PPE 167 respondents (98.8%), bad behavior 2 respondents (1.2%). Health workers have good knowledge, attitude and behavior overall about the importance of PPE
Evaluasi Kandungan Fitokimia, Kapasitas Antioksidan, dan Toksisitas Ekstrak Daun Stevia rebaudiana Frankson, Desvin; Hendrawan, Siufui; Ferdinal, Frans
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12151

Abstract

Oxidative stress leads to numerous clinical problems, such as autoimmune, vascular and respiratory impairment, as well as many other degenerative diseases. While daily exposure to UV light, air pollution, and smoke largely contribute to oxidative stress, endogenous antioxidants mostly fail to neutralize these high amounts of free radicals. Stevia rebaudiana or “candyleaf” is largely found in Indonesia, known for its application as a natural sweetener, owing to its content of stevioside compound. This study is experimental research which aims to assess the potential of stevia extract as an antioxidant supplement, which has not been widely applied. In vitro study was performed by extracting stevia leaves in methanol through simple maceration and percolation methods. Subsequently, the stevia extract was subjected to biochemical analysis, i.e. phytochemical screening, total phenolic content assay, antioxidant capacity assay, and toxicity assay. Herein, we found that stevia extract contains flavonoid, saponin, tannin, terpenoid, and phenolic compounds, with total phenolic content of 86.30±1.14 mg GAE/g DW. Moreover, antioxidant capacity assay through 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method showed that IC50 of stevia extract is 20.13 µg/mL, slightly higher than Trolox (vitamin E analog) with IC50 of 16.50 µg/mL, which indicated that stevia extract is a very strong antioxidant. As for toxicity bioassay, Brine Shrimp Lethality Test indicated that stevia extract is non-toxic with LC50 value of 3388.44 µg/mL.
PROGRAM PENGABDIAN MASYARAKAT UNTUK MENINGKATKAN PENGETAHUAN MENGENAI PENYAKIT GINJAL KRONIS MELALUI EDUKASI SKRINING FUNGSI GINJAL Hendrawan, Siufui; Alvianto, Fidelia; Lumintang, Valentino Gilbert
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2024): Volume 5 No. 3 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i3.29755

Abstract

Penyakit Ginjal Kronis (PGK) merupakan kondisi medis yang ditandai dengan penurunan fungsi ginjal yang berlangsung lebih dari tiga bulan, yang dapat berkembang menjadi gagal ginjal kronis. Kegiatan pengabdian masyarakat ini bertujuan untuk melakukan skrining fungsi ginjal dan edukasi mengenai PGK dengan tujuan meningkatkan kesadaran dan deteksi dini PGK pada populasi lanjut usia. Metode PDCA diterapkan dalam kegiatan ini yang dilaksanakan dengan melakukan sesi edukasi dan skrining fungsi ginjal. Hasil skrining menunjukkan rata-rata usia peserta 74,05 tahun dengan 20,4% laki-laki dan 79,6% perempuan. Sebanyak 86% memiliki kadar kreatinin normal, sementara 14% mengalami hiperkreatininemia. Laju filtrasi glomerulus (eLFG) rata-rata adalah 62,89 mL/menit/1,73 m², dengan 50,5% responden memiliki eLFG normal dan 49,5% mengalami penurunan eLFG. Analisis jenis kelamin menunjukkan 84,2% laki-laki dan 86,5% perempuan memiliki kadar kreatinin normal, dengan 15,8% laki-laki dan 13,5% perempuan mengalami hiperkreatininemia. Hasil ini menekankan pentingnya pemantauan rutin fungsi ginjal dan edukasi kesehatan dalam upaya pencegahan dan manajemen PGK pada lansia, sehingga diharapkan dapat terjadi peningkatan kualitas hidup dan pengurangan risiko komplikasi PGK pada lansia.
Analisis Fitokimia, Aktivitas Antioksidan dan Toksisitas Ekstrak Metanol Daun Kucai (Allium schoenoprasum) secara In Vitro Tanowijono, Gabriella Frederica; Hendrawan, Siufui; Ferdinal, Frans
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 7, No 2 (2025): November 2025
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v7i2.6682

Abstract

The development of degenerative diseases is influenced by oxidative stress, which stems from an imbalance between free radicals and the body’s antioxidant defenses. Therefore, natural antioxidant supplementation is considered an essential preventive strategy. Chives leaves (Allium schoenoprasum) are functional foods containing various bioactive compounds; however, their potential as natural antioxidants remains underexplored. This study aims to evaluate the antioxidant activity and toxicity profile of the extract through in vitro assays. The extraction process using maceration and percolation techniques with methanol as the solvent. The analytical procedures encompassed phytochemical profiling, quantification of total phenolic compounds using the Folin–Ciocalteu reagent, and antioxidant capacity evaluations utilizing the Ferric Reducing Antioxidant Power (FRAP) and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)). The resulting total phenolic content of 439.45 μg/mL, equivalent to 14.65 mg gallic acid equivalent (GAE) per gram of dry weight (DW). The IC₅₀ values were 21.93 μg/mL (ABTS) and 13.06 μg/mL (FRAP), indicating strong antioxidant activity. Toxicity assessment using the Brine Shrimp Lethality Test yielded an LC₅₀ value of 333.86 μg/mL, suggesting low toxicity.  These results indicate that the extract holds a great promise as a safe and effective source of natural antioxidants.
UJI PROFIL FITOKIMIA, KAPASITAS ANTIOKSIDAN, DAN TOKSISITAS EKSTRAK METANOL DAUN TAPAK LIMAN (Elephantopus scaber L.) Hartono, Daniswara Aliya; Hendrawan, Siufui; Ferdinal, Frans
EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Vol 6, No 2 (2025)
Publisher : FKIP Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/edunaturalia.v6i2.98715

Abstract

Exposure to environmental pollutants leads to the accumulation of free radicals, overbalancing endogenous antioxidant, and exacerbating oxidative stress level within the body. Oxidative stress is one of primary factors causing numerous health issues, such as aging, cardiovascular, and neurodegenerative disorders, highlighting the need for additional antioxidant supplementation. Elephantopus scaber L., known as tapak liman, is a medicinal plant traditionally utilized to manage diseases, including malaria, anemia, and skin infections. However, its potential as an antioxidant supplement remains underexplored. This research investigates the methanol extract of tapak liman leaves, evaluating its phytochemical content, antioxidant activity, and toxicity. Phytochemical screening identified various secondary metabolites, such as of alkaloids, flavonoids, cardiac glycosides, coumarins, phenolics, quinones, betacyanins, tannins, and saponins. Total phenolic content was found at 17,22 ± 0,15 mg GAE/g. Antioxidant capacity was assessed using ABTS (2,2-azinobis-3-etilbenzotiazolin-6-sulfonat) and FRAP (Ferric Reducing Antioxidant Power) assays, resulting IC50 values of 18,78 µg/mL and 19,26 µg/mL, respectively. These values indicated very strong antioxidant activity, slightly higher than those of Trolox® as a vitamin E analog, which showed IC50 values of 13,27 µg/mL (ABTS) and 10,42 µg/mL (FRAP). Toxicity evaluation through brine shrimp lethality test displayed an LC50 of 394,54 µg/mL, indicating moderate toxicity and potential antimitotic activity, which may correlate with anticancer properties. Owing to its vast bioactive components and strong antioxidant capacity, tapak liman leaf extract demonstrates potential as a safe and effective natural antioxidant agent for further development.
Co-Authors Alexander Halim Santoso Alvianto, Fidelia Alvionica, Selina Anggita Tamaro Ani R. Prijanti Bayu Ifana, Shomadya Chesia Angelina Chrispian Oktafbipian Mamudi, Chrispian Oktafbipian Destra, Edwin Edwin Destra Enny Yulianti, Enny Erma Mexcorry Sumbayak Felix Felix Frankson, Desvin Frans Ferdinal Gaofman, Brian Albert Gracienne, Gracienne Gunaidi, Farell Christian Hariesti, Ribka Anggeline Hartono, Daniswara Aliya Hartono, Eric Hawari, Irawati Hendsun, Hendsun Ida Ayu Putu Sri Widnyani Jeffry Luwito Kartika, Ronald Winardi Khoto, Anthon Eka Prayoga Kusuma, Kanaya Fide Lumintang, Valentino Gilbert Mohamad Sadikin Nathaniel, Fernando Pasa, Muhamad Alvin Putra Pati, Vanessa Irenea Santoso, Alexander Halim Satyanegara, William Gilbert Septelia I. Wanandi Setiawan, Fiona Valencia Soeltanong, Dianova Sri W.A. Jusman Tamaro, Anggita Tanowijono, Gabriella Frederica Tirtasari, Silviana Wijaya, Dean Ascha Wijaya Yohanes Firmansyah Zefiro Letius, Fairuz